ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(31), P. 20101 - 20110
Published: July 23, 2024
Osteoarthritis
(OA)
is
a
prevalent
degenerative
disease
that
afflicts
more
than
250
million
people
worldwide,
impairing
their
mobility
and
quality
of
life.
However,
conventional
drug
therapy
palliative.
Exosomes
(Exo),
although
with
the
potential
to
fundamentally
repair
cartilage,
face
challenges
in
efficient
enrichment
delivery.
In
this
study,
we
developed
magnetic
polysaccharide
hydrogel
particles
as
microcarriers
for
synergistic
OA.
The
were
composed
modified
natural
polysaccharides,
hyaluronic
acid
(HAMA),
chondroitin
sulfate
(CSMA),
generated
from
microfluidic
electrospray
combination
cryogelation
process.
Magnetic
nanoparticles
spiny
structures
capable
capturing
stem
cell
Exo
encapsulated
within
together
an
anti-inflammatory
diclofenac
sodium
(DS).
released
DS
had
effect
alleviating
OA
symptoms
promoting
cartilage
repair.
vitro
vivo
results
demonstrated
excellent
performance
microcarrier
treatment.
We
believe
work
has
other
related
diseases.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 27, 2024
With
the
accelerated
aging
tendency,
osteoarthritis
(OA)
has
become
an
intractable
global
public
health
challenge.
Stem
cells
and
their
derivative
exosome
(Exo)
have
shown
great
potential
in
OA
treatment.
Research
this
area
tends
to
develop
functional
microcarriers
for
stem
cell
Exo
delivery
improve
therapeutic
effect.
Herein,
we
a
novel
system
of
Exo-encapsulated
cell-recruitment
hydrogel
from
liquid
nitrogen-assisted
microfluidic
electrospray
Benefited
advanced
droplet
generation
capability
microfluidics
mild
cryogelation
procedure,
resultant
particles
show
uniform
size
dispersion
excellent
biocompatibility.
Moreover,
acryloylated
recruitment
peptides
SKPPGTSS
are
directly
crosslinked
within
by
ultraviolet
irradiation,
thus
simplifying
peptide
coupling
process
preventing
its
premature
release.
The
SKPPGTSS-modified
can
recruit
endogenous
promote
cartilage
repair
released
further
enhances
performance
through
synergistic
effects.
These
features
suggest
that
proposed
microcarrier
is
promising
candidate
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9149 - 9149
Published: Aug. 23, 2024
Osteoarthritis
(OA)
is
a
leading
cause
of
pain
and
disability
worldwide
in
elderly
people.
There
critical
need
to
develop
novel
therapeutic
strategies
that
can
effectively
manage
improve
the
quality
life
for
older
Mesenchymal
stem
cells
(MSCs)
have
emerged
as
promising
cell-based
therapy
age-related
disorders
due
their
multilineage
differentiation
strong
paracrine
effects.
Notably,
MSC-derived
exosomes
(MSC-Exos)
gained
significant
attention
because
they
recapitulate
MSCs
into
benefits
without
causing
any
associated
risks
compared
with
direct
cell
transplantation.
These
help
transport
bioactive
molecules
such
proteins,
lipids,
nucleic
acids,
which
influence
various
cellular
processes
related
tissue
repair,
regeneration,
immune
regulation.
In
this
review,
we
provided
an
overview
MSC-Exos
considerable
treatment
option
osteoarthritis.
This
review
will
go
over
underlying
mechanisms
by
may
alleviate
pathological
hallmarks
OA,
cartilage
degradation,
synovial
inflammation,
subchondral
bone
changes.
Furthermore,
summarized
current
preclinical
evidence
highlighted
results
from
vitro
vivo
studies,
well
progress
clinical
trials
using
treat
OA.
Biochemical Pharmacology,
Journal Year:
2024,
Volume and Issue:
228, P. 116226 - 116226
Published: April 23, 2024
Osteoarthritis
(OA)
is
a
degenerative
joint
condition
that
contributes
to
years
lived
with
disability.
Current
therapeutic
approaches
are
limited
as
there
no
disease-modifying
interventions
able
delay
or
inhibit
the
progression
of
disease.
In
recent
has
been
an
increasing
interest
in
immunomodulatory
and
regenerative
properties
mesenchymal
stem/stromal
cells
(MSCs)
develop
new
OA
therapies.
