Effects of Multidisciplinary Rehabilitation Program in Patients with Long COVID-19: Post-COVID-19 Rehabilitation (PCR SIRIO 8) Study

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(2), P. 420 - 420

Published: Jan. 4, 2023

Up to 80% of COVID-19 survivors experience prolonged symptoms known as long COVID-19. The aim this study was evaluate the effects a multidisciplinary rehabilitation program in patients with composed physical training (aerobic, resistance, and breathing exercises), education, group psychotherapy. After 6 weeks 97 COVID-19, body composition analysis revealed significant decrease abdominal fatty tissue (from 2.75 kg 2.5 kg; p = 0.0086) concomitant increase skeletal muscle mass 23.2 24.2 0.0104). Almost participants reported dyspnea improvement assessed modified Medical Research Council scale. Patients’ capacity Minute Walking Test increased from 320 382.5 m (p < 0.0001), number repetitions 30 s Chair Stand improved 13 16 well fitness Short Physical Performance Battery 14 0.0001). impact fatigue on everyday functioning reduced Modified Fatigue Impact Scale 37 27 Cardiopulmonary exercise test did not show any change. has composition, dyspnea, patients.

Language: Английский

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Long COVID: Costs for the German economy and health care and pension system

BMC Health Services Research, Journal Year: 2023, Volume and Issue: 23(1)

Published: June 14, 2023

Abstract Background Patients with acute COVID-19 can develop persistent symptoms (long/post syndrome). This study aimed to project the economic, health care, and pension costs due long/post-COVID-19 syndrome new onset in Germany 2021. Methods Using secondary data, economic were calculated based on wage rates loss of gross value-added. Pension payments determined incidence, duration, amount disability pensions. Health care expenditure was rehabilitation expenses. Results The analysis estimated a production 3.4 billion euros. value-added be 5.7 financial burden systems SARS-CoV-2 infection approximately 1.7 Approximately 0.4 percent employees are projected wholly or partially withdrawn from labor market medium term long/post-COVID Conclusion Costs 2021 not negligible for German economy but may still manageable.

Language: Английский

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Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(16), P. 10362 - 10362

Published: Aug. 19, 2022

The physio-affective phenome of Long COVID-19 is predicted by (a) immune-inflammatory biomarkers the acute infectious phase, including peak body temperature (PBT) and oxygen saturation (SpO2), (b) subsequent activation immune oxidative stress pathways during COVID. purpose this study was to delineate effects PBT SpO2 infection, as well increased neurotoxicity on physical, psychological, social environmental domains health-related quality life (HR-QoL) in people with We recruited 86 participants COVID 39 normal controls, assessed WHO-QoL-BREF (World Health Organization Quality Life Instrument-Abridged Version, Geneva, Switzerland) (comprising depression, anxiety fibromyalgia-fatigue rating scales) measured (NT, comprising serum interleukin (IL)-1β, IL-18 caspase-1, advanced oxidation protein products myeloperoxidase, calcium insulin resistance) found that 70.3% variance HR-QoL explained regression phenome, lowered NT, whilst 61.5% calcium, PBT, SpO2, female sex vaccination AstraZeneca Pfizer. were mediated NT yielding severity which largely affects HR-QoL. In conclusion, HR-Qol neuro-immune neuro-oxidative

Language: Английский

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Utilization of antidepressants, anxiolytics, and hypnotics during the COVID-19 pandemic in Scandinavia

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 323, P. 292 - 298

Published: Nov. 25, 2022

To study patterns of antidepressant, anxiolytic, and hypnotic drug utilization in Denmark, Norway, Sweden during the first year COVID-19 pandemic.The monthly observed number prescription fills antidepressants, benzodiazepines benzodiazepine-related hypnotics (BZ), other anxiolytics (OAH) per population 2020 were compared with predicted numbers based on analysis covariance 2015-2019.In March 2020, there was an increased for anxiolytics, youths adults aged 20-59 years Sweden. Antidepressant between 13.5 % 31.3 at end all age groups Denmark 17.4 Norway. BZ by 20.8 group decreased 16.7 A general increase OAH countries (range 24.0-80.0 11.5-30.8 9.1-12.1 Sweden). Increases occurred earlier Denmark.Aggregated data lack information indications.Peaks may reflect medication stock piling. Increased antidepressant Norwegian together Scandinavian late indicate symptoms depression anxiety, as well disturbed sleep.

Language: Английский

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Chronic Fatigue, Depression and Anxiety Symptoms in Long COVID Are Strongly Predicted by Neuroimmune and Neuro-Oxidative Pathways Which Are Caused by the Inflammation during Acute Infection

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(2), P. 511 - 511

Published: Jan. 8, 2023

Long-term coronavirus disease 2019 (long COVID) is associated with physio-somatic (chronic fatigue syndrome and somatic symptoms) affective (depression anxiety) symptoms. The severity of the long COVID physio-affective phenome largely predicted by increased peak body temperature (BT) lowered oxygen saturation (SpO2) during acute infectious phase. This study aims to delineate whether association BT SpO2 phase mediated neurotoxicity (NT) resulting from activated immune-inflammatory oxidative stress pathways.We recruited 86 patients (3-4 months after phase) 39 healthy controls assessed serum C-reactive protein (CRP), caspase 1, interleukin (IL) 1β, IL-18, IL-10, myeloperoxidase (MPO), advanced oxidation products (AOPPs), total antioxidant capacity (TAC), calcium (Ca), as well phase.Cluster analysis revealed that a significant part (34.9%) (n = 30) show highly elevated NT index computed based on IL-1β, CRP, MPO, AOPPs. Partial least squares showed 61.6% variance in could be explained index, Ca, BT/SpO2 prior vaccinations AstraZeneca or Pfizer. most important predictors are AOPPs, MPO.The infection-immune-inflammatory core COVID-19 strongly predicts development symptoms 3-4 later, these effects partly neuro-immune neuro-oxidative pathways.

