The association between low-dose aspirin intake and osteoarthritis: a population-based cross-sectional study based on NHANES DOI Creative Commons

Binglang Xiong,

Cheng Zhang, Xuhan Cao

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 9, 2024

Objectives Low-dose aspirin is widely used as a preventive medication for cardiovascular diseases. However, there controversy regarding the impact of low-dose on articular cartilage. The aim this study to explore association between intake and osteoarthritis (OA). Methods We conducted cross-sectional based United States population data from National Health Nutrition Examination Survey (NHANES) 2011–2018. investigation diagnosis OA was self-reporting in questionnaires. Multivariate regression models assess relationship OA. In addition, subgroup interaction analysis were performed robustness results. Results A total 12,215 participants included study. logistic showed that use had significantly increased odds (OR = 1.14; 95% CI: 1.01–1.28; p 0.035). significant consistent with still observed each stratified by gender, age, presence comorbidities including diabetes, coronary heart disease, hypertension, stroke. results illustrated stable all subgroups no interaction. Conclusion Our confirmed may increase risk Attention should be paid possibility joint degenerative changes patients who take chronically. further studies are needed possible mechanisms behind association.

Language: Английский

Harnessing the potential of hyaluronic acid methacrylate (HAMA) hydrogel for clinical applications in orthopaedic diseases DOI Creative Commons
Junliang Lu, Zongzhan Gao, Wei He

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 111 - 128

Published: Jan. 1, 2025

The treatment of orthopaedic diseases, such as fractures and osteoarthritis, remains a significant challenge due to the complex requirements for mechanical strength tissue repair. Hydrogels based on hyaluronic acid methacrylate (HAMA) show promise engineering materials these conditions. Hyaluronic (HA) is natural component extracellular matrix, known its good compatibility. HAMA-based hydrogels can be adjusted through crosslinking by combining them with other materials. This review provides an overview recent research applications in diseases. First, we summarize techniques preparation characterization HAMA hydrogels. Next, offer detailed use treating conditions cartilage injuries, bone defects, meniscus injuries. Additionally, discuss diseases related orthopaedics. Finally, point out challenges propose future directions clinical translation strong translational potential orthopaedics their biocompatibility, adjustable properties, regenerative capabilities. With ongoing research, are well-positioned applications, particularly repair, osteoarthritis treatment.

Language: Английский

Citations

3
How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis? A Comprehensive Review DOI Creative Commons
Manoj Rajankunte Mahadeshwara, Maisoon Al‐Jawad, Richard M. Hall

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(6), P. 541 - 541

Published: May 24, 2024

Cartilage degeneration is a characteristic of osteoarthritis (OA), which often observed in aging populations. This due to the breakdown articular cartilage (AC) mechanical and tribological properties primarily attributed lubrication failure. Understanding reasons behind these failures identifying potential solutions could have significant economic societal implications, ultimately enhancing quality life. review provides an overview developments field AC, focusing on its properties. The emphasis role degraded offering insights into structure function relationship. Further, it explores fundamental connection between AC mechano-tribological advancement degradation puts forth recommendations for strategies boost efficiency.

Language: Английский

Citations

6
Bone and Joint‐on‐Chip Platforms: Construction Strategies and Applications DOI
Chengcheng Du, Jiacheng Liu, Senrui Liu

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: May 19, 2024

Organ-on-a-chip, also known as "tissue chip," is an advanced platform based on microfluidic systems for constructing miniature organ models in vitro. They can replicate the complex physiological and pathological responses of human organs. In recent years, development bone joint-on-chip platforms aims to simulate processes occurring bones joints, including cell-cell interactions, interplay various biochemical factors, effects mechanical stimuli, intricate connections between multiple future, will integrate advantages disciplines, bringing more possibilities exploring disease mechanisms, drug screening, personalized medicine. This review explores construction application Organ-on-a-chip technology joint research, proposes a modular concept, discusses new opportunities future challenges platforms.

Language: Английский

Citations

6
Elevated expression of Piezo1 activates the cGAS-STING pathway in chondrocytes by releasing mitochondrial DNA DOI

Lin Sun,

Yao Wang,

Tianyou Kan

et al.

Osteoarthritis and Cartilage, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Is There a Role of Photoacoustic Imaging in Sports Medicine: Evidence Today DOI Creative Commons
Charlie Ma,

Aditi Chadha,

Cheng‐Chia Wu

et al.

