Clinical Epidemiological Characteristics of Hospitalized Pediatric Viral Community-Acquired Pneumonia in Mainland China

Journal of Infection, Journal Year: 2025, Volume and Issue: 90(3), P. 106450 - 106450

Published: Feb. 24, 2025

Community acquired pneumonia (CAP) is a major global public health concern among children, with viral pathogens playing significant role. Despite this, national multicenter studies on community (VCAP) in hospitalized children remain scarce. The study employed approach to investigate the clinical epidemiology and burden of VCAP across China. Data were extracted from face sheets discharge medical records (FSMRs) within FuTang Update Medical Records (FUTURE) database, spanning 2016 2022. cases 33 tertiary children's hospitals identified analyzed. Epidemiological characteristics, length stay (LOS), hospitalization costs compared using appropriate statistical methods. Between January December 2022, 72,905 CAP confirmed diagnoses documented, accounting 4.07% all (72,905/1,791,343). Respiratory syncytial virus (RSV) was leading cause, responsible for 57.21% cases, followed by adenovirus, parainfluenza virus, human rhinovirus influenza virus. male-to-female ratio 1.69:1, infants under 1 year age represented 59.84% hospitalizations. Temporal trends showed an increase hospitalizations 2019, decline 2020, resurgence 2021 Seasonally, majority occurred during winter (December February, 41.67%), while summer (June August) had lowest proportion (16.80%). A total 40 deaths reported, representing mortality rate 0.05%. median LOS 7 days, cost 907.38 USD. Although pathogen China relatively low, remains children. RSV most prevalent cause VCAP, particularly affecting age, adenovirus associated highest mortality, longest LOS, costs. peak months. While prognosis generally favorable, disease continues pose considerable challenge.

Language: Английский

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Pediatric Respiratory Syncytial Virus Hospitalizations, 2017-2023

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(6), P. e2416077 - e2416077

Published: June 11, 2024

Importance Respiratory syncytial virus (RSV) transmission was disrupted worldwide following the COVID-19 pandemic, and further study is required to better understand these changes. Objective To compare observed expected RSV hospital intensive care unit (ICU) admission rates characteristics of admitted children during 2021-2022 2022-2023 seasons. Design, Setting, Participants A population-based cohort all aged younger than 5 years in Ontario, Canada, July 1, 2017, through March 31, 2023, conducted. Exposures Individual neighborhood-level sociodemographic clinical were identified from administrative data, including age, palivizumab eligibility, complex medical conditions, rurality, living a marginalized neighborhood. Main Outcomes Measures The main outcome RSV-associated hospitalization. Secondary outcomes included ICU admissions, mechanical ventilation, extracorporeal membrane oxygenation, in-hospital death. Poisson generalized estimating equations used model weekly age- sex-specific hospitalization estimate postpandemic era; adjusted rate ratios (RRs) 95% CIs are reported. Results This approximately 700 000 per year. Compared with prepandemic (2017-2018, 2018-2019, 2019-2020), season peaked slightly earlier, but overall comparable (289.1 vs 281.4-334.6 100 000, or 2000 admissions). month earlier resulted more twice as many hospitalizations (770.0 000; n = 4977 proportion an (13.9%) higher (9.6%-11.4%); however, triple levels (106.9 27.6-36.6 Ontario). With exception palivizumab-eligible children, health status associated lower-than-expected 2021-2022. In contrast, older age patients higher-than-expected (ie, 24-59 months: RR, 1.90; CI, 1.35-2.66). Conclusions Relevance There notable differences epidemiologic Ontario pandemic. It not yet clear whether how long atypical epidemics may persist. Clinicians program planners should consider potential for ongoing impacts capacity immunization programs.

