Crosstalk Between Aging, Circadian Rhythm, and Melatonin DOI
Avnish Kumar Verma, Mohammad Idreesh Khan, Fauzia Ashfaq

et al.

Rejuvenation Research, Journal Year: 2023, Volume and Issue: 26(6), P. 229 - 241

Published: Oct. 17, 2023

Circadian rhythms (CRs) are 24-hour periodic oscillations governed by an endogenous circadian pacemaker located in the suprachiasmatic nucleus (SCN), which organizes physiology and behavior of organisms. rhythm disruption (CRD) is also indicative aging process. In mammals, melatonin primarily synthesized pineal gland participates a variety multifaceted intracellular signaling networks has been shown to synchronize CRs. Endogenous synthesis its release tend decrease progressively with advancing age. Older individuals experience frequent CR disruption, hastens process aging. A profound understanding relationship between CRs potential improve existing treatments facilitate development novel chronotherapies that target age-related disorders. This review article aims examine regulatory mechanisms plays key role signaling. We describe basic architecture molecular clock functional decline age detail. Furthermore, we discuss regulation redox homeostasis during Moreover, protective effect exogenous supplementation age-dependent sheds light on this pleiotropic molecule how it can be used as effective chronotherapeutic medicine.

Language: Английский

Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms DOI Creative Commons

Haowen Zou,

Hongliang Zhou, Rui Yan

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Aug. 10, 2022

The circadian rhythm is crucial for physiological and behavioral functions. Chronotype, which represents individual preferences activity performance, associated with human health issues, particularly psychiatric disorders. This narrative review, focuses on the relationship between chronotype mental disorders, provides an insight into potential mechanism. Recent evidence indicates that (1) evening a risk factor depressive disorders substance use whereas morning protective factor. (2) Evening individuals bipolar disorder tend to have more severe symptoms comorbidities. (3) only related anxiety symptoms. (4) schizophrenia remains unclear, despite increasing their link. (5) significantly eating majority of studies focused binge Furthermore, underlying mechanisms or influence factors are described in detail, including clock genes, brain characteristics, neuroendocrinology, light/dark cycle, social factors, psychological sleep These findings provide latest chronotypes serve as valuable reference researchers.

Language: Английский

Citations

105
Interorgan rhythmicity as a feature of healthful metabolism DOI
Joseph Bass

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(4), P. 655 - 669

Published: Feb. 8, 2024

Language: Английский

Citations

20
Roles of clock genes in the pathogenesis of Parkinson's disease DOI
Anastasiia D. Shkodina, Shing Cheng Tan, Mohammad Mehedi Hasan

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 74, P. 101554 - 101554

Published: Dec. 30, 2021

Language: Английский

Citations

54
Association between exposure to light at night (LAN) and sleep problems: A systematic review and meta-analysis of observational studies DOI

Yu-xiang Xu,

Jianghui Zhang,

Tao Fang-biao

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159303 - 159303

Published: Oct. 10, 2022

Language: Английский

Citations

34
Always Pay Attention to Which Model of Motor Learning You Are Using DOI Open Access

Wolfgang I. Schöllhorn,

Nikolas Rizzi, Agnė Slapšinskaitė

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(2), P. 711 - 711

Published: Jan. 9, 2022

This critical review considers the epistemological and historical background of theoretical construct motor learning for a more differentiated understanding. More than simply reflecting critically on models that are used to solve problems-whether they applied in therapy, physical education, or training practice-this seeks respond constructively recent discussion caused by replication crisis life sciences. To this end, an in-depth contemporary approaches is provided, with pragmatism-oriented clarification researcher's intentions fundamentals (what?), subjects (for whom?), time intervals (when?), purpose what?). The complexity which processes movement acquisition, learning, refinement take place removes their predictable linear character therefore, from point view, invites great deal caution when trying make generalization claims. Particularly we attempt understand study these phenomena unpredictable dynamic contexts, it recommended scientists practitioners seek better central role individual situatedness plays system. In way, will be closer making meaningful authentic contribution advancement knowledge, not merely sake renaming inventions.

Language: Английский

Citations

31
The Association between Circadian Syndrome and Frailty in US adults: a cross-sectional study of NHANES Data from 2007 to 2018 DOI Creative Commons
Lirong Sun,

Xingwei Huo,

Shanshan Jia

et al.

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: May 7, 2024

Frailty and Circadian Syndrome (CircS) are prevalent among the elderly, yet link between them remains underexplored. This study aims to examine association CircS frailty, particularly focusing on impact of various components frailty.