Extracellular
vesicles
(EVs)
mediate
many
biological
effects
these
may
represent
alternative
avoiding
limitations
cell-based
therapy.
There
also
growing
EV
modifications
enhance
their
efficacy
applications.
Recent
preclinical
studies
have
provided
strong
evidence
supporting
potential
MSC
EVs
for
development
treatments.
Thus,
regulate
chondrocyte
functions
avoid
cartilage
destruction,
abnormal
subchondral
bone
metabolism
synovial
tissue
alterations,
control
pain
behavior.
actions
be
mediated
by
transfer
cargo
target
cells,
important
role
proteins
non-coding
RNAs
modulating
signaling
pathways
relevant
progression.
Nevertheless,
additional
investigations
needed
concerning
optimization,
standardization
preparation
procedures.
More
research
required
better
knowledge
possible
on
different
phenotypes,
pharmacokinetics,
mechanism
action,
long-term
safety
profile.
Furthermore,
high
vehicles
drug
delivery
adjuvant
therapy
potentiate
complement
other
approaches.
Medicine,
Journal Year:
2025,
Volume and Issue:
104(6), P. e41459 - e41459
Published: Feb. 7, 2025
The
BixizelanYin
(BXZLY)
is
a
traditional
herbal
formula
for
treating
damp-heat
type
knee
osteoarthritis
(KOA).
This
study
aimed
to
investigate
the
potential
therapeutic
effects
of
BXZLY
on
KOA
by
using
network
pharmacology
and
molecular
docking.
Active
ingredients
their
corresponding
targets
were
screened
through
Traditional
Chinese
Medicine
Systems
Pharmacology
Database
Analysis
Platform.
known
disease
retrieved
from
GeneCards
Online
Mendelian
Inheritance
in
Man
database.
effective
obtained
with
Venny
platform.
A
drug-component-target
diagram
was
constructed
Cytoscape
3.7.2
software,
protein–protein
interaction
established
via
STRING
visualized
software.
biological
functions
wereanalyzed
Gene
Ontology
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analysis
DAVID
KEGG
visualization
bubble
charts
generated
OmicShare
online
platform
explore
KOA.
main
signaling
pathways
investigated
analysis.
Finally,
AutoDockTools
software
used
docking
validation
key
molecules
drug
proteins
disease.
total
108
active
compounds
280
target
identified.
There
2816
disease-related
related
KOA,
among
which
99
targeted
treatment.
Key
included
β-sitosterol,
stigmasterol,
campesterol,
quercetin,
dioscin.
Core
consisted
STAT3,
ESR1,
EGFR,
JUN,
PTGS2.
mainly
involved
advanced
glycation
end
products
–
receptor
products,
estrogen,
HIF-1,
relaxin
signal
pathways.
Molecular
showed
strong
binding
affinity
between
core
proteins.
Docking
candidates
selected
based
oral
bioavailability
≥
30%,
drug-likeness
0.18,
degree
values
Cytoscape.
strategy
ensured
reliable
selection
high
relevance.
provides
comprehensive
treatment
regulating
cell
proliferation
alleviating
inflammation
its
multi-component,
multi-target,
multi-pathway
effects.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 5, 2025
Osteoarthritis
(OA)
is
a
debilitating
disease
that
predominantly
impacts
the
hip,
hand,
and
knee
joints.
Its
pathology
defined
by
progressive
degradation
of
articular
cartilage,
formation
bone
spurs,
synovial
inflammation,
resulting
in
pain,
joint
function
limitations,
substantial
societal
familial
burdens.
Current
treatment
strategies
primarily
target
pain
alleviation,
yet
improved
interventions
addressing
underlying
are
scarce.
Recently,
exosomes
have
emerged
as
subject
growing
interest
OA
therapy.
Numerous
studies
investigated
to
offer
promising
therapeutic
approaches
for
through
diverse
vivo
vitro
models,
elucidating
mechanisms
which
from
various
cell
sources
modulate
cartilage
microenvironment
promote
repair.
Preclinical
investigations
demonstrated
regulatory
effects
originating
human
cells,
including
mesenchymal
stem
cells
(MSC),
fibroblasts,
chondrocytes,
macrophages,
derived
Chinese
herbal
medicines,
on
modulation
repair
signaling
pathways.
Additionally,
encompass
matrix,
proliferation
migration
autophagy,
apoptosis,
mitigation
oxidative
stress.
