Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation, and neurotoxicity in rat models of Alzheimer's disease DOI
Manickam Rajkumar,

Prabha Govindaraj,

Karuppaiya Vimala

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Abstract Alzheimer's disease (AD) is a neurodegenerative characterized by amyloid-beta (Aβ) aggregation, neuroinflammation, oxidative stress, and dysfunction in the mitochondria cholinergic system. In this study, synthesis of chitosan-polylactic acid-loaded magnesium oxide nanocomposite (CH/PLA/MgONCs) was examined using green precipitation method. The synthesized CH/PLA/MgONCs were confirmed UV-Vis spectrum, FT-IR, SEM-EDAX, physical properties. experiments carried out male Wistar rats injecting streptozotocin (STZ) bilaterally into brain's ventricles through intracerebroventricular (ICV) route at dose 3 mg/kg. We also evaluated effects doses 10 To assess cognitive induced ICV-STZ, we performed behavioral, biochemical, histopathological analyses. our study results, spectrum analysis showed 285 nm, FT-IR analyses that various functional groups present, SEM-EDAX cauliflower-like spherical shape, Mg O present. Treatment with (10 mg/kg) significant improvement spatial non-spatial memory functions. This further supported biochemical showing improved antioxidant enzyme (GSH, SOD, CAT, GPx activity) activities significantly attenuated activity stress. CH/PLA/MgONCs-treated group, observed mitochondrial complex activity. ICV-STZ-induced as indicated increased levels TNF-α, IL-6, CRP, reduced treatment. Additionally, treated histological results healthy neuronal cells brain. Furthermore, silico studies confirm these molecules have good binding affinity inhibit Aβ aggregation. conclusion, treatment reversed AD pathology improving reducing dysfunction. These findings recommend are possible therapeutic agents to treat AD.

Language: Английский

Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis DOI Creative Commons
Jiaxuan He,

Peiye Xu,

Ting Xu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 7, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder, with amyloid-beta (Aβ) aggregation playing key role in its pathogenesis. Aβ-induced oxidative stress leads to neuronal damage, mitochondrial dysfunction, and apoptosis, making antioxidative strategies promising for AD treatment. This study investigates the effects of hydrogen-rich water (HRW) zebrafish model. Zebrafish were exposed aluminum chloride induce AD-like pathology then treated HRW using nanobubble device. Behavioral assays, ELISA, Hematoxylin-eosin (H&E) staining, reactive oxygen species (ROS) neutrophil fluorescence labeling employed assess HRW's impact. Additionally, 16S rRNA sequencing analyzed effect on gut microbiota. can significantly improve cognitive impairment depression-like behavior model, reduce Aβ deposition (p < 0.0001), regulate liver Soluble epoxide hydrolase (sEH) levels 0.05), neuroinflammation, stress. Furthermore, reduced number harmful bacteria linked by restoring balance microbiota gut. These findings suggest that has potential as therapeutic strategy targeting stress, inflammation, gut-brain axis modulation.

Language: Английский

Citations

1
Efficacy of curcumin-selenium nanoemulsion in alleviating oxidative damage induced by aluminum chloride in a rat model of Alzheimer’s disease DOI

S. A. Awad,

Yasser A. Attia, Hassan Elsayed

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: March 28, 2025

Language: Английский

Citations

1
Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration DOI Creative Commons
Jannis Kountouras, Michael Doulberis, Apostolis Papaefthymiou

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(3), P. 504 - 504

Published: March 4, 2023

Helicobacter pylori infection consists a high global burden affecting more than 50% of the world's population. It is implicated, beyond substantiated local gastric pathologies, i.e., peptic ulcers and cancer, in pathophysiology several neurodegenerative disorders, mainly by inducing hyperhomocysteinemia-related brain cortical thinning (BCT). BCT has been advocated as possible biomarker associated with central nervous system disorders such Alzheimer's disease, Parkinson's multiple sclerosis, and/or glaucoma, termed "ocular disease". According to hypothesis relation neurodegeneration, non-commensal gut microbiome trigger mediator diseases, development disease. Among others, pylori-related inflammatory mediators, defensins, autophagy, vitamin D, dietary factors, role probiotics, some pathogenetic considerations including relevant involved genes are discussed within this opinion article. In conclusion, controlling impact hyperhomocysteinemia on might offer benefits, additional research warranted clarify crucial topic currently representing major worldwide burden.

Language: Английский

Citations

18
The Interplay of Protein Aggregation, Genetics, and Oxidative Stress in Alzheimer’s Disease: Role for Natural Antioxidants and Immunotherapeutics DOI Creative Commons
Ali Jawad, Kyonghwan Choe, Jun Sung Park

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 862 - 862

Published: July 18, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that comprises amyloid-beta protein (Aβ) as main component of neuritic plaques. Its deposition considered trigger for AD pathogenesis, progression, and the clinical symptoms cognitive impairment. Some distinct pathological features include phosphorylation tau protein, oxidative stress, mitochondrial dysfunction. These consequences tend to produce reactive oxygen species (ROS), resulting in dysregulation various signaling pathways neuroinflammation neurodegeneration. The relationship between Aβ cascade stress pathogenesis like “chicken egg” story, with etiology regarding these two factors remaining question “which comes first.” However, this review, we have tried our best clarify interconnection mechanisms show precise cause-and-effect relationship. Based on above hallmarks AD, several therapeutic strategies using natural antioxidants, monoclonal antibodies, vaccines are employed anti-Aβ therapy decrease ROS, burden, chronic neuroinflammation, synaptic failure. antioxidants immunotherapeutics demonstrated significant neuroprotective effects symptomatic relief vitro vivo models, well trials AD. none them received final approval enter drug market mitigating In extensively elaborate pitfalls, assurances, important crosstalk concerning current therapy. Additionally, discuss future development more Aβ-targeted approaches optimization treatment mitigation.

