Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: June 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Language: Английский

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Biomedical rare-earth magnesium alloy: Current status and future prospects

Journal of Magnesium and Alloys, Journal Year: 2024, Volume and Issue: 12(4), P. 1260 - 1282

Published: April 1, 2024

Biomedical magnesium (Mg) alloys have garnered significant attention because of their unique biodegradability, favorable biocompatibility, and suitable mechanical properties. The incorporation rare earth (RE) elements, with distinct physical chemical properties, has greatly contributed to enhancing the performance, degradation behavior, biological performance biomedical Mg alloys. Currently, a series RE-Mg are being designed investigated for orthopedic implants cardiovascular stents, achieving substantial encouraging research progress. In this work, comprehensive summary state-of-the-art in is provided. physiological effects design standards RE elements discussed. Particularly, behavior including underlying action studied in-depth. Furthermore, preparation techniques current application status reviewed. Finally, we address ongoing challenges propose future prospects guide development high-performance Mg-RE

Language: Английский

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Application and progress of 3D printed biomaterials in osteoporosis

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and formation. Conventional treatments, such as pharmaceutical drugs hormone replacement therapy, often yield suboptimal are frequently associated with side effects. Recently, biomaterial-based approaches have gained attention promising alternatives for managing osteoporosis. This review summarizes the current advancements 3D-printed biomaterials designed osteoporosis treatment. The benefits of compared to traditional systemic drug therapies discussed. These materials can be broadly categorized based on their functionalities, including promoting osteogenesis, reducing inflammation, exhibiting antioxidant properties, inhibiting osteoclast activity. 3D printing has advantages speed, precision, personalization, etc. It is able satisfy requirements irregular geometry, differentiated composition, multilayered structure articular osteochondral scaffolds boundary layer structure. limitations existing critically analyzed future directions considered.

Language: Английский

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Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

Theranostics, Journal Year: 2023, Volume and Issue: 13(10), P. 3245 - 3275

Published: Jan. 1, 2023

Large bone defects are a major global health concern.Bone tissue engineering (BTE) is the most promising alternative to avoid drawbacks of autograft and allograft bone.Nevertheless, how precisely control stem cell osteogenic differentiation has been long-standing puzzle.Compared with biochemical cues, physicomechanical stimuli have widely studied for their biosafety stability.The mechanical properties various biomaterials (polymers, bioceramics, metal alloys) become main source stimuli.By altering stiffness, viscoelasticity, topography materials, different strengths transmit into precise signals that mediate differentiation.In addition, externally forces also play critical role in promoting osteogenesis, such as compression stress, tensile fluid shear stress vibration, etc.When exposed forces, mesenchymal cells (MSCs) differentiate lineages by sensing through sensors, including integrin focal adhesions (FAs), cytoskeleton, primary cilium, ions channels, gap junction, activating osteogenic-related mechanotransduction pathways, yes associated proteins (YAP)/TAZ, MAPK, Rho-GTPases, Wnt/β-catenin, TGFβ superfamily, Notch signaling.This review summarizes signals, directly regulate MSCs differentiation, transduction mechanisms MSCs.This provides deep broad understanding discusses challenges remained clinical translocation well outlook future improvements.

Language: Английский

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Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical, osteogenesis and antibacterial performances for GBR applications

Journal of Magnesium and Alloys, Journal Year: 2024, Volume and Issue: 13(2), P. 792 - 809

Published: Feb. 23, 2024

Language: Английский

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An Overview on the Big Players in Bone Tissue Engineering: Biomaterials, Scaffolds and Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3836 - 3836

Published: March 29, 2024

Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor sites for along immune rejection. To surmount challenges, engineering has emerged a promising avenue injury repair reconstruction. It involves use different biomaterials development three-dimensional porous matrices scaffolds, alongside osteoprogenitor cells growth factors stimulate natural regeneration. This review compiles methodologies that can be used develop are important replacement Biomaterials orthopedic implants, several scaffold types production methods, well techniques assess biomaterials’ suitability human use—both laboratory settings within living organisms—are discussed. Even researchers have had some success, there is still room improvements their processing techniques, especially ones make scaffolds mechanically stronger without weakening biological characteristics. Bone therefore area rise bone-related injuries.

