Association of the traditional Chinese medicine treatment intensity and negative conversion time of SARS-CoV-2 nuclear acid in mild COVID-19 patients DOI Open Access
Shun-Xian Zhang,

Yu Tian,

Ping Yin

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: May 19, 2023

The association between traditional Chinese medicine (TCM) treatment intensity (TI) and the clinical therapeutic outcomes of patients with mild to moderate COVID-19 symptoms has not been fully understood. A retrospective cohort study was undertaken assess effect on COVID-19. Between April May 2022, a total 6,120 confirmed cases were enrolled from temporary hospitals in Shanghai City. Patients receiving TCM identified through their daily prescriptions. nonlinearity cutoff point this relationship determined using restricted cubic spline model. included median (range) age 43.0 (2.0, 75.0) years,a hospitalization duration 9.7 (4.1, 22.5) days, taking 2.0 (0.0, 15.0) negative conversion time SARS-CoV-2 nucleic acid 6.67 (95% confidence interval [ CI]: 4.1, 1854 women (30.3%) among participants. model revealed significant nonlinear TCMTI time, statistical test results all three parameters statistically significant. value is 0.65. high group showed reduction (hazard ratio HR]=1.769 [95% CI: 1.575, 1.986]) decrease (coefficient=-0.146, P<0.001) compared low after adjustment for confounding variables. mean 1.909 (1.675, 2.144) days shorter than that ( P<0.001). These findings could be utilized recommend use treat prevent overburdening medical facilities. Trial Registration: trial prospectively registered Clinical Registry (ChiCTR, ChiCTR2200063151, [http://www.chictr.org.cn/](http://www.chictr.org.cn/) ).

Language: Английский

Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review DOI Creative Commons

Hadi Al-Jamal,

Sara Idriss,

Rabih Roufayel

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 320 - 320

Published: Feb. 20, 2024

In 2020, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) challenged the world with a global outbreak that led to millions of deaths worldwide. Coronavirus disease 2019 (COVID-19) is symptomatic manifestation this virus, which can range from flu-like symptoms utter clinical complications and even death. Since there was no clear medicine could tackle infection or lower its minimal adverse effects on patients’ health, health organization (WHO) developed awareness programs rate limit fast spread virus. Although vaccines have been as preventative tools, people still prefer going back traditional herbal medicine, provides remarkable benefits either prevent viral progression through different mechanistic pathways relatively insignificant side effects. This comprehensive review scientific evidence elucidating effect 10 plants against SARS-CoV-2, paving way for further studies reconsider plant-based extracts, rich in bioactive compounds, into more advanced assessments order identify their impact patients suffering COVID-19.

Language: Английский

Citations

4
Computational and in vitro evaluation of sumac-derived ©Rutan compounds towards Sars-CoV-2 Mpro inhibition DOI Creative Commons
Muzaffar Kayumov, Parthiban Marimuthu, Jamoliddin Razzokov

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 4, 2025

The emergence of the SARS-CoV-2 virus caused COVID-19 outbreak leading to a global pandemic. Natural substances started being screened for their antiviral activity by computational and in-vitro techniques. Here, we evaluated anti-SARS-CoV-2 main protease (M pro ) efficacy © Rutan, which contains five polyphenols (R5, R6, R7, R7’, R8) extracted from sumac Rhus coriaria L. We obtained three fractions after large-scale purification: fraction 1 held R5, 2 consisted R7 3 R8. In vitro results showed anti-M potential: IC 50 values R5 R8 made 42.52 µM 5.48 µM, respectively. Further, studied M -polyphenol interactions in silico analysis understand mechanistic extrapolation Rutan binding nature with . extensively incorporated series Initially, docking protocol validation, redocking co-crystal ligand GC-376* pocket was carried out. representative docked complexes were subjected long-range 500 ns molecular dynamics simulations. free energy (BFE kcal/mol) components calculated as follows: (−104.636) &gt; R6 (−93.754) R7’ (−92.113) (−81.115) (−67.243). correspond outcomes. Furthermore, per-residue decomposition C145, E166, Q189 residues hotspot contributing maximum BFE energies. All effectively interact catalytic form stable that allow estimation inhibitory activity. Assay kit analyses revealed its have effective

Language: Английский

Citations

0
Ethnomedicinal Uses of the Flora as an Alternative During the Treatment of SARS-CoV-2 in the Mayan Communities of the Yucatan Peninsula, Mexico DOI
Ángel Ríos-Oviedo, William Cetzal‐Ix, Héctor M. J. López-Castilla

et al.

Journal of Herbs Spices & Medicinal Plants, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: April 28, 2025

Language: Английский

Citations

0
In silico anti-SARS-CoV-2, antiplasmodial, antioxidant, and antimicrobial activities of crude extracts and homopterocarpin from heartwood of Pterocarpus macrocarpus Kurz. DOI Creative Commons
Dwi Kusuma Wahyuni,

Sumrit Wacharasindhu,

Wichanee Bankeeree

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(2), P. e13644 - e13644

Published: Feb. 1, 2023

Natural products play an essential role in new drug discovery. In the present study, we determined anti-SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2), antioxidant, antiplasmodial, and antimicrobial activities of Pterocarpus macrocarpus Kurz. heartwood structurally characterized bioactive compounds. P. was macerated with n-hexane, ethyl acetate, ethanol, respectively, for 7 days, three times. The compounds were isolated by recrystallization n-hexane evaluated thin-layer chromatography (TLC), gas chromatography-mass spectrophotometry (GC-MS), Fourier transform infrared spectroscopy (FITR), nuclear magnetic resonance (NMR) spectroscopy. Ethyl extracts, homopterocarpin exhibited antiplasmodial activity at 1.78, 2.21, 7.11, 0.52 μg/ml, against falciparum 3D7 low toxicity (selectivity index/SI ≥ 28.46). GC-MS identified compound showed silico binding affinity stigmasterol SARS-CoV-2 helicase −8.2 kcal/mol. acetate extract best antioxidant DPPH (0.76 ± 0.92 μg/ml) ABTS (0.61 0.46 μg/ml). They also demonstrated B. subtilis, ethanol extracts E. coli C. albicans, S. aureus diameter zone inhibition more than 1 cm. results highlighted from its potent to proteins toxicity. This study confirmed that activities. Further studies are needed assess safety clinical trial development as candidate.

