Long COVID: a clinical update

The Lancet, Journal Year: 2024, Volume and Issue: 404(10453), P. 707 - 724

Published: July 31, 2024

Language: Английский

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Immune Cells, Gut Microbiota, and Vaccines: A Gender Perspective

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 526 - 526

Published: March 17, 2024

The development of preventive and therapeutic vaccines has played a crucial role in preventing infections treating chronic non-communicable diseases, respectively. For long time, the influence sex differences on modifying health disease not been addressed clinical preclinical studies. interaction genetic, epigenetic, hormonal factors plays sex-related epidemiology manifestations, response to treatment. Moreover, is one leading influencing gut microbiota composition, which could further explain different predisposition diseases men women. In same way, between sexes occur also immune vaccines. This narrative review aims highlight these differences, focusing Comparative data about responses, vaccine effectiveness, side effects are reviewed. Hence, intricate interplay sex, immunity, will be discussed for its potential vaccination. Embracing sex-oriented perspective research may improve efficacy allow design tailored schedules.

Language: Английский

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Intimate neoliberal violence and ungrievable meno bodies

Journal of Marketing Management, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: Feb. 24, 2025

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Menstrual disorders following COVID-19 vaccination: a review using a systematic search

Frontiers in Drug Safety and Regulation, Journal Year: 2024, Volume and Issue: 4

Published: Jan. 31, 2024

Introduction: Menstrual disorders are commonly reported after COVID-19 vaccination and heavy menstrual bleeding was added to the product information of vaccines Moderna Pfizer. The aim this review, using a systematic search, is provide an overview available literature on risk vaccination. Methods: review conducted according Preferred Reporting Items for Systematic reviews Meta-Analysis (PRISMA) guidelines. A PubMed search performed 15 August 2023, including solely quantitative studies in English Dutch. Results: total 61 were included, which 40 cross-sectional studies, 18 cohort three self-controlled case series. Outcomes included wide variety disorders, changes cycle length ( n = 54), amount 44), menses 30), experience (pre)menstrual pain 21), breakthrough 18). All found higher percentage at least one disorder first different types doses. Discussion: In conclusion, evidence suggests that may cause women reproductive age. However, there need more longitudinal because important limitations study designs many studies. Although short-lived predominantly mild, it healthcare professionals be informed about these potential adverse reactions assess events clinical trials vaccines.

Language: Английский

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Factors associated with menstrual-related disturbances following SARS-CoV-2 vaccination: a Spanish retrospective observational study in formerly menstruating women

Women & Health, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Jan. 17, 2025

A growing body of evidence suggests a potential link between the SARS-CoV-2 vaccine and menstrual changes in women who were menstruating at time vaccination. Nevertheless, prevalence this event those with secondary amenorrhea for different causes, i.e. formerly women, remains unclear. It is plausible that, analogous to observed currently they experienced some degree alteration their reproductive health, defined here as menstrual-related disturbances. The aim was analyze phenomenon identify factors associated occurrence disturbances subpopulation. Study design: retrospective observational cross-sectional study conducted among adult Spanish December 2021 using an online survey (N = 17,512). present analysis includes subpopulation vaccinated 548). General characteristics, medical history, adverse events following COVID-19 vaccination recorded. Chi-square, Mann-Whitney U McNemar mid-P tests performed. Bivariate logistic regression then used key influencing unexpected event. In comparison first dose, significantly higher percentages respondents (dose 1: 38.5 percent vs. dose 2: 44.8 percent) after receiving second one. Among them, related length flow stand out, being long-term nature about 17-20 cases. Interindividual 1 may include weight, perimenopause, preexisting diagnoses non-autoimmune rheumatic/articular conditions, use hormonal contraceptives, suffering from other side effects - such arm pain number previous pregnancies; 2, these alterations 1, well contraceptives perimenopause. Formerly might experience Potential pregnancies.

Language: Английский

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Network analysis of adverse event patterns following immunization with mRNA COVID-19 vaccines: real-world data from the European pharmacovigilance database EudraVigilance

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 19, 2025

To analyses real-world safety data of mRNA COVID-19 vaccines within the European Economic Area (EEA), using Individual Case Safety Reports (ICSR), and to evaluate variability in profiles between different vaccine versions. We utilized EudraVigilance from 1 January 2020, 31 December 2023, focusing on Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) against COVID-19. performed descriptive statistics, co-occurrence analysis, correspondence analysis identify patterns clusters adverse events following immunization (AEFI). retrieved 993,199 ICSR (Moderna: 394,484; Pfizer: 605,794), with most reports related women patients (69%) non-healthcare professionals (65%). A total 10,804 distinct AEFI terms were described across ICSR, a cumulative occurrence frequency 3,558,219 1,555,638; 2,031,828). The prominent serious included headache, fatigue, pyrexia, myalgia, arthralgia, malaise, nausea, chills, which frequently co-occurred vaccination failure. Specific like fever, injection site pain, inflammation, warmth more often linked Moderna, while Pfizer was commonly associated failure, menstrual disorders (heavy bleeding dysmenorrhea), hypoesthesia. In older adults, confusional states, cerebrovascular accidents, myocardial infarctions, myocarditis pericarditis noted younger males. Although rare, systemic AEFI, anaphylactic reactions, identified but require further causality evaluation. overall for mass is supported, continuous pharmacovigilance remains essential. Identified particularly ones, although rare potentially influenced by other underlying causes, underscore need monitoring epidemiological investigations explore potential causal relationships.

