Selenium nanoparticles based on Amphipterygium glaucum extract with antibacterial, antioxidant, and plant biostimulant properties

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 3, 2023

Abstract Background In recent years, crop production has expanded due to the variety of commercially available species. This increase in led global competition and search for biostimulant products that improve quality yield. At same time, agricultural protect against diseases caused by phytopathogenic microorganisms are needed. Thus, green synthesis selenium nanoparticles (SeNPs) is a proposal achieving these needs. this research, SeNPs were synthesized from methanolic extract Amphipterygium glaucum leaves, chemically biologically characterized. Results The characterization was conducted ultraviolet–visible spectrophotometry (UV–Vis), scanning electron microscopy (SEM), transmission (TEM), Dynamic Light Scattering (DLS), energy dispersion X-ray spectroscopy (EDX), infrared (FTIR) techniques. with an average size 40–60 nm spherical needle-shaped morphologies obtained. antibacterial activity Serratia marcescens , Enterobacter cloacae Alcaligenes faecalis evaluated. results indicate extracts A . presented high antioxidant activity. effect (10, 20, 50, 100 µM) evaluated vinca ( Catharanthus roseus ), calendula Calendula officinalis ) plants under greenhouse conditions, they improved growth parameters such as height, fresh dry weight roots, stems, leaves; number flowers calendula. Conclusions antibacterial, antioxidant, properties A. demonstrated study support their use promising tool production. Graphical

Language: Английский

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Imidazo[1,2-a]pyridine-appended chalcone and Schiff base conjugates: Synthetic, spectrophotometric, biological, and computational aspects

Chemical Physics Impact, Journal Year: 2024, Volume and Issue: 9, P. 100694 - 100694

Published: July 23, 2024

Herein we describe 2-chloroimidazo[1,2-a]pyridine-appended Schiff base and chalcone conjugates, exploring their synthetic, spectrophotometric, biological, computational aspects. UV–visible study revealed that scaffolds VIc VIIIa exhibit bathochromic hypsochromic shifts respectively compared to analogs, due auxochrome effect. The molecular docking simulations were performed investigate the binding interactions of motifs with three cancerous target proteins (4HJO, 1M14, 1M17) four microbial proteins. compound VIIIb exhibited significant anti-lung cancer activity (GI50: 22.3) against A-459 cell line. Moreover, synthesized compounds auspicious antibacterial Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, MIC ranging from 64 175 µg/mL. Additionally, in-silico prediction analysis suggested a considerable likelihood (26.7%) acting on kinases for VIIIc. In-silico toxicity scrutiny anticipated all as non-fatal less toxic they belong class 4 (300 < LD50 ≤ 2000). Further structural insights into gained through optimized geometries, FMOs, MEP plots, global reactivity descriptors (µ, ɳ, S, ω), aiding in understanding features, potential reactivity, toxicity. Overall, these results highlight prepared moieties hopeful intrants further development.

Language: Английский

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Drying as a Preservation Strategy for Medicinal Plants: Physicochemical and Functional Outcomes for Food and Human Health

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100762 - 100762

Published: Feb. 1, 2025

Language: Английский

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Pullulan/Poly(vinyl alcohol) Hydrogels Loaded with Calendula officinalis Extract: Design and In Vitro Evaluation for Wound Healing Applications

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1674 - 1674

Published: June 7, 2023

The therapeutic efficiency of plant extracts has been limited by their poor pharmaceutical availability. Hydrogels have promising potential to be applied as wound dressings due high capacity absorb exudates and enhanced performance in loading releasing extracts. In this work, pullulan/poly (vinyl alcohol) (P/PVA) hydrogels were first prepared using an eco-friendly method based on both a covalent physical cross-linking approach. Then, the loaded with hydroalcoholic extract Calendula officinalis simple post-loading immersion method. Different capacities investigated terms physico-chemical properties, chemical composition, mechanical water absorption. exhibited hydrogen bonding interactions between polymer extract. retention well properties decreased increase amount hydrogel. However, higher amounts hydrogel improved bioadhesiveness. release from was controlled Fickian diffusion mechanism. Extract-loaded expressed antioxidant activity, reaching 70% DPPH radical scavenging after 15 min buffer solution at pH 5.5. Additionally, showed antibacterial activity against Gram-positive Gram-negative bacteria non-cytotoxic HDFa cells.

Language: Английский

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Medicinal Plants Used by Oromo Community in Kofale District, West-Arsi Zone, Oromia Regional State, Ethiopia

Journal of Experimental Pharmacology, Journal Year: 2024, Volume and Issue: Volume 16, P. 81 - 109

Published: March 1, 2024

Purpose: The purpose of this study was to record the utilization medicinal plants by Oromo people in Kofale District, Oromia Regional State, Ethiopia, control human and animal health problems. Methods: Data regarding use were collected using ethnobotanical methods from 84 traditional medicine practitioners 304 general informants sampled employing purposive systematic random sampling methods, respectively, District. analyzed different indices, including a preference ranking exercise, informant consensus factor (ICF), fidelity level (FL) relative popularity (RPL). Results: In district, 106 claimed be used for treatment 43 18 livestock illnesses, which 75 (71%) manage problems, 23 (21.5%) treat both ailments eight (7.5%) utilized Most (76.4%) harvested wild. Leaves most commonly plant part (55.6%) remedy preparations. Skin diseases scored highest ICF value (0.97), followed gastrointestinal disorders (ICF = 0.95), cancer 0.93), hemorrhoids 0.91). Medicinal that (100%) rank order priority (ROP) values included Justicia schimperiana, Embelia schimperi, Ekebergia capensis Datura stramonium , have been liver disorders, tapeworm infections, babesiosis, rabies, respectively. There significant differences ( p < 0.05) mean numbers social groups: older, illiterate, reported higher than younger, literate, informants, Conclusion: This indicated richness species with FL ROP those disease categories should prioritized future phytochemical pharmacological investigations. Keywords: study, medicine, knowledge, herbal

