
Acta Crystallographica Section E Crystallographic Communications, Journal Year: 2024, Volume and Issue: 80(5), P. 550 - 554
Published: April 30, 2024
The complex [Pt(C
Language: Английский
Acta Crystallographica Section E Crystallographic Communications, Journal Year: 2024, Volume and Issue: 80(5), P. 550 - 554
Published: April 30, 2024
The complex [Pt(C
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 499, P. 215453 - 215453
Published: Oct. 24, 2023
Language: Английский
Citations
20Dalton Transactions, Journal Year: 2023, Volume and Issue: 52(15), P. 4737 - 4751
Published: Jan. 1, 2023
Twenty new zinc(II) complexes with 8-hydroxyquinoline (H-Q1-H-Q6) in the presence of 1,10-phenanthroline derivatives (D1-D10) were synthesized and formulated as [Zn(Q1)2(D1)] (DQ1), [Zn(Q2)2(D2)]·CH3OH (DQ2), [Zn(Q1)2(D3)] (DQ3), [Zn(Q1)2(D4)] (DQ4), [Zn(Q3)2(D5)] (DQ5), [Zn(Q3)2(D4)] (DQ6), [Zn(Q4)2(D5)]·CH3OH (DQ7), [Zn(Q4)2(D6)] (DQ8), [Zn(Q4)2(D3)]·CH3OH (DQ9), [Zn(Q4)2(D1)]·H2O (DQ10), [Zn(Q5)2(D4)] (DQ11), [Zn(Q6)2(D6)]·CH3OH (DQ12), [Zn(Q5)2(D2)]·5CH3OH·H2O (DQ13), [Zn(Q5)2(D7)]·CH3OH (DQ14), [Zn(Q5)2(D8)]·CH2Cl2 (DQ15), [Zn(Q5)2(D9)] (DQ16), [Zn(Q5)2(D1)] (DQ17), [Zn(Q5)2(D5)] (DQ18), [Zn(Q5)2(D10)]·CH2Cl2 (DQ19) [Zn(Q5)2(D3)] (DQ20). They characterized using multiple techniques. The cytotoxicity DQ1-DQ20 was screened human cisplatin-resistant SK-OV-3/DDP ovarian cancer (SK-OV-3CR) cells normal hepatocyte (HL-7702) cells. Complex DQ6 showed low IC50 values (2.25 ± 0.13 μM) on SK-OV-3CR cells, more than 3.0-8.0 times cytotoxic DQ1-DQ5 DQ7-DQ20 (≥6.78 μM), even 22.2 standard cisplatin, corresponding free H-Q1-H-Q6 D1-D10 alone (>50 μM). As a comparison, displayed nontoxic rates against healthy HL-7702 Furthermore, DQ11 induced significant apoptosis via mitophagy pathways. also significantly inhibited tumor growth an vivo SK-OV-3-xenograft model (ca. 49.7%). Thus, may serve lead complex for discovery antitumor agents.
Language: Английский
Citations
19Journal of Inorganic Biochemistry, Journal Year: 2023, Volume and Issue: 248, P. 112361 - 112361
Published: Aug. 25, 2023
Language: Английский
Citations
11Journal of Inorganic Biochemistry, Journal Year: 2023, Volume and Issue: 251, P. 112443 - 112443
Published: Dec. 2, 2023
Language: Английский
Citations
10European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107084 - 107084
Published: April 1, 2025
Language: Английский
Citations
0Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142499 - 142499
Published: April 1, 2025
Language: Английский
Citations
0Dalton Transactions, Journal Year: 2023, Volume and Issue: 52(35), P. 12318 - 12331
Published: Jan. 1, 2023
We synthesized and analyzed nine unique copper(II) hydrazylpyridine salicylaldehyde 1,10-phenanthroline complexes, [Cu(L1a)(phen)] (Cugdupt1), [Cu(L2a)(phen)]·(CH3CN) (Cugdupt2), [Cu(L3a)(phen)] (Cugdupt3), [Cu(L4a)(phen)]·(CH3CN) (Cugdupt4), [Cu(L5a)(phen)] (Cugdupt5), [Cu(L6a)(phen)] (Cugdupt6), [Cu(L7a)(phen)] (Cugdupt7) [Cu(L8a)(phen)] (Cugdupt8) [Cu(L9a)(phen)]·0.5(H2O) (Cugdupt9). were motivated by the intriguing properties of coupled ligands hydrazylpyridine, salicylaldehyde, 1,10-phenanthroline. The MTT assay demonstrated that Cugdupt1-Cugdupt9 have higher anticancer activity than L1H2-L9H2, phen cisplatin on A549/DDP cancer cells (A549cis). superior to with IC50 values 1.6-100.0 fold A549cis (IC50(Cugdupt1-Cugdupt9) = 0.5-30.5 μM, IC50(cisplatin) 61.5 ± 1.0 μM). However, had lower cytotoxicity toward HL-7702 normal cells. Cugdupt1 Cugdupt8 can induce reduction mitochondrial respiratory chain complexes I/IV (MRCC-I/IV), mitophagy pathways, eventually protein regulation adenosine triphosphate (ATP) depletion in findings indicated caused cell death via both ATP diminution pathways. Finally, high efficacy no obvious A549 tumor-bearing mice. This study thus helps evaluate potential salicylaldehyde-copper(II)-1,10-phenanthroline compounds for cisplatin-resistant tumor therapy.
Language: Английский
Citations
9Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(6)
Published: May 25, 2025
ABSTRACT A series of eight heteroleptic derivatives titanium(IV) has been synthesized and characterized systematically employing physico‐chemical methods. Derivatives Ti 1 [(C 37 H 32 N 2 O 6 )Ti], 38 34 3 31 FN 4 ClN 5 BrN 8 7 F )Ti] were developed by refluxing an anhydrous benzene solution Ti(OPr i ) , acetylacetone, appropriate bidentate ligands (L ‑L in 1:2:1 stoichiometry. The electronic structure properties complexes (Ti ‑Ti studied density functional theory (DFT). UV–Visible method was used to determine the stability at periodic intervals. Binding interactions bovine serum albumin (BSA) calf thymus DNA (CT‐DNA) with corresponding assessed spectroscopic techniques such as absorption, fluorescence, circular dichroism have established intercalation static quenching for BSA effective manner. docking investigations also revealed that ‐Ti are well engaged via intercalative mode favorably occupy active site protein through hydrogen bonding. Furthermore, cytotoxicity against A549 (lung carcinoma) cell lines MTT (methylthiazolyldiphenyl‐tetrazolium) assay, IC 50 values found be range from 16.77 75.60 μM. displayed significant apoptosis induced cycle arrest G phase line.
Language: Английский
Citations
0Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 152, P. 110712 - 110712
Published: April 8, 2023
Language: Английский
Citations
6European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 272, P. 116478 - 116478
Published: May 4, 2024
Language: Английский
Citations
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