Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review DOI Creative Commons
Jie Ji, Chen Gong, Gengxi Lu

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(12), P. 3501 - 3516

Published: Dec. 16, 2024

Vision restoration presents a considerable challenge in the realm of regenerative medicine, while recent progress ultrasound stimulation has displayed potential as non-invasive therapeutic approach. This narrative review offers comprehensive overview current research on ultrasound-stimulated neuromodulation, emphasizing its treatment modality for various nerve injuries. By examining efficacy different types modulating peripheral and optic nerves, we can delve into their underlying molecular mechanisms. Furthermore, underscores sonogenetics vision restoration, which involves leveraging pharmacological genetic manipulations to inhibit or enhance expression related mechanosensitive channels, thereby strength response. We also address how methods such viral transcription be utilized render specific neurons organs highly responsive ultrasound, leading significantly improved outcomes.

Language: Английский

Animal Models for the Evaluation of Retinal Stem Cell Therapies DOI
Biju B. Thomas, Deepthi S. Rajendran Nair,

Mana Rahimian

et al.

Progress in Retinal and Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 101356 - 101356

Published: April 1, 2025

Language: Английский

Citations

0
Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review DOI Creative Commons
Jie Ji, Chen Gong, Gengxi Lu

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(12), P. 3501 - 3516

Published: Dec. 16, 2024

Vision restoration presents a considerable challenge in the realm of regenerative medicine, while recent progress ultrasound stimulation has displayed potential as non-invasive therapeutic approach. This narrative review offers comprehensive overview current research on ultrasound-stimulated neuromodulation, emphasizing its treatment modality for various nerve injuries. By examining efficacy different types modulating peripheral and optic nerves, we can delve into their underlying molecular mechanisms. Furthermore, underscores sonogenetics vision restoration, which involves leveraging pharmacological genetic manipulations to inhibit or enhance expression related mechanosensitive channels, thereby strength response. We also address how methods such viral transcription be utilized render specific neurons organs highly responsive ultrasound, leading significantly improved outcomes.

Language: Английский

Citations

0