Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(4), P. 473 - 473

Published: April 12, 2024

Introduction: Long COVID (LC) is a global public health crisis affecting more than 70 million people. There emerging evidence of different pathophysiological mechanisms driving the wide array symptoms in LC. Understanding relationships between and helps guiding clinical management identifying potential treatment targets. Methods: This was mixed-methods systematic review with two stages: Stage one (Review 1) included only existing reviews (meta-review) 2) all primary studies. The search strategy involved Medline, Embase, Emcare, CINAHL databases to identify studies that described statistical analysis and/or discussion plausible causal symptoms. Only control arm for comparison were included. Studies assessed quality using National Heart, Lung, Blood Institute assessment tools. Results: 19 Review 1 46 2. Overall, reporting across this second moderate poor. strong immune system dysregulation, cerebral hypoperfusion, impaired gas transfer lungs. Other weak endothelial damage hypercoagulation, mast cell activation, auto-immunity vascular receptors. Conclusions: LC complex condition multiple organs diverse presentations (or traits) underpinned by mechanisms. A ‘treatable trait’ approach may help certain groups target specific interventions. Future research must include understanding response intervention based on these mechanism-based traits.

Language: Английский

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Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders

Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1436 - 1436

Published: Aug. 27, 2024

The influence of gut microbiome, metabolites, omics, hormones, and stress on general mental health is increasingly being recognized. Ancient cultures recognized the importance diet overall an individual. Western science modern scientific methods are beginning to unravel foundations mechanisms behind some ancient beliefs customs. organ itself, now thought almost all other organs, ranging from brain reproductive systems. Gut biological sex also a myriad conditions that range disorders, obesity, gastrointestinal cardiovascular diseases health. Here, we review history current understanding gut-brain axis bidirectional talk in various disorders with special emphasis anxiety depressive whose prevalence has increased by over 50% past three decades COVID-19 pandemic biggest risk factor last few years. vagal nerve important contributor this talk, but pathways contribute, most remain understudied. Probiotics containing

Language: Английский

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Resilience and Social Support Improve Mental Health and Quality of Life in Patients with Post-COVID-19 Syndrome

European Journal of Investigation in Health Psychology and Education, Journal Year: 2024, Volume and Issue: 14(1), P. 230 - 242

Published: Jan. 15, 2024

Physical and mental health problems among post-COVID-19 patients are common, even a year after infection. As there is no prior study available, we investigated the impacts of resilience social support on anxiety, depression, quality life with syndrome. We conducted cross-sectional convenience sample. The measures included demographic clinical characteristics patients, Brief Resilience Scale, Multidimensional Scale Perceived Social Support, Patient Health Questionnaire-4 (PHQ-4), EuroQol-5D-3L. mean age was 44.8 years. total PHQ-4 score suggested that 32.8% syndrome experienced severe psychological distress, moderate 23% mild 11.5% had distress. Moreover, 60.7% anxiety scores ≥3 69.7% depression ≥3, indicating possible major or disorder. EQ-5D-3L index value 0.36, VAS 54.1. Multivariable analysis identified reduced patients. Also, found significant positive relationship between support, life. Our findings suggest can be protective by reducing improving Policymakers should develop implement healthcare management programs to provide these

Language: Английский

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Meta-analysis of Cognitive Function Following Non-severe SARS-CoV-2 Infection

Neuropsychology Review, Journal Year: 2024, Volume and Issue: unknown

Published: June 12, 2024

Language: Английский

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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Post COVID-19 condition (PCC) is increasingly recognized as a debilitating characterized by persistent symptoms following SARS-CoV-2 infection. Neuropsychological deficits, including cognitive impairments and fatigue, are prevalent in individuals with PCC. The PoCoRe study aimed to evaluate the burden of neuropsychological deficits PCC patients undergoing multidisciplinary indoor rehabilitation describe possible changes this symptomatology. study, prospective, non-randomized, controlled longitudinal recruited from six German centers. Eligible participants underwent comprehensive assessments at admission discharge. Various measures were employed, fatigue scale for motor functioning cognition (FSMC), Test Battery Attention (TAP) Montreal Cognitive Assessment (MoCA). Out 1,086 participants, total N = 701 included main data analysis. prevalence on was high (84.6%) decreased significantly discharge (77.4%), mild effect size. Reaction times alertness subtest abnormal 70% 50% Sustained attention 55% admission, decreasing 43% These differences significant sizes. Furthermore, 27% pathological MoCA scores 63% improved normative levels during rehabilitation, indicating treatment (p ≤ 0.001). However, demonstrated limited sensitivity detecting deficits. highlights patients, notable improvements observed rehabilitation. Challenges remain accurately identifying addressing these underscoring importance assessment tailored interventions. Further research warranted optimize screening tools enhance care both outpatient settings.

Language: Английский

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