Sleep disturbances and dementia risk: A multicenter study

Alzheimer s & Dementia, Journal Year: 2018, Volume and Issue: 14(10), P. 1235 - 1242

Published: July 17, 2018

Abstract Introduction Few longitudinal studies assessed whether sleep disturbances are associated with dementia risk. Methods Sleep were in three population‐based (H70 study and Kungsholmen Project [Sweden]; Cardiovascular Risk Factors, Aging Dementia [Finland]). Late‐life baseline analyses (3–10 years follow‐up) used all (N = 1446). Baseline ages ≈ 70 (Cardiovascular Dementia, H70), ≈84 (Kungsholmen Project). Midlife (age 50 years) (21 32 1407). Results insomnia (fully adjusted hazard ratio 1.24, 95% confidence interval 1.02–1.50) late‐life terminal odds 1.94, 1.08–3.49) a higher long duration (>9 hours) was also an increased risk (adjusted 3.98, 1.87–8.48). Discussion or

Language: Английский

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The role of melatonin, a multitasking molecule, in retarding the processes of ageing

Ageing Research Reviews, Journal Year: 2018, Volume and Issue: 47, P. 198 - 213

Published: Aug. 6, 2018

Language: Английский

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Circadian rhythm phase shifts caused by timed exercise vary with chronotype

JCI Insight, Journal Year: 2020, Volume and Issue: 5(3)

Published: Jan. 2, 2020

BACKGROUND. The circadian system entrains behavioral and physiological rhythms to environmental cycles, modern lifestyles disrupt this entrainment. We investigated a timed exercise intervention phase shift the internal rhythm.

Language: Английский

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Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19

Frontiers in Medicine, Journal Year: 2020, Volume and Issue: 7

Published: May 15, 2020

The coronavirus, COVID-19, has infected hundreds of thousands and killed tens individuals worldwide. This highly infectious condition continues to ravage the world population yet reach it peak infective rate in some countries. Many conventional drugs including hydroxychloroquine/chloroquine, lipinovir, remdisvir, etc., have been repurposed as treatments for this often deadly disease, but there is no specifically-designed effective drug available; also, these mentioned significant side effects their efficacy unknown. New vaccines are being designed COVID-19 treatment, development testing will require months years. Time not a luxury that crisis has. Thus, serious unmet need identification currently-available safe molecules which can be used slow or treat disease. Several suggested purpose, best known may vitamin C. Here, we suggest melatonin given consideration prophylactic use treatment alone combination with other drugs. Melatonin's multiple actions an anti-inflammatory, anti-oxidant anti-viral (against viruses) make reasonable choice use. Melatonin readily available, easily synthesized large quantities, inexpensive, very high safety profile self-administered. endogenously-produced molecule small amounts its production diminishing increased age. Under current critical conditions, doses currently-recommended drugs, e.g., resist infection would seem judicious.

Language: Английский

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Sex differences in age-related changes in the sleep-wake cycle

Frontiers in Neuroendocrinology, Journal Year: 2017, Volume and Issue: 47, P. 66 - 85

Published: July 27, 2017

Language: Английский

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The multiple functions of melatonin in regenerative medicine

Ageing Research Reviews, Journal Year: 2018, Volume and Issue: 45, P. 33 - 52

Published: April 6, 2018

Language: Английский

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Mammalian circadian systems: Organization and modern life challenges

Acta Physiologica, Journal Year: 2020, Volume and Issue: 231(3)

Published: Sept. 1, 2020

Abstract Humans and other mammalian species possess an endogenous circadian clock system that has evolved in adaptation to periodically reoccurring environmental changes drives rhythmic biological functions, as well behavioural outputs with approximately 24‐hour period. In mammals, body clocks are hierarchically organized, encompassing a so‐called pacemaker the hypothalamic suprachiasmatic nucleus (SCN), non‐SCN brain peripheral clocks, cell‐autonomous oscillators within virtually every cell type. A functional machinery on molecular level, alignment among synchronization between exogenous cycles been shown be crucial for our health well‐being. Yet, modern life constantly poses widespread challenges internal example artificial lighting, shift work trans‐meridian travel, potentially leading disruption or misalignment emergence of associated diseases. For instance many us experience mismatch sleep timing free days (social jetlag) everyday lives without being aware consequences may arise from such chronic misalignment, Hence, this review provides overview organization built‐up system, its interactions outside world, pathologies arising misalignment.

Language: Английский

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Human circadian variations

Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 131(16)

Published: Aug. 15, 2021

Circadian rhythms, present in most phyla across life, are biological oscillations occurring on a daily cycle. Since the discovery of their molecular foundations model organisms, many inputs that modify this tightly controlled system humans have been identified. Polygenic variations and environmental factors influence each person's circadian rhythm, contributing to trait known as chronotype, which manifests degree morning or evening preference an individual. Despite normal variation much society operates "one size fits all" schedule can be difficult adjust to, especially for certain individuals whose endogenous phase is extremely advanced delayed. This public health concern, misalignment associated with number adverse outcomes. Additionally, modern technology (such electric lights computer, tablet, phone screens emit blue light) lifestyles shift irregular work schedules) disrupting consistency increasing people. Though medical lifestyle interventions alleviate some these issues, growing research variability sensitivity suggests broader social changes may necessary minimize impact health.

Language: Английский

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Can Melatonin Be a Potential “Silver Bullet” in Treating COVID-19 Patients?

Diseases, Journal Year: 2020, Volume and Issue: 8(4), P. 44 - 44

Published: Nov. 26, 2020

The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences COVID-19 infections has been advocated. Because its wide-ranging effects an antioxidant, anti-inflammatory, and immunomodulatory compound, could be unique in impairing SARS-CoV-2 infection. Moreover, indirect evidence points out possible antiviral action by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also effective reverse circadian disruption social isolation control delirium severely affected patients. As cytoprotector, serves combat several comorbidities such diabetes, metabolic syndrome, ischemic non-ischemic cardiovascular diseases, which aggravate disease. In view on occurrence neurological sequels COVID-19-infected patients, another putative application emerges based neuroprotective properties. Since means cognitive decay minimal impairment, significance for infection should considered. Finally, yet importantly, exogenous can adjuvant capable augmenting efficacy anti-SARS-CoV-2 vaccines. We discuss this review experimental suggesting that “silver bullet” COVID 19 pandemic.

Language: Английский

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Elderly as a High-risk Group during COVID-19 Pandemic: Effect of Circadian Misalignment, Sleep Dysregulation and Melatonin Administration

Sleep and Vigilance, Journal Year: 2020, Volume and Issue: 4(2), P. 81 - 87

Published: Sept. 26, 2020

Language: Английский

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