Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Dec. 30, 2024
Accumulating
evidence
indicates
that
cellular
senescence
is
closely
associated
with
osteoarthritis.
However,
there
limited
research
on
the
mechanisms
underlying
fibroblast-like
synoviocyte
and
its
impact
osteoarthritis
progression.
Here,
we
elucidate
a
positive
correlation
between
progression
reveal
GATD3A
deficiency
induces
senescence.
Mechanistically,
enhances
binding
of
Sirt3
to
MDH2,
leading
deacetylation
decreased
activity
MDH2.
Reduced
MDH2
impairs
tricarboxylic
acid
cycle
flux,
resulting
in
mitochondrial
dysfunction
Intra-articular
injection
recombinant
adeno-associated
virus
carrying
significantly
alleviates
phenotype
male
mice.
This
study
increases
our
current
understanding
function.
In
particular,
novel
mechanism
senescence,
suggesting
targeting
potential
therapeutic
approach
for
The
are
unclear.
authors
show
mice
demonstrate
symptoms
mouse
models
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 16, 2025
RNA
interference
(RNAi)
and
oxidative
stress
inhibition
therapeutic
strategies
have
been
extensively
utilized
in
the
treatment
of
osteoarthritis
(OA),
most
prevalent
degenerative
joint
disease.
However,
synergistic
effects
these
approaches
on
attenuating
OA
progression
remain
largely
unexplored.
In
this
study,
matrix
metalloproteinase-13
siRNA
(siMMP-13)
was
incorporated
onto
polyethylenimine
(PEI)-polyethylene
glycol
(PEG)
modified
Fe3O4
nanoparticles,
forming
a
nucleic
acid
nanocarrier
termed
si-Fe
NPs.
Subsequently,
poly(vinyl
alcohol)
(PVA)
crosslinked
phenylboronic
(PBA)-modified
hyaluronic
(HA)
hydrogel
(HPP)
used
to
encapsulate
NPs,
resulting
bifunctional
(si-Fe-HPP)
with
reactive
oxygen
species
(ROS)-responsive
RNAi
properties.
Studies
vitro
demonstrated
that
si-Fe-HPP
exhibited
excellent
biocompatibility,
anti-inflammatory
prolonged
stable
retention
time
knee
joint.
Intra-articular
injection
significantly
attenuated
cartilage
degradation
mice
destabilization
medial
meniscus
(DMM)-induced
OA.
The
not
only
notably
alleviated
synovitis,
osteophyte
formation
subchondral
bone
sclerosis,
but
also
markedly
improved
physical
activity
reduced
pain
DMM-induced
mice.
This
study
reveals
si-Fe-HPP,
its
ROS-responsive
abilities,
can
protect
chondrocytes
attenuate
progression,
providing
novel
insights
directions
for
development
materials
treatment.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 4, 2025
Abstract
Chondrocyte
senescence
is
an
important
pathogenic
factor
causing
osteoarthritis
(OA)
progression
through
persistently
producing
pro‐inflammatory
factors.
Mesenchymal
stem
cells‐derived
small
extracellular
vesicles
(MSC‐sEVs)
have
shown
anti‐inflammatory
effects
in
OA
models,
while
persistent
existence
of
senescent
chondrocytes
still
promotes
cartilage
destruction.
Therefore,
improving
the
targeted
elimination
ability
on
required
to
facilitate
translation
MSC‐sEVs
treatment.
In
this
study,
versatile
engineered
are
developed
targetedly
clear
and
maintain
metabolic
homeostasis.
Specifically,
loaded
with
siRNA
mouse
double
minute
2
homologue
(siMDM2)
modified
cartilage‐targeting
peptide
WYRGRL‐PEG
2K
‐DSPE
(WPD),
named
WPD‐sEVs
siMDM2
.
The
results
demonstrate
modification
improves
cellular
uptake
chondrocytes,
thus
antiaging
effects.
Importantly,
multifunctional
enhances
penetration
extends
joint
retention
time
MSC‐sEVs.
both
post‐traumatic
mice
naturally
aged
mice,
more
effectively
eliminates
maintained
matrix
By
using
P53
phosphorylation
inhibitor,
essential
role
MDM2‐P53
pathway
function
verified.
ex
vivo
cultured
human
explants,
it
confirmed
that
alleviates
phenotype.
Altogether,
findings
suggest
promising
translational
potential
for
npj Women s Health,
Journal Year:
2025,
Volume and Issue:
3(1)
Published: Feb. 25, 2025
Osteoarthritis
(OA)
is
a
chronic
joint
disease
characterized
by
cartilage
degradation,
inflammation,
and
pain.
While
multiple
factors
contribute
to
OA
development,
age
sex
are
primary
risk
factors,
particularly
affecting
postmenopausal
women.
The
dramatic
increase
in
after
menopause
suggests
estrogen
deficiency
accelerates
progression.
This
review
explores
the
molecular
mechanisms
connecting
aging
focusing
on
key
genes
pathways
identified
through
RNA
sequencing.
Frontiers in Surgery,
Journal Year:
2025,
Volume and Issue:
12
Published: April 10, 2025
This
study
aims
to
systematically
analyze
the
intersection
of
OA
and
chondrocyte
hypertrophy
using
bibliometric
methods,
providing
an
quantitative
comprehensive
overview
current
research
status
emerging
trends
in
this
field.
Relevant
publications
were
retrieved
from
Web
Science
Core
Collection
database
search
query
TS
=
("chondrocyte*
hypertroph*"
OR
"hypertrophic
chondrocyte*"
"cartilage
hypertroph*")
AND
("osteoarthriti*"
"OA"
"degenerative
arthritis").
Several
tools,
including
Vosviewer,
CiteSpace,
R
package
(bibliometrix),
Excel
2021,
utilized
on
OA.
A
total
639
publications,
published
between
1995
2025,
identified.
The
findings
indicate
a
steady
global
increase
hypertrophy,
with
increasing
number
studies
being
high-impact
journals,
suggesting
promising
developmental
trajectory.
China
United
States
are
leading
OSTEOARTHRITIS
CARTILAGE
is
identified
as
core
journal
area,
while
ANNALS
OF
THE
RHEUMATIC
DISEASES
has
highest
impact
factor
among
top
publishing
journals.
Keyword
analysis
reveals
that
hotspots
primarily
focus
stem
cells,
tissue
engineering,
cartilage
repair,
inflammation,
oxidative
stress,
autophagy,
apoptosis,
senescence,
related
bioactive
factors.
elucidates
at
crucial
references
for
future
research.
Future
should
continue
these
potential
therapeutic
approaches,
key
phenotypes,
regulatory
mechanisms,
enhance
international
cooperation
develop
more
effective
strategies
treatments
