A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654

Published: Jan. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Language: Английский

---

Synthesis, characterization, and evaluation of copper-doped zinc oxide nanoparticles anticancer effects: in vitro and in vivo experiments

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 8, 2025

Zinc oxide and copper nanoparticles are known for their promising biological activities. This study aims to synthesize zinc copper-doped harness the combined cytotoxic anticancer effects of them in vitro vivo studies. nanoparticles, both doped undoped, were synthesized using a chemical co-precipitation method. All synthetized examined shape, crystal structure morphology/ microstructure X-ray diffractometers, scanning electron microscopy transmission microscopy. The hydrodynamic diameter zeta-potential was measured by dynamic light scattering. Energy Dispersive Spectroscopy evaluated doping nanoparticles. tested on bone cancer fibroblast cells normal lung cell viability test, colony formation assay, lactate dehydrogenase assay at concentrations 0, 1, 10, 17.5, 25, 50, 100, 200 μg/ml. In experiments assessed serum markers (Aspartate aminotransferase, Alanine transaminase, blood urea nitrogen creatinine) liver malondialdehyde levels response 5 mg/kg 50 doses. exhibited spherical morphology good dispersion, with an average grain size ranging from 15–39 nm. Copper-doped displayed mixture rod-like grain-like structures, larger 18–68 diffraction analysis confirmed wurtzite types While individual sizes varied, mean particle all samples, including those increasing doping, approximately 100 ± 0.1 Both negative zeta potential. studies revealed that bulk activity (cell < 80%) induced apoptosis 17.5 μg/ml after 72 h (P 0.05). demonstrated higher cytotoxicity compared also showed significant inhibition proliferation over 10 days indicated no changes Aspartate nitrogen, creatinine mg/kg. However, dose significantly increased these Histological injury rats treated but not 0.5 exhibit enhanced oxide, particularly concentrations. High doses could induce biochemical vivo, highlighting need careful management.

Language: Английский

---

Silver Nanoparticles in 3D Printing: A New Frontier in Wound Healing

ACS Omega, Journal Year: 2024, Volume and Issue: 9(40), P. 41107 - 41129

Published: Sept. 16, 2024

This review examines the convergence of silver nanoparticles (AgNPs), three-dimensional (3D) printing, and wound healing, focusing on significant advancements in these fields. We explore unique properties AgNPs, notably their strong antibacterial efficacy potential applications enhancing recovery. Furthermore, delves into 3D printing technology, discussing its core principles, various materials employed, recent innovations. The integration AgNPs 3D-printed structures for regenerative medicine is analyzed, emphasizing benefits this combined approach identifying challenges that must be addressed. comprehensive overview aims to elucidate current state field direct future research toward developing more effective solutions healing.

Language: Английский

---

Hybrid Metal Oxide (Ag–ZnO) Impregnated Biocomposite in the Development of an Eco-Friendly Sustainable Film

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(6), P. 3854 - 3864

Published: May 31, 2024

Nanotechnology offers an innovative application as eco-friendly food packaging film fabricated along with a degradable active mixture (AM). The AM is assortment of alloyed metal oxide nanoparticles (Ag–ZnO), citron powder (AA), and Curcuma peel (CPP). Alloyed (NPs) were observed to exhibit hexagonal structure from the experimental X-ray diffraction. Compositional morphological study NPs (22.69 nm) (32 was done using energy-dispersive spectroscopy (EDX), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, ζ- potential be −14.7 mV, indicating stability NPs. prepared more effective antibacterial analysis against Escherichia coli, exhibiting 72% inhibition antioxidant activity IC50: 51.56% 2,2 diphenyl-1-picrylhydrazyl (DPPH) assay. Film 1, 2, 3, 4 perfectly encapsulated by PVA XRD. FESEM images aggregation biocomposites in perfect distribution. mechanical properties such Young's modulus, elongation at break, tensile strength, ultimate strength (UTS- 5.37 MPa) experimented for films. degradation rate 6.12% 1 soil burial method. emphasizes that biocomposite upgrade sustainability improved physicochemical properties. synthesized biomaterials could used "green" package store fruits, vegetables, sweets industry.