Language: Английский

Citations

5
Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response DOI Creative Commons
Yifei Zhu, Yao Zheng,

Rongyu Dai

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Circadian rhythm is a self-regulating 24-hour system that synchronizes with the day and night cycle in organisms. The regulation of this controlled by clock genes, which function to harmoniously express molecular levels facilitate orderly coordination various cellular processes, such as sleep, metabolism, endocrine function, cell proliferation immunity. root cause tumorigenesis body loses its normal growth at genetic level. Long-term disruptions circadian rhythms caused factors shift work, jet lag, unstable sleep patterns can impact health, leading health problems, including cancer. controls most functions related cancer progression, has significant on ability immune cells detect promote their clearance crucial implication for future tumor immunotherapy. This article aims review crosstalk between dysregulation tumorigenesis, response. Additionally, we discuss role disruption therapy, highlighting potential optimize treatment timing improve therapeutic outcomes.

Language: Английский

Citations

5
Circadian rhythms in cardiovascular (dys)function: approaches for future therapeutics DOI Creative Commons
Margaux Lecacheur,

Daniëlle J. M. Ammerlaan,

Pieterjan Dierickx

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Sept. 23, 2024

Abstract The circadian clock is an evolutionarily conserved time-keeper that regulates physiological processes across 24 h. In the cardiovascular system, several parameters, such as blood pressure, heart rate, and metabolism, exhibit time-of-day variations. These features are in part driven by clock. Chronic perturbation of diurnal rhythmicity due to shift work or irregular social schedules has been associated with increased risk hypertension, arrhythmias, myocardial infarction. This review discusses impact rhythms on human health effect disruption occurrence adverse cardiac events. Additionally, we discuss how main factors diseases, obesity, sleep disorders, aging, affect rhythms. Finally, elaborate chronotherapy well targeting highlight novel approaches translate our scientific understanding into clinical practice.

Language: Английский

Citations

5
Berberine Ameliorates Metabolic-Associated Fatty Liver Disease Mediated Metabolism Disorder and Redox Homeostasis by Upregulating Clock Genes: Clock and Bmal1 Expressions DOI Creative Commons
Cunsi Ye, Weidong Han,

Shaomin Lin

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(4), P. 1874 - 1874

Published: Feb. 16, 2023

Metabolic-associated fatty liver disease (MAFLD) is one of the most common chronic diseases, which in turn triggers mild inflammation, metabolic dysfunction, fibrosis, and even cancer. Accumulating evidence has suggested that Berberine (BBR) could significantly improve MAFLD progression. Clock Bmal1 as heterodimer proteins highly participated development MAFLD, but whether BBR targets remains poorly understood. The result protein levels were decreased mice, was negatively correlated with elevated reactive oxygen species (ROS) accumulation, H2O2 level, insulin resistance. mRNA also glucosamine-induced HepG2 cells, are related to glucose uptake, ROS level. More importantly, siRNA mimic effect glucosamine cells. Interestingly, rescue metabolism disorder redox homeostasis through enhancing expression vivo vitro. Therefore, might be an effective natural compound for alleviating homeostasis, disorder, pathological changes by activating expression.

Language: Английский

Citations

12
Evaluating the Relationship between Circadian Rhythms and Sleep, Metabolic and Cardiovascular Disorders: Current Clinical Evidence in Human Studies DOI Creative Commons

Maria Mentzelou,

Sousana Κ. Papadopoulou, Dimitrios Papandreou

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(3), P. 370 - 370

Published: March 1, 2023

Circadian rhythms are generated by the circadian clock, a self-sustained internal timing system that exhibits 24-h in body. Many metabolic, cellular, behavioral and physiological processes regulated clock coordination with environmental cues. The present study is comprehensive review of currently existing evidence concerning relationship between sleep, cardiovascular disorders. We thoroughly searched online databases PubMed, Scopus, Web Science to find clinical studies from last twenty-three years (2000–2023). misalignment was found be associated an increase risk metabolic disorders, diseases, obesity, as well inadequate sleep quality. In this article, all included had strength protocol design them were conducted on humans. However, most common limitations small sample size short time intervention. conclusion, managing factors disrupt optimal function central peripheral clocks can help reduce improving also Future should further explore underlying mechanisms interconnections This may provide new opportunities for advance chronotherapy approach.

Language: Английский

Citations

12