Advances in the Epidemiology, Pathogenesis, Diagnostic Methods, and Vaccine Development of Dengue Fever: A Comprehensive Review

Viral Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Dengue fever (DF) is a common mosquito-borne viral infection caused by any of the four dengue virus (DENV) serotypes. In recent years, global incidence DF has risen rapidly, which widely threatened health millions people in United States, Southeast Asia, and Western Pacific. The challenges for prevention control DENV have become increasingly severe. Over advances area research been continuously updating. this review, we provide an updated more in-depth overview epidemiology pathogenesis, along with progress diagnostic approaches (including methods to address cross-reactivity other flaviviruses) expanded discussion current vaccine development, such as CYD-TDV (Dengvaxia), TV003/TV005, new TAK-003. This comprehensive perspective aims offer references prevention, clinical diagnosis, disease.

Language: Английский

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Multi-epitope peptide vaccines targeting dengue virus serotype 2 created via immunoinformatic analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 31, 2024

The Middle East has witnessed a greater spread of infectious Dengue viruses, with serotype 2 (DENV-2) being the most prevalent form. Through this work, multi-epitope peptide vaccines against DENV-2 that target E and nonstructural (NS1) proteins were generated through an immunoinformatic approach. MHC class I II LBL epitopes among NS1 envelope sequences predicted their antigenicity, toxicity, allergenicity investigated. Studies population coverage denoted high prevalence envelope-E different countries where endemic. Further, both CTL HTL retrieved from exhibited conservancies' percentages other DENV serotypes (1, 3, 4). Three vaccine constructs created expected immune responses for estimated using C-IMMSIM HADDOCK (against TLR 2,3,4,5, 7). Molecular dynamics simulation construct TLR4 binding affinity stability receptor which might foretell favorable in vivo interaction responses.

Language: Английский

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DENGUE: ASPECTOS EPIDEMIOLÓGICOS E SUA ASSOCIAÇÃO COM SINAIS E SINTOMAS ENTRE 2021 e 2023, EM LAJEADO, RIO GRANDE DO SUL, BRASIL

Brazilian Journal of Implantology and Health Sciences, Journal Year: 2025, Volume and Issue: 7(1), P. 1274 - 1296

Published: Jan. 15, 2025

A dengue é uma doença viral transmitida, no Brasil, pelo mosquito Aedes aegypti. O presente estudo teve como objetivo avaliar a incidência da infecção vírus município de Lajeado, período 2021 2023. retrospectivo e transversal analisou 5.679 fichas do Sistema Informação Agravos Notificação (SINAN) avaliado. Os resultados revelaram que, entre os 4.322 casos confirmados, seis foram com sinais alarme somente dois classificados grave. Houve um predomínio mulheres (55,1%) sintomas mais frequentes mialgia (85,8%), febre (84%), cefaleia (81,5%) náusea (54%). média geral idade em indivíduos sem foi 40,46 (±19,93). maioria (65,3%) classificada base clínicos, enquanto que 34,7% através exames laboratoriais. 99,4% dos evoluíram sucesso para cura, (0,1%) óbito agravo. Sorotipo prevalente 100% nos três anos avaliados o DENV-1. Com conclui-se avaliado ocorreram manifestações brandas doença, comuns à forma clássica, incluindo mialgia, cefaleia. Destaca-se reforça importância coleta análise dados contínua precisa., reforçando necessidade ações preventivas acompanhamento circulação sorotipos, fim prevenir desfechos maior gravidade.

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A Review of Recent Developments and Control Methodsfor Dengue Fever by herbal and synthetic drugs

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e41939 - e41939

Published: Jan. 1, 2025

Dengue virus represents a global public health threat, being prevalent in tropical and subtropical regions, with an increasing geographical distribution rising incidence worldwide. This mosquito-borne viral agent causes wide range of clinical manifestations, from mild febrile illness to severe cases potentially fatal outcomes due hemorrhage shock syndrome. The etiological agent, dengue (DENV), has four distinct serotypes, each capable inducing outcomes. current therapeutic landscape remains limited, management strategies mainly focused on supportive cares. However, recent advances pharmaceutical research have yielded promising developments anti-dengue drugs. Extensive investigations been conducted various synthetic compounds, including JNJ-1802, 1,4-pyran naphthoquinones, arylnaphthalene lignan derivatives. Additionally, natural compounds derived medicinal plants such as Hippophae rhamnoides, Azadirachta indica, Cymbopogon citratus demonstrated potential antiviral properties both vitro vivo studies, based inhibition DENV replication. none these are date approved by the U.S. Food Drug Administration (FDA). Although many vaccines recognized candidates stages trials, only limited number protective efficacy against infection. aspect underscores need for highly effective immunization interventions, whether botanical sources or through manufacturing, that exhibit low adverse effects. review examines innovative approaches prevention treatment, encompassing phytochemical strategies.