Language: Английский

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Review on application of herbal extracts in biomacromolecules-based nanofibers as wound dressings and skin tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133666 - 133666

Published: July 5, 2024

Language: Английский

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Synthesis, crystal structure investigation, and theoretical approaches to discover potential 6-bromo-3-cyanocoumarin as a potent inhibitor MetAP (methionine aminopeptidase) 2

Chemical Physics Impact, Journal Year: 2024, Volume and Issue: 8, P. 100477 - 100477

Published: Jan. 17, 2024

It has been ascertained that trifluoroacetic acid accelerates the Knoevenagel condensation reaction of 5-bromosalicylaldehyde and ethyl ester cyanoacetic acid. As a result, 6-bromo-3-cyanocoumarin compound synthesized structure was eventually confirmed by X-ray analysis. Based on structure-activity relationship literature survey we found this potent inhibitor for MetAP (methionine aminopeptidase) further have studied molecular docking to understand binding interactions also performed ADME/T studies compound. The surface reactivity intermolecular were investigated Hirshfeld Energy framework analysis shows interaction between pair fragments with neighbour molecules. Furthermore, DFT study is investigate structural stability at B3LY/6-311+G(d,p) functional. decreased HOMO-LUMO gap (3.97 eV) indicates its higher soft nature. Molecular electrostatic potential (MESP) NBO charges indicate structure's reactive site charge transfer. Excited using TD-DFT get excitation energy (ΔE), absorbance, oscillator strength (fo) crucial transition. Theoretically predicted values polarizability (αo) hyperpolarizability (βo) suggest their excellent optical Nnar (NLO) properties.

Language: Английский

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Medicinal Herbs: Promising Immunomodulators for the Treatment of Infectious Diseases

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8045 - 8045

Published: Dec. 12, 2023

Humans are constantly at high risk of emerging pandemics caused by viral and bacterial infections. The emergence new is mainly evolved viruses bacteria that highly resistant to existing medications. rapid evolution infectious agents demands the urgent investigation therapeutic strategies prevent treat these infections an early stage. One includes use medicinal herbs for their antibacterial antiviral properties. herbal medicines as remedies very ancient has been employed centuries. Many studies have confirmed antimicrobial activities against various pathogens in vitro vivo. effect attributed natural bioactive molecules present plants such alkaloids, flavonoids, terpenoids. Different mechanisms proposed how enhance immune system combat pathogens. Such include disruption cell membranes, suppression protein synthesis, limitation pathogen replication through inhibition nucleic acid synthesis. Medicinal shown a number diseases modulating system's components. For instance, many alleviate inflammation reducing pro-inflammatory cytokines (e.g., tumor necrosis factor-alpha (TNF-α), interleukin-1, IL-6) while promoting production anti-inflammatory IL-10). also play role defense intracellular enhancing proliferation functions killer cells, T-helper-1 macrophages. In this review, we will explore most common preventing treating non-infectious diseases. Using current recently published studies, focus on immunomodulatory effects induced responses during

Language: Английский

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Natural Deep Eutectic Solvents as a Novel Bio-Based Matrix for Ready-to-Use Natural Antioxidants-Enriched Ingredients: Extraction and Formulation Optimization

Cosmetics, Journal Year: 2024, Volume and Issue: 11(1), P. 17 - 17

Published: Jan. 25, 2024

The escalating consumer demand for sustainable cosmetic ingredients poses distinct challenges, particularly concerning their stability within the final formulation. Although natural resources offer a pool of antioxidant molecules with diverse structures and polarities, achieving stabilization combined comprehensive profile often proves incompatible practical preformulation considerations. Notably, Calendula, which is rich in both polar (glycosylated flavonoids) nonpolar (carotenoids) antioxidants, standout candidate. Nevertheless, market lacks an ingredient embodying this diversity, primarily due to limited polarity range available usable solvents. Natural deep eutectic solvents (NaDESs) emerge as promising solution. This study explores NaDES technology goal developing unique Calendula extract enriched polarities composition that unattainable traditional A screening 12 NaDESs varying highlighted based on betaine glycerol effective, outperforming ethanol. Leveraging response surface methodology, optimal mechanical stirring procedure extraction was identified. resulting showed total flavonoid content 45.42 ± 0.85 mg eq rutin/g biomass carotenoid 383.54 4.73 µg/g biomass. It then incorporated into cream (1% 10%wt) using innovative mixing technology. creams demonstrated over 90 days, no significant deviations pH or rheological properties compared control, droplet size inferior 10 µm. lays foundation pioneering cocktail-loaded are suitable eco-friendly formulations, substantiating viability integrating environmentally friendly ingredient-based

Language: Английский

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Rational Approach toward COVID-19′s Main Protease Inhibitors: A Hierarchical Biochemoinformatics Analysis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6715 - 6715

Published: June 18, 2024

This study investigated the potential of selected compounds as inhibitors SARS-CoV-2 Mpro through pharmacokinetic and toxicological analyses, molecular docking, dynamics simulations. In silico docking simulations revealed promising ligands with favorable binding affinities for Mpro, ranging from −6.2 to −9.5 kcal/mol. Moreover, demonstrated stability protein–ligand complexes over 200 ns, maintaining protein secondary structures. MM-PBSA analysis interactions between negative energy values. Hydrogen bond formation capacity during was confirmed, indicating consistent catalytic residues. Based on these findings, show promise future studies in developing COVID-19 treatments.

Language: Английский

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