Language: Английский

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Genomic evolution of human respiratory syncytial virus during a decade (2013–2023): bridging the path to monoclonal antibody surveillance

Journal of Infection, Journal Year: 2024, Volume and Issue: 88(5), P. 106153 - 106153

Published: April 6, 2024

OBJECTIVESThis study investigated the prevalence, genetic diversity, and evolution of human respiratory syncytial virus (HRSV) in Barcelona from 2013 to 2023.METHODSRespiratory specimens patients with RTI suspicion at Hospital Universitari Vall d'Hebron were collected October/2013 May/2023 for laboratory-confirmation viruses. Next-generation sequencing was performed randomly-selected samples Illumina technology. Phylogenetic analyses whole genome sequences BEAST v1.10.4. Signals selection evolutionary pressures inferred by population dynamics analyses. Mutations major surface proteins structurally characterised, emphasizing those within antigenic epitopes.RESULTSAnalyzing 139,625 samples, 5.3% HRSV-positive (3,008 HRSV-A, 3,882 HRSV-B, 56 HRSV-A –B, 495 unsubtyped HRSV), a higher prevalence observed paediatric population. Pandemic-related shifts seasonal patterns returned normal 2022-2023. A total 198 whole-genome obtained (6.6% positive samples) belonging GA2.3.5 lineage. For 167 sequenced (4.3% HRSV-B samples), GB5.0.2, GB5.0.4a GB5.0.5a. exhibited rate. Post-SARS-CoV-2 pandemic, both subtypes showed increased rates decreased effective size initially, followed sharp increase. Analyses indicated negative selective pressure on HRSV. epitopes, including S276N M274I palivizumab-targeted site II, I206M, Q209R, S211N nirsevimab-targeted Ø, identified.DISCUSSIONParticularly context large-scale use 2023-2024 season nirsevimab, continuous epidemiological genomic surveillance is crucial.

Language: Английский

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The Changing Landscape of Respiratory Viruses Contributing to Hospitalizations in Quebec, Canada: Results From an Active Hospital-Based Surveillance Study

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e40792 - e40792

Published: March 20, 2024

Background A comprehensive description of the combined effect SARS-CoV-2 and respiratory viruses other than (ORVs) on acute infection (ARI) hospitalizations is lacking. Objective This study aimed to compare viral etiology ARI before pandemic (8 prepandemic influenza seasons, 2012-13 2019-20) during 3 years (periods increased ORV circulation in 2020-21, 2021-22, 2022-23) from an active hospital-based surveillance network Quebec, Canada. Methods We compared detection ORVs that 8 seasons among patients hospitalized with who were tested systematically by same multiplex polymerase chain reaction (PCR) assay periods intense virus (RV) circulation. The proportions infections between using appropriate statistical tests. Results During overall RV was 92.7% (1384/1493) (respiratory syncytial [RSV]: 721/1493, 48.3%; coinfections: 456/1493, 30.5%) children (<18 years) 62.8% (2723/4339) (influenza: 1742/4339, 40.1%; 264/4339, 6.1%) adults. Overall lower but 58.6% (17/29) 2020-21 (all ORVs; 7/29, 24.1%) 90.3% (308/341) 2021-22 (ORVs: 278/341, 82%; SARS-CoV-2: 30/341, 8.8%; 110/341, 32.3%) 88.9% (361/406) 2022-23 339/406, 84%; 22/406, 5.4%; 128/406, 31.5%). In adults, also 43.7% (333/762) 26/762, 3.4%; 307/762, 40.3%; 7/762, 0.9%) 57.8% (731/1265) 179/1265, 14.2%; 552/1265, 43.6%; 42/1265, 3.3%) 50.1% (746/1488) 409/1488, 27.5%; 337/1488, 22.6%; 36/1488, 2.4%). No or RSV detected 2020-21; however, their 2 subsequent did not reach levels. Compared period, peaks hospitalization shifted (16 weeks earlier) (15 earlier). Moreover, (17 later) (4 Age distribution different especially first year. Conclusions Significant shifts etiology, seasonality, age occurred years. Changes observed our may reflect modifications landscape circulating RVs contribution hospitalizations. had a low pediatric hospitalizations, while it main contributor adult dropped below third season. Evolving epidemiology underscores need for scrutiny inform tailored public health recommendations.

