Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

Endocrine Reviews, Journal Year: 2012, Volume and Issue: 33(3), P. 378 - 455

Published: March 14, 2012

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional concepts in toxicology, particular the dogma “the dose makes poison,” because EDCs can effects at low doses that are not predicted by higher doses. Here, we review two major EDC studies: and nonmonotonicity. Low-dose were defined National Toxicology Program as those occur range human exposures or observed below used for toxicological studies. We mechanistic data low-dose use a weight-of-evidence approach to analyze five examples from literature. Additionally, explore nonmonotonic dose-response curves, nonlinear relationship between effect where slope curve changes sign somewhere within examined. provide detailed discussion mechanisms responsible generating these phenomena, plus hundreds cell culture, animal, epidemiology illustrate responses remarkably common natural hormones EDCs. Whether influence certain disorders is no longer conjecture, epidemiological show environmental associated with diseases disabilities. conclude when curves occur, cannot be high Thus, fundamental chemical testing safety determination needed protect health.

Language: Английский

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Epidemiology of Prostate Cancer

World Journal of Oncology, Journal Year: 2019, Volume and Issue: 10(2), P. 63 - 89

Published: Jan. 1, 2019

Prostate cancer is the second most frequent diagnosis made in men and fifth leading cause of death worldwide. may be asymptomatic at early stage often has an indolent course that require only active surveillance. Based on GLOBOCAN 2018 estimates, 1,276,106 new cases prostate were reported worldwide 2018, with higher prevalence developed countries. Differences incidence rates reflect differences use diagnostic testing. mortality are strongly related to age highest being seen elderly (> 65 years age). African-American have more aggressive type compared White men. There no evidence yet how prevent cancer; however, it possible lower risk by limiting high-fat foods, increasing intake vegetables fruits performing exercise. Screening highly recommended 45 for familial history Up-to-date statistics occurrence outcomes along a better understanding etiology causative factors essential primary prevention this disease. World J Oncol. 2019;10(2):63-89 doi: https://doi.org/10.14740/wjon1191

Language: Английский

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Bisphenol A – Sources, toxicity and biotransformation

Environmental Toxicology and Pharmacology, Journal Year: 2014, Volume and Issue: 37(2), P. 738 - 758

Published: Feb. 8, 2014

Language: Английский

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Metabolism disrupting chemicals and metabolic disorders

Reproductive Toxicology, Journal Year: 2016, Volume and Issue: 68, P. 3 - 33

Published: Oct. 19, 2016

The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and syndrome have largely been attributed to genetic background changes in diet, exercise aging. However, there is now considerable evidence that other environmental factors may contribute the rapid increase incidence these diseases. This review will examine T2D non-alcoholic fatty disease (NAFLD), contribution genetics describe role endocrine system disorders. It then specifically focus on disrupting chemicals (EDCs) etiology NAFLD while finally integrating information EDCs multiple could lead syndrome. We linking EDC exposures during critical periods development with diseases manifest later life across generations.

Language: Английский

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50th Anniversary Perspective: There Is a Great Future in Sustainable Polymers

Macromolecules, Journal Year: 2017, Volume and Issue: 50(10), P. 3733 - 3749

Published: May 1, 2017

It is likely that a half-century ago even enthusiastic and optimistic proponents of the synthetic polymer industry (Mr. McGuire included) could not have predicted massive scale on which polymers would be manufactured used today. Ultimately, future success this will rely development sustainable polymers—materials derived from renewable feedstocks are safe in both production use can recycled or disposed ways environmentally innocuous. Meeting these criteria an economical manner cannot achieved without transformative basic research hallmark journal. In Perspective we highlight five topics—the synthesis monomers degradable polymers, chemical recycling strategies, new classes reprocessable thermosets, design advanced catalysts—that believe play vital role polymers. We also offer our outlook several outstanding challenges facing community broad area

Language: Английский

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Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations

