Cited by Role of dietary and nutritional interventions in ceramide-associated diseases

Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies DOI

Alfred H. Merrill

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 650 - 650

Published: Jan. 14, 2025

Sphingolipidomic mass spectrometry has provided valuable information-and surprises-about sphingolipid structures, metabolism, and functions in normal biological processes disease. Nonetheless, many noteworthy compounds are not routinely determined, such as the following: most of sphingoid bases that mammals biosynthesize de novo other than sphingosine (and sometimes sphinganine) or acquire from exogenous sources; infrequently considered metabolites bases, N-(methyl)n-derivatives; "ceramides" common N-acylsphingosines; complex sphingolipids sphingomyelins simple glycosphingolipids, including glucosyl- galactosylceramides, which usually reported "monohexosylceramides". These subspecies discussed, well some circumstances when they likely to be seen (or present missed) due experimental conditions can influence uptake diet microbiome, artifacts produced during extraction analysis. If these factors kept mind design interpretation lipidomic studies, investigators surprised by how often appear thereby advance knowledge about them.

Language: Английский

Citations

Sphingosine kinase 2 in cancer: A review of its expression, function, and inhibitor development DOI

Yanqun Luo,

Haiping Xue, Ying Gao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141392 - 141392

Published: Feb. 1, 2025

Language: Английский

Citations

Altered liver lipidome markedly overlaps with human plasma lipids at diabetes risk and reveals adipose-liver interaction DOI

Ratika Sehgal, Markus Jähnert,

Michail Lazaratos

et al.

Journal of Lipid Research, Journal Year: 2025, Volume and Issue: unknown, P. 100767 - 100767

Published: March 1, 2025

Language: Английский

Citations

Chikungunya Replication and Infection Is Dependent upon and Alters Cellular Hexosylceramide Levels in Vero Cells DOI

J. Scott Noble, Kingsley Bimpeh, M. Pisciotta

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 509 - 509

Published: March 31, 2025

Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes significant global morbidity, including fever, rash, and persistent arthralgia. Utilizing untargeted lipidomics, we investigated how CHIKV infection alters host cell lipid metabolism in Vero cells. induced marked catabolism of hexosylceramides, reducing their levels while increasing ceramide byproducts. Functional studies revealed reliance on fatty acid synthesis, β-oxidation, glycosphingolipid biosynthesis. Notably, inhibition uridine diphosphate glycosyltransferase 8 (UGT8), essential for galactosylceramide production, significantly impaired replication entry Sensitivity to UGT8 was reproduced disease-relevant line, mouse hepatocytes (Hepa1-6). also sensitive evacetrapib, cholesterol ester transfer protein (CETP) inhibitor, though the mechanism appeared independent CETP itself, suggesting an off-target effect. These findings highlight specific pathways, particularly metabolism, as critical further refine our understanding exploits networks. This study provides new insights into biology suggests that targeted investigation pathways may inform future therapeutic strategies.

Language: Английский

Citations

Study on the synthesis, characterization, and antitumor mechanism investigation of QZQ-01115 via targeting sphingosine kinase 2 DOI

Caiyu Liu,

Yaxin Guo,

Yutong Dong

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167829 - 167829

Published: April 1, 2025

Language: Английский

Citations

The contribution of the sphingosine 1-phosphate signaling pathway to chronic kidney diseases: recent findings and new perspectives DOI

Stephanie Schwalm,

Roxana Manaila,

Anke Oftring

et al.

Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: 476(12), P. 1845 - 1861

Published: Oct. 9, 2024

Abstract Chronic kidney disease (CKD) is a multifactorial condition with diverse etiologies, such as diabetes mellitus, hypertension, and genetic disorders, often culminating in end-stage renal (ESRD). A hallmark of CKD progression fibrosis, characterized by the excessive accumulation extracellular matrix components, for which there currently no effective anti-fibrotic therapy. Recent literature highlights critical role sphingosine 1-phosphate (S1P) signaling pathogenesis fibrosis. This review provides an in-depth analysis latest findings on S1P metabolism fibrosis specific CKDs, including diabetic nephropathy (DN), lupus nephritis (LN), focal segmental glomerulosclerosis (FSGS), Fabry (FD), IgA (IgAN). Emerging studies underscore therapeutic potential modulating receptor modulators inhibitors, fingolimod (FTY720) more selective agents like ozanimod cenerimod. Additionally, current knowledge about effects established protective therapies glucocorticoids SGLT2 ACE inhibitors will be summarized. Furthermore, biomarker models, particularly nephropathy. Advanced technologies, spatial transcriptomics, are further refining our understanding S1P’s within compartments. Collectively, these insights emphasize need continued research into pathways promising targets treatment strategies.

Language: Английский

Citations

Role of dietary and nutritional interventions in ceramide-associated diseases DOI

Shengnan Wang,

Zihui Jin,

Biyu Wu

et al.

Journal of Lipid Research, Journal Year: 2024, Volume and Issue: unknown, P. 100726 - 100726

Published: Dec. 1, 2024

Language: Английский

Citations