Language: Английский

Citations

8
Doped Graphene Quantum Dots as Biocompatible Radical Scavenging Agents DOI Creative Commons

Adam Bhaloo,

Steven Nguyen,

Bong Lee

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(8), P. 1536 - 1536

Published: July 31, 2023

Oxidative stress is proven to be a leading factor in multitude of adverse conditions, from Alzheimer’s disease cancer. Thus, developing effective radical scavenging agents eliminate reactive oxygen species (ROS) driving many oxidative processes has become critical. In addition conventional antioxidants, nanoscale structures and metal–organic complexes have recently shown promising potential for scavenging. To design an optimal ROS agent, we synthesized ten types biocompatible graphene quantum dots (GQDs) augmented with various metal dopants. The abilities these novel metal-doped GQD were, the first time, assessed via DPPH, KMnO4, RHB (Rhodamine B protectant) assays. While all GQDs consistently demonstrate antioxidant properties higher than undoped cores, aluminum-doped exhibit 60–95% ability ascorbic acid positive control. Tm-doped match KMnO4 assay. All doped possess fluorescence imaging capabilities that enable their tracking vitro, ensuring successful cellular internalization. Given such multifunctionality, antioxidants can prospective candidates multimodal therapeutics, including reduction concomitant therapeutic delivery cancer tumors.

Language: Английский

Citations

15
Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer’s in Rats: Insights into the Underlying Mechanisms DOI
Grandhi Sandeep Ganesh, Prasad Konduri, Aravinda Sai Kolusu

et al.

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(18), P. 3444 - 3459

Published: Sept. 5, 2023

Alzheimer's disease (AD) is one of the most prevalent and progressive neurodegenerative disorders, hallmarked by increased amyloid-β deposition enhanced oxidative load in brain, ensuing cognitive decline. The present study aimed at elucidating neuroprotective effect saroglitazar, a dual peroxisome-proliferator-activated receptor (PPARα/γ) agonist used treatment diabetic dyslipidemia, against memory impairment induced intraperitoneal scopolamine injection. 30 male Wistar rats were randomly divided into following five groups: (A) Veh + Veh, (B) SGZ (C) SCOP, (D) DPZ (E) SCOP. Rats respective groups pretreated with saroglitazar (10 mg/kg, p.o.) donepezil (3 once daily for 16 days. During final 9 days study, injection i.p.) was administered to groups. Adjacent injection, behavioral tests such as open field, Y maze, novel object recognition test, Morris water maze conducted assess learning memory. Additionally, biochemical parameters acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), nitric oxide (NO), malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), brain-derived neurotrophic factor (BDNF), β-amyloid levels, NF-κB measured hippocampus. that received injections showed significantly impaired short-term spatial This associated an increase β-amyloid, iNOS, malondialdehyde, NF-κB, TNF-α levels hippocampus AD rats. On other hand, has provided promising data on its protective role cognition protecting BDNF, SOD, GSH As result, found be therapy upregulating antioxidant status cholinergic activity preventing loss. Collectively, findings revealed protected suppressing scopolamine-mediated deficits, stress, damage. Studying these mechanisms may conclude AD. However, further studies transgenic animals will provide numerous insights contribute developing therapeutic intervention

Language: Английский

Citations

11
Effects silymarin and rosuvastatin on amyloid-carriers level in dyslipidemic Alzheimer’s patients: A double-blind placebo-controlled randomized clinical trial DOI Creative Commons
Auob Rustamzadeh,

Nader Sadigh,

Zahra Vahabi

et al.

IBRO Neuroscience Reports, Journal Year: 2024, Volume and Issue: 17, P. 108 - 121

Published: July 20, 2024

Language: Английский

Citations

4
Antioxidant activity study and GC-MS profiling of Camellia sinensis Linn DOI Creative Commons

Md. Rashed Hasan,

Mohammad Majedul Haque,

Mohammad Amirul Hoque

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23514 - e23514

Published: Dec. 10, 2023

The antioxidant activity of tea leaves extract is a widely researched topic. Tea leaves, particularly those from the

Language: Английский

Citations

10
Bioactive compounds and dietary patterns in Alzheimer's disease DOI Creative Commons

Guilherme Christimann,

Gabriela Rocha dos Santos, J. Sattler

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily affects the elderly, leading to severe cognitive decline and loss of autonomy. The accumulation amyloid-β peptides tau proteins in brain considered central pathogenic mechanism, which results neuronal dysfunction cell death. Various metabolic disruptions, such as chronic oxidative stress inflammatory processes, further exacerbate progression AD. This review, based on literature from PubMed, SciELO, MDPI, ScienceDirect, evaluates role bioactive compounds dietary patterns, specifically Mediterranean MIND diets, mitigating These rich vitamins, flavonoids, carotenoids, omega-3 fatty acids, have shown potential reducing damage inflammation brain, offering neuroprotective benefits. findings suggest vitamin E isomers polyphenols may delay decline, presenting promising avenue for future interventions aimed at optimizing consumption these prevent or slow onset Further research needed determine optimal doses combinations maximize their protective effects.

Language: Английский

Citations

0
Lactic acid bacterial fermentation as a biotransformation strategy to enhance the bioavailability of phenolic antioxidants in fruits and vegetables: A comprehensive review DOI Creative Commons

Indeewarie Hemamali Dissanayake,

Wahida Tabassum,

Muhammad A. Alsherbiny

et al.

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116283 - 116283

Published: March 1, 2025

Language: Английский

Citations

0