Disposal of SARS-CoV-2 corpses: experiences of environmental health officers DOI Creative Commons
Edward Wilson Ansah, Jacob Owusu Sarfo, Daniel Apaak

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 6, 2024

Though the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is no more of a public health emergency, experiences from burying SARS-CoV-2 infectious dead bodies may remain with workers. For Environmental Health Officers (EHOs), dealing decedents during outbreak arouse strong feelings pity, horror, repulsion, disgust, and anger at tragedy. Therefore, this study aims to explore EHOs in disposing off confirmed or suspected fatalities Ghana. Using an 18-item interview guide, we gathered data 27 three regions We followed steps Descriptive Phenomenology conducting analysis. i. were confronted several occupational safety (OHS) hazards like physical chemical injuries, threat harm, psychological ii. The officers also faced severe shortage personal protective equipment (PPE). Unfortunately, they not provided any form support period. Ghana exposed major fault lines safety/disaster emergency preparedness towards burial disease bodies. Clearly, disposal exercise failed uphold Sustainable Development Goals (SDGs) 4.4, 8.3, 8.5, which advocate for promotion decent jobs all. Ghana's Ministries Health, Local Government, Sanitation Water Resources need attach Clinical Psychologists security personnel teams future exercises provide team. studies on Africa exist, very little known about outbreak.

Language: Английский

Sequences in the Cytoplasmic Tail Contribute to the Intracellular Trafficking and the Cell Surface Localization of SARS-CoV-2 Spike Protein DOI Creative Commons
Evgeniya E. Burkova, Irina A. Bakhno

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 280 - 280

Published: Feb. 14, 2025

Spike protein is a surface glycoprotein of the SARS-CoV-2 coronavirus, providing interaction coronavirus with angiotensin-converting enzyme 2 (ACE2) on host cell. The cytoplasmic tail S plays an important role in intracellular transport and translocation to plasma membrane. domain contains binding sites for COPI, COPII, SNX27, which are required trafficking this glycoprotein. In addition, S-palmitoylation sites. increases hydrophobicity by regulating its has signaling sequence that provides ERM family proteins, may mediate communication between cell membrane actin cytoskeleton. This review examines Understanding these processes necessary not only development vaccines based mRNA or adenovirus vectors encoding full-length spike (S) protein, but also therapy new infection (COVID-19).

Language: Английский

Citations

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Antiviral Activity of Halogenated Compounds Derived from L-Tyrosine Against SARS-CoV-2 DOI Creative Commons

Paula A. Velásquez-Bedoya,

María I. Zapata-Cardona, Laura Milena Monsalve-Escudero

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1419 - 1419

Published: March 22, 2025

Introduction: Currently, there are no effective medications for treating all the clinical conditions of patients with COVID-19. We aimed to evaluate antiviral activity compounds derived from L-tyrosine against B.1 lineage SARS-CoV-2 in vitro and silico. Methodology: The cytotoxicities 15 halogenated were evaluated Vero-E6 cells by MTT assay. was using four strategies, viral quantification performed a plaque assay qRT-PCR. toxicity ADMET predictor software. affinity these or cellular proteins stability their conformations determined docking molecular dynamics, respectively. Results: TODC-3M, TODI-2M, YODC-3M reduced titer >40% inhibited replication RNA without significant cytotoxicity. In silico analyses revealed that presented low binding energies between −4.3 −5.2 Kcal/mol three (spike, Mpro, RdRp). TODC-3M most stable proteins. Conclusions: promising YODC-3M, which toxicity, potential through different favorable affinities targets. Therefore, they candidates vivo studies.

Language: Английский

Citations

0
Exploring the role of traditional remedies, cultural practices, and belief interventions in combating COVID-19 in Dodoma City, Tanzania DOI Creative Commons
Jackson Henry Katonge

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100225 - 100225

Published: April 1, 2025

Language: Английский

Citations

0
Risk Mitigation: Numerical Analysis of COVID-19's Impact on Major Global Construction Economies DOI Creative Commons

V.E.G. Vilchis,

S. Joseph Antony,

Sumit Munjal

et al.