Language: Английский

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Peri‐implant gas accumulation in response to magnesium‐based musculoskeletal biomaterials: Reframing current evidence for preclinical research and clinical evaluation

Journal of Magnesium and Alloys, Journal Year: 2024, Volume and Issue: 12(1), P. 59 - 71

Published: Jan. 1, 2024

Historically, the rapid degradation and massive gas release from magnesium (Mg) implants resulted in severe emphysema mechanical failure. With advent of new alloys surface treatment methods, optimized Mg have re-entered clinics since last decade with reliable performance. However, optimization aims at slowing down process, rather than exemption release. This study involved a systematic evaluation current preclinical clinical evidence, regarding physical signs, symptoms, radiological features, pathological findings complications potentially associated peri‑implant accumulation (PIGA) after musculoskeletal implantation. The literature search identified 196 relevant publications, 51 papers were enrolled for further analysis, including 22 tests 29 studies published 2005 to 2023. Various Mg-based materials been evaluated animal research, application pure reported follow-ups involving multiple anatomical sites disorders. Soft tissue intraosseous PIGA are common both follow-ups, certain adverse events. Radiological examinations especially micro-CT CT scans provide valuable information quantitative longitudinal analysis. While according simulation implantation chemical processing, fixation could lead an increase volume cavity, thus results obtained ex vivo imaging or histopathological evaluations should be interpreted caution. There still lacks standardized procedures consensus PIGA. by providing focused insights into topic, this evidence-based will facilitate future evaluations, support developing biocompatible

Language: Английский

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Magnesium-based biomaterials for coordinated tissue repair: A comprehensive overview of design strategies, advantages, and challenges

Journal of Magnesium and Alloys, Journal Year: 2024, Volume and Issue: 12(8), P. 3025 - 3061

Published: June 25, 2024

Magnesium-based biomaterials (MBMs) are one of the most promising materials for tissue engineering due to their unique mechanical properties and excellent functional properties. This review describes development, advantages, challenges MBMs biomedical applications, especially repair regeneration. The history use from beginning 20th century is traced, transformative advances in contemporary applications areas such as orthopedics cardiovascular surgery emphasized. also provides insight into signaling pathways affected by MBMs, PI3K/Akt RANKL/RANK/OPG pathways, which critical osteogenesis angiogenesis. advocates that future research should focus on optimizing alloy compositions, surface modification exploring innovative technologies 3D printing improve efficacy complex repair. potential regenerative medicine significant, urging further exploration interdisciplinary collaboration maximize therapeutic effects.

Language: Английский

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Polycaprolactone/graphene oxide/magnesium oxide as a novel composite scaffold for bone tissue engineering: Preparation and physical/biological assessment

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105531 - 105531

Published: March 4, 2024

Language: Английский

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More than the barrier effect: Biodegradable Mg-Ag alloy membranes for guided bone/tissue regeneration

Journal of Magnesium and Alloys, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Magnesium (Mg) and its alloys have emerged as promising candidates for guided bone/tissue regeneration (GBR/GTR) due to their good mechanical properties, biosafety, biodegradability. In this study, we present a pioneering application of Mg-Ag featuring tunable corrosion behaviors GBR/GTR membranes, showcasing in vitro antibacterial effects, cell migration, osteogenic differentiation abilities. with different Ag contents were engineered facilitate the migration murine fibroblasts (L929) rat bone mesenchymal stem cells (rBMSCs). The alloy consisted recrystallized α-Mg grains fine Mg4Ag second phases, an observable refinement average grain size 5.6 µm increasing content. Among alloys, Mg-9Ag exhibited optimal strength moderate plasticity (tensile yield 205.7 MPa, elongation 20.3%, maximum bending load 437.2 N). Furthermore, alloying accelerated cathodic reaction pure Mg, leading slightly increased rate while maintaining acceptable general corrosion. Notably, compared had superior effects against Porphyromonas gingivalis (P. gingivalis) Staphylococcus aureus (S. aureus). Taken together, these results provide evidence significant clinical potential membranes.

Language: Английский

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