Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 Mice DOI Open Access
Monica N. Goodland, Subhashis Banerjee,

Michael L. Niehoff

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 23, 2023

ABSTRACT Cannabidiol (CBD) has gained a lot of interest in recent years for its purported medicinal properties. CBD been investigated the treatment anxiety, depression, epilepsy, neuroinflammation, and pain. Recently there an as possible age-related disorders such Alzheimer’s disease related (ADRD). Here we tested hypothesis that chronic administration would improve learning memory SAMP8 mouse model disease. mice aged 11 months (at start study) were administered vehicle or (3 30 mg/Kg) daily via oral gavage 2 months. Vehicle-treated young (age 3 at served unimpaired controls. After days (4 12 age), memory, activity, strength dexterity assessed. High dose significantly improved 12-month-old T maze. Novel object recognition was also by treated mice. Aged displayed less anxiety elevated plus maze test compared to However, activity levels similar between groups. Biochemical analysis revealed decreased markers oxidative stress, providing mechanism which impacts learning, anxiety. These results highlight potential use therapeutic age cognitive impairment dementia.

Language: Английский

An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L. DOI Creative Commons

Kiran Shahane,

Madhuri Kshirsagar,

Srushti Tambe

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 611 - 611

Published: April 18, 2023

Calendula officinalis Linn. (CO) is a popular medicinal plant from the kingdom’s Asteraceae family that has been used for millennia. This contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil, amino acids, steroids, sterols, and quinines. These chemical constituents confer multifaceted biological effects such as anti-inflammatory, anti-cancer, antihelminthic, antidiabetes, wound healing, hepatoprotective, antioxidant activities. Additionally, it employed in cases of certain burns gastrointestinal, gynecological, ocular, skin conditions. In this review, we have discussed recent research last five years on therapeutic applications CO emphasized its myriad capabilities traditional medicine. We also elucidated CO’s molecular mechanisms clinical studies. Overall, review intends to summarize, fill gaps existing research, provide wealth possibilities researchers working validate claims advance safe effective use treating various ailments.

Language: Английский

Citations

87
Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease DOI Creative Commons
Jordan P. Hickey, Andrila E. Collins,

Mackayla L. Nelson

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4379 - 4402

Published: May 6, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative and the most common form of dementia globally. Although direct cause AD remains under debate, neuroinflammation oxidative stress are critical components in its pathogenesis progression. As result, compounds like cannabidiol (CBD) being increasingly investigated for their ability to provide antioxidant anti-inflammatory neuroprotection. CBD primary non-psychotropic phytocannabinoid derived from Cannabis sativa. It has been found beneficial outcomes variety medical conditions gaining increasing attention potential therapeutic application AD. not psychoactive lipophilic nature allows rapid distribution throughout body, including across blood–brain barrier (BBB). also possesses anti-inflammatory, antioxidant, neuroprotective properties, making it viable candidate treatment. This review outlines CBD’s mechanism action, role AD, effectiveness limitations preclinical models

Language: Английский

Citations

9
Cannabidiol Alleviates Neurological Deficits After Traumatic Brain Injury by Improving Intracranial Lymphatic Drainage DOI

Shiying Dong,

Hongwei Zhao, Meng Nie

et al.

Journal of Neurotrauma, Journal Year: 2024, Volume and Issue: 41(15-16), P. e2009 - e2025

