Enantioseparation system based on a novel nanomaterial synthesized from chiral molecularly imprinted polymers and achiral metal–organic frameworks by capillary electrochromatography

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(3)

Published: Feb. 18, 2025

Language: Английский

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Recent advances in microextraction techniques using sustainable green solvents for mass spectrometry analysis

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 170, P. 117412 - 117412

Published: Nov. 7, 2023

Language: Английский

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Enantiomeric analysis of chiral phenyl aromatic compounds by coated capillary electrochromatography based on a MOF-on-MOF stationary phase

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(3)

Published: Feb. 27, 2024

Language: Английский

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Magnetic 3D macroporous MOF oriented urinary exosome metabolomics for early diagnosis of bladder cancer

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 2, 2024

Bladder cancer (BCa) exhibits the escalating incidence and mortality due to untimely inaccurate early diagnosis. Urinary exosome metabolites, carrying critical tumor cell information directly related bladder, emerge as promising non-invasive diagnostic biomarkers of BCa. Herein, magnetic 3D ordered macroporous zeolitic imidazolate framework-8 (magMZIF-8) is synthesized used for efficient urinary isolation. Notably, beyond retaining single crystals micropores conventional ZIF-8, MZIF-8 further enhanced with highly oriented macropores (150 nm) large specific surface area (973 m

Language: Английский

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Rapid and in-situ preparation COFs coated capillary by adsorption method for the separation and determination of phthalate ester using CEC

Talanta, Journal Year: 2023, Volume and Issue: 270, P. 125617 - 125617

Published: Dec. 30, 2023

Language: Английский

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Recent developments and applications of solid membrane in chiral separation

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1743, P. 465652 - 465652

Published: Jan. 2, 2025

Language: Английский

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Development of carboxylated/thiolated phenolic resin via click chemistry for chiral separation of salbutamol racemate

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132556 - 132556

Published: March 1, 2025

Language: Английский

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Design of an amino‐functionalized molecularly imprinted polymer via thiol–maleimide click chemistry for chiral separation of ketoprofen

Polymer International, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract A molecularly imprinted polymer was developed to selectively adsorb S ‐ketoprofen (S‐KP) and chirally separate it from a racemic mixture. Synthesis involves condensation polymerization of 4‐mercaptophenol 4‐nitrophenol with formaldehyde obtain thiolated/nitro‐functionalized that further reduced an amino‐functionalized (HS‐P‐NH 2 ) using sodium dithionite. Finally, the ‐imprinted (S‐KP‐P) prepared by imprinting S‐KP onto HS‐P‐NH , followed post‐crosslinking bis(maleimido)ethane through thiol–maleimide click reaction. Confirmation successful functionalization crosslinking done via structural characterization techniques. Kinetic studies showed reaction second‐order kinetics, thermodynamic analysis indicating spontaneous, exothermic process. In adsorption experiments, S‐KP‐P manifested better enantioselectivity in maximum capacity adsorptions 422 mg g −1 for versus 243 R‐KP. The Langmuir model provided best fit isotherm data, confirming monolayer on homogeneous binding sites. Chiral separation experiments column chromatography demonstrated ability resolve (±)‐KP, yielding 97% enantiomeric excess (ee) R‐KP first elution 94% ee second. contrast, non‐imprinted no enantioselectivity. results confirm potential efficient enantioselective pharmaceutical applications. © 2025 Society Chemical Industry.

Language: Английский

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Post-crosslinked amino-functionalized molecularly imprinted polymers via click chemistry for selective chiral recognition of S-etodolac

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112983 - 112983

Published: Feb. 1, 2025

Language: Английский

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Development of Acid‐Functionalized Molecularly Imprinted Phenolic Resin for Chiral Recognition of S‐Venlafaxine

Chirality, Journal Year: 2025, Volume and Issue: 37(3)

Published: Feb. 17, 2025

ABSTRACT This article reports the synthesis of a molecularly imprinted phenolic formaldehyde resin for selective recognition cationic S‐enantiomer venlafaxine. The was developed through condensation polymerization p‐hydroxybenzoic acid (4‐HBA) and 4‐nitrophenol (4‐NP) with in an acidic medium. resultant polymer reduced to introduce amino groups into obtain dual‐functional carboxylic (CA‐P). After uptake S‐VF, glutaraldehyde cross‐linking stabilized formed its enantioselective cavities. Adsorption studies showed that optimum conditions occurred at pH 7, whereas maximum adsorption capacity 420 mg/g according Langmuir isotherm. selectivity coefficient S‐VF‐IP 13 times NIP, confirming imprinting process indeed occurred. Chiral separation experiments using SV‐imprinted (S‐VF‐IP) column resulted 98% enantiomeric excess R‐VF, respective NIP did not provide any enantioselectivity. These results show great possibility efficient offer promising method purification chiral drugs from racemic mixtures pharmaceutical applications.

Language: Английский

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