Language: Английский

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Exploring immunity debt: Dynamic alterations in RSV antibody levels in children under 5 years during the COVID-19 pandemic

Journal of Infection, Journal Year: 2023, Volume and Issue: 88(1), P. 53 - 56

Published: Oct. 29, 2023

Language: Английский

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Epidemiology of respiratory syncytial virus in hospitalized children over a 9-year period and preventive strategy impact

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 22, 2024

Background: Respiratory Syncytial Virus (RSV) is the primary cause of respiratory infections and hospitalizations in young children globally, leading to substantial disease burden mortality. The aim present study was review provide updates on how SARS-CoV-2 pandemic have significantly influenced RSV epidemiology hospitalized due infection. A potential impact available preventive strategies same population were provided. Methods: All aged 0–6 years at Meyer Children’s Hospital IRCCS for infection from September 2014 March 2023 retrospectively recorded. Seasonal trends before after pandemic, age distribution, ICU admission co-infections, comorbidities prematurity retrieved. Predictions number avoided by deployment different Results: total 1,262 with included study. 70% them had less than 1 year-of-age moment hospitalization almost 50% 3 months. In post-pandemic seasons, a 317% increase recorded significant older compared pre-pandemic seasons. support required 22% children, majority whom under months age. Almost 16% born preterm only 27% prior comorbidities. rate among increased Nirsevimab prophylaxis could prevented more 46% this cohort. strategy addressing also 7 6 co-existing would that above 57%. Discussion: identification hospitalization-related features informing decision-maker wisest approach scale.

Language: Английский

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Burden of disease of RSV in infants, children and pregnant women and people

Canada Communicable Disease Report, Journal Year: 2024, Volume and Issue: 50(1/2), P. 1 - 15

Published: Feb. 29, 2024

Background: Passive immunization products for infants and pregnant women people have sparked interest in understanding Canada's respiratory syncytial virus (RSV) burden.This rapid review examines RSV burden of disease infants, young children people.Methods: Electronic databases were searched to identify studies systematic reviews reporting data on outpatient visits, hospitalizations, intensive care unit admissions, deaths preterm labour associated with RSV.We also contacted Canadian surveillance experts additional data.Results: Overall, 17 10 included, addition primary from one territory (Yukon).There higher rates medical utilization than older children.Hospitalization highest under six months (more 1% annually), 5% needing admission, but mortality was low.Severe outcomes often occurred healthy full-term influenza.Respiratory attack rate 10%-13% among people.Only study found a hospitalization compared non-pregnant people.Limited evidence death birth people. Conclusion:While risk severe is larger high-risk children, healthcare greatest term infants.The severity appears be similar that

Language: Английский

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RSV Prevention Within Reach for Older Infants and Toddlers: The Role of Active Immunization

Journal of the Pediatric Infectious Diseases Society, Journal Year: 2024, Volume and Issue: 13(Supplement_2), P. S125 - S130

Published: July 12, 2024

This review article will summarize the vaccines and monoclonal antibodies currently under evaluation for prevention of RSV disease in older infants, toddlers young children. We rationale passive protection during first months life, role active immunization afterwards, either with live attenuated, protein-based or mRNA vaccines.

Language: Английский

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Global contribution of statistical control charts to epidemiology monitoring: A 23-year analysis with optimized EWMA real-life application on COVID-19

Medicine, Journal Year: 2024, Volume and Issue: 103(27), P. e38766 - e38766

Published: July 5, 2024

Control charts help epidemiologists and healthcare professionals monitor disease incidence prevalence in real time, preventing outbreaks health emergencies. However, there remains a notable gap the comprehensive exploration application of these techniques, particularly context monitoring managing outbreaks. This study analyses categorizes worldwide control chart applications from 2000 to 2023 outbreak over 20 countries, focusing on corona-virus (COVID-19), chooses optimal for US COVID-19 death waves February 2020 December 2023. The systematic literature review analyzes available 35 articles, categorizing data by year, variable, country, type, design. A selected is applied patterns USA. adoption epidemiology increased during pandemic, with annual showing rise 2021 (18%, 36%, 41%). Important variables 2019 include influenza counts, Salmonella cases, infection rates, while studies focus more symptoms, deaths. Among 22 USA (29%) top applier charts. deaths reveals 8 varying severity > . associated JN.1 variant, highlights ongoing challenges. emphasizes significance early diagnosis intervention. workers manage epidemics using data-driven methods, improving public health. mortality analysis their importance, encouraging use.

Language: Английский

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Pediatric COVID-19 severity by SARS-CoV-2 lineage and vaccine status in Canada: an IMPACT study

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

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