Published: March 30, 2024

Traumatic brain injury (TBI) persists as a substantial clinical dilemma, largely because of the absence effective treatments. This challenge is exacerbated by hindered clearance intracranial metabolic byproducts and continual accrual deleterious proteins. The glymphatic system (GS) meningeal lymphatic vessels (MLVs), key elements network, play critical roles in harmful substances. Cannabidiol (CBD) has shown promise reducing metabolite overload bolstering cognitive performance various neurodegenerative diseases. precise mechanisms attributing to its beneficial effects TBI scenarios, however, are yet be distinctly understood. Utilizing fluid percussion paradigm, our research adopted multifaceted approach, encompassing behavioral testing, immunofluorescence immunohistochemical analyses, laser speckle imaging, western blot techniques, bilateral cervical efferent ligation. methodology aimed discern influence CBD on both neurological outcomes murine model. We observed that administration notably ameliorated motor, memory, functions, concurrently with significant reduction concentration phosphorylated tau protein amyloid-β. In addition, expedited turnover elimination tracers, increased cerebral blood flow, enhanced efficacy fluorescent tracer migration from MLVs deep lymph nodes (dCLNs). Remarkably, treatment also induced reversion aquaporin-4 (AQP-4) polarization curtailed neuroinflammatory indices. A pivotal discovery was surgical interruption conduits neck nullified CBD's positive contributions waste disposal improvement, anti-neuroinflammatory actions remained unaffected. These insights suggest may enhance clearance, potentially via regulation system, thereby offering neurofunctional prognostic improvement models. Our findings underscore potential therapeutic applicability interventions, necessitating further comprehensive investigations validations substantiate these initial conclusions.

Language: Английский

Citations

5
Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy DOI Creative Commons
Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 9, 2024

Abstract Mutations in the KCNT1 potassium channel cause severe forms of epilepsy which are poorly controlled with current treatments. In vitro studies have shown that KCNT1- mutations gain function, significantly increasing K + amplitudes. To investigate if Drosophila can be used to model human , we generated melanogaster lines carrying patient mutation G288S, R398Q or R928C. Expression each mutant GABAergic neurons gave a seizure phenotype responded either positively negatively 5 frontline drugs most commonly administered patients -epilepsy, often little no improvement seizures. Cannabidiol showed greatest reduction while some increased phenotype. Our study shows has potential - and as tool assess new treatments for epilepsy.

Language: Английский

Citations

4
ZKSCAN3 affects the autophagy‑lysosome pathway through TFEB in Parkinson's disease DOI Open Access

Ming Yang,

Shukai Lin,

Baofei Sun

et al.

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(4), P. 1 - 10

Published: Feb. 25, 2025

The present study aimed to explore the effects of zinc finger with KRAB and SCAN domains 3 (ZKSCAN3)/transcription factor EB (TFEB) on autophagy‑lysosome pathway in Parkinson's disease (PD). SH‑SY5Y cells were treated 6‑hydroxydopamine establish a PD cell model. A ZKSCAN3 overexpression vector short interfering (si)RNAs also constructed. TFEB was transfected into siRNA vector. Reverse transcription‑quantitative western blotting performed detect expression levels Beclin‑1, LC3II/I, α‑synuclein lysosomal‑associated membrane protein 1 (Lamp‑1). Lysosomes labelled LysoTracker Red morphological changes lysosomes detected by using laser confocal scanning microscopy. Transmission electron microscopy used observe autophagosomes lysosomes. Compared those normal group, model group presented decreases LC3B, ZKSCAN3, TFEB, Beclin‑1 Lamp‑1 mRNA increases LC3A, LC3II/I levels. resulted decrease LC3I mRNA, LC3 II/I levels, as well an increase LC3II interference LC3A protein, LC3B α‑synuclein. reversed ZKSCAN3. results lysosome detection revealed that, compared that fluorescence intensity lower. greater than empty group. number In conclusion, affected occurrence development through TFEB‑mediated pathway.

Language: Английский

Citations

0
Unravelling the Impact: Pulmonary Side Effects of Anti-Seizure Medications DOI
Ambra Butera,

M. Pirrone,

A. Accetta

et al.