Language: Английский

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Albumin Infusion in Children With Fluid Refractory Severe Dengue: A Comparative Study

Indian Pediatrics, Journal Year: 2025, Volume and Issue: 62(2), P. 102 - 108

Published: Jan. 30, 2025

Language: Английский

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Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis

The Ultrasound Journal, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 3, 2025

Abstract Background The prevalence of dengue fever (DF), a mosquito-borne viral disease, is rising worldwide. Its severe manifestations like thrombocytopenia and plasma leakage are associated with increased mortality. Ultrasound-detected gallbladder wall thickening (GBWT) has been suggested as potential indicator the severity disease. Aims This systematic review meta-analysis evaluated predictive value GBWT in identifying patients at risk for dengue. Methods Following PRISMA 2020 guidelines, we conducted search Web Science, PubMed, Embase, Scopus. Among inclusion criteria were original studies that assessed across various categories. Then, performed using random effects model subgroup analyses based on to determine relationship between Results For meta-analysis, 19 qualified criteria. There was significant association dengue, according odds ratio (OR) 2.35 (95% CI 1.88–2.82, p < 0.001). analysis revealed consistent results (OR: 2.65) 2.26), among other Conclusions A reliable ultrasound indicator, can help identify early on, improving clinical decision-making patient outcomes. However, possibility differential diagnosis requires cautious interpretation.

Language: Английский

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Prognostic factors for mortality in children with severe dengue: A single-centre retrospective cohort study

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e43021 - e43021

Published: Feb. 1, 2025

Language: Английский

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Migration und tropische Erkrankungen in der Intensivmedizin

Intensivmedizin up2date, Journal Year: 2025, Volume and Issue: 21(01), P. 57 - 73

Published: March 1, 2025

Die Bedeutung tropischer Erkrankungen im allgemeinmedizinischen Bereich, aber auch in der Intensivmedizin nimmt den letzten Jahren deutlich zu. Dieser Entwicklung liegen 2 Hauptfaktoren zugrunde: eine stetig steigende globale Reiseaktivität und damit ein Anstieg Zahl erkrankter Reiserückkehrer*innen sowie Migrationsbewegungen. Der Beitrag stellt einige wesentliche deren Therapie vor.

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Anesthetic management of a 17-month-old patient with severe dengue fever, anemia, ascites, and secondary acinetobacter baumannii infection: A case report

Multidisciplinary Science Journal, Journal Year: 2025, Volume and Issue: 7(8), P. 2025402 - 2025402

Published: Feb. 15, 2025

Dengue fever, especially in its severe forms such as dengue hemorrhagic fever (DHF) and shock syndrome (DSS), is a significant global health concern. This case report discusses the anesthetic management of 17-month-old male with complicated by profound anemia, ascites, secondary infection Acinetobacter baumannii. The child presented tachycardia, tachypnea, thrombocytopenia, hepatomegaly. His critical condition required multidisciplinary approach to ensure optimal care favorable outcome. Preoperative assessment highlighted need for addressing hematological abnormalities fluid imbalances. Thrombocytopenia was enough necessitate platelet transfusions. Anemia addressed red blood cell Fluid balance hard maintain because ascites danger overload. Monitoring adjustments had be very meticulous. Secondary bacterial specific antibiotics, which were begun early. Since critically surgical intervention, general anesthesia administered escharotomy. Invasive monitoring arterial central venous catheters allowed continuous hemodynamics, status, oxygenation. Collaboration between anesthesiology team PICU staff during perioperative period also crucial. managed postoperatively PICU, close vital signs, respiratory functions, fluid-electrolyte balance. A effort ensured substantial clinical improvement, proof value teamwork-based approach. Specialized interdepartmental collaboration complex pediatric patients are crucial factors achieve safety promote recovery among most vulnerable populations.

Language: Английский

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Migration und tropische Erkrankungen in der Intensivmedizin

Published: March 1, 2025

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