Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 197 - 197

Published: Jan. 17, 2025

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration plasma cells into endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women's health, contributing to conditions such as uterine bleeding endometriosis. Treatment typically involves antibiotic therapy; however, efficacy these treatments increasingly compromised rise antimicrobial resistance (AMR). This paper examines critical links between AMR CE, proposing strategies enhance clinical management optimize treatment outcomes.

Language: Английский

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Assessing the endometrium: An update on current and potential novel biomarkers of receptivity

Journal of Reproductive Immunology, Journal Year: 2023, Volume and Issue: 160, P. 104162 - 104162

Published: Oct. 7, 2023

Language: Английский

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Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1641 - 1641

Published: Aug. 10, 2024

Recurrent Pregnancy Loss (RPL) affects 1–2% of women, and its triggering factors are unclear. Several studies have shown that the vaginal, endometrial, gut microbiota may play a role in RPL. A decrease quantity Lactobacillus crispatus local has been associated with an increase (vaginal endometrial) inflammatory response immune cell activation leads to pregnancy loss. The be triggered by gram-negative bacteria, lipopolysaccharides (LPS), viral infections, mycosis, or atypia (tumor growth). Bacterial structures metabolites produced could involved modulation responsible for molecular mimicry. Gut metabolic products amount circulating pro-inflammatory lymphocytes, which, turn, will migrate into vaginal endometrial tissues. Local Th1 Th17 subpopulations Treg tolerogenic NK cells accountable modulate response, increasing success. Analyzing necessary characterize some RPL patients. Although oral supplementation probiotics not modify microbiota, it benefit transplantation vagina enhance required achieve normal pregnancy. effect hormone stimulation progesterone maintain early on adequately studied, more research is needed this area. Well-designed clinical trials ascertain

Language: Английский

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Pro- and anti-inflammatory cytokines and growth factors in patients undergoing in vitro fertilization procedure treated with prednisone

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 6, 2023

Embryo implantation is a key moment in pregnancy. Abnormal production of pro- and anti-inflammatory cytokines, their receptors other immune factors may result embryo failure pregnancy loss. The aim this study was to determine the profile selected blood plasma patients undergoing vitro fertilization (IVF) control women who achieved after natural conception. examined were administered steroid prednisone. We present results concern levels IFN-ɣ, BDNF, LIF, VEGF-A, sTNFR1 IL-10. found that IVF receiving steroids differed significantly from not such treatment terms IFN-γ IL-10 levels. Moreover, secretion all tested with fertile controls. Our indicated secrete at least 1409 pg/ml have chance become pregnant naturally give birth child, while must achieve concentration 962.3 for successful In addition, secreting VEGF-A above 43.28 greater risk miscarriage or failed transfer comparison below value. conclusion, different growth compared recurrent (RIF).

Language: Английский

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Microbiome dysbiosis in patients with chronic endometritis and Clostridium tyrobutyricum ameliorates chronic endometritis in mice

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 30, 2024

Abstract Chronic endometritis is associated with the imbalance of female reproductive tract microbiota and pathogenic microbial infection. This study aimed to identify specific changes in endometrial microbiome patients explore how Clostridium tyrobutyricum ( C.t ) influences progression mice for further elucidating pathogenesis. For this purpose, tissues from 100 participants were collected divided into positive, weakly negative groups based on CD138 levels, while differences detected analyzed using 16S rRNA gene sequencing. Staphylococcus aureus S. )-induced mouse model was established, followed by treatment , inflammatory response, epithelial barrier, TLR4/NF-κB pathway evaluated. Results showed that α- β-diversity significantly lower positive group compared or groups, where had more unique operational taxonomic units. The abundance Proteobacteria found be increased, Actinobacteria Firmicutes, Bacteroidetes reduced group, area under curve value 0.664. Furthermore, resulted alleviation -induced barrier damage, activation mice. Clinical samples analysis revealed diversity altered having mechanistic investigations alleviated inactivating pathway. findings are envisaged provide a diagnostic therapeutic potential endometritis.

Language: Английский

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How does chronic endometritis influence pregnancy outcomes in endometriosis associated infertility? A retrospective cohort study

Reproductive Health, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 14, 2024

Endometriosis (EMS) and chronic endometritis (CE) frequently coexist. This study aimed to examine the impact of CE on reproductive outcomes in patients with EMS. We enrolled 685 endometriosis-associated infertility from January 2018 December 2020. The were divided into (318) non-CE (367) groups. A subset 123 clinically pregnant women group 369 was selected for detailed comparison. Pregnancy delivery data meticulously collected hospital records through telephone interviews. diagnosed 46.42% EMS patients. Higher pregnancy rates observed Fertility Index (EFI) scores 7–10. had increased risks placenta previa (13.01%), gestational hypertension (5.69%), cesarean sections (59.34%). CE, which is prevalent among patients, linked complications, including previa, hypertension, delivery. Although combined hysteroscopy laparoscopy improve rates, they demand careful management these complications.

