Synthesis, crystal structure and anticancer activity of the complex chlorido(η2-ethylene)(quinolin-8-olato-κ2 N,O)platinum(II) by experimental and theoretical methods DOI Creative Commons
Nguyễn Thị Thanh,

Ngo Tuan Cuong,

Tran Thu Trang

et al.

Acta Crystallographica Section E Crystallographic Communications, Journal Year: 2024, Volume and Issue: 80(5), P. 550 - 554

Published: April 30, 2024

The complex [Pt(C

Language: Английский

Quinoline-based metal complexes: Synthesis and applications DOI
Rohit Kumar, Ankita Thakur,

Sachin

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 499, P. 215453 - 215453

Published: Oct. 24, 2023

Language: Английский

Citations

20

Synthesis and anticancer mechanisms of zinc(ii)-8-hydroxyquinoline complexes with 1,10-phenanthroline ancillary ligands DOI

Ling-Qi Du,

Tianyu Zhang, Xiaomei Huang

et al.

Dalton Transactions, Journal Year: 2023, Volume and Issue: 52(15), P. 4737 - 4751

Published: Jan. 1, 2023

Twenty new zinc(II) complexes with 8-hydroxyquinoline (H-Q1-H-Q6) in the presence of 1,10-phenanthroline derivatives (D1-D10) were synthesized and formulated as [Zn(Q1)2(D1)] (DQ1), [Zn(Q2)2(D2)]·CH3OH (DQ2), [Zn(Q1)2(D3)] (DQ3), [Zn(Q1)2(D4)] (DQ4), [Zn(Q3)2(D5)] (DQ5), [Zn(Q3)2(D4)] (DQ6), [Zn(Q4)2(D5)]·CH3OH (DQ7), [Zn(Q4)2(D6)] (DQ8), [Zn(Q4)2(D3)]·CH3OH (DQ9), [Zn(Q4)2(D1)]·H2O (DQ10), [Zn(Q5)2(D4)] (DQ11), [Zn(Q6)2(D6)]·CH3OH (DQ12), [Zn(Q5)2(D2)]·5CH3OH·H2O (DQ13), [Zn(Q5)2(D7)]·CH3OH (DQ14), [Zn(Q5)2(D8)]·CH2Cl2 (DQ15), [Zn(Q5)2(D9)] (DQ16), [Zn(Q5)2(D1)] (DQ17), [Zn(Q5)2(D5)] (DQ18), [Zn(Q5)2(D10)]·CH2Cl2 (DQ19) [Zn(Q5)2(D3)] (DQ20). They characterized using multiple techniques. The cytotoxicity DQ1-DQ20 was screened human cisplatin-resistant SK-OV-3/DDP ovarian cancer (SK-OV-3CR) cells normal hepatocyte (HL-7702) cells. Complex DQ6 showed low IC50 values (2.25 ± 0.13 μM) on SK-OV-3CR cells, more than 3.0-8.0 times cytotoxic DQ1-DQ5 DQ7-DQ20 (≥6.78 μM), even 22.2 standard cisplatin, corresponding free H-Q1-H-Q6 D1-D10 alone (>50 μM). As a comparison, displayed nontoxic rates against healthy HL-7702 Furthermore, DQ11 induced significant apoptosis via mitophagy pathways. also significantly inhibited tumor growth an vivo SK-OV-3-xenograft model (ca. 49.7%). Thus, may serve lead complex for discovery antitumor agents.

Language: Английский

Citations

19

Antitumor studies evaluation of triphenylphosphine ruthenium complexes with 5,7-dihalo-substituted-8-quinolinoline targeting mitophagy pathways DOI
Zhenfeng Wang, Xiaoqiong Huang,

Run-Chun Wu

et al.

Journal of Inorganic Biochemistry, Journal Year: 2023, Volume and Issue: 248, P. 112361 - 112361

Published: Aug. 25, 2023

Language: Английский

Citations

11

8-hydroxyquinoline-N-oxide copper(II)- and zinc(II)-phenanthroline and bipyridine coordination compounds: Design, synthesis, structures, and antitumor evaluation DOI

Ling-Qi Du,

Chujie Zeng,

Dong-Yin Mo

et al.