International Journal of Disaster Risk Reduction, Journal Year: 2025, Volume and Issue: unknown, P. 105471 - 105471

Published: April 1, 2025

Language: Английский

Citations

0
Beyond the Pandemic Era: Recent Advances and Efficacy of SARS-CoV-2 Vaccines Against Emerging Variants of Concern DOI Creative Commons
Ankita Saha, Sounak Ghosh Roy, Richa Dwivedi

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 424 - 424

Published: April 17, 2025

Vaccination has been instrumental in curbing the transmission of SARS-CoV-2 and mitigating severity clinical manifestations associated with COVID-19. Numerous COVID-19 vaccines have developed to this effect, including BioNTech-Pfizer Moderna’s mRNA vaccines, as well adenovirus vector-based such Oxford–AstraZeneca. However, emergence new variants subvariants SARS-CoV-2, characterized by enhanced transmissibility immune evasion, poses significant challenges efficacy current vaccination strategies. In review, we aim comprehensively outline landscape emerging concern (VOCs) sub-lineages that recently surfaced post-pandemic years. We assess effectiveness existing their booster doses, against these subvariants, BA.2-derived sub-lineages, XBB BA.2.86 (Pirola). Furthermore, discuss latest advancements vaccine technology, multivalent pan-coronavirus approaches, along development several next-generation coronavirus exosome-based, virus-like particle (VLP), mucosal, nanomaterial-based vaccines. Finally, highlight key critical areas for future research address evolving threat develop strategies combating viral threats, thereby improving preparedness pandemics.

Language: Английский

Citations

0
Myocarditis Associated with COVID-19 Vaccination DOI Creative Commons
Kamila Florek, Mateusz Sokolski

Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1193 - 1193

Published: Oct. 19, 2024

Myocarditis after the COVID-19 vaccine is one of important adverse events following immunization, observed mainly mRNA-based vaccines. Importantly, post-vaccination myocarditis was less common than SARS-CoV-2 infection, as it scored at 19.7 per 1,000,000 doses and 2.76 1000 infections. Predominantly, its course benign and, compared with significantly fewer patients developed heart failure or died among myocarditis. The group highest risk related to vaccination were young males who received a second dose an mRNA vaccine. It that, vaccines, specifically mRNA-1273 associated higher mechanism underlying still under investigation certain processes are being considered. Currently, some follow-up assessments vaccine-induced available suggest favorable prognosis. aim this review discuss most recent data on considering epidemiology, clinical presentation, diagnosis, management, relative potential mechanism,

Language: Английский

Citations

3
Case reports as early safety signals: learning from the COVID-19 vaccination campaign DOI Creative Commons
Michel Goldman, Rebecca E. Chandler

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 9, 2024

OPINION article Front. Med., 09 January 2024Sec. Regulatory Science Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1348376

Language: Английский

Citations

1
Steroidal lactones from Withania somnifera effectively target Beta, Gamma, Delta and Omicron variants of SARS-CoV-2 and reveal a decreased susceptibility to viral infection and perpetuation: a polypharmacology approach DOI
Aditi Srivastava, Rumana Ahmad, Irshad A. Wani

et al.

In Silico Pharmacology, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 27, 2024

Language: Английский

Citations

1
Exploring the detailed role of interleukins in cancer: A comprehensive review of literature DOI
Raed Obaid Saleh, Saade Abdalkareem Jasim, Wesam R. Kadhum

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 257, P. 155284 - 155284

Published: April 8, 2024

Language: Английский

Citations

1
Case of Myocarditis, Pericarditis, and Fatal Aortic Dissection following Covid-19 mRNA Vaccination DOI Open Access

Eduardo J Balbona,

Heather Hudson,

Janci Lindsay

et al.

Published: Jan. 26, 2024

We present a case study of 34-year-old male who was in good health prior to his COVID-19 mRNA vaccination. Sixteen days after first dose, he experienced acute inflammation, sudden thoracic aortic dissection, and pericardial tamponade, rapidly leading death. Studies suggest that young males, particular, appear be at increased risk adverse cardiac events following Although the incidence such complications are believed low, we propose information gaps exist criteria findings inform both public agencies on rates even severe myocarditis This view is shared within many vaccine studies evident this Myocarditis, Pericarditis, Fatal Aortic Dissection presented here.

Language: Английский

Citations

0