Language: Английский

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Dose-, stage- and sex- difference of prenatal prednisone exposure on placental morphological and functional development

Toxicology Letters, Journal Year: 2024, Volume and Issue: 402, P. 68 - 80

Published: Nov. 22, 2024

Language: Английский

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Antibiotic cured chronic endometritis remains a risk factor for early pregnancy loss in the subsequent frozen euploid embryo transfer

Reproductive BioMedicine Online, Journal Year: 2023, Volume and Issue: 48(2), P. 103611 - 103611

Published: Oct. 13, 2023

Language: Английский

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CORRELATION RATIO OF CHRONIC ENDOMETRITIS WITH ANAMNESTIC FACTORS AND ULTRASOUND CHARACTERISTICS OF THE ENDOMETRIUM IN WOMEN OF REPRODUCTIVE AGE

Neonatology surgery and perinatal medicine, Journal Year: 2024, Volume and Issue: 14(1(51)), P. 69 - 75

Published: April 8, 2024

The diagnosis of chronic endometritis is problematic because its asymptomatic course and the need for invasive uterineprocedures to confi rm histologically. Therefore, it important identify factors that indicate a high risk this condition. Aim: aim study have statistically signifi cant correlation with presence CE in women reproductive age validate them by histologic examination endometrium.Material Methods. A retrospective analysis 400 histories who underwent hysteroscopyand endometrial biopsy was performed. Histologically, 154 (38.5 %) were found havechronic (the group endometritis), while 246 (61.5 otherconditions unrelated without endometritis). Analysis anamnestic ultrasound criteria associated an increased likelihood performed when comparing data from these groups. strength relationship between on one hand development other assessed calculating Kendall’s τ (tau) rank coeffi cient. mentioned factor considered strong (+++) cient 0.5 or higher, moderate (++) range 0.2 0.499, weak (+) 0.1 0.199. τ-coeffi value 0 0.099 indicated no endometritis.The conducted accordance principles patient- centered care, requirements Tokyo Declaration World Medical Association, international recommendations Helsinki Human Rights, Convention Council Europe Rights Biomedicine, laws Ukraine, Code Ethics Ukrainian Physician.The paper excerpt initiative scientifi c research project Department Obstetrics Gynecology No.2 at Poltava State University, entitled «Optimization approaches management pregnancy obstetric perinatal pathology» (State registration number 0122U201228, duration: 10.2022-09.2027) collaboration Pathological Physiology University.Results Discussion. determination allowed us strongestassociation endometritis. Among are 5 infectious factors: cervicitis past medical history (τ 0.625245229; p<0.0000000001); infl ammation uterine appendages 0.522536031; sexually transmitted diseases 0.547218916; urogenital ammatory sexual partner 0. 529314979; previous multiple use intrauterine contraception (τ-coeffi 0.502383401; 4 symptomatic consequential infertility 0.683492482; missed miscarriages 644489429; recurrent early loss 0.625942138; abnormal bleeding 0.650850348; criteria, such as local thickening form polyp 0.641820318; p<0. 0000000001); echogenicity endometrium 0.665249637; heterogeneity echo structure areas decreased 0.693152163; hyperechogenic structures basal layer 0.521658745; p<0.0000000001). In our opinion, combination criterion indicates probability absence signs, 1 symptomatic- To confirm representativeness method, we analyzed biopsies obtained curettage 100 factors. rmed histologically 87 women. Conclusion. Our proposed assessment high-risk endometritis, based infectious,symptomatic- consequential, allows predicting pathology % patients withoutтthe interventions. This helps improve patient selection hysteroscopy avoid unnecessary interventions planning pregnancy.

Language: Английский

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Female Autoimmune Disorders with Infertility: A Narrative Review

Al- Anbar Medical Journal, Journal Year: 2023, Volume and Issue: 0(0), P. 0 - 0

Published: April 24, 2023

Autoimmunity is a condition in which the immune system cannot recognize self from non-self-antigens. relatively more common females than males. The process of embryo implantation considered most significant restricting factor female reproduction. immunological may affect success or failure pregnancy by its effect on extremely important steps ovulation to processes, thus ensuring importance autoimmunity for women sub-fertility. association between and reproduction receives increased attention nowadays. A successful conception result multiple complex interactions developed receptive uterus usually under immune-hormonal control. In certain circumstances, ovary can be target an autoimmune attack, like some organ‐specific systemic disorders subsequently resulting clinically ovarian dysfunction, failure, Consequently, specific auto-antibody etiology infertility remains unknown. This review focused auto-antibodies that fertility.

Language: Английский

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