PLoS ONE, Journal Year: 2013, Volume and Issue: 8(1), P. e55387 - e55387

Published: Jan. 24, 2013

Environmental compounds are known to promote epigenetic transgenerational inheritance of adult onset disease in subsequent generations (F1–F3) following ancestral exposure during fetal gonadal sex determination. The current study was designed determine if a mixture plastic derived endocrine disruptor bisphenol-A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP) at two different doses promoted associated DNA methylation epimutations sperm. Gestating F0 generation females were exposed either the "plastics" or "lower dose plastics" embryonic days 8 14 determination incidence evaluated F1 F3 rats. There significant increases total disease/abnormalities male female animals from plastics lineages. Pubertal abnormalities, testis disease, obesity, ovarian (primary insufficiency polycystic ovaries) increased animals. Kidney prostate only observed direct fetally lineage Analysis sperm epigenome previously identified 197 differential regions (DMR) gene promoters, termed epimutations. A number these DMR form unique connection network have been shown correlate with pathologies identified. Observations demonstrate that compounds, BPA phthalates, can disease. provide potential biomarkers for and/or environmental exposures.

Language: Английский

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Global Assessment of Bisphenol A in the Environment

Dose-Response, Journal Year: 2015, Volume and Issue: 13(3)

Published: July 1, 2015

Because bisphenol A (BPA) is a high production volume chemical, we examined over 500 peer-reviewed studies to understand its global distribution in effluent discharges, surface waters, sewage sludge, biosolids, sediments, soils, air, wildlife, and humans. Bisphenol was largely reported from urban ecosystems Asia, Europe, North America; unfortunately, information lacking large geographic areas, megacities, developing countries. When sufficient data were available, probabilistic hazard assessments performed environmental quality concerns. Exceedances of Canadian Predicted No Effect Concentrations for aquatic life >50% effluents America but as 80% water reports Asia. Similarly, maximum concentrations BPA sediments Asia higher than Europe. mostly fish, ranged 0.2 13 000 ng/g. We observed 60% 40% exceedences median levels by the US Centers Disease Control Prevention's National Health Nutrition Examination Survey Europe respectively. These findings highlight utility coordinating sensing contaminants efforts through integration monitoring specimen banking identify regions implementation more robust assessment management programs.

Language: Английский

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Heterogeneous Fenton catalysts: A review of recent advances

Journal of Hazardous Materials, Journal Year: 2020, Volume and Issue: 404, P. 124082 - 124082

Published: Oct. 2, 2020

Heterogeneous Fenton catalysts are emerging as excellent materials for applications related to water purification. In this review, recent trends in the synthesis and application of heterogeneous abatement organic pollutants disinfection microorganisms discussed. It is noted that complexity cell wall increases, resistance level towards various disinfectants increases it requires either harsh conditions or longer exposure time complete disinfection. case viruses, enveloped viruses (e.g. SARS-CoV-2) found be more susceptible than non-enveloped viruses. The introduction plasmonic with broadens visible light absorption efficiency hybrid material, incorporation semiconductor material improves rate regeneration Fe(II) from Fe(III). A special emphasis given use antibacterial applications. Composite magnetite ferrites remain a champion area because their easy separation reuse, owing magnetic properties. Iron minerals supported on clay materials, perovskites, carbon zeolites metal-organic frameworks (MOFs) dramatically increase catalytic degradation contaminants by providing high surface area, good mechanical stability, improved electron transfer. Moreover, insights zero-valent iron its capacity remove wide range pollutants, heavy metals bacterial contamination also Real world role natural matter summarised. Parameter optimisation source, dosage catalyst, concentration H

Language: Английский

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A review of solar and visible light active TiO2 photocatalysis for treating bacteria, cyanotoxins and contaminants of emerging concern

Materials Science in Semiconductor Processing, Journal Year: 2015, Volume and Issue: 42, P. 2 - 14

Published: Aug. 25, 2015

Language: Английский

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Metal–organic frameworks (MOFs) for the removal of emerging contaminants from aquatic environments

Coordination Chemistry Reviews, Journal Year: 2018, Volume and Issue: 380, P. 330 - 352

Published: Nov. 13, 2018

Language: Английский

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