Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Nutrients, Journal Year: 2020, Volume and Issue: 12(6), P. 1864 - 1864

Published: June 23, 2020

Minerals and trace elements are micronutrients that essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies these related widespread health problems. This review article is focused on some of minerals element deficiencies their consequences diabetes insulin resistance. The levels vary considerably among different populations, contingent composition diet. In several Asian countries, large proportions population affected by a number micronutrient deficiencies. Local differences selenium, zinc, copper, iron, chromium iodine diet occur both developed developing largely due malnutrition dependence indigenous nutrition. These overall and, few cases, excess may lead imbalances glucose homeostasis most extensive problems affecting one billion people or more worldwide associated with inadequate supply including iodine, calcium, chromium, cobalt, boron magnesium. comprises various randomized controlled trials, cohort case-controlled studies, observational laboratory-based studies substantial outcomes resistance diverse racial inhabitants from parts Asia, Africa, North America. Changes serum urine subjects indicate trajectory toward metabolic changes, oxidative stress provide disease-relevant information.

Language: Английский

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Zinc as a Therapeutic Agent in Bone Regeneration

Materials, Journal Year: 2020, Volume and Issue: 13(10), P. 2211 - 2211

Published: May 12, 2020

Zinc is an essential mineral that required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able promote regeneration. However, the cellular molecular pathways through which promotes growth, homeostasis, regeneration are poorly understood. can positively affect chondrocyte osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role in homeostasis Based on effects of cell populations therapeutic approaches using improve being developed. This review focuses providing overview existing studies use as therapeutic.

Language: Английский

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Oxidative stress pathways in pancreatic β-cells and insulin-sensitive cells and tissues: importance to cell metabolism, function, and dysfunction

AJP Cell Physiology, Journal Year: 2019, Volume and Issue: 317(3), P. C420 - C433

Published: June 19, 2019

It is now accepted that nutrient abundance in the blood, especially glucose, leads to generation of reactive oxygen species (ROS), ultimately leading increased oxidative stress a variety tissues. In absence an appropriate compensatory response from antioxidant mechanisms, cell, or indeed tissue, becomes overwhelmed by stress, activation intracellular stress-associated pathways. Activation same similar pathways also appears play role mediating insulin resistance, impaired secretion, and late diabetic complications. The ability antioxidants protect against induced hyperglycemia elevated free fatty acid (FFA) levels vitro suggests causative latter clinical conditions. this review, we describe common biochemical processes associated with driven and/or FFA resulting outcomes: β-cell dysfunction peripheral tissue resistance.

Language: Английский

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Role of Magnesium in Type 2 Diabetes Mellitus

Biological Trace Element Research, Journal Year: 2019, Volume and Issue: 196(1), P. 74 - 85

Published: Nov. 11, 2019

Language: Английский

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Zinc

Advances in food and nutrition research, Journal Year: 2021, Volume and Issue: unknown, P. 251 - 310

Published: Jan. 1, 2021

Language: Английский

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Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: July 12, 2021

Abstract Metal ions have been identified as important bone metabolism regulators and widely used in the field of tissue engineering, however their exact role during regeneration remains unclear. Herein, aim study was to comprehensively explore interactions between osteoinductive osteo-immunomodulatory properties these metal ions. In particular, zinc (Zn 2+ ), well its with local immune microenvironment healing process, investigated this using a sustained Zn delivery system incorporating into β-tricalcium phosphate/poly(L-lactic acid) (TCP/PLLA) scaffolds. The presence largely enhanced osteogenic differentiation periosteum-derived progenitor cells (PDPCs), which coincident increased transition from M1 M2 macrophages (M $$\varphi $$ φ s). We further confirmed that induction polarization by realized via PI3K/Akt/mTOR pathway, whereas marker molecules on pathway were strictly regulated addition . Synergically, favorable immunomodulatory effect improved PDPCs induced vitro. Consistently, spontaneous osteogenesis pro-healing osteoimmunomodulation scaffolds thoroughly vivo rat air pouch model calvarial critical-size defect model. Taken together, -releasing bioactive ceramics could be ideal engineering due reciprocal characteristics. Clarification synergic pave way develop more sophisticated metal-ion based orthopedic therapeutic strategies.

Language: Английский

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Zinc Deficiency Induces Inflammation and Apoptosis via Oxidative Stress in the Kidneys of Mice

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(2), P. 739 - 750

Published: Feb. 24, 2022

Language: Английский

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Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Type 2 diabetes mellitus is a chronic metabolic disease characterized by insulin resistance, with high morbidity and mortality worldwide. Due to the tightly intertwined connection between resistance pathway PI3K/AKT signaling pathway, regulating its associated targets essential for hypoglycemia prevention of type mellitus. In recent years, metabolites isolated from traditional Chinese medicine has received more attention acceptance superior bioactivity, safety, fewer side effects. Meanwhile, numerous in vivo vitro studies have revealed that present possess better bioactivities balance glucose metabolism, ameliorating preventing via pathway. this article, we reviewed literature related improving IR possessing therapeutic potential targeting focusing on hypoglycemic mechanism elaborating significant role order provide reference clinical treatment

Language: Английский

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Zinc chelator TPEN induces pancreatic cancer cell death through causing oxidative stress and inhibiting cell autophagy

Journal of Cellular Physiology, Journal Year: 2019, Volume and Issue: 234(11), P. 20648 - 20661

Published: May 3, 2019

Abstract The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems including immunodeficiency sensory dysfunctions. Previous studies had shown that availability was also important for tumor growth progression. aim the present study to investigate potential mechanisms N,N,N,N‐Tetrakis(2‐pyridylmethyl)‐ethylenediamine (TPEN) (a membrane permeable chelator) induced pancreatic cancer cell death. text inductively coupled plasma‐mass spectrometry (ICP‐MS) showed human samples content higher than adjacent tissues. lines Panc‐1, 8988T, BxPc‐3, L3.6 were used this study. Our results indicated TPEN markedly death, via increasing reactive oxygen species (ROS) restraining autophagy. data TPEN‐stimulated mitochondrial metabolism produced much ROS. Meanwhile, reduced levels glutathione (GSH) triggered ROS outbreak, which main In addition, autophagy significantly depressed Panc‐1 cells treated by TPEN, due ability disrupting lysosomal TPEN. Thus, we thought depletion therapeutic strategy cancer.

Language: Английский

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The cGAS–STING pathway: more than fighting against viruses and cancer

Cell & Bioscience, Journal Year: 2021, Volume and Issue: 11(1)

Published: Dec. 1, 2021

Abstract In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can control production type I and nuclear factor kappa-light-chain-enhancer activated B cells to promote activation pro-inflammatory molecules, which are mainly induced during antiviral responses. However, with progress in this area research, studies focused on autoimmune diseases chronic inflammatory conditions that may be relevant cGAS–STING pathways have been conducted. This review highlights functions pathway diseases. Importantly, has a major impact lipid metabolism. Different research groups confirmed plays an important role status various organs. not studied depth diabetes diabetes-related complications. Current shown targeted therapy caused by inflammation via promising outcomes.

Language: Английский

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