Functionalized aluminum hydroxide-based self-adjuvanted nanovaccine orchestrates antitumor immune responses via Dectin-1 signaling DOI
Xiaoli Ling,

Zhipeng Tian,

Dong Chen

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 559 - 572

Published: Dec. 25, 2024

Language: Английский

Gallic acid loaded self-nano emulsifying hydrogel-based drug delivery system against onychomycosis DOI
Mohammad Sameer Khan, Mahak Fatima, Shadma Wahab

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(25), P. 2065 - 2083

Published: Aug. 15, 2024

To developed and investigate gallic acid (GA) loaded self-nanoemulsifying drug delivery systems (SNEDDS) for treating onychomycosis via transungual route.

Language: Английский

Citations

24
Beta-glucan: An overview in biological activities, derivatives, properties, modifications and current advancements in food, health and industrial applications. DOI
Great Iruoghene Edo, Winifred Ndudi,

Raghda Makia

et al.

Process Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

19
Vaccine adjuvants for immunotherapy: type, mechanisms and clinical applications DOI Creative Commons
Nimeet Desai,

Sherrin Gotru,

Sagar Salave

et al.

Frontiers in Biomaterials Science, Journal Year: 2025, Volume and Issue: 4

Published: Feb. 12, 2025

Immunotherapy has emerged as a powerful approach in treating various diseases, yet its success often hinges on the efficacy of adjuvants, agents that boost immune responses to therapeutic targets. Traditional adjuvants have offered foundational support but may fall short achieving specificity and potency required for advanced therapies. This review highlights new generation poised address these limitations. We explore range innovative agents, including non-inflammatory nucleic acid bacterial derivatives, synthetic molecules, which are redefining role immunotherapy. These emerging hold promise enhancing while tailoring therapies specific disease contexts, from cancer infectious diseases. By examining applications potential this aims provide comprehensive understanding how they can advance immunotherapy levels precision. Through development novel stands achieve more targeted sustained impacts, paving way improved outcomes patient care.

Language: Английский

Citations

0
Polysaccharide nanoparticles as potential immune adjuvants: Mechanism and function DOI Creative Commons
Yuhong Jiang, Shanshan Qi, Canquan Mao

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Citations

0
What happens in toxic metal detection using an electrochemical aptasensor? A review DOI
Dongxing Zhang, Najmeh Zare, Tom Wu

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114459 - 114459

Published: April 1, 2025

Language: Английский

Citations

0
Unlocking the Potential: Receptor-Mediated Targeted Drug Delivery in Cancer Therapy DOI

Balaji Palanisamy,

Abul Kalam Azad Mandal

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155955 - 155955

Published: April 1, 2025

Language: Английский

Citations

0
β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery DOI Creative Commons
Nate Dowdall, Todd Hoare

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Innate immune cells such as macrophages and dendritic play major roles in the progression of many cancerous, fibrotic, autoimmune diseases, often due to environmental cues that skew these toward a phenotype progresses or exacerbates disease state. As such, growing focus treating diseases is placed on exploiting high plasticity modify reverse their pro‐disease phenotypes using immunomodulatory materials. β‐1,3 glucans are one type material has exhibited diverse effects cells, including mitigation reversal adverse dysregulated cells. In this review, we outline various fabrication techniques produce glucan‐derived microparticles nanoparticles discuss particle properties can be obtained by tuning glucan chemistry, method, formulation components. Furthermore, applications particles highlighted with cell targeting, modulation, delivery small molecule macromolecular therapeutics.

Language: Английский

Citations

0
Surfactant-based drug delivery systems for cancer therapy: Advances, challenges, and future perspectives DOI
Karuppiah Nagaraj

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125655 - 125655

Published: May 1, 2025

Language: Английский

Citations

0
Liver-Targeted Nanoparticles Loaded with Cannabidiol Based on Redox Response for Effective Alleviation of Acute Liver Injury DOI Creative Commons
Xuan Zhang, Xiangzhou Yi,

Xia Gao

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2464 - 2464

Published: Aug. 4, 2024

The purpose of this work was to construct liver-targeted nanoparticles based on the redox response effectively deliver cannabidiol (CBD) for prevention acute liver injury (ALI). CBD-loaded (CBD NPs) with a particle size 126.5 ± 1.56 nm were prepared using polymer DA-PP-LA obtained by grafting pullulan polysaccharide deoxycholic acid (DA) and α-lipoic (α-LA). CBD NPs showed typical redox-response release behavior. Interestingly, exhibited admirable targeting ability, significantly accumulated in liver, promoted internalization cells, thus reducing H

Language: Английский

Citations

1
Enhanced Phagocytosis and Endosomal Escape of Glucan-Modified Microparticles in Antigen-Presenting Cells DOI

Tongtong Kang,

Ru‐Xia Zhang,

Shusen Hou

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106405 - 106405

Published: Nov. 1, 2024

Language: Английский

Citations

0