Journal of Food Biochemistry,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 26
Published: Oct. 31, 2023
Zinc
is
crucial
for
physiological
processes;
however,
deficiency
persists
globally.
Binding
zinc
to
plant
proteins
enhances
absorption,
minimizing
toxicity
risks
and
offering
a
potential
solution
deficiency.
Mineral
binding
efficiency
of
the
unmodified
protein
limited;
hence,
dual
modification
(succinylation
ultrasonication)
potentially
used
achieve
higher
efficiency.
Enhancing
uptake
cellular
health
due
its
vital
roles
in
various
biological
processes
including
enzymatic
activity,
DNA
repair,
immune
function,
antioxidant
defense,
hormone
regulation,
brain
signaling,
growth,
gene
expression,
reproduction.
Therefore,
this
research
aimed
develop
chickpea
protein-zinc
complex
evaluate
influence
on
their
physiochemical,
bioavailability,
mineral
attributes.
Succinylation
exhibited
significant
improvements
water-holding
capacity
by
28.73%,
oil-holding
34.09%,
solubility
5.46%
as
compared
native
complex.
bioavailability
increased
8.32%,
there
were
notable
increases
2.10%,
retention
5.80%,
transport
3.96%,
respectively.
Furthermore,
approach
resulted
decrease
particle
size
complex,
with
substantial
reduction
73.25%
an
zeta
value
−21
mV
succinylated
As
well,
concurrently
led
decline
48.04%
sulfhydryl
(SH)
content,
coupled
marked
increase
21.92%
surface
hydrophobicity.
In
addition,
uptake,
retention,
further
enhanced
1.89,
3.34,
4.8%
through
modification.
Our
findings
highlight
that
shows
promising
strategy
enhancing
techno-functional
characteristics,
zinc,
which
could
be
better
platform
developing
vegan
foods.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(5), P. 714 - 714
Published: May 17, 2022
Disruption
of
cerebral
iron
regulation
appears
to
have
a
role
in
aging
and
the
pathogenesis
various
neurodegenerative
disorders.
Possible
unfavorable
impacts
accumulation
include
reactive
oxygen
species
generation,
induction
ferroptosis,
acceleration
inflammatory
changes.
Whole-brain
iron-sensitive
magnetic
resonance
imaging
(MRI)
techniques
allow
examination
macroscopic
patterns
brain
deposits
vivo,
while
modern
analytical
methods
ex
vivo
enable
determination
metal-specific
content
inside
individual
cell-types,
sometimes
also
within
specific
cellular
compartments.
The
present
review
summarizes
whole
brain,
cellular,
subcellular
diseases
genetic
sporadic
origin.
We
provide
an
update
on
mechanisms,
biomarkers,
effects
these
disorders,
focusing
recent
publications.
In
Parkinson’s
disease,
Friedreich’s
several
disorders
neurodegeneration
with
group,
there
is
focal
siderosis,
typically
regions
most
pronounced
neuropathological
second
group
including
multiple
sclerosis,
Alzheimer’s
amyotrophic
lateral
sclerosis
shows
globus
pallidus,
caudate,
putamen,
cortical
regions.
Yet,
other
such
as
aceruloplasminemia,
neuroferritinopathy,
or
Wilson
disease
manifest
diffuse
deep
gray
matter
pattern
comparable
even
more
extensive
than
that
observed
during
normal
aging.
On
microscopic
level,
are
mostly
dystrophic
microglia
variably
accompanied
by
iron-laden
macrophages
astrocytes,
implicating
changes
blood–brain
barrier
disturbance
accumulation.
Options
potential
benefits
reducing
strategies
discussed.
Future
research
investigating
whether
predispositions
play
Fe
necessary.
If
confirmed,
prevention
further
uptake
individuals
at
risk
may
be
key
for
preventing
Redox Biology,
Journal Year:
2024,
Volume and Issue:
70, P. 103048 - 103048
Published: Jan. 17, 2024
The
redox
process
and
cellular
senescence
are
involved
in
a
range
of
essential
physiological
functions.
However,
they
also
implicated
pathological
processes
underlying
age-related
neurodegenerative
disorders,
including
Alzheimer's
disease
(AD).
Elevated
levels
reactive
oxygen
species
(ROS)
generated
as
result
abnormal
accumulation
beta-amyloid
peptide
(Aβ),
tau
protein,
heme
dyshomeostasis
is
further
aggravated
by
mitochondria
dysfunction
endoplasmic
reticulum
(ER)
stress.
Excessive
ROS
damages
vital
components
such
proteins,
DNA
lipids.
Such
damage
eventually
leads
to
impaired
neuronal
function
cell
death.
