Evaluation of the Pharmaceutical Activities of Chuanxiong, a Key Medicinal Material in Traditional Chinese Medicine

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1157 - 1157

Published: Aug. 31, 2024

Szechwan lovage rhizome (SLR, the of Ligusticum chuanxiong Hort., Chuanxiong in Chinese transliteration) is one materia medica (CMM) commonly used to activate blood circulation and remove stasis. SLR applicable most stasis syndromes. It has significant clinical efficacy relation human diseases cardiocerebrovascular system, nervous respiratory digestive urinary etc. Apart from China, also Singapore, Malaysia, European Union, United States America. However, current chemical markers pharmacopeia or monography for quality assessment are not well characterized specifically characterized, nor do they fully reflect medicinal SLR, resulting being effectively controlled. CMM can only have when applied vivo an organism. The intensity their pharmaceutical activities more directly represent CMM. Therefore, constituents pharmacological actions reviewed this paper. In order demonstrate promoting removing stasis, bioassay methods put forward evaluate improve hemorheology, hemodynamics, vascular microcirculation, as its anti-platelet aggregation anticoagulation properties. Through comprehensive analyses these properties, therapeutic value ascertained.

Language: Английский

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Screening for Q-markers of Antiviral Granules based on neuraminidase inhibitors and Effect-constituent index

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 17(2), P. 105580 - 105580

Published: Dec. 24, 2023

Antiviral granules (AG) is a classic traditional Chinese medicine commonly employed for influenza treatment. However, there an urgent need to improve its quality control standards. The markers (Q-markers), guided by the Effect-constituent Index (ECI), were screened through in vitro and vivo component identification, molecular docking, neuraminidase (NA) inhibition experiments. chemical components AG underwent analysis using UPLC-Q-Orbitrap HRMS GC-MS, serum pharmacochemistry was analyze absorbed into bloodstream. Molecular docking used evaluate affinity of prototype NA, inhibitory activity candidate later confirmed NA inhibitor Following this, UHPLC-MS/MS method developed screen quantify Q-markers 20 sample batches. Lastly, ECI formulated multi-index comprehensive evaluation that combines composition, content, activity. A total 246 compounds identified AG, 89 19 metabolic detected rats. revealed binding energy 35 active ingredients better than original ligand target protein. Among these ingredients, 12 demonstrated significant effects experiments, with IC50 values ranging from 0.954 3.408 mM. content determination established quantification 11 Q-markers, including Forsythiaside A, Pogostone, Verbascoside, Mangiferin, 5-methoxy-8-hydroxypsoralen, Curcumenol, Luteolin-7-glucuronide, Kaempferol-3-O-rutinoside, Baicalin, Rutin, Bergaptol, batches samples. calculated based on Q-markers. Pearson's correlation effect samples resulted R value 0.859, indicating good correlation. Furthermore, this coefficient surpassed those observed between each Q-marker effect. treating have been successfully screened, has constructed. These findings will provide beneficial strategies improving level AG.

Language: Английский

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Promotion of a quality standard for Paris polyphylla var. yunnanensis based on the efficacy-oriented effect-constituent index

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2023, Volume and Issue: 238, P. 115843 - 115843

Published: Nov. 8, 2023

Language: Английский

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Direct Analysis of Blood Concentration and Pharmacokinetics of Active Constituents of Xuebijing Injection in Rats Using Miniature Mass Spectrometry

Green Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 100196 - 100196

Published: Dec. 1, 2024

Language: Английский

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