Language: Английский

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Associations of subjective and objective cognitive functioning after COVID-19: A six-month follow-up of ICU, ward, and home-isolated patients

Brain Behavior & Immunity - Health, Journal Year: 2023, Volume and Issue: 27, P. 100587 - 100587

Published: Jan. 5, 2023

Subjective and objective cognitive dysfunction are reported after COVID-19 but with limited data on their congruence associations the severity of acute disease. The aim this cohort study is to describe prevalence subjective at three six months symptoms psychological disease-related factors.We assessed a 184 patients COVID-19: 82 admitted Intensive Care Unit (ICU), 53 regular hospital wards, 49 isolated home. A non-COVID control group individuals was included. Demographic clinical were collected. symptoms, impairment, depressive post-traumatic stress disorder (PTSD) assessed.At months, impairment by 32.3% ICU-treated, 37.3% ward-treated, 33.3% home-isolated observed in 36.1% 34.7% 8.9% patients. associated PTSD female sex, not assessment or metrics.One-third patients, regardless disease severity, high levels which results from screening demographic factors. Our stresses importance thorough reporting long-term for underlying mental health related factors such as depression.

Language: Английский

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Mental health conditions of Chinese international students and associated predictors amidst the pandemic

Journal of Migration and Health, Journal Year: 2023, Volume and Issue: 7, P. 100185 - 100185

Published: Jan. 1, 2023

The current study aims to examine the mental health conditions and associated predictors among Chinese international students. A sample of 256 students aged 16 or above living primarily in Canada were asked complete an online survey. Mental assessed with Depression, Anxiety, Stress Scale-21 Physical Health Summary Scales. 15.3%, 20.4%, 10.5% respondents reported severe extremely depression, anxiety, stress levels, respectively. Univariate analysis variance models multiple linear regression identified education financial status as significant sociodemographic while controlling for effect physical status. Higher lower level better conditions. These findings shed light on our understanding risk factors during COVID-19 pandemic.

Language: Английский

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Prevalence of depressive symptoms in U.S. adults during the COVID-19 pandemic: A systematic review

SSM - Population Health, Journal Year: 2023, Volume and Issue: 21, P. 101348 - 101348

Published: Jan. 28, 2023

The COVID-19 pandemic has led to a worsening of mental health among U.S. adults. However, no review date synthesized the overall prevalence population depressive symptoms in over pandemic. We aimed document and psychological distress across time since start pandemic, both identify patterns that emerged literature assess data sources, methods, sampling, measurement used examine during In systematic peer literature, we identified 49 articles reporting 88 points related constructs nationally representative samples adults from March 2020 June 2021. First, found average poor studies was 12.9% for severe depression, 26.0% at least moderate 36.0% mild depression. Second, women reported significantly higher probable depression than men 63% levels by gender results on statistically significant differences between racial ethnic groups were mixed. Third, published based 12 studies; most common sources Household Pulse Survey (n = 15, 31%), AmeriSpeak panel 8, 16%), Qualtrics Understanding America Study 5, 10%). Prevalence estimates varied screening instruments cutoffs used. commonly Patient Health Questionnaire (PHQ) 36, 73%) Kessler 16%) series. While depending survey instruments, severity, reported, remained high through 2021 severity. scope can help policymakers providers address prepare meet ongoing future needs post-COVID-19 context beyond.

Language: Английский

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Harnessing the Power of Hugging Face Transformers for Predicting Mental Health Disorders in Social Networks

IEEE Access, Journal Year: 2024, Volume and Issue: 12, P. 28025 - 28035

Published: Jan. 1, 2024

Early diagnosis of mental disorders and intervention can facilitate the prevention severe injuries improvement treatment results. This study uses social media pre-trained language models to explore how user-generated data predict disorder symptoms. Our compares four different BERT Hugging Face with standard machine learning techniques used in automatic depression recent literature. The results show that new outperform previous approach an accuracy rate up 97%. Analyzing while complementing past findings, we find even tiny amounts (Like users' bio descriptions) have potential disorders. We conclude is excellent source health screening, effectively automate this critical task.

Language: Английский

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Reactivation of herpesvirus type 6 and IgA/IgM-mediated responses to activin-A underpin long COVID, including affective symptoms and chronic fatigue syndrome

Acta Neuropsychiatrica, Journal Year: 2024, Volume and Issue: 36(3), P. 172 - 184

Published: April 4, 2024

Persistent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reactivation of dormant viruses, and immune-oxidative responses are involved in long COVID.

Language: Английский

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