Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration DOI Creative Commons
Asmaa Yehia, Osama A. Abulseoud

Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 19, 2024

Abstract The unprecedented pandemic of COVID-19 swept millions lives in a short period, yet its menace continues among survivors the form post-COVID syndrome. An exponentially growing number suffer from cognitive impairment, with compelling evidence trajectory accelerated aging and neurodegeneration. novel enigmatic nature this yet-to-unfold pathology demands extensive research seeking answers for both molecular underpinnings potential therapeutic targets. Ferroptosis, an iron-dependent cell death, is strongly proposed underlying mechanism post-COVID-19 neurodegeneration discourse. incites neuroinflammation, iron dysregulation, reactive oxygen species (ROS) accumulation, antioxidant system repression, renin-angiotensin (RAS) disruption, clock gene alteration. These events pave way ferroptosis, which shows signature COVID-19, premature aging, neurodegenerative disorders. In search treatment, melatonin shines as promising ferroptosis inhibitor repeatedly reported safety tolerability. According to various studies, has proven efficacy attenuating severity certain manifestations, validating reputation anti-viral compound. Melatonin well-documented anti-aging properties combating neurodegenerative-related pathologies. can block leading since it efficient anti-inflammatory, chelator, antioxidant, angiotensin II antagonist, regulator. Therefore, we propose culprit behind melatonin, well-fitting inhibitor, treatment.

Language: Английский

Causal effects of COVID-19 on structural changes in specific brain regions: a Mendelian randomization study DOI Creative Commons
Shaojiong Zhou, Tao Wei,

Xiaoduo Liu

et al.

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 19, 2023

Abstract Background Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure cognitive function, but it remains unclear whether COVID-19 causes structural which specific regions are affected. Herein, we conducted Mendelian randomization (MR) study to investigate this causal relationship identify vulnerable COVID-19. Methods Genome-wide association (GWAS) data for phenotypes (28,900 cases 3,251,161 controls) were selected as exposures, GWAS traits (cortical thickness surface area from 51,665 participants volume of subcortical structures 30,717 participants) outcomes. Inverse-variance weighted method was used the main estimate method. The median, MR-Egger, MR-PRESSO global test, Cochran’s Q statistic detect heterogeneity pleiotropy. Results genetically predicted infection phenotype nominally associated with reduced cortical caudal middle frontal gyrus ( β = − 0.0044, p 0.0412). hospitalized lateral orbitofrontal 0.0049, 0.0328) rostral 0.0022, 0.0032) well temporal 10.8855, 0.0266). These relationships also identified severe phenotype. Additionally, cuneus 0.0024, 0.0168); pericalcarine 2.6628, 0.0492), superior parietal 5.6310, 0.0408), parahippocampal 0.1473, 0.0297); hippocampus 15.9130, 0.0024). Conclusions Our indicates suggestively significant genetic predisposition atrophy functional human brain. Patients impairment should be actively managed alleviate neurocognitive symptoms minimize long-term effects.

Language: Английский

Citations

26
Cognitive dysfunction after covid-19 DOI Creative Commons
Emma Ladds, Julie Darbyshire, Nawar Diar Bakerly

et al.

BMJ, Journal Year: 2024, Volume and Issue: unknown, P. e075387 - e075387

Published: Feb. 1, 2024

Language: Английский

Citations

15
Psychological factors associated with Long COVID: a systematic review and meta-analysis DOI Creative Commons
Petra Engelmann, Max Reinke, Clara Stein

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 74, P. 102756 - 102756

Published: July 27, 2024

Language: Английский

Citations

14
Cognitive domains affected post‐COVID‐19; a systematic review and meta‐analysis DOI Creative Commons
Jack B. Fanshawe, Brendan Sargent, James Badenoch