Heightened
oxidative
stress
can
induce
via
activation
the
senescence-associated
secretory
phenotype
exacerbate
inflammation
tissue
dysfunction.
In
this
review,
we
focus
on
how
changes
system
contribute
AD
affected
perturbations
metabolism
mitochondrial
function.
While
potential
therapeutic
strategies
targeting
have
received
some
attention,
more
research
necessary
bring
them
into
clinical
application.
PubMed,
Journal Year:
2023,
Volume and Issue:
22, P. 809 - 827
Published: Jan. 1, 2023
Zinc
is
a
multipurpose
trace
element
for
the
human
body,
as
it
plays
crucial
part
in
various
physiological
processes,
such
cell
growth
and
development,
metabolism,
cognitive,
reproductive,
immune
system
function.
Its
significance
health
widely
acknowledged,
this
has
led
scientific
community
towards
more
research
that
aims
to
uncover
all
of
its
beneficial
properties,
especially
when
compared
other
essential
metal
ions.
One
notable
area
where
zinc
shown
effects
prevention
treatment
diseases,
including
cancer.
This
review
explain
involvement
specific
conditions
cancer,
coronavirus
disease
2019
(COVID-19)
neurological
disorders
like
Alzheimer's
disease,
well
impact
on
gut
microbiome.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Feb. 7, 2022
Alzheimer's
disease
is
pathologically
characterized
by
abnormal
accumulation
of
amyloid-beta
plaques,
neurofibrillary
tangles,
oxidative
stress,
neuroinflammation,
and
neurodegeneration.
Metal
dysregulation,
including
excessive
zinc
released
presynaptic
neurons,
plays
an
important
role
in
tau
pathology
oxidase
activation.
The
activities
mammalian
target
rapamycin
(mTOR)/ribosomal
S6
protein
kinase
(p70S6K)
are
elevated
the
brains
patients
with
disease.
Zinc
induces
hyperphosphorylation
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(5), P. 2152 - 2175
Published: Jan. 19, 2023
We
describe
the
development
of
quinolylnitrones
(QNs)
as
multifunctional
ligands
inhibiting
cholinesterases
(ChEs:
acetylcholinesterase
and
butyrylcholinesterase-hBChE)
monoamine
oxidases
(hMAO-A/B)
for
therapy
neurodegenerative
diseases.
identified
QN
19,
a
simple,
low
molecular
weight
nitrone,
that
is
readily
synthesized
from
commercially
available
8-hydroxyquinoline-2-carbaldehyde.
Quinolylnitrone
19
has
no
typical
pharmacophoric
element
to
suggest
ChE
or
MAO
inhibition,
yet
unexpectedly
showed
potent
inhibition
hBChE
(IC50
=
1.06
±
0.31
nmol/L)
hMAO-B
4.46
0.18
μmol/L).
The
crystal
structures
with
provided
structural
basis
binding,
which
was
further
studied
by
enzyme
kinetics.
Compound
acted
free
radical
scavenger
biometal
chelator,
crossed
blood-brain
barrier,
not
cytotoxic,
neuroprotective
properties
in
6-hydroxydopamine
cell
model
Parkinson's
disease.
In
addition,
vivo
studies
anti-amnesic
effect
scopolamine-induced
mouse
AD
without
adverse
effects
on
motoric
function
coordination.
Importantly,
chronic
treatment
double
transgenic
APPswe-PS1δE9
mice
reduced
amyloid
plaque
load
hippocampus
cortex
female
mice,
underscoring
disease-modifying
19.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(1), P. 180 - 180
Published: Jan. 12, 2023
Alzheimer’s
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
progressive
memory
loss
and
cognitive
decline.
Although
substantial
research
has
been
conducted
to
elucidate
the
complex
pathophysiology
of
AD,
therapeutic
approach
still
limited
efficacy
in
clinical
practice.
Oxidative
stress
(OS)
established
as
an
early
driver
several
age-related
diseases,
including
neurodegeneration.
In
increased
levels
reactive
oxygen
species
mediate
neuronal
lipid,
protein,
nucleic
acid
peroxidation,
mitochondrial
dysfunction,
synaptic
damage,
inflammation.
Thus,
identification
novel
antioxidant
molecules
capable
detecting,
preventing,
counteracting
AD
onset
progression
utmost
importance.
However,
although
studies
have
published,
comprehensive
up-to-date
overviews
principal
anti-AD
agents
harboring
properties
remain
scarce.
this
narrative
review,
we
summarize
role
vitamins,
minerals,
flavonoids,
non-flavonoids,
mitochondria-targeting
molecules,
organosulfur
compounds,
carotenoids
non-enzymatic
antioxidants
with
diagnostic,
preventative,
potential,
thereby
offering
insights
into
relationship
between
OS
