High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy DOI Open Access
Haibin Guan, Jia Chen,

Kirtan Kaur

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Objective We previously found that per- and polyfluoroalkyl substances (PFAS) mixture exposure is inversely associated with SARS-CoV-2 IgG (IgG) antibody levels in pregnant individuals. Here, we aim to identify metabolites mediating this relationship elucidate the underlying biological pathways. Methods included 59 participants from a US-based pregnancy cohort. Untargeted metabolomic profiling was performed using Liquid Chromatography-High Resolution Sass spectrometry (LC-HRMS), weighted Quantile Sum (WQS) regression applied assess PFAS effects on IgG. Metabolite indices positively or negatively were constructed separately their mediation examined independently jointly. Results The PFAS-index (beta=-0.273, p=0.002), PFHpS PFHxS as major contributors. Two metabolite-indices constructed, one (beta=1.260, p<0.001) (beta=-0.997, Key contributors for these protoporphyrin, 5-hydroxytryptophan, n-acetylproline, tyrosine. Analysis of single mediator showed 48.9% (95%CI: 21.9%,125.0%) 50.1% (95% CI: 8.1%, 90.1%) index-IgG total effect mediated by negative positive metabolite-indices, respectively. Joint analysis indicated cumulative 73.6% 44.9%, 116.4%). Enriched pathways phenylalanine, tyrosine, tryptophan biosynthesis arginine metabolism. Conclusions observed significant plasma PFAS-IgG relationship, suggesting disrupts balance contributes reduced production.

Language: Английский

From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment DOI
Daniele Mattei, Dilansu Güneykaya, Bilge Ugursu

et al.

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 269 - 285

Published: Jan. 1, 2025

Language: Английский

Citations

0
Association of antenatal or neonatal SARS-COV-2 exposure with developmental and respiratory outcomes, and healthcare usage in early childhood: a national prospective cohort study DOI

Rebecca Jackson,

Rosie Cornish, Zoe Daskalopoulou

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 72, P. 102628 - 102628

Published: May 3, 2024

Language: Английский

Citations

2
High-dimensional mediation analysis to elucidate the role of metabolites in the association between PFAS exposure and reduced SARS-CoV-2 IgG in pregnancy DOI Open Access
Haibin Guan, Jia Chen,

Kirtan Kaur

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Objective We previously found that per- and polyfluoroalkyl substances (PFAS) mixture exposure is inversely associated with SARS-CoV-2 IgG (IgG) antibody levels in pregnant individuals. Here, we aim to identify metabolites mediating this relationship elucidate the underlying biological pathways. Methods included 59 participants from a US-based pregnancy cohort. Untargeted metabolomic profiling was performed using Liquid Chromatography-High Resolution Sass spectrometry (LC-HRMS), weighted Quantile Sum (WQS) regression applied assess PFAS effects on IgG. Metabolite indices positively or negatively were constructed separately their mediation examined independently jointly. Results The PFAS-index (beta=-0.273, p=0.002), PFHpS PFHxS as major contributors. Two metabolite-indices constructed, one (beta=1.260, p<0.001) (beta=-0.997, Key contributors for these protoporphyrin, 5-hydroxytryptophan, n-acetylproline, tyrosine. Analysis of single mediator showed 48.9% (95%CI: 21.9%,125.0%) 50.1% (95% CI: 8.1%, 90.1%) index-IgG total effect mediated by negative positive metabolite-indices, respectively. Joint analysis indicated cumulative 73.6% 44.9%, 116.4%). Enriched pathways phenylalanine, tyrosine, tryptophan biosynthesis arginine metabolism. Conclusions observed significant plasma PFAS-IgG relationship, suggesting disrupts balance contributes reduced production.

Language: Английский

Citations

0