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 20, 2024

Abstract Background and purpose This review aims to characterize the pattern of post‐COVID‐19 cognitive impairment, allowing better prediction impact on daily function inform clinical management rehabilitation. Methods A systematic meta‐analysis neurocognitive sequelae following COVID‐19 was conducted, PRISMA‐S guidelines. Studies were included if they reported domain‐specific assessment in patients with at >4 weeks post‐infection. deemed high‐quality had >40 participants, utilized healthy controls, low attrition rates mitigated for confounders. Results Five seven primary Diagnostic Statistical Manual Mental Disorders (DSM‐5) domains assessed by enough studies facilitate meta‐analysis. Medium effect sizes indicating impairment versus controls seen across executive (standardised mean difference (SMD) −0.45), learning memory (SMD −0.55), complex attention −0.54) language −0.54), perceptual motor appearing be impacted a greater degree −0.70). narrative synthesis 56 low‐quality also suggested no obvious impairment. Conclusions found moderate impairments multiple cognition post‐COVID‐19, specific pattern. The literature significantly heterogeneous, wide variety tasks, small sample disparate initial disease severities limiting interpretability. finding consistent range tasks suggests broad, as opposed domain‐specific, brain dysfunction. Future should utilize harmonized test battery inter‐study comparisons, whilst accounting interactions between COVID‐19, neurological mental health, interplay which might explain

Language: Английский

Citations

11
Neurocognitive Impairment in Long COVID: A Systematic Review DOI Creative Commons

Ευγενία Παναγέα,

Lambros Messinis,

Maria Christina Petri

et al.

Archives of Clinical Neuropsychology, Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Abstract Objective Although Coronavirus disease 2019 (COVID-19) is primarily a respiratory infectious disease, it has also been associated with wide range of other clinical manifestations. It widely accepted in the scientific community that many patients after recovery continue to experience COVID-19-related symptoms, including cognitive impairment. The aim this systematic review was investigate profile long-COVID syndrome. Methods A search empirical studies conducted through PubMed/Medline and Scopus electronic databases. Cross-sectional longitudinal published between 2020 2023 were included. Results Of 516 assessed for eligibility, 36 met inclusion criteria. All included support presence persistent changes COVID-19 disease. Executive function, memory, attention, processing speed appear be domains are predominantly syndrome, whereas language an area not sufficiently investigated. Conclusions In review, high frequency impairment evident. If we consider functioning affects our ability live independently key determinant quality life, imperative precisely define those factors may induce survivors, ultimate goal early diagnosis and, consequently, development targeted rehabilitation interventions address them.

Language: Английский

Citations

10
Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study DOI Creative Commons

Michael Jöbges,

Melanie Tempfli,

Carmen Kohl

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Post COVID-19 condition (PCC) is increasingly recognized as a debilitating characterized by persistent symptoms following SARS-CoV-2 infection. Neuropsychological deficits, including cognitive impairments and fatigue, are prevalent in individuals with PCC. The PoCoRe study aimed to evaluate the burden of neuropsychological deficits PCC patients undergoing multidisciplinary indoor rehabilitation describe possible changes this symptomatology. study, prospective, non-randomized, controlled longitudinal recruited from six German centers. Eligible participants underwent comprehensive assessments at admission discharge. Various measures were employed, fatigue scale for motor functioning cognition (FSMC), Test Battery Attention (TAP) Montreal Cognitive Assessment (MoCA). Out 1,086 participants, total N = 701 included main data analysis. prevalence on was high (84.6%) decreased significantly discharge (77.4%), mild effect size. Reaction times alertness subtest abnormal 70% 50% Sustained attention 55% admission, decreasing 43% These differences significant sizes. Furthermore, 27% pathological MoCA scores 63% improved normative levels during rehabilitation, indicating treatment (p ≤ 0.001). However, demonstrated limited sensitivity detecting deficits. highlights patients, notable improvements observed rehabilitation. Challenges remain accurately identifying addressing these underscoring importance assessment tailored interventions. Further research warranted optimize screening tools enhance care both outpatient settings.

Language: Английский

Citations

1
Long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months DOI Creative Commons

Godhavarma Gopinath,

Chinmay Ajit Suryavanshi,

L C Pallavi

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 16, 2025

The COVID-19 pandemic, caused by SARS-CoV-2, has had profound global impacts since its emergence in late 2019. Whilst acute symptoms are well-documented, increasing evidence suggests long-term consequences extending beyond the phase. This study aimed to investigate cognitive and autonomic effects of young adults. We conducted a cross-sectional comparing adults with history (n = 34) matched controls 34). Cognitive function was assessed using Sternberg Task, Stroop Go/No-Go Task (GNG). Autonomic evaluated heart rate variability (HRV) parameters. average time interval between infection testing 28.2 months. group showed significantly increased reaction 2-item absent condition (p 0.044) errors 4-item present 0.012) neutral response 0.028) normalized for completing task 0.022) Task. No significant differences were found GNG HRV parameters did not differ groups, although trends toward higher overall observed group. Young who approximately 28 months ago show minimal impact on regulation. However, subtle inefficiencies persist, particularly working memory executive tasks. These findings suggest generally favorable prognosis following mild moderate but highlight need further investigation into persistent effects.

