ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(42)
Published: Nov. 1, 2024
Abstract
In
this
study,
new
Schiff
base
derivatives
of
α‐naphthalene
acetic
acid
containing
alkyl
phenyl
ether
fragment
have
been
effectively
synthesized
through
multistep
reaction
process,
characterized
by
1
H‐NMR
and
13
C‐NMR
spectroscopy.
These
tested
for
their
in
vitro
α‐amylase
α‐glucosidase
inhibitory
activities.
the
series,
8
compounds
(
2j,
2f,
2e,
2m,
2a,
2b,
2l,
2c
)
exhibited
promising
inhibition
with
IC
50
values
from
5.38
±
0.36
to
14.59
0.64
µg/mL.
Similarly,
case
activity,
10
2c,
2i,
2d,
2l
excellent
activity
having
6.96
0.39
16.27
0.31
µg/mL,
wheras
remaining
good‐to‐least
antidiabetic
potential.
The
ADME
properties
were
calculated
all
using
Swiss‐ADME
web
tool.
Furthermore,
docking
studies
identified
binding
modes
compounds.
Future Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 16
Published: Jan. 30, 2025
Background:
Due
to
the
divers
biological
applications
of
Cu(II)
complexes,
we
in
this
study
reports
various
complexes.
The
aims
synthesize
and
assess
new
complexes
as
powerful
β-glucuronidase
inhibitors.
Methods:
Five
Schiff
base
ligands
their
were
synthesized,
characterized,
screened
against
inhibitory
activity.
Results:
In
series,
compounds
3e,
3c,
2b,
2c
ascribed
inhibition
ranging
from
(IC50
=
3.0
±
0.7
µM)
19.2
0.8
µM).
A
precise
particular
arrangement
atoms
is
suggested
by
triclinic
p-1
space
group
existence
a
single
molecule
an
asymmetric
unit,
which
are
indispensable
for
reactivity
well
stability
compounds.
analysis
Hirshfeld
surface
provides
information
about
hydrogen
intermolecular
π–π
interactions.
Based
on
molecular
docking,
binding
potency
increasing
complexation
3a-e
compared
2a-e
reference
Saccharic
acid
uronic
isofagomine
inhibitor,
suggesting
that
it
may
be
potent
inhibitor
these
receptors.
Conclusion:
work
recognizes
latent
active
novel
β-glucoronidase
inhibitors,
further
support
harnessed
development
drugs.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(7)
Published: Feb. 1, 2025
Abstract
Four
azomethine
compounds
(
L
1
–L
4
)
derived
from
the
reaction
of
p
‐hydroxybenzaldehyde
and
various
primary
amines
are
reported
herein.
Various
analytical
spectroscopic
techniques
were
employed
to
characterize
synthesized
compounds.
The
antidiabetic
properties
evaluated
by
exploring
α‐amylase
α‐glucosidase
assays,
where
2
3
displayed
good
with
an
IC
50
values
0.06
0.03
mg/ml
for
assay,
respectively,
better
than
acarbose
(standard
drug)
value
0.08
mg/ml.
With
exception
L4,
antioxidant
activity
showed
nitric
oxide
radical
scavenging
capacity
their
significant
DPPH
free
ability.
antibacterial
activities
dose‐dependent,
notable
activities.
Computational
studies
using
density
functional
theory
molecular
docking
methods
indicated
that
had
energy
gap
7.10
eV,
making
it
least
reactive,
while
6.52
most
chemically
reactive.
New Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Ferroptosis
plays
an
extremely
significant
role
in
the
development
of
hepatocellular
carcinoma
(HCC),
and
targeting
tumor
cells
to
induce
ferroptosis
has
emerged
as
a
new
approach
for
treatment
cancer.
