Function of intramitochondrial melatonin and its association with Warburg metabolism

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111754 - 111754

Published: March 1, 2025

Language: Английский

Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: 4

Published: March 24, 2025

The SAR-CoV-2 virus has evolved to co-exist with human hosts, albeit at a substantial energetic cost resulting in post-infection neurological manifestations [Neuro-post-acute sequelae of SARS-CoV-2 infection (PASC)] that significantly impact public health and economic productivity on global scale. One the main molecular mechanisms responsible for development Neuro-PASC, individuals all ages, is formation inadequate proteolysis/clearance phase-separated amyloid crystalline aggregates—a hallmark feature aging-related neurodegenerative disorders. Amyloidogenesis during viral persistence natural, inevitable, protective defense response exacerbated by SARS-CoV-2. Acting as chemical catalyst, accelerates hydrophobic collapse heterogeneous nucleation amorphous amyloids into stable β-sheet aggregates. clearance aggregates most effective slow wave sleep, when high levels adenosine triphosphate (ATP)—a biphasic modulator biomolecular condensates—and melatonin are available solubilize removal. dysregulation mitochondrial dynamics SARS-CoV-2, particular fusion fission homeostasis, impairs proper distinct subpopulations can remedy challenges created diversion substrates away from oxidative phosphorylation towards glycolysis support replication maintenance. subsequent reduction ATP inhibition synthesis sleep results incomplete brain aggregates, leading commonly associated age-related Exogenous not only prevents dysfunction but also elevates production, effectively augmenting solubilizing effect moiety ensure timely, optimal disaggregation pathogenic prevention attenuation Neuro-PASC.

Language: Английский

Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 25 - 25

Published: Dec. 28, 2024

Traumatic brain injury (TBI) is a disease resulting from external physical forces acting against the head, leading to transient or chronic damage tissue. Primary an immediate and, therefore, rather irreversible effect of trauma, while secondary results complex cascade pathological processes, among which oxidative stress and neuroinflammation are most prominent. As TBI significant cause mortality disability, with high social costs all over world, any form therapy that may mitigate trauma-evoked desirable. Melatonin, sleep–wake-cycle-regulating neurohormone, exerts strong antioxidant anti-inflammatory effects well tolerated when used as drug. Due these properties, it very reasonable consider melatonin potential therapeutic molecule for treatment. This review summarizes data in vitro studies, animal models, clinical trials focus on usage TBI.

Language: Английский