Language: Английский

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Menstrual disturbance associated with COVID-19 vaccines: A comprehensive systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0320162 - e0320162

Published: May 16, 2025

Background The relationship between COVID-19 vaccines and menstrual disturbance is unclear, in part because researchers have measured different outcomes (e.g., delays vs. changes to cycle length) with various study designs. Menstrual disruption could be a decisive factor people’s willingness accept the vaccine. Methods We searched Medline, Embase, Web of Science for studies investigating length, flow volume, post-menopausal bleeding, unexpected or intermenstrual bleeding. Data were analyzed using fixed-effects meta-analysis Shore’s adjusted confidence intervals heterogeneity. Findings Seventeen >1·9 million participants analyzed. found 19% greater risk increase length as compared unvaccinated people pre-vaccination time-periods (summary relative (sRR): 1·19; 95% CI: 1·11–1·26; n = 23,718 participants). was same Pfizer-BioNTech (sRR: 1·15; 1·05–1·27; 16,595) Moderna 1·05–1·25; 7,523), similar AstraZeneca 1·27; 1·02–1·59; 532), higher Janssen 1·69; 1·14–2·52; 751) In first after vaccination, increased by <half-day mean difference (sMD): 0·34 days; 0·21–0·46 30,320) dose 0·62 days (sMD: 0·62: 0·41–0·82; 17,608) second dose. not elevated –0·02; –0·16–0·12; 18,602). 7–9% but statistically insignificant heavier flow; 7% bleeding (first dose: 1·07; 1·01–1·12; 1,321,268 1·03–1·11; 1,482,884); 16–41% 1·16; 0·83–1·61; 1,303,687 1·41; 0·99–2·01; 1,390,317). Interpretation observed mild associated vaccines. Such risks are likely clinically unmeaningful. Vaccine recipients should appropriately counseled.

Language: Английский

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Adverse Menstrual Events Reported After and Before (or Without) COVID‐19 Vaccination: A Systematic Review and Meta‐Analysis of Comparative Observational Studies

Pharmacoepidemiology and Drug Safety, Journal Year: 2024, Volume and Issue: 33(8)

Published: Aug. 1, 2024

ABSTRACT Background Reports of adverse menstrual events emerged during the COVID‐19 vaccination campaign in multiple countries. This raised question whether these reports were caused by vaccines. The aim this systematic review was to evaluate comparative studies on topic (registered at PROSPERO [CRD42022324973]). Methods We included observational such as cohort and surveys comparing response self‐reported questionnaires between post‐ versus pre‐vaccination data. PubMed Cochrane Library searches conducted 1 September 2023. primary outcome incidence any prespecified event, measure risk ratio. meta‐analysis using Mantel–Haenszel method random effects model. summarized results factors well key findings included. Results retrieved 161 references from electronic databases additional sources lists. Of those, we considered 21 studies. event reported 12 resulted a pooled estimate (risk ratio 1.13; 95% CI, 0.96–1.31) that did not favor group. analysis constrained considerable clinical statistical heterogeneity. Risk for changes history infection, concern about vaccines, smoking, previous cycle irregularities, depression, stress, other issues. Conclusions group heterogeneity prevalent among Most suggested temporary, minor, nonserious.

Language: Английский

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Examining the effect of COVID-19 vaccines on the menstrual cycle: A study from Turkey

Medicine, Journal Year: 2023, Volume and Issue: 102(50), P. e36638 - e36638

Published: Dec. 15, 2023

Concerns about a possible relationship between vaccination against Coronavirus Disease 2019 (COVID-19) and menstrual disorders have been raised in the media. In addition, different studies shown that COVID-19 vaccine may be associated with changes. This study was conducted to investigate effects of vaccines on cycle women. cross-sectional descriptive August 16 September 17, 2021. Data were collected through self-administered questionnaire via an online form sent participants social 586 women included this study. A total 82.4% (n = 483) aged 31 50 years. The BioNTech (2 doses) administered 75.8% 444), Sinovac (3 9.0% 53) participants. 53.1% 311) experienced changes their cycles. most common after delayed menstruation 176; 30.0%) prolonged duration 132; 22.5%). Menstrual delay, duration, heavy bleeding, early more than prior receiving (P < .05). More half vaccine. Women significantly higher rates bleeding compared before vaccination.

Language: Английский

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COMPLICACIONES DE LA VACUNA CHADOX1 EN PACIENTES CON ENFERMEDADES CARDIOVASCULARES: REVISIÓN BIBLIOGRÁFICA.

International Journal of Health Science, Journal Year: 2024, Volume and Issue: 4(2), P. 2 - 12

Published: Jan. 4, 2024

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