Sleep in Normal Aging

Sleep Medicine Clinics, Journal Year: 2017, Volume and Issue: 13(1), P. 1 - 11

Published: Nov. 22, 2017

Language: Английский

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Association between circadian rhythms and neurodegenerative diseases

The Lancet Neurology, Journal Year: 2019, Volume and Issue: 18(3), P. 307 - 318

Published: Feb. 12, 2019

Language: Английский

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Microglia, Lifestyle Stress, and Neurodegeneration

Immunity, Journal Year: 2020, Volume and Issue: 52(2), P. 222 - 240

Published: Jan. 7, 2020

Language: Английский

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Circadian disruption: What do we actually mean?

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 51(1), P. 531 - 550

Published: Nov. 7, 2018

The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re-synchronization local environmental cues, but this is oftentimes accompanied by adverse short-term consequences. When are chronically, adaptation may not be achieved, for example case of rotating night shift workers. transient chronic disturbance most frequently referred "circadian disruption", many other terms have been proposed used refer similar situations. It now beyond doubt that contributes health disease, emphasizing need clear terminology describing their goal review provide an overview describe disruption discuss quantifications experimental observational settings with a focus on human research, highlight limitations currently available tools. For research advance translational science, clear, operationalizable, scalable key, they enable improved assessment reproducibility results, ideally ranging from mechanistic settings, including animal large-scale randomized clinical trials.

Language: Английский

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Circadian autophagy drives iTRF-mediated longevity

Nature, Journal Year: 2021, Volume and Issue: 598(7880), P. 353 - 358

Published: Sept. 29, 2021

Language: Английский

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Genetics of circadian rhythms and sleep in human health and disease

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 24(1), P. 4 - 20

Published: Aug. 26, 2022

Language: Английский

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Associations of sleep disorders with all-cause MCI/dementia and different types of dementia – clinical evidence, potential pathomechanisms and treatment options: A narrative review

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 22, 2024

Due to worldwide demographic change, the number of older persons in population is increasing. Aging accompanied by changes sleep structure, deposition beta-amyloid (Aß) and tau proteins vascular can turn into mild cognitive impairment (MCI) as well dementia. Sleep disorders are discussed both a risk factor for consequence MCI/dementia. Cross-sectional longitudinal population-based case–control studies revealed disorders, especially sleep-disorderded breathing (SDB) excessive or insufficient durations, factors all-cause Regarding different dementia types, SDB was associated with while insomnia/insufficient related an increased Alzheimer’s disease (AD). Scarce still inconsistent evidence suggests that therapy continuous positive airway pressure (CPAP) SDB, improve cognition patients without comorbid delay onset MCI/dementia previous impairment. potential pathomechanisms via which lead MCI/dementia, disturbed sleep, chronic deficit impair glymphatic clearance amyloid aggregation resulting brain structures responsible cognition. Orexins modulate Aß pathology. Their diurnal fluctuation suppressed fragmentation expression at point hippocampal atrophy, contributing progression Additionally, profile such inflammation, endothelial dysfunction atherosclerosis foster neurodegenerative There ample indicating structure aging also disorder Therefore, should be identified treated early.

Language: Английский

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Neurodegeneration and the Circadian Clock

Frontiers in Aging Neuroscience, Journal Year: 2017, Volume and Issue: 9

Published: May 29, 2017

Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes diminished hormone release) biochemical activities antioxidant production). Circadian disturbances are among earliest symptoms these diseases, molecular mechanisms system suspected to play a pivotal, possibly causal, role their natural histories. Here, we review abnormalities observed ADs, PDs HDs, summarize evidence that clockwork directly influences course disease states. On basis this research, explore circadian-oriented interventions proposed treatments for neurological disorders.

Language: Английский

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Circadian disturbances in Alzheimer's disease progression: a prospective observational cohort study of community-based older adults

The Lancet Healthy Longevity, Journal Year: 2020, Volume and Issue: 1(3), P. e96 - e105

Published: Nov. 12, 2020

Summary

Background

Circadian disturbances are commonly seen in people with Alzheimer's disease and have been reported individuals without symptoms of dementia but pathology. We aimed to assess the temporal relationship between circadian progression.

Methods

did a prospective cohort study 1401 healthy older adults (aged >59 years) enrolled Rush Memory Aging Project (Rush University Medical Center, Chicago, IL, USA) who had followed up for 15 years. Participants underwent annual assessments cognition (with battery 21 cognitive performance tests) motor activities actigraphy). Four measures were extracted from actigraphy quantify daily rhythmicity, which amplitude 24-h activity rhythm, acrophase (representing peak time), interdaily stability intradaily variability hourly fragmentation rhythm. used Cox proportional hazards models logistic regressions whether predict an increased risk incident conversion mild impairment dementia. linear mixed-effects investigate how rhythms changed longitudinally change integrated

Findings

median age 81·8 (IQR 76·3–85·7) Risk developing was lower (1 SD decrease, hazard ratio [HR] 1·39, 95% CI 1·19–1·62) higher increase, 1·22, 1·04–1·43). In participants impairment, predicted by HR 1·46, 1·24–1·72), 1·36, 1·15–1·60), 1·21, 1·02–1·44). A faster transition odds [OR] 2·08, 1·53–2·93), 1·97, 1·43–2·79), decreased 1·35, 1·01–1·84). amplitude, acrophase, progressively over time, time. progression accelerated these aging effects doubling or more than changes after diagnosis further doubled them The longitudinal global positively correlated negatively variability.

Interpretation

Our results indicate link dysregulation progression, implying either bidirectional relation shared common underlying pathophysiological mechanisms.

Funding

National Institutes Health, BrightFocus Foundation.

Language: Английский

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Disrupting Sleep: The Effects of Sleep Loss on Psychotic Experiences Tested in an Experimental Study With Mediation Analysis

Schizophrenia Bulletin, Journal Year: 2017, Volume and Issue: unknown

Published: July 13, 2017

Our view is that insomnia may be a causal factor in the occurrence of psychotic experiences such as paranoia and hallucinations. However, relationship not established. The aim study was to investigate role via sleep restriction manipulation. within-subjects crossover design included planned mediation analysis. Sixty-eight nonclinical volunteers underwent loss condition (restricted 4 h for 3 nights) control (standard sleep) randomized order 2 consecutive weeks, with weekend washout period. Psychotic (paranoia, hallucinations, grandiosity, cognitive disorganization) candidate mediating variables (negative affect related processes, working memory, decision making, perceptual processing) were assessed before after each condition. Actigraphy verified an average duration 5 15 min condition, vs 6 58 After relative participants reported significant increases paranoia, disorganization, no changes grandiosity. also associated negative affect, self other cognitions, worry, memory impairment. Mediation analyses indicated mediated by but overall conclusion has certain experiences, key route affect.

Language: Английский

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