Language: Английский

Citations

10
Magnetic graphitized carbon black based on crystal growth method combined with high-resolution mass spectrometry for screening of 300 pesticide residues in Radix Codonopsis and Angelica sinensis DOI
Hongyan Zhang, Qiaoying Chang, Fang Yang

et al.

Journal of Chromatography B, Journal Year: 2023, Volume and Issue: 1226, P. 123788 - 123788

Published: June 10, 2023

Language: Английский

Citations

7
An integrated strategy combining UPLC-MS/MS, chemometrics, molecular docking, and molecular dynamics simulation for metabolic profiling of onion (Allium cepa L.) cultivars and unravelling potential anti-COVID-19 metabolites DOI

Mariam M. Elattar,

Hala M. Hammoda, Doaa A. Ghareeb

et al.

South African Journal of Botany, Journal Year: 2023, Volume and Issue: 162, P. 885 - 900

Published: Oct. 14, 2023

Language: Английский

Citations

3
A liquid chromatography-time-of-flight/mass spectrometry method for analysis of pesticides and transfer behavior in Radix Codonopsis and Angelica sinensis decoctions DOI
Hongyan Zhang, Qiaoying Chang, Jian Li

et al.

Analytical Methods, Journal Year: 2023, Volume and Issue: 15(17), P. 2121 - 2131

Published: Jan. 1, 2023

A QuEChERS-LC-Q-TOF/MS analysis method for the detection of 255 pesticides in Radix Codonopsis and Angelica sinensis decoctions was established. The transfer behaviours 22 frequently detected were analysed.

Language: Английский

Citations

2
Virtual Screening of Syzygium cumini (L.) Skeels Flavonoid Compounds as SARS-CoV-2 Main Protease Therapy Candidates DOI Creative Commons
Himyatul Hidayah, Ruswanto Ruswanto,

Desri Ayu Lestari

et al.

Jurnal Kimia Sains dan Aplikasi, Journal Year: 2024, Volume and Issue: 27(7), P. 336 - 345

Published: July 12, 2024

In December 2019, the first COVID-19 cases were in Wuhan, China. This case is a global concern and threat to public health. Based on previous research using molecular docking methods, it was found that flavonoids exhibit strong inhibitory activity SARS-CoV-2 main proteases. The study aims determine flavonoid compound Syzygium cumini (L.) Skeels can interact with protease receptor be used as candidate for therapy virtual screening. Myricetin 4”-O-acetyl-2-O-gallate has lowest Gibbs free energy (ΔG) of -9.82 kcal/mol. dynamics best compound, Myrcetin 4-O-acetyl-2-O-gallate, RMSD, RSMF values are quite stable. As result pharmacokinetic prediction toxicity, compounds have relatively good profile non-toxic. Thus, concluded 4”-O-acetyl-2-o-gallate predicted (7C6S) potential drug therapy.

Language: Английский

Citations

0
Synthesis, in vitro and in silico evaluation of gallamide and selenogallamide derivatives as inhibitors of the SARS‐CoV‐2 main protease DOI

Maryelle A. G. de Carvalho,

Gabriella B. Souza, Tiago Tizziani

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(11)

Published: Aug. 15, 2024

The present work reports the inhibitory effect of amides derived from gallic acid (gallamides) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M

Language: Английский

Citations

0
Java plum (Syzygium Cumini) leaves as a potential inhibitor of SARS-CoV-2 3- Chymotrypsine-Like Protease (3CLpro) DOI Creative Commons

Diah Oktavianti,

Berna Elya, I Gede Eka Perdana Putra

et al.

Tropical Journal of Natural Product Research, Journal Year: 2023, Volume and Issue: 7(8)

Published: Aug. 31, 2023

The 3-Chymotrypsine-Like Protease (3CLpro) is an enzyme that has a major function in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) life cycle. It can be utilized s protein target search for new medications. Herbal plants are expected to have contributions prevention and treatment of 2019 Corona Virus Disease (COVID-19), as many herbal might strong affinity 3CLpro COVID-19. purpose this study examine inhibitory activity, pytochemical components, antioxidant extracts from nine extracted by Ultrasound Assisted Extraction (UAE) method potential inhibit recombinant SARS-CoV-2 using vitro result, it used find novel medication candidates COVID-19 therapy. Determining activity DPPH ABTS method, total polyphenol flavonoid content Folin Ciocalteu quercetin method. From tested, Java Plum leaves (Syzygium cumini) had most active with value (IC50 = 226 μg/ml) 413±1.83 mg GAE/g extract 12.091±0.037 QE/g extract. Measurement obtained IC50 3.751 ± 0.0149 μg/ml, gives 4.43±0.06μg/ml. This suggests could source anti-COVID.

Language: Английский

Citations

1