Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1422 - 1422

Published: May 8, 2024

Breastfeeding is the most appropriate source of a newborn’s nutrition; among plethora its benefits, modulation circadian rhythmicity with melatonin as potential neuroendocrine transducer has gained increasing interest. Transplacental transfer assures provision for fetus, who devoid secretion. Even after birth, neonatal pineal gland not able to produce rhythmically several months (with an even more prolonged deficiency following preterm birth). In this context, human breast milk constitutes main natural melatonin: diurnal dynamic changes, acrophase early midnight, and changes in concentrations according gestational age during different stages lactation have been reported. Understudied thus far are factors impacting on (changes in) content their clinical significance chronobiological adherence neonate: maternal well environmental aspects be investigated detail guide nursing mothers optimal feeding schedules which probably means synchronized instead mistimed practice. This review aims thought-provoking regarding critical role chrononutrition breastfeeding, highlighting entrainment therefore optimizing (neuro)developmental outcomes setting.

Language: Английский

---

Basic research on circadian disruption using animal and human organoid models: a review

Biological Rhythm Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Feb. 1, 2025

Language: Английский

---

The impact of circadian rhythms on retinal immunity

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Feb. 7, 2025

The eye is an immune-protected organ, which driven by factors such as cytokines, chemicals, light, and mechanical stimuli. circadian clock intrinsic timing mechanism that influences the immune activities, cell count activity, well inflammatory responses. Recent studies have demonstrated also possesses rhythm, this rhythmic regulation participates in ocular modulation. In review, we discuss immunoregulatory mechanisms of within eye, reveal new perspectives for prevention treatment diseases.

Language: Английский

---

Conversion of streetlights to light-emitting diode (LED) type

Journal of Electrical Systems and Information Technology, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 13, 2025

Abstract For the rising need for energy conservation and improving outdoor experience, current streetlights require an upgrade to light-emitting diode (LED) lighting. LEDs are well-known their better operating hours, brighter color temperature, reduced consumption. As per US Energy Information Administration, lighting accounts 17% of consumption commercial buildings as reported by U. S. Adminstration (2024). In this paper, a methodology was presented overcome challenges LED transformation. sample case based on existing profile high-pressure sodium (HPS), incandescent (INC), fluorescent (FL), metal halide (MH), mercury vapor (MV) in District Columbia, from conversion HPS type presented. A total savings GHG reduction gave positive outcome large-scale replacements with LED. drivers capable withstanding stresses that exposed to. However, additional considerations equipment specifier select more robust capacitors high heat frequencies required. simple evaluation vs showed higher performance at lower-rated wattage luminaires.

Language: Английский

---

Research on Indoor Health Lighting Design Based on Silicon Substrate Golden Light LED Technology

Buildings, Journal Year: 2025, Volume and Issue: 15(6), P. 932 - 932

Published: March 15, 2025

Silicon substrate golden light LED, as an emerging blue-light-free health lighting technology, has become one of the key technologies for home environments. This study uses silicon LED source lighting, and based on demands two indoor types, employs DIALux Evo simulation software to simulate environment. First, simulated data various areas are compared with national standards (GB/T50034-2024) verify whether type meets requirements. Next, a comparison is made between efficiency reference sample validate possesses high low power consumption. Finally, long-term exposure both used record secretion levels melatonin in human body. The experimental results show that not only provides sufficient but also demonstrates Additionally, under illumination concentration significantly increases (960 ± 15) pg/mL after 2.5 h exposure, which 8.2 times higher than conventional group (t = 12.34, df 14, p < 0.001). technology feasible solution design by creating zero-blue-light

Language: Английский

---

Mental Health and Smartphone Addiction

Advances in human and social aspects of technology book series, Journal Year: 2025, Volume and Issue: unknown, P. 23 - 62

Published: Jan. 31, 2025

In today's hyper-connected world, smartphones are indispensable, but their excessive use is triggering a digital mental health crisis. This chapter delves into the rising phenomenon of smartphone addiction, behavioural condition marked by compulsive usage that disrupts daily life and well-being. Focusing on consequences, examines how addiction fuels anxiety, depression, sleep disorders, social isolation. It also explores vulnerable populations, particularly adolescents young adults, disproportionately affected this addiction. Solutions such as detox, mindfulness interventions, cognitive-behavioural therapy discussed to help individuals regain control habits promote healthier relationships with technology. By addressing complex link between health, contributes broader conversation safeguarding well-being in age.

Language: Английский

---

Melatonin and brain barriers: The protection conferred by melatonin to the blood-brain barrier and blood-cerebrospinal fluid barrier

Frontiers in Neuroendocrinology, Journal Year: 2024, Volume and Issue: 75, P. 101158 - 101158

Published: Oct. 1, 2024

The blood-brain barrier and the blood-cerebrospinal fluid separate blood from brain tissue cerebrospinal fluid. These barriers are important to maintain homeostasis complex functions by protecting xenobiotics harmful endogenous compounds. disruption of is a characteristic neurologic diseases. Melatonin lipophilic hormone that mainly produced pineal gland. melatonin-binding sites. Among several melatonin actions, most one regulation sleep-wake cycles, has anti-inflammatory antioxidant properties. Since can arise inflammation oxidative stress, knowing influence on integrity extremely important. Therefore, objective this review gather discuss available literature about melatonin.

