Parkinson's disease is associated with low striated esophagus contractility potentially contributing to the development of dysphagia DOI
Alexander Kerschner, Hamza Hassan, Mark Kern

et al.

Neurogastroenterology & Motility, Journal Year: 2024, Volume and Issue: 36(8)

Published: May 26, 2024

Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disorder, and more than 80% of PD patients will develop oropharyngeal dysphagia. Despite its striated histology, proximity to airway, potential negative impact dysfunction on bolus transport airway safety, contractile function esophagus in has not been systematically studied. Methods Using our repository clinical manometry Milwaukee ManoBank, we analyzed high‐resolution (HRM) studies 20 patients, mean age 69.1 (range 38–87 years); 30 non‐PD with dysphagia, 64.0 (44–86 32 healthy volunteers, 65.3 (39–86 years). Patients abnormal findings based Chicago Classification 4.0 were identified. Repeat analysis was performed 20% manometric tracings by a different investigator inter‐rater concordance between 0.91 0.99. Key Results The esophageal integral significantly lower that dysphagic controls ( p = 0.03 <0.01, respectively). This significant difference persisted after excluding concurrent motility disorders 0.02 0.01, In both analyses, distal did show any groups 0.58 0.93, Conclusions & Inferences associated decrease contractility compared controls. finding may play pathophysiologic role development dysphagia this patient population.

Language: Английский

Delivering Multidisciplinary Rehabilitation Care in Parkinson’s Disease: An International Consensus Statement DOI Creative Commons
Jennifer G. Goldman,

Daniele Volpe,

Terry D. Ellis

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(1), P. 135 - 166

Published: Jan. 23, 2024

Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder impacting everyday function and quality of life. Rehabilitation plays crucial role in improving symptoms, function, life reducing disability, particularly given the lack disease-modifying agents limitations medications surgical therapies. However, rehabilitative care under-recognized under-utilized PD often only utilized later stages, despite research guidelines demonstrating its positive effects. Currently, there consensus regarding fundamental topics related to services PD. Objective: The goal international Foundation Medicine Task Force was develop statement incorporation rehabilitation care. Methods: Force, comprised multidisciplinary experts people directly affected by PD, met virtually discuss such as services, existing therapy literature gaps needs. A systematic, interactive, iterative process used consensus-based statements on core components discipline-specific interventions. Results: expert-based outlines key tenets including approach guidance for occupational therapy, physical speech language pathology/therapy, psychology/neuropsychology across all stages. Conclusions: Rehabilitative interventions should be an essential component comprehensive treatment from diagnosis advanced disease. Greater education awareness benefits with their partners, further evidence-based scientific study are encouraged.

Language: Английский

Citations

28
Gastrointestinal Issues in Depression, Anxiety, and Neurodegenerative Diseases: A Systematic Review on Pathways and Clinical Targets Implications DOI

Ian Richard Lucena Andriolo,

Bruna Cristina Longo,

Dayse Machado de Melo

et al.

CNS & Neurological Disorders - Drug Targets, Journal Year: 2024, Volume and Issue: 23(11), P. 1371 - 1391

Published: March 20, 2024

Introduction: Multiple illnesses commonly involve both the Central Nervous System (CNS) and Gastrointestinal Tract (GI) simultaneously. Consistent evidence suggests that neurological disorders impair GI tract function worsen symptomatology pathophysiology of digestive disorders. On other hand, it has been proposed early functional changes in contribute to genesis several CNS illnesses. Additionally, role played by gut these diseases can be seen as a paradigm for how brain interact. Methods: We mentioned significant symptoms discussed affects central nervous system illnesses, including depression, anxiety, Alzheimer's disease, Parkinson's disease this study. also explored potential pathophysiological underpinnings novel targets creation future therapies targeted at gut-brain connections. Results & Discussion: In situation, modulating microbiota through administration fecal transplants or probiotics may represent new therapeutic option population, not only treat problems but behavioral problems, given dysbiosis leaky play many Conclusion: Accurate diagnosis treatment co-existing require coordination between psychiatrists, neurologists, gastroenterologists, specialties, well thorough history physical examination.

Language: Английский

Citations

4
Physical Rehabilitation of Patients with Parkinson’s Disease DOI
Erwin E. H. van Wegen, Marc B. Rietberg, Tim Vanbellingen

et al.

Cambridge University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 238 - 251

Published: Jan. 7, 2025

Language: Английский

Citations

0
Trends in mortality and disparities in dilated cardiomyopathy across gender, race, and region in the United States (1999-2020) DOI Open Access

T Ashraf,

Omar Abunada,

Aashish Kumar

et al.

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(3), P. 1589 - 1598

Published: Jan. 30, 2025

Language: Английский

Citations

0
Guidelines for Parkinson's disease management part II: consensus from the movement disorders scientific department of the Brazilian Academy of Neurology – non-motor symptoms DOI Creative Commons
Débora Palma Maia, Rubens Gisbert Cury, Pedro Renato de Paula Brandão

et al.

