Epidemiology and determinants of reemerging bacterial sexually transmitted infections (STIs) and emerging STIs in Europe

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 34, P. 100742 - 100742

Published: Oct. 26, 2023

In this scoping review, we offer a comprehensive understanding of the current and recent epidemiology, challenges, emerging issues related to bacterial sexually transmitted infections (STIs) in WHO European Region. We endeavour collating data from both EU/EEA non- countries, thereby giving complete picture region which highlights higher notification rates Northern Western countries than other regions, likely due differences testing, access surveillance capacity. provide an up-to-date review on knowledge determinants persistent inequities key populations as well use molecular epidemiology for identifying transmission networks gonorrhoea syphilis, detecting chlamydia mutations that evade diagnosis. Finally, explore STIs evolving routes food waterborne diseases into sexual transmission. Our findings call harmonized STI systems, proactive strategies, policies address social factors, staying vigilant STIs.

Language: Английский

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Treatment of bacterial sexually transmitted infections in Europe: gonorrhoea, Mycoplasma genitalium, and syphilis

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 34, P. 100737 - 100737

Published: Oct. 26, 2023

This review explores the therapeutic challenges of sexually transmitted infections (STI) in Europe, which include increasing antimicrobial resistance and limited progress drug discovery. We primarily focus on gonorrhoea,

Language: Английский

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Control of HIV across the WHO European region: progress and remaining challenges

The Lancet Regional Health - Europe, Journal Year: 2025, Volume and Issue: 52, P. 101243 - 101243

Published: Feb. 20, 2025

Language: Английский

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Clostridioides difficileinfection following self-directed post-exposure antibiotic use for STI prevention

Sexually Transmitted Infections, Journal Year: 2025, Volume and Issue: unknown, P. sextrans - 056479

Published: March 13, 2025

Language: Английский

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In Vitro Bactericidal Activity of Biogenic Copper Oxide Nanoparticles for Neisseria gonorrhoeae with Enhanced Compatibility for Human Cells

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21633 - 21642

Published: April 18, 2024

Resistance to antibiotics and antimicrobial compounds is a significant problem for human animal health globally. The development introduction of new are urgently needed, copper oxide nanoparticles (CuO NPs) have found widespread application across various sectors including biomedicine, pharmacy, catalysis, cosmetics, many others. What makes them particularly attractive the possibility their synthesis through biogenic routes. In this study, we synthesized green tea (GT, Camellia sinensis)-derived CuO NPs (GT examined biophysical properties, in vitro toxicity mammalian cells culture, then tested against Neisseria gonorrhoeae, an exemplar Gram-negative bacterium from World Health Organization's Priority Pathogen List. We compared our GT CuOP with commercial (Com NPs). Com were significantly more cytotoxic (IC50 7.32 μg/mL) than 106.1 μg/mL). showed no increase bax, bcl2, il6, il1β mRNA expression cells, whereas there notable rises after treatment NPs. GT-CuO required concentrations 0.625 3.125 μg/mL kill 50 100% bacteria, respectively, Com-CuO needed 15.625 30 antibiotic ceftriaxone killed μg/mL. Gonococci could be within min exposure up 107 1 h. summary, first report knowledge that describes bioactivity N. gonorrhoeae. Our data suggest nanoparticle has advantages over traditional chemical routes highlights potential addressing challenges posed by multidrug-resistant gonorrhoeae infections.

Language: Английский

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The Impact of Information Seeking Behavior on the Prevention and Management of Sexually Transmitted Diseases: A Review of Literature

˜The œjournal of desk research review and analysis., Journal Year: 2025, Volume and Issue: 2(2), P. 159 - 177

Published: Jan. 16, 2025

The review of information-seeking behaviour in the prevention and management sexually transmitted diseases (STDs) has highlighted key themes that significantly impact public health strategies. explored various information sources, such as healthcare providers, online platforms, educational materials, to shape effective STD practices. Understanding how influences behavioural changes, like promoting safer sex practices timely testing, is pivotal empowering individuals make informed decisions about seek appropriate care. Addressing knowledge gaps myths through enhances comprehension decision-making prevention. Overcoming access barriers ensures accurate dissemination STD-related information, leading improved outcomes. Emphasizing digital literacy crucial, especially navigating resources today's age. Behavioural interventions play a critical role sexual treatment adherence. Clear culturally sensitive communication strategies are essential mitigate transmission promote healthy behaviours. By synthesizing research spanning from 2000 June 2024, central underscored. Insights gained can enhance guide future this crucial field. identified analysis stress multifaceted seeking on acquisition, empowerment, decision-making, addressing barriers, literacy, interventions, within management.