Language: Английский

---

Impact of Blue Light Intervention on Physiological Parameters and Circadian Rhythms: Insights from a Wistar Rat Model Study

Biomedical and Biotechnology Research Journal (BBRJ), Journal Year: 2024, Volume and Issue: 8(2), P. 160 - 165

Published: April 1, 2024

Abstract Background: This study investigates the impact of blue light-emitting diode (LED) lighting on physiological responses Wistar rats. The circadian system plays a vital role in regulating functions, allowing organisms to anticipate and adapt environmental rhythms. synchronization endogenous clocks with external cues, such as light-dark cycles, is essential for optimal performance. However, emerging technologies, like LED lighting, present new challenges rhythms, highlighting need continued research this area. Methods: study, approved by Animal Ethics Committee, involved total 12 male rats, which were divided into two groups: Control group light (BL) treated group, each consisting six BL model was established subjecting rats h exposure daily period 3 months. Half sacrificed at end period, while remaining transitioned normal (NL) conditions another months before being euthanized. Blood tissue samples collected analysis, including measurements body weight, blood glucose, insulin, melatonin, lipid profile, well messenger RNA expression reverse transcription-polymerase chain reaction global DNA methylation enzyme-linked immunosorbent assay. Results: found that led higher monthly increase elevated glucose levels, decreased insulin melatonin levels compared controls. also caused decrease cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein. Gene analysis revealed downregulation Period1, Cryptochrome1, brain muscle arnt-like protein 1 (Bmal1) hypothalamus, significant upregulation upon returning NL conditions. induced hypermethylation sequences, partially reverted after Conclusion: Our reveals broad BL/artificial contributing incidence obesity metabolic disorders. With rise blue-rich more needed understand its long-term effects health. contributes deeper understanding intricate relationship between health, emphasizing importance informed decisions regarding technologies mitigate potential health risks.

Language: Английский

---

Investigating the effects of indoor lighting on measures of brain health in older adults: protocol for a cross-over randomized controlled trial

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 11, 2024

Abstract Background The worldwide number of adults aged 60 years and older is expected to double from 1 billion in 2019 2.1 by 2050. As the population lives longer, rising incidence chronic diseases, cognitive disorders, behavioral health issues threaten adults’ span. Exercising, getting sufficient sleep, staying mentally socially active can improve quality life, increase independence, potentially lower risk for Alzheimer’s disease or other dementias. Nonpharmacological approaches might help promote such behaviors. Indoor lighting may impact sleep quality, physical activity, function. Dynamically changing indoor brightness color throughout day has positive effects on function, activity its occupants. aim this study investigate how different conditions affect measures healthier aging. Methods This protocol a randomized, cross-over, single-site trial followed an exploratory third intervention. Up 70 independent living residences at senior facility will be recruited. During 16-week study, participants experience three conditions. Two cohorts first static dynamic condition cluster-randomized cross-over design. have fixed match typically provided facility. For condition, change with increased morning. After both another morning determine if there saturation effect between light exposure health-related measures. Light intake, measured using wearable devices. Sleep, mood, social engagement assessed surveys assessments. Discussion We hypothesize better greater during compared condition. Additionally, we maximal threshold which health-outcomes based exposure. Study findings identify optimal solutions healthy aging adults. Trial registration ClinicalTrials.gov Identifier: NCT05978934.

Language: Английский

---

Gender differences in the effects of urban environment on nighttime exercise behaviours: a qualitative study

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Objective With the acceleration of urbanization, nighttime exercise behaviours have rapidly emerged. Existing research indicates a correlation between urban environments and physical activity; however, studies focusing specifically on are still insufficient, particularly regarding gender differences. This study aims to identify key factors in that influence residents’ explore differences within these influences. Methods Purposeful sampling was employed conduct semi-structured interviews with 30 residents who regularly engage exercise. All transcribed were analyzed using Colaizzi’s phenomenological data analysis method. Results The findings revealed environment environmental perception two primary influencing behaviour. These further divided into 10 specific sub-themes: lighting, green spaces, site facilities layout, traffic coherence, entertainment facilities, smart sports equipment, sense safety, convenience, pleasure, belonging. Conclusion Females demonstrate heightened sensitivity environment, placing greater emphasis feelings experiences it provides. Males, other hand, focus more direct impact such as its effects performance. Future planning public policy should give consideration use ensuring meet needs different genders. approach will contribute enhancing overall community vitality improving health.

Language: Английский

---