Arquivos de Neuro-Psiquiatria, Journal Year: 2025, Volume and Issue: 83(01), P. 001 - 015

Published: Jan. 1, 2025

Abstract The treatment of Parkinson's disease (PD) is a challenge, especially because it considered highly individualized. Brazilian Academy Neurology (ABN) has identified the need to disseminate knowledge about its management, adapting best evidence population. present article aims report recommendations for non-motor symptoms PD, developed by group specialists in movement disorders from ABN's scientific department. In 2021, first part, referring motor was published. main were addressed—among them neuropsychiatric symptoms, such as depression, anxiety, cognitive alteration, and psychosis—as well possible recommended therapies medications used control pain, sleep disorders, dysautonomia.

Language: Английский

Citations

0
Effect of Elevation Training Mask on Swallowing Function in Individuals with Parkinson’s Disease DOI Creative Commons
Yuval Nachalon,

Dina Shpunt,

Anat Zait

et al.

Dysphagia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract To evaluate the impact of elevation training mask (ETM) on swallowing safety and efficiency in patients with Parkinson’s disease (PWP) when used as a respiratory muscle strengthening tool. Study Design. Prospective cohort study. Setting. Tertiary university-affiliated medical center. Thirteen PWP underwent Fiberoptic Endoscopic Evaluation Swallowing spirometry assessments both before after 4-week ETM use, which included incrementally increasing resistance each week. Measurements taken EAT-10, disturbances questionnaire (SDQ), Penetration Aspiration Score (PAS), Yale Pharyngeal Residue Severity Rating Scale, Peak Expiratory Flow (PEF). Disease severity was assessed using Unified Scale (UPDRS). Eleven out 13 male participants (median age 70 years, UPDRS 33, duration 8.5 years) completed protocol (84.6% completion rate). Vallecular residue significantly decreased for solids from 3.0 [IQR: 2.0–3.0] to 2.0 1.0–2.0], p = 0.028) semi-solids (from 2.0–4.0] 1.0–3.0], 0.025), non-significant improvement liquids 2.0–2.0] 0.19). Patient-reported outcomes (EAT-10, SDQ, VHI-10, RSI) PEF showed trends toward improvement. A use ETM, serving form strengthening, demonstrated specific improvements vallecular semi-solid solid consistencies dysphagia. While other measures positive trends, these changes did not reach statistical significance. Further research larger is needed ETM’s role rehabilitation.

Language: Английский

Citations

0
Evaluation of Quality of Life in Patients Presenting with Dysphagia Pre and Post Swallowing Therapy DOI

A. R. Babu,

M. B. Bharathi,

D. Sandhya

et al.

Indian Journal of Otolaryngology and Head & Neck Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

Citations

0
Assessment and treatment of neurogenic dysphagia in stroke and Parkinson's disease DOI
Giuseppe Cosentino, Massimiliano Todisco,

Carla Giudice

et al.

Current Opinion in Neurology, Journal Year: 2022, Volume and Issue: 35(6), P. 741 - 752

Published: Oct. 11, 2022

Purpose of review Neurogenic dysphagia worsens quality life and prognosis patients with different neurological disorders. Management neurogenic can be challenging. This provides a comprehensive overview current evidence on screening, diagnosis, treatment in stroke Parkinson's disease, suggesting clues for clinical practice. Recent findings The pros cons diagnostic techniques are discussed the light updated evidence. Findings from recent meta-analyses approaches, including traditional therapy, peripheral central neurostimulation techniques, botulinum toxin, critically discussed, emphasizing inconsistencies controversial issues. Summary Screening tests swallow examination should routinely performed at risk dysphagia. In testing positive dysphagia, first-line instrumental investigations, represented by fiberoptic endoscopic evaluation swallowing or videofluoroscopic study, to confirm presence assess its severity, inform treatment. Second-line third-line methods used selected clarify specific pathophysiological aspects oropharyngeal Treatment strategies personalized, combination therapy innovative approaches may increase chance restoring effective safe swallowing.

Language: Английский

Citations

16
Stemming the Tide: The Proactive Role of Allied Health Therapy in Parkinson’s Disease DOI Creative Commons
Miriam R. Rafferty, Erin R. Foster, Angela Roberts

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(s1), P. S7 - S19

Published: June 4, 2024

Motor and nonmotor symptoms occur in early Parkinson’s disease (PD), or even the prodromal stage. Many of these can be addressed by allied health therapies, including physical therapy, occupational speech psychological therapies. However, referrals to services are low. We provide a review summarizing efficacy proactive interventions on motor daily function disease. also highlight areas for additional research recommendations improve care individuals with PD within each discipline. recognize overlapping roles disciplines support integrated transdisciplinary beginning soon after diagnosis help stem tide progression disability.

Language: Английский

Citations

3
New and Evolving Treatments for Neurologic Dysphagia DOI
Ayodele Sasegbon, Ivy Cheng, Bendix Labeit

et al.

Drugs, Journal Year: 2024, Volume and Issue: 84(8), P. 909 - 932

Published: July 2, 2024

Language: Английский

Citations

3