Mapping the Lipid Signatures in COVID-19 Infection: Diagnostic and Therapeutic Solutions

Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(21), P. 14411 - 14433

Published: Oct. 30, 2023

The COVID-19 pandemic ignited research centered around the identification of robust biomarkers and therapeutic targets. SARS-CoV-2, virus responsible, hijacks metabolic machinery host cells. It relies on lipids lipoproteins cells for entry, trafficking, immune evasion, viral replication, exocytosis. infection causes cell lipid remodelling. Targeting lipid-based processes is thus a promising strategy countering COVID-19. Here, we review role in different steps SARS-CoV-2 pathogenesis identify lipid-centric targetable avenues. We discuss lipidome changes infected patients their relevance as potential clinical diagnostic or prognostic biomarkers. summarize emerging direct indirect approaches targeting using lipid-inspired approaches. Given that protein-targeted therapies may become less effective due to mutations variants, interventions provide additional perhaps better means combating this future pandemics.

Language: Английский

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Isolation and characterization of a novel single-chain variable fragment (scFv) against Lymphocyte function-associated antigen-1 (LFA-1) using phage display method

Medical Oncology, Journal Year: 2023, Volume and Issue: 41(1)

Published: Dec. 11, 2023

Language: Английский

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The concentrations of essential/toxic elements in serum of COVID-19 patients are not directly related to the severity of the disease

Journal of Trace Elements in Medicine and Biology, Journal Year: 2023, Volume and Issue: 78, P. 127160 - 127160

Published: March 27, 2023

In recent months, the current COVID-19 pandemic has generated thousands of studies directly or indirectly related with this disease and/or coronavirus SARS-CoV-2 causing infection. On August 22, 2022, database PUBMED included 287,639 publications containing term COVID-19. However, in spite importance trace elements human health, including immune system, data on levels metals/metalloids patients is very limited.The concentrations As, Cd, Cr, Cu, Hg, Fe, Mg, Mn, Pb, Se, V and Zn were determined by inductively coupled plasma-mass spectrometry (ICP-MS) 126 serum samples individuals infected SARS-CoV-2, as well 88 non-infected individuals. Participants divided into four groups: i) positive (COVID-19 +) an asymptomatic infection course; ii) suffering mild COVID-19; iii) severe COVID-19, iv) negative (COVID-19-) (control group). The occurrence analyzed was evaluated along biochemical profile, blood cell counts, lipids, proteins crucial enzymes.Serum V, Pb higher than those control group. Although no significant differences observed between different groups patients, showed a tendency to be showing symptoms being asymptomatic. Arsenic Hg rarely detected, regardless if subjects not. results did not show rest according severity (asymptomatic, severe).In here obtained, we highlight need reduce exposure minimize potential adverse health outcomes after other hand, although protective role essential found, Mg Cu

Language: Английский

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A Randomized, Double-Blind, Placebo-Controlled Investigation of Selenium Supplementation in Women at Elevated Risk for Breast Cancer: Lessons for Re-Emergent Interest in Selenium and Cancer

Biomedicines, Journal Year: 2022, Volume and Issue: 11(1), P. 49 - 49

Published: Dec. 25, 2022

Damage to cellular macromolecules such as DNA and lipid, induced via reactive oxygen species, indicators of cell proliferation potential insulin-like growth factor (IGF) metabolic status are intermediate biomarkers breast cancer risk. Based on reports that selenium can affect these markers, a randomized, placebo-controlled, double-blind experiment was conducted investigate the supplementation modulate Using placebo tablet or containing 200 μg provided high-selenium yeast daily for one year, concentrations in blood urine were assessed at baseline after 6 12 months intervention. The intervention used this study is presumed mediate its effect induction glutathione peroxidase activity consequential impact active form protein oxidative damage. We found no evidence support hypothesis indicate systemic IGF affected. Critical knowledge gaps must be addressed resurgence interest garner clinical relevance. Those include identification specific, high-affinity metabolite target(s) which it binds, demonstration determinant binds plays critical role initiation, promotion, progression specific type cancer.

Language: Английский

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Association of vitamins and minerals with COVID-19: A mini review

Asia-Pacific Journal of Molecular Biology and Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 11 - 20

Published: July 4, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease 2019 (COVID-19). SARS-CoV-2 has potential to multiorgan failure (MOF), which lethal. This review aims evaluate levels some vitamins (vitamins C, A, D, and E) minerals (zinc, iron, selenium) in individuals infected with coronavirus. All studies reviewed indicate a deficiency mentioned above. We conclude that micronutrients play significant role immune system their deficiencies have effect on system. Although most antioxidants are believed be present diets, it been suggested taking more will boost immunity. constantly active, specific immunity activated when pathogens present. The metabolites vitamin other nutrients control expression genes cells.

Language: Английский

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