Cellular Immunology, Journal Year: 2025, Volume and Issue: 409-410, P. 104928 - 104928
Published: Jan. 23, 2025
Language: Английский
Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 511 - 511
Published: March 14, 2024
Neuroinflammatory and neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s (PD), traumatic brain injury (TBI) Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions these pathogeneses is currently not clearly understood. These show dysregulated inflammatory responses, activation neurons, glial cells, neurovascular unit damage associated with excessive release proinflammatory cytokines, chemokines, neurotoxic mediators, infiltration peripheral immune cells into brain, as well entry mediators through damaged endothelial blood–brain barrier tight junction proteins. Activation leads to many molecules that cause neuroinflammation neurodegeneration. Gulf War Illness (GWI) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) also dysfunctions. Currently, there no effective disease-modifying therapeutic options available for diseases. Human induced pluripotent stem cell (iPSC)-derived astrocytes, microglia, pericytes used models drug discovery. This review highlights certain recent trends in neuroinflammatory responses iPSC-derived applications
Language: Английский
Citations
29
Cellular Immunology, Journal Year: 2025, Volume and Issue: 409-410, P. 104928 - 104928
Published: Jan. 23, 2025
Language: Английский
Citations
0