An
increasing
number
exosome
carrier
scaffolds
under
development.
Our
review
adopts
multidimensional
approach
enhance
comprehension
pivotal
functions
exerted
sourced
types
OA.
Ultimately,
our
aim
pinpoint
targets
capable
regulating
facilitating
Cells,
Journal Year:
2023,
Volume and Issue:
12(23), P. 2716 - 2716
Published: Nov. 27, 2023
Cells
can
communicate
with
each
other
through
extracellular
vesicles
(EVs),
which
are
membrane-bound
structures
that
transport
proteins,
lipids
and
nucleic
acids.
These
have
been
found
to
mediate
cellular
differentiation
proliferation
apoptosis,
as
well
inflammatory
responses
senescence,
among
others.
The
cargo
of
these
may
include
immunomodulatory
molecules,
then
contribute
the
pathogenesis
various
diseases.
By
contrast,
EVs
secreted
by
mesenchymal
stem
cells
(MSCs)
shown
important
immunosuppressive
regenerative
properties.
Moreover,
be
modified
used
drug
carriers
precisely
deliver
therapeutic
agents.
In
this
review,
we
aim
summarize
current
evidence
on
roles
in
progression
treatment
rheumatoid
arthritis
(RA)
osteoarthritis
(OA),
prevalent
joint
diseases
a
significant
global
burden.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(3), P. 246 - 246
Published: March 1, 2024
The
unique
physical
demands
of
tactical
athletes
put
immense
stress
on
the
knee
joint,
making
these
individuals
susceptible
to
injury.
In
order
ensure
operational
readiness,
management
options
must
restore
and
preserve
native
architecture
minimize
downtime,
while
optimizing
functionality.
Osteochondral
lesions
(OCL)
have
long
been
acknowledged
as
significant
sources
pain
functional
deficits.
OCL
is
predicated
certain
injury
characteristics,
including
lesion
location
extent
subchondral
disease.
Techniques
such
marrow
stimulation,
allograft
autologous
chondrocyte
implantation
are
examined
in
detail,
with
a
focus
their
application
suitability
athlete
populations.
Moreover,
restoration
osteochondral
unit
(OCU)
highlighted
central
aspect
joint
preservation.
discussion
encompasses
biomechanical
considerations
outcomes
associated
various
cartilage
techniques.
Factors
influencing
procedure
selection,
size,
location,
patient-specific
variables,
thoroughly
examined.
Additionally,
review
underscores
critical
role
post-operative
rehabilitation
conditioning
programs
outcomes.
Strengthening
surrounding
musculature,
enhancing
stability,
refining
movement
patterns
paramount
facilitating
successful
integration
preservation
procedures.
This
narrative
aims
provide
comprehensive
resource
for
surgeons,
engineers,
sports
medicine
practitioners
engaged
care
field
restoration.
advanced
techniques
tailored
protocols
offers
promising
avenue
sustaining
health
function
this
demanding
population.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 23, 2024
Osteoarthritis
(OA)
is
the
most
common
type
of
arthritis
characterized
by
progressive
cartilage
degradation,
with
its
pathogenesis
closely
related
to
chondrocyte
autophagy.
Chondrocytes
are
only
cells
in
articular
cartilage,
and
function
chondrocytes
plays
a
vital
role
maintaining
homeostasis.
Autophagy,
an
intracellular
degradation
system
that
regulates
energy
metabolism
cells,
incredibly
important
OA.
During
early
stages
OA,
autophagy
enhanced
chondrocytes,
acting
as
adaptive
mechanism
protect
them
from
various
environmental
changes.
However,
progress
gradually
decreases,
leading
accumulation
damaged
organelles
macromolecules
within
cell,
prompting
apoptosis.
Numerous
studies
have
shown
influenced
senescence
apoptosis
which
associated
reduced
The
relationship
between
autophagy,
senescence,
complex.
While
generally
believed
inhibit
cellular
promote
cell
survival,
recent
some
proteins
degraded
selective
secretion
senescence-associated
secretory
phenotype
(SASP)
or
increased
SA-β-Gal
activity
senescent
region
human
OA
cartilage.
Autophagy
activation
may
lead
different
outcomes
depending
on
timing,
duration,
activation.
Thus,
our
study
explored
complex
well
regulatory
molecules
signaling
pathways,
providing
new
insights
for
future
development
safe
effective
drugs
targeting
improve
