Journal of Global Health,
Journal Year:
2023,
Volume and Issue:
13
Published: Dec. 1, 2023
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
presented
numerous
challenges
to
public
health,
including
the
emergence
of
subjective
dry
eye
symptoms
among
individuals.
However,
there
is
currently
a
dearth
comprehensive
knowledge
regarding
associated
factors
with
in
general
population.A
nationwide
survey
China
was
carried
out
from
20
June
31
August
2022,
involving
21
916
participants.
Subjective
were
assessed
using
Ocular
Surface
Disease
Index-6.
We
employed
random
forest
classification
select
potential
based
on
socioecological
model.
also
conducted
univariate
and
multivariable
logistic
regression
analyses
explore
symptoms.
Network
network
structure
factors.The
item
"watching
TV
(or
similar
task)"
displayed
highest
node
strength
exhibited
predictability
within
network.
results
multivariate
analysis
demonstrated
significant
associations
between
several
factors,
loneliness
(odds
ratio
(OR)
=
1.29;
95%
confidence
interval
(CI)
1.26
1.32),
problematic
Internet
use
(OR
1.08;
CI
1.08
1.09),
family
communication
1.01;
1.00
1.01),
presence
depression
1.53;
1.39
1.68)
anxiety
1.31;
1.17
1.47)
symptoms,
older
age
1.01
self-rated
health
status
0.99;
0.98
0.99),
0.97;
0.96
0.97),
literacy
0.98;
0.97
0.99)
agreeableness
personality
trait
0.95
0.99).These
findings
have
important
implications
for
interventions
targeting
prevention
management
population.
Strategies
addressing
individual
risk
supporting
psychological
well-being
may
prove
beneficial
mitigating
burden
The Ocular Surface,
Journal Year:
2024,
Volume and Issue:
33, P. 80 - 98
Published: April 28, 2024
Corneal
neuropathy
involves
corneal
nerve
damage
that
disrupts
ocular
surface
integrity,
negatively
impacting
quality-of-life
from
pain
and
impaired
vision.
Any
or
systemic
condition
damages
the
trigeminal
can
lead
to
neuropathy.
However,
currently
does
not
have
standardized
diagnostic
criteria
treatment
protocols.
The
primary
aim
of
this
systematic
review
was
evaluate
efficacy
safety
interventions
for
treating
Randomized
controlled
trials
(RCTs)
investigated
treatments
were
eligible
if
intervention(s)
compared
a
placebo
active
comparator.
Comprehensive
searches
conducted
in
Ovid
MEDLINE,
Embase
clinical
trial
registries
inception
July
2022.
Cochrane
Risk-of-Bias
2
tool
used
assess
study
methodological
quality.
Certainty
body
evidence
assessed
using
Grading
Recommendations
Assessment,
Development
Evaluation
(GRADE)
approach.
Overall,
20
RCTs
included.
Evaluated
comprised
regenerative
therapies
(n
=
6
studies),
dietary
supplements
4),
anti-glycemic
agents
3),
combination
therapy
supportive
2)
pharmacotherapies
2).
Nine
judged
at
high
risk
bias
most
outcomes.
Definitions
populations
varied
substantially
across
studies,
consistent
with
lack
consensus
on
criteria.
A
diverse
range
outcomes
quantified,
likely
reflecting
absence
an
agreed
core
outcome
set.
There
insufficient
draw
definitive
conclusions
any
intervention.
low
very
certainty
several
neuroregenerative
improving
fiber
length
due
dry
eye
disease
diabetes.
Low
found
altering
immune
cell
density.
This
identifies
need
standardize
definition
define
minimum
set
measures.
Together,
will
provide
foundation
improved
phenotyping
improve
capacity
synthesize
data
inform
evidence-based
care.
Protocol
registration:
PROSPERO
ID:
CRD42022348475.