Language: Английский

Citations

1
Cognition and objective sleep quality in post-COVID-19 patients DOI Creative Commons
Anna Carnes, Gerard Piñol‐Ripoll, Adriano Targa

et al.

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

In the current study, we aimed (i) to evaluate sleep quality via wrist actigraphy monitoring of nonhospitalized and hospitalized post-COVID-19 condition (PCC) participants; (ii) correlate measures with subjective quality, such as Pittsburgh Sleep Quality Index (PSQI); (iii) investigate whether total time or efficiency could affect PCC cognitive performance. We included 49 individuals from NAUTILUS Project (NCT05307549 NCT05307575) who were monitored for 1 week also assessed a comprehensive neuropsychological battery PSQI. found that there significant differences between PCCs in number awakenings. correlation both (actigraphy PSQI), but did not observe correlations objective parameters latency efficiency. Regarding cognition measures, was trend statistical significance performance immediate visual memory, attention span social according conclusion, results indicate although PSQI provides clinically relevant indicators sleep, are divergent self-reported (actigraphy). Furthermore, tendency toward participants their which is more important function patients than time.

Language: Английский

Citations

1
Fatigue and Cognitive Dysfunction Are Associated with Occupational Status in Post-COVID Syndrome DOI Open Access
Cristina Delgado‐Alonso, Constanza Cuevas,

Silvia Oliver‐Mas

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(20), P. 13368 - 13368

Published: Oct. 16, 2022

Post-COVID syndrome (PCS) is a medical condition characterized by the persistence of wide range symptoms after acute infection SARS-CoV-2. The work capacity consequences this disorder have scarcely been studied. We aimed to analyze factors associated with occupational status in patients PCS. This cross-sectional study involved 77 PCS on active before SARS-CoV-2 infection. Patients were evaluated 20.71 ± 6.50 months clinical onset. conducted survey activity and cognitive symptoms. association between fatigue, depression, anxiety, sleep quality, testing was analyzed. Thirty-eight (49.4%) working, thirty-nine (50.6%) not. Of those not working at moment assessment, 36 (92.3%) sick leave. In 63 (81.8% sample), leave needed some point due mean duration 12.07 8.07 months. According patient’s perspective, most disabling complaints (46.8%) fatigue (31.2%). Not assessment higher levels lower performance Stroop test. No found depression anxiety questionnaires. Our an influence capacity. Fatigue issues frequent loss

Language: Английский

Citations

38
Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID DOI Creative Commons
Tania Llana, Marta Méndez, Sara Garcés-Arilla

et al.

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

Background and purpose The coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. persistent symptoms of anosmia or hyposmia were in previous studies the development memory impairment mood disturbances. We aimed to investigate association between chronicity reported dysfunction subjective objective cognitive performance long-COVID patients explore whether their emotional are related cognition. Methods One hundred twenty-eight participants recruited. Reported symptomatology, complaints, anxiety depression trait-anxiety assessed. Subjective complaints disturbances compared among groups as an acute (AOD), (POD), nonexistent (NOD) symptom. Seventy-six volunteers also participated a face-to-face session assess on tests general function verbal declarative memory. Objective AOD, POD, NOD groups. Results similar groups, but score was lower than those no at any time. Participants’ positively symptoms. relationship depressive symptomatology interacted dysfunction, it only occurred without Depressive negatively delayed performance. months elapsed from diagnosis assessment predicted Anxious immediate ability recall information who did not present phase infection. Conclusion Olfactory infection by COVID-19 is deficits tests, self-reported These findings may contribute further understanding neuropsychological aspects long-COVID.

Language: Английский

Citations

22