Revealing the Phenolic Composition and the Antioxidant, Antimicrobial and Antiproliferative Activities of Two Euphrasia sp. Extracts

Plants, Journal Year: 2024, Volume and Issue: 13(13), P. 1790 - 1790

Published: June 28, 2024

The species of the genus Euphrasia present important medicinal potential according to their traditional uses. However, few studies aim sustain this fact by scientific evidence. study aimed explore phytochemical profile and investigate antioxidant, antimicrobial antiproliferative E. officinalis subsp. pratensis Fr. (EO) stricta J.P.Wolff ex J.F.Lehm (ES). tested samples consisted ethanolic extracts. identification quantification phenolic compounds were performed using spectrophotometric LC–MS/MS methods. antioxidant capacity was evaluated DPPH, FRAP xanthine oxidase Antimicrobial properties screened disk diffusion, broth microdilution anti-biofilm assays, while assessed on a colorectal adenocarcinoma human cancer cell line (DLD-1). analysis showed chlorogenic acid rutin as dominant constituents in activity assays for both samples; vitro exhibited, especially against Gram-positive bacteria, an inhibitory observed proliferation DLD-1 line. findings contribute recommendation EO ES prevention treatment oxidative stress-related pathologies, microbial infections.

Language: Английский

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Plant Antioxidants: Therapeutic Potential in Cardiovascular Diseases

Compounds, Journal Year: 2024, Volume and Issue: 4(3), P. 479 - 502

Published: Aug. 12, 2024

Cardiovascular diseases (CVDs) are a global health problem. The mortality associated with them is one of the highest. Essentially, CVDs occur when heart or blood vessels damaged. Oxidative stress an imbalance between production reactive oxygen species (free radicals) and antioxidant defenses. Increased can cause cardiac vascular injuries, leading to CVDs. Antioxidant therapy has been shown have beneficial effects on Plants rich source bioactive antioxidants our planet. Several classes these compounds identified. Among them, carotenoids phenolic most potent antioxidants. This review summarizes role some (a/β-carotene, lycopene lutein), polyphenols such as acids (caffeic, p-coumaric, ferulic chlorogenic acids), flavonoids (quercetin, kaempferol epigallocatechin gallate), hydroxytyrosol in mitigating by studying their biological mechanisms. Through detailed analysis, we aim provide deeper understanding how natural be integrated into cardiovascular strategies help reduce overall burden CVD.

Language: Английский

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In Vitro Antioxidant and Antibacterial Activities of Medicinal Flower Laligurans Rhododendron arboreum Collected from Kathmandu Valley, Nepal

International Journal of Food Science, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Rhododendron arboreum , known as Nepal’s national flower and belonging to the Ericaceae family, thrives throughout Himalayan region. This study investigates antioxidant antimicrobial potential of flowers. Three different extracts were prepared at concentrations ranging from 10 640 μ g/mL assessed for their total phenolic content (TPC), flavonoid (TFC), DPPH radical scavenging activity. Results showed significant accumulation compounds ( P < 0.05), with TPC levels 37.78, 67.29, 53.46 mg GAE/g TFC values 49.46, 67.46, 65.71 QE/g LGP, LGE, LGA g/mL, respectively. activity was highest in LGE (96.33%), followed by (87.11%) LGP (76.59%), compared standard (77.38%). The antibacterial properties against Aeromonas hydrophila Staphylococcus aureus Escherichia coli 100% concentration, inhibition rates 15%, 16%, 17% LGA, These findings indicate that petals, rich bioactive compounds, possess strong properties, making them candidates developing cost‐effective therapeutic formulations. Further research should focus on isolating specific understanding molecular mechanisms enhance efficacy.

Language: Английский

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Determination of Antioxidant Activities of Viscum album L.: First Report on Interaction of Phenolics with Survivin Protein using in silico Analysis

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(12)

Published: March 21, 2023

Abstract Mistletoe , Viscum album L., ( VA ) known as “Ökse Otu” in Turkey, is a hemiparasitic shrub that grows especially on the trunks and crowns of broadleaf trees. This study aimed to determination ’s antioxidant compounds evaluate their vitro activities growing twelve different host trees silico approach against survivin protein. At same time, active ingredients determined HPLC analysis, were performed with molecular docking dynamics analysis protein, an apoptosis inhibitor protein cancer. Antioxidant methanolic extracts organs determined. Phytochemical properties samples taken from hosts varied well. Total phenolic content was at highest rate fruits, followed by leaves branches, respectively. flavonoid amounts leaves, branches activity values evaluated DPPH (using radical), ABTS radical cation) FRP tests. The plant rate, During Quercetin, Rosmarinic acid Catechin found bind effectively. These substances can have potential become pharmaceutical working proteins future.

Language: Английский

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Aspergillus niger fermentation of cocoa pod husk for increased total crude protein utilizing response surface methodology

Biomass Conversion and Biorefinery, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 25, 2024

Language: Английский

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The effect of ZnAl-LDH-based host material on optical, antioxidant and antibacterial characteristics of Zingiber montanum (Koenig) Link ex Dietr. extract

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(7), P. 4119 - 4128

Published: Feb. 1, 2024

Language: Английский

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Phytochemical Profiling, FT-IR Spectroscopy, and Antioxidant Evaluation of Select Lamiaceae Species

Intelligent Pharmacy, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Hypoglycemic and antioxidant activities of J. officinale with identification and characterization of phytocompounds

Heliyon, Journal Year: 2024, Volume and Issue: 10(21), P. e39165 - e39165

Published: Oct. 10, 2024

Language: Английский

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Green Synthesis, Characterization and Pharmaceutical Applications of Biocompatible Zinc Oxide Nanoparticles Using Heliotropium rariflorum Stocks

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1457 - 1457

Published: Oct. 31, 2024

Zinc oxide nanoparticles are safe, non-toxic, and biocompatible. These NPs used in food packaging materials, self-cleaning glass, ceramics, deodorants, sunscreens, paints, coatings, ointments, lotions, as preservatives. This study explored the biological potential of ZnO synthesized using

Language: Английский

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Synthesis of Zinc Oxide Nanoparticles (ZnO NPs) from Leaf Extract of Carthamus oxycantha and its In Vitro Biological Applications

Austin Journal of Analytical and Pharmaceutical Chemistry, Journal Year: 2023, Volume and Issue: 10(2)

Published: Oct. 9, 2023

Nanotechnology and nanosciences are emerging as new fast-growing fields due to their unique characteristics phenomenal properties. In this study, we synthesized zinc oxide nanoparticles (ZnO NPs) by using leaf extract of Carthamus oxycantha. The morphological features were evaluated standard characterization techniques. irregular hexagonal, average size was 11nm, revealed Scanning Electron Microscopy (SEM) X-ray crystallography (XRD). Flavonoids other phytochemicals found be capping metabolites for the nanoparticles. showed significant inhibition bacterial fungal strains. cytotoxicity assay 80% mortality marine larvae Artemia salina at a sample concentration 40μg/ml. crystallized ZnO NPs exhibited toxicity against MFC-7 breast cancer cells displayed higher antioxidants profile i.e. free radical scavenging activity (76.824±1.22%), total reducing power (90.21±1.12μgAAE/mg), antioxidant potential (72.936±0.93 μgAAE/mg). Quantity 80 μg/ml resulted in 11.69±0.41% hemolysis human red blood cells. Due potent biological activities, from oxycantha could used efficiently transdisciplinary research future.

Language: Английский

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