Dalton Transactions,
Journal Year:
2023,
Volume and Issue:
52(15), P. 4737 - 4751
Published: Jan. 1, 2023
Twenty
new
zinc(II)
complexes
with
8-hydroxyquinoline
(H-Q1-H-Q6)
in
the
presence
of
1,10-phenanthroline
derivatives
(D1-D10)
were
synthesized
and
formulated
as
[Zn(Q1)2(D1)]
(DQ1),
[Zn(Q2)2(D2)]·CH3OH
(DQ2),
[Zn(Q1)2(D3)]
(DQ3),
[Zn(Q1)2(D4)]
(DQ4),
[Zn(Q3)2(D5)]
(DQ5),
[Zn(Q3)2(D4)]
(DQ6),
[Zn(Q4)2(D5)]·CH3OH
(DQ7),
[Zn(Q4)2(D6)]
(DQ8),
[Zn(Q4)2(D3)]·CH3OH
(DQ9),
[Zn(Q4)2(D1)]·H2O
(DQ10),
[Zn(Q5)2(D4)]
(DQ11),
[Zn(Q6)2(D6)]·CH3OH
(DQ12),
[Zn(Q5)2(D2)]·5CH3OH·H2O
(DQ13),
[Zn(Q5)2(D7)]·CH3OH
(DQ14),
[Zn(Q5)2(D8)]·CH2Cl2
(DQ15),
[Zn(Q5)2(D9)]
(DQ16),
[Zn(Q5)2(D1)]
(DQ17),
[Zn(Q5)2(D5)]
(DQ18),
[Zn(Q5)2(D10)]·CH2Cl2
(DQ19)
[Zn(Q5)2(D3)]
(DQ20).
They
characterized
using
multiple
techniques.
The
cytotoxicity
DQ1-DQ20
was
screened
human
cisplatin-resistant
SK-OV-3/DDP
ovarian
cancer
(SK-OV-3CR)
cells
normal
hepatocyte
(HL-7702)
cells.
Complex
DQ6
showed
low
IC50
values
(2.25
±
0.13
μM)
on
SK-OV-3CR
cells,
more
than
3.0-8.0
times
cytotoxic
DQ1-DQ5
DQ7-DQ20
(≥6.78
μM),
even
22.2
standard
cisplatin,
corresponding
free
H-Q1-H-Q6
D1-D10
alone
(>50
μM).
As
a
comparison,
displayed
nontoxic
rates
against
healthy
HL-7702
Furthermore,
DQ11
induced
significant
apoptosis
via
mitophagy
pathways.
also
significantly
inhibited
tumor
growth
an
vivo
SK-OV-3-xenograft
model
(ca.
49.7%).
Thus,
may
serve
lead
complex
for
discovery
antitumor
agents.
Dalton Transactions,
Journal Year:
2023,
Volume and Issue:
52(35), P. 12318 - 12331
Published: Jan. 1, 2023
We
synthesized
and
analyzed
nine
unique
copper(II)
hydrazylpyridine
salicylaldehyde
1,10-phenanthroline
complexes,
[Cu(L1a)(phen)]
(Cugdupt1),
[Cu(L2a)(phen)]·(CH3CN)
(Cugdupt2),
[Cu(L3a)(phen)]
(Cugdupt3),
[Cu(L4a)(phen)]·(CH3CN)
(Cugdupt4),
[Cu(L5a)(phen)]
(Cugdupt5),
[Cu(L6a)(phen)]
(Cugdupt6),
[Cu(L7a)(phen)]
(Cugdupt7)
[Cu(L8a)(phen)]
(Cugdupt8)
[Cu(L9a)(phen)]·0.5(H2O)
(Cugdupt9).
were
motivated
by
the
intriguing
properties
of
coupled
ligands
hydrazylpyridine,
salicylaldehyde,
1,10-phenanthroline.
The
MTT
assay
demonstrated
that
Cugdupt1-Cugdupt9
have
higher
anticancer
activity
than
L1H2-L9H2,
phen
cisplatin
on
A549/DDP
cancer
cells
(A549cis).
superior
to
with
IC50
values
1.6-100.0
fold
A549cis
(IC50(Cugdupt1-Cugdupt9)
=
0.5-30.5
μM,
IC50(cisplatin)
61.5
±
1.0
μM).
However,
had
lower
cytotoxicity
toward
HL-7702
normal
cells.
Cugdupt1
Cugdupt8
can
induce
reduction
mitochondrial
respiratory
chain
complexes
I/IV
(MRCC-I/IV),
mitophagy
pathways,
eventually
protein
regulation
adenosine
triphosphate
(ATP)
depletion
in
findings
indicated
caused
cell
death
via
both
ATP
diminution
pathways.
Finally,
high
efficacy
no
obvious
A549
tumor-bearing
mice.
This
study
thus
helps
evaluate
potential
salicylaldehyde-copper(II)-1,10-phenanthroline
compounds
for
cisplatin-resistant
tumor
therapy.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(6)
Published: May 25, 2025
ABSTRACT
A
series
of
eight
heteroleptic
derivatives
titanium(IV)
has
been
synthesized
and
characterized
systematically
employing
physico‐chemical
methods.
Derivatives
Ti
1
[(C
37
H
32
N
2
O
6
)Ti],
38
34
3
31
FN
4
ClN
5
BrN
8
7
F
)Ti]
were
developed
by
refluxing
an
anhydrous
benzene
solution
Ti(OPr
i
)
,
acetylacetone,
appropriate
bidentate
ligands
(L
‑L
in
1:2:1
stoichiometry.
The
electronic
structure
properties
complexes
(Ti
‑Ti
studied
density
functional
theory
(DFT).
UV–Visible
method
was
used
to
determine
the
stability
at
periodic
intervals.
Binding
interactions
bovine
serum
albumin
(BSA)
calf
thymus
DNA
(CT‐DNA)
with
corresponding
assessed
spectroscopic
techniques
such
as
absorption,
fluorescence,
circular
dichroism
have
established
intercalation
static
quenching
for
BSA
effective
manner.
docking
investigations
also
revealed
that
‐Ti
are
well
engaged
via
intercalative
mode
favorably
occupy
active
site
protein
through
hydrogen
bonding.
Furthermore,
cytotoxicity
against
A549
(lung
carcinoma)
cell
lines
MTT
(methylthiazolyldiphenyl‐tetrazolium)
assay,
IC
50
values
found
be
range
from
16.77
75.60
μM.
displayed
significant
apoptosis
induced
cycle
arrest
G
phase
line.