Journal of Inorganic Biochemistry, Journal Year: 2023, Volume and Issue: 251, P. 112443 - 112443

Published: Dec. 2, 2023

Language: Английский

Citations

10

Synthesis, transformations and biological evaluation of 5-chloro-8-hydroxyquinoline hybrids DOI Creative Commons

Dóra Hegedűs,

Nikoletta Szemerédi,

Dorka Gubó

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107084 - 107084

Published: April 1, 2025

Language: Английский

Citations

0

Synthesis, characterization and anticancer evaluation for Cu(II) complexes through in-situ reaction syntheses DOI
Yating Chen,

Xueyang Hu,

Lingyu Yuan

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142499 - 142499

Published: April 1, 2025

Language: Английский

Citations

0

Hydrazylpyridine salicylaldehyde–copper(ii)–1,10-phenanthroline complexes as potential anticancer agents: synthesis, characterization and anticancer evaluation DOI
Yating Chen,

Zhilin Ke,

Lingyu Yuan

et al.

Dalton Transactions, Journal Year: 2023, Volume and Issue: 52(35), P. 12318 - 12331

Published: Jan. 1, 2023

We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde 1,10-phenanthroline complexes, [Cu(L1a)(phen)] (Cugdupt1), [Cu(L2a)(phen)]·(CH3CN) (Cugdupt2), [Cu(L3a)(phen)] (Cugdupt3), [Cu(L4a)(phen)]·(CH3CN) (Cugdupt4), [Cu(L5a)(phen)] (Cugdupt5), [Cu(L6a)(phen)] (Cugdupt6), [Cu(L7a)(phen)] (Cugdupt7) [Cu(L8a)(phen)] (Cugdupt8) [Cu(L9a)(phen)]·0.5(H2O) (Cugdupt9). were motivated by the intriguing properties of coupled ligands hydrazylpyridine, salicylaldehyde, 1,10-phenanthroline. The MTT assay demonstrated that Cugdupt1-Cugdupt9 have higher anticancer activity than L1H2-L9H2, phen cisplatin on A549/DDP cancer cells (A549cis). superior to with IC50 values 1.6-100.0 fold A549cis (IC50(Cugdupt1-Cugdupt9) = 0.5-30.5 μM, IC50(cisplatin) 61.5 ± 1.0 μM). However, had lower cytotoxicity toward HL-7702 normal cells. Cugdupt1 Cugdupt8 can induce reduction mitochondrial respiratory chain complexes I/IV (MRCC-I/IV), mitophagy pathways, eventually protein regulation adenosine triphosphate (ATP) depletion in findings indicated caused cell death via both ATP diminution pathways. Finally, high efficacy no obvious A549 tumor-bearing mice. This study thus helps evaluate potential salicylaldehyde-copper(II)-1,10-phenanthroline compounds for cisplatin-resistant tumor therapy.

Language: Английский

Citations

9

Investigation on Cytotoxicity Against Lung Carcinoma Cell Line at New Metallacyclic Complexes of Titanium(IV) Incorporated With β‐Diketone and 4‐(1,4,5‐Triphenyl‐1H‐Imidazol‐2‐Yl) Benzene‐1,2‐Diol Derivatives DOI
Sathish Thanigachalam, Mahabarathi Subramaniyan, Shivabasayya V. Salimath

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(6)

Published: May 25, 2025

ABSTRACT A series of eight heteroleptic derivatives titanium(IV) has been synthesized and characterized systematically employing physico‐chemical methods. Derivatives Ti 1 [(C 37 H 32 N 2 O 6 )Ti], 38 34 3 31 FN 4 ClN 5 BrN 8 7 F )Ti] were developed by refluxing an anhydrous benzene solution Ti(OPr i ) , acetylacetone, appropriate bidentate ligands (L ‑L in 1:2:1 stoichiometry. The electronic structure properties complexes (Ti ‑Ti studied density functional theory (DFT). UV–Visible method was used to determine the stability at periodic intervals. Binding interactions bovine serum albumin (BSA) calf thymus DNA (CT‐DNA) with corresponding assessed spectroscopic techniques such as absorption, fluorescence, circular dichroism have established intercalation static quenching for BSA effective manner. docking investigations also revealed that ‐Ti are well engaged via intercalative mode favorably occupy active site protein through hydrogen bonding. Furthermore, cytotoxicity against A549 (lung carcinoma) cell lines MTT (methylthiazolyldiphenyl‐tetrazolium) assay, IC 50 values found be range from 16.77 75.60 μM. displayed significant apoptosis induced cycle arrest G phase line.

Language: Английский

Citations

0

Synthesis and anticancer mechanisms of nickel(II)-2-amino-8-quinolinol complexes with 2,2′-bipyridine ancillary ligands DOI
Zhen Zhou,

Ling-Qi Du,

Dong- Yin Mo

et al.

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 152, P. 110712 - 110712

Published: April 8, 2023

Language: Английский

Citations

6

Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways DOI
Xiaoqiong Huang,

Run-Chun Wu,

Jianmin Liang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 272, P. 116478 - 116478

Published: May 4, 2024

Language: Английский

Citations

2