Contact Lens and Anterior Eye,
Journal Year:
2023,
Volume and Issue:
46(4), P. 101854 - 101854
Published: May 10, 2023
To
conduct
a
review
of
the
literature
in
order
to
identify
potential
association
between
physical
activity
or
exercise
and
objective
signs
and/or
subjective
symptoms
dry-eye
disease.A
PubMed
Web
Science
databases
was
performed,
according
PRISMA
guidelines.
The
papers
included
addressed
relationship
with
associated
(changes
tear
volume,
osmolarity
biochemical
composition)
symptoms.A
total
16
were
included.
In
eight,
changes
film
composition
studied
after
single,
acute
bout
aerobic
exercise.
another
relation
habitual
practice
prescribed
programmes.
Acute
responses
included:
a)
an
increase
without
break-up
time;
b)
trend
osmolarity,
although
within
its
physiological
range;
c)
reduced
concentration
several
cytokines,
other
molecular
markers
inflammation
oxidative
stress.
Long-term
exposure
programmes
relief
increased
time.Despite
high
heterogeneity
population,
study
designs
methods,
current
body
evidence
suggests
role
for
as
modulatory
stimulus
proper
functioning
symptoms.
Aging
is
a
process
often
associated
with
various
age-related
diseases.Senescence
one
of
the
hallmarks
aging,
and
senescent
cells
acquire
complex,
pro-inflammatory,
secretory
phenotype
termed
senescence-associated
(SASP).Here,
we
show
that
ocular
surface
from
human
cornea
become
upon
X-irradiation,
characterized
by
increased
β-galactosidase
activity,
decreased
cell
proliferation,
expression
p16,
disruption
epithelial
barrier.Comprehensive
transcriptomic
proteomic
analysis
revealed
(SOCs)
an
SASP
disrupts
barrier
function.During
aging
in
mice,
SOCs
accumulate,
resulting
chronic
inflammation.Lacrimal
gland
excision,
which
leads
to
symptoms
dry
eye
(DE),
resulted
corneal
opacity
severe
angiogenesis
only
aged
mice
but
not
young
early
senolytic
treatment
protected
old
DE
opacity.In
conclusion,
alter
microenvironment
through
their
eliminating
these
could
represent
potential
approach
alleviate
surface.
Journal of Global Health,
Journal Year:
2023,
Volume and Issue:
13
Published: Dec. 1, 2023
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
presented
numerous
challenges
to
public
health,
including
the
emergence
of
subjective
dry
eye
symptoms
among
individuals.
However,
there
is
currently
a
dearth
comprehensive
knowledge
regarding
associated
factors
with
in
general
population.A
nationwide
survey
China
was
carried
out
from
20
June
31
August
2022,
involving
21
916
participants.
Subjective
were
assessed
using
Ocular
Surface
Disease
Index-6.
We
employed
random
forest
classification
select
potential
based
on
socioecological
model.
also
conducted
univariate
and
multivariable
logistic
regression
analyses
explore
symptoms.
Network
network
structure
factors.The
item
"watching
TV
(or
similar
task)"
displayed
highest
node
strength
exhibited
predictability
within
network.
results
multivariate
analysis
demonstrated
significant
associations
between
several
factors,
loneliness
(odds
ratio
(OR)
=
1.29;
95%
confidence
interval
(CI)
1.26
1.32),
problematic
Internet
use
(OR
1.08;
CI
1.08
1.09),
family
communication
1.01;
1.00
1.01),
presence
depression
1.53;
1.39
1.68)
anxiety
1.31;
1.17
1.47)
symptoms,
older
age
1.01
self-rated
health
status
0.99;
0.98
0.99),
0.97;
0.96
0.97),
literacy
0.98;
0.97
0.99)
agreeableness
personality
trait
0.95
0.99).These
findings
have
important
implications
for
interventions
targeting
prevention
management
population.
Strategies
addressing
individual
risk
supporting
psychological
well-being
may
prove
beneficial
mitigating
burden