Language: Английский

---

In vitro evaluation of silver-zinc oxide-eugenol nanocomposite for enhanced antimicrobial and wound healing applications in diabetic conditions

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 23, 2025

Diabetic wounds with chronic infections present a significant challenge, exacerbated by the growing issue of antimicrobial resistance, which often leads to delayed healing and increased morbidity. This study introduces novel silver-zinc oxide-eugenol (Ag+ZnO+EU) nanocomposite, specifically designed enhance activity promote wound healing. The nanocomposite was thoroughly characterized using advanced analytical techniques, confirming its nanoscale structure, stability chemical composition. Ag+ZnO+EU demonstrated potent efficacy against range associated pathogens, including standard clinical isolates Staphylococcus aureus, Pseudomonas aeruginosa Candida albicans. Minimum inhibitory concentrations for were significantly lower than those individual components, highlighting synergistic effect nanocomposite. Time-kill assays revealed rapid microbial eradication, achieving complete sterility within 240-min. Importantly, effectively eliminated persister-like cells, are typically resistant conventional treatments, suggesting potential solution persistent infections. In vitro scratch human keratinocyte cells that accelerated closure, near-complete observed 24-h, indicating enhanced cell migration tissue regeneration. Additionally, showed antidiabetic effects increasing glucose uptake up 97.21% in an assay 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose, fluorescent analog, applications beyond These findings highlight as promising candidate addressing both resistance impaired diabetic contexts.

Language: Английский

---

Biogenic Copper/Zinc Oxide Nanocomposites from Bixa orellana: Anticancer Effects through ROS Generation and Apoptosis Induction in Cervical Carcinoma

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 4, 2025

Language: Английский

---

Emerging roles of non-coding RNAs in modulating the PI3K/Akt pathway in cancer

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 10, P. 1 - 15

Published: Aug. 9, 2024

Cancer progression results from the dysregulation of molecular pathways, each with unique features that can either promote or inhibit tumor growth. The complexity carcinogenesis makes it challenging for researchers to target all pathways in cancer therapy, emphasizing importance focusing on specific targeted treatment. One such pathway is PI3K/Akt pathway, which often overexpressed cancer. As cells progress, expression increases, further driving advancement. This study aims explore how ncRNAs regulate PI3K/Akt. NcRNAs are found both cytoplasm and nucleus, their functions vary depending location. They bind promoters PI3K Akt, reducing increasing expression, thus influencing tumorigenesis. ncRNA/PI3K/Akt axis plays a crucial role determining cell proliferation, metastasis, epithelial-mesenchymal transition (EMT), even chemoresistance radioresistance human cancers. Anti-tumor compounds modulate axis. Moreover, directly indirectly.

Language: Английский

---

In Vitro Evaluation of Silver-Zinc Oxide-Eugenol Nanocomposite for Enhanced Antimicrobial and Wound Healing Applications in Diabetic Conditions

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Diabetic wounds with chronic infections present a significant challenge, exacerbated by the growing issue of antimicrobial resistance, which often leads to delayed healing and increased morbidity. This study introduces novel silver-zinc oxide-eugenol (Ag+ZnO+EU) nanocomposite, specifically designed enhance activity promote wound healing. The nanocomposite was thoroughly characterized using advanced analytical techniques, confirming its nanoscale structure, stability chemical composition. Ag+ZnO+EU demonstrated potent efficacy against range associated pathogens, including standard clinical isolates Staphylococcus aureus, Pseudomonas aeruginosaand Candida albicans. Minimum inhibitory concentrations for were significantly lower than those individual components, highlighting synergistic effect nanocomposite. Time-kill assays revealed rapid microbial eradication, achieving complete sterility within 240-min. Importantly, effectively eliminated persister-like cells, are typically resistant conventional treatments, suggesting potential solution persistent infections. In vitro scratch human keratinocyte cells that accelerated closure, near-complete observed 24 hours, indicating enhanced cell migration tissue regeneration. Additionally, showed antidiabetic effects increasing glucose uptake up 97.21% in an in assay 2- [N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose (2-NBDG), fluorescent analog, applications beyond These findings highlight as promising candidate addressing both resistance impaired diabetic contexts.

Language: Английский

---

Cytotoxic Effects of Ag-ZnO Bimetallic Nanoparticles Synthesized with Alchemilla vulgaris Extract on Colon Cancer Cell Lines HT-29 and Caco-2

Applied In Vitro Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Language: Английский

---