Orthopaedic Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Diagnostic imaging in sports medicine includes traditional modalities such as x-ray, computed tomography (CT), and magnetic resonance (MRI). Despite having certain advantages, these techniques often have lower sensitivity specificity, making it difficult to detect soft tissue injuries early-stage cartilage damage. They also lack the ability assess biomechanical properties functional states of tissues. Photoacoustic (PAI) offers a powerful, non-ionizing, cost-effective alternative diagnosis therapeutic monitoring injuries. PAI combines benefits optical ultrasound provide high-resolution images deep tissues, including tendons ligaments. This technology uses pulsed lasers irradiate causing thermal expansion generating waves, which are then captured converted into images. is particularly adept at depicting blood vessels tissues with high resolution absorption contrasts oxy- deoxyhemoglobin. It can oxygenation metabolic activities, crucial for evaluating healing process Herein, role assessed its advantages over methods x-rays, CT scans, MRI scans diagnosing musculoskeletal

Language: Английский

Citations

0
Application characteristics and clinical effectiveness of clinical finding staging in guiding non-surgical treatment of knee osteoarthritis involving 92 medical institutions DOI Creative Commons

Yan Yan,

Baohong Mi, Jiawen Zhang

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 20, 2024

Accumulating evidence suggests that the radiographic phenotypes of patients with knee osteoarthritis (KOA) often do not correlate their clinical findings, which are primary reason for seeking medical care. Therefore, at OARSI 2024, we proposed a finding staging system—Chinese medicine (CMS)—to guide treatment KOA. However, effectiveness and application characteristics CMS in guiding non-surgical KOA remain unclear. A total 14,985 were included study. Data from 13,983 used to analyze application, while 1465 evaluate CMS-guided effectiveness, 152 comparative analysis without guidance. The demographic CMS-using population examined, correlation between modalities was analyzed clarify characteristics. VAS WOMAC scores compared non-CMS-guided groups both before week 8 treatment, using minimal clinically significant difference as benchmark. In characteristics, regarding nonsurgical treatments, an increase led decrease basic nonpharmacological pharmacological treatments (P < 0.001). Regarding surgical no change proportion interventions observed worsening > 0.05). significantly lower group (VSA: 3.51; 95% CI, 3.42–3.60, Pain: 3.55; 3.40–3.70, Stiffness: 1.18; 1.11–1.25, Function: 12.57; 12.07–13.08, Total: 17.31; 16.63–17.99), had higher net than 3.30; 3.05–3.54, 3.14; 2.68–3.60, 0.95; 0.76–1.15, 11.36; 9.80–12.91, 15.45; 13.40–17.49). differences all MCID. is consistent patient's finding, suitable can achieve therapeutic effects.

Language: Английский

Citations

0
Metal-organic frameworks (MOFs) and their derivatives as emerging biomaterials for the treatment of osteoarthritis DOI Creative Commons

Yufu Liu,

Hongwei Zhang, Tianyan Chen

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 18, 2024

As a novel class of smart biomaterials with promising potentials, metal-organic frameworks (MOFs) are widely utilized in the field biomedicine. Current researches indicate that therapeutic strategies for osteoarthritis (OA) highly limited to achieving symptom improvement and reducing both pain inflammation. Together, introduction MOFs into treatment OA holds potential offer significant benefits. This is because not only have intrinsic biological activities, but also act as carriers facilitate controlled drug delivery prolong duration management OA. paper presents review recent studies explored usage drugs or OA, which examines progress tissue engineering These anticipated enhance comprehension provide strong evidence favor their utilization

Language: Английский

Citations

0
The association between low-dose aspirin intake and osteoarthritis: a population-based cross-sectional study based on NHANES DOI Creative Commons

Binglang Xiong,

Cheng Zhang, Xuhan Cao

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 9, 2024

Objectives Low-dose aspirin is widely used as a preventive medication for cardiovascular diseases. However, there controversy regarding the impact of low-dose on articular cartilage. The aim this study to explore association between intake and osteoarthritis (OA). Methods We conducted cross-sectional based United States population data from National Health Nutrition Examination Survey (NHANES) 2011–2018. investigation diagnosis OA was self-reporting in questionnaires. Multivariate regression models assess relationship OA. In addition, subgroup interaction analysis were performed robustness results. Results A total 12,215 participants included study. logistic showed that use had significantly increased odds (OR = 1.14; 95% CI: 1.01–1.28; p 0.035). significant consistent with still observed each stratified by gender, age, presence comorbidities including diabetes, coronary heart disease, hypertension, stroke. results illustrated stable all subgroups no interaction. Conclusion Our confirmed may increase risk Attention should be paid possibility joint degenerative changes patients who take chronically. further studies are needed possible mechanisms behind association.

Language: Английский

Citations

0