Language: Английский

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The role of tenofovir-based HIV pre-exposure prophylaxis in preventing HBV infection among men who have sex with men: insights from China

Infectious Diseases of Poverty, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 27, 2025

Abstract Background Oral emtricitabine-tenofovir disoproxil fumarate (F/TDF) for HIV pre-exposure prophylaxis (PrEP) demonstrates dual potential through antiviral activity against hepatitis B virus (HBV). While F/TDF lacks C (HCV), the use of PrEP may elevate HCV risk compensation. This study aims to investigate HBV/HCV incidence among men who have sex with (MSM) using F/TDF-based PrEP, addressing evidence gaps in low- and middle-income countries. Methods We conducted a secondary analysis China Real-World Intake (CROPrEP) study, multicenter prospective cohort MSM (F/TDF users/non-users) from Beijing, Shenyang, Shenzhen, Chongqing. Participants underwent testing at baseline 12-month follow-up. Only HBV-susceptible (hepatitis surface antigen-negative, core antibody-negative) were included analysis, calculate HBV incidence. The primary outcomes rates Bayesian Poisson regression identified infection factors. Results CROPrEP prospectively recruited 1023 users 507 non-users baseline. 259 120 as At follow-up, no incident infections occurred group, only one group. new was 0.00/100 person-years (PY) [95% confidence interval ( CI ): 0.00 – 1.32] 0.77/100 PY (95% CI: 0.02–4.20) non-users. reduced compared [adjusted rate ratio (aIRR): 0.00; 95% 0.00–0.00]. 0.31/100 0.06–0.90) 0.00–0.74) after 12 months, respectively. lower than (aIRR: 0.00–0.25). Conclusions suggests benefit reducing highlighting integrated prevention strategies both risks programmes. Trial registration : ChiCTR, ChiCTR-IIN-17013762. Registered 8 December 2017, https://www.chictr.org.cn/showproj.html?proj=22916 . Graphical

Language: Английский

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PERFIL EPIDEMIOLÓGICO DE IDOSOS COM SÍFILIS NO OESTE DO PARANÁ ENTRE 2016 E 2020

Revista Multidisciplinar do Nordeste Mineiro, Journal Year: 2025, Volume and Issue: 8(1), P. 1 - 15

Published: April 30, 2025

A sífilis adquiria é uma doença infecciosa crônica que ainda se faz muito presente e permanece como questão relevante de saúde pública. Pode manifestar em diferentes estágios- primário, secundário, latente terciário seu tratamento realizado através antibioticoterapia específica. O objetivo do estudo foi analisar a incidência adquirida idosos no oeste Paraná período 2016 2020. Estudo ecológico, série temporal, abordagem quantitativa natureza descritiva, com dados obtidos partir SINAN/ DATASUS. Foram incluídos todos os casos notificados 2020 estado nos municípios pertencem à região pessoas cima 60 anos. análise mostrou um aumento progressivo até 2019, queda nas notificações 2020, fato possivelmente relacionado pandemia da COVID-19. Observou-se maior sexo masculino ambas as regiões analisadas, refletindo associação fatores culturais, sociais comportamentais distanciam o homem serviço contribui para cenário vulnerabilidade. comparativo entre certa homogeneidade na distribuição dos notificados, sugerindo boa estrutura regionalização acesso aos serviços básicos saúde. Conclui-se crescimento reforça alta doença, necessitando abordagens públicas voltadas especificamente população idosa.

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Computational and Experimental Study of Metal–Organic Frameworks (MOFs) as Antimicrobial Agents against Neisseria gonorrhoeae

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

The emergence of drug-resistant superbugs poses a critical global health threat, necessitating innovative treatment strategies. Neisseria gonorrhoeae (Ng) causes sexually transmitted disease called gonorrhea, and the bacterium has shown alarming resistance to conventional antibiotics, underscoring urgent need for novel therapeutic approaches. In current study, we interfaced computational biology materials science investigate interactions between in-house synthesized metal-organic frameworks (MOFs) penicillin-binding protein 2 (PBP2) Ng, key target β-lactam antibiotics. Using molecular docking interaction analyses, identified three promising MOFs, namely, Fe-BDC-258445, Cu-BDC-687690, Ni-BDC-638866, with optimum binding scores stable interactions. These indicated strong PBP2, suggesting their potential as agents. Antimicrobial screening using standard disk diffusion assay demonstrated that Cu-BDC MOFs were bactericidal multiple strains whereas Ni-BDC Fe-BDC nonbactericidal. MOF did not kill other Gram-negative bacteria, thus demonstrating specificity showed low toxicity human Chang conjunctival epithelial cells in vitro. No significant leaching biological activity was observed MOF, microscopy loss gonococcal piliation damage cell membrane. findings underscore antimicrobial agents further development.

Language: Английский

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Health literacy and socioeconomic characteristics of young people in Serbia and their influence on reproductive health and sexual behaviour

Central European Journal of Public Health, Journal Year: 2025, Volume and Issue: 33(1), P. 24 - 29

Published: March 31, 2025

Having adequate level of health literacy is a very powerful tool improving health. "Emerging adulthood" described as period between age 18-25 years, characterized by changing life circumstances, developing personality and exploring possibilities. The aim this study was to establish the relationship socioeconomic status young adults in Serbia their individual influence on reproductive sexual behaviour. This research conducted observational, cross-sectional study. We used STOFHLA assess people general information questionnaire for demographic, social economic characteristics respondents, knowledge behaviour area Chi-square test performed existence association categorical variables using Statistical Package Social Sciences (SPSS). Results our found significant connection levels groups, marital status, but also with living rural place. Socio-demographic factors had impact various aspects knowledge. importance reflected its