Current Respiratory Medicine Reviews, Journal Year: 2024, Volume and Issue: 21(1), P. 29 - 47

Published: Feb. 2, 2024

Background: Epilepsy is a chronic brain condition affecting over 50 million people worldwide. Several new anti-seizure medications (ASMs) have been introduced to treat epilepsy in recent decades. Objective: Nearby the specific therapeutic action, ASMs, like other types of pharmacotherapy, can produce various side effects. In this review, we shall analyze different pharmaceutical classes their mechanism and interaction with respiratory system. Methods: This manuscript based on retrospective review English publications indexed by Pubmed, UpToDate datasheets published European Medicines Agency Food Drug Administration (FDA), using terms reminiscent ASMs pulmonary function. Results: act organism homeostasis ways, acting lung function directly indirectly playing protective or damaging role. A direct involvement ranged from infections, hypersensitivity reactions, depression structured diseases. Meanwhile, indirect effect, might be constituted artery hypertension. On hand, effect expression developmental processing, decreasing airway remodelling asthma patients, vascular hypertension and, nonetheless, anti-inflammatory immunomodulatory actions. Conclusion: An adequate awareness effects system seems essential for better managing frail individuals or/and those predisposed disorders improve our patients' clinical outcomes.

Language: Английский

Citations

1
Navigating neurological disorders: harnessing the power of natural compounds for innovative therapeutic breakthroughs. DOI
Rapuru Rushendran, Rukaiah Fatma Begum,

Ankul Singh S

et al.

PubMed, Journal Year: 2024, Volume and Issue: 23, P. 534 - 569

Published: Jan. 1, 2024

Novel treatments are needed as neurological issues become more frequent worldwide. According to the report, plants, oceans, microorganisms, and animals contain interesting drug discovery compounds. Alzheimer's, Parkinson's, stroke reviews emphasize disorders' complexity natural substances' safety. Learn about marine-derived herbal neuroprotective characteristics applications. Molecular pathways show these healing effects. This article discusses clinical usage of Bryostatin-1, Fucoidan, Icariin, Salvianolic acid, Curcumin, Resveratrol, etc. Their potential benefits for asthma Alzheimer's disease complex. Although limited, study promotes rigorous scientific research collaboration between traditional alternative medical practitioners. Unexplored compounds, quality control, well-structured trials, interdisciplinary should guide future study. Developing employing chemicals treat illnesses requires ethical sourcing, sustainability, public awareness. detailed analysis covers chemicals' current state, challenges, opportunities in disorder treatment. See also graphical abstract(Fig. 1).

Language: Английский

Citations

1
Outcomes and Outlooks of Therapeutic Application of Modulators of Endogenous Cannabinoid System in Parkinson's Disease DOI Open Access
Л. Г. Хаспеков, С. Н. Иллариошкин

Published: June 3, 2024

Recent studies have shown that the endogenous cannabinoid system (ECS) of brain is essentially involved in pathogenesis Parkinson's disease (PD), influencing its symptoms by regulating level cannabinoids and altering activation receptors (CBR). Therefore, modulation ECS with new drugs developed for this purpose may prove to be a promising strategy treatment PD. However, fine regulation quite challenge due functional diversity CBR basal ganglia. Our review analyses effects modulators on experimental PD models patients PD, as well presents outlooks development motor non-motor

Language: Английский

Citations

1
Effect of cannabidiol as a neuroprotective agent on neurodevelopmental impairment in rats with neonatal hypoxia DOI

Ángela Hernández-Suárez,

Luis A. Marín-Castañeda, Carmen Rubio

et al.

Brain and Development, Journal Year: 2024, Volume and Issue: 46(9), P. 294 - 301

Published: July 27, 2024

Language: Английский

Citations

1
Therapeutic Application of Modulators of Endogenous Cannabinoid System in Parkinson’s Disease DOI Open Access
Л. Г. Хаспеков, С. Н. Иллариошкин

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8520 - 8520

Published: Aug. 5, 2024

The endogenous cannabinoid system (ECS) of the brain plays an important role in molecular pathogenesis Parkinson’s disease (PD). It is involved formation numerous clinical manifestations by regulating level cannabinoids and changing activation receptors (CBRs). Therefore, ECS modulation with new drugs specifically designed for this purpose may be a promising strategy treatment PD. However, fine regulation quite complex task due to functional diversity CBRs basal ganglia other parts central nervous system. In review, effects modulators various experimental models PD vivo vitro, as well patients PD, are analyzed. Prospects development motor non-motor symptoms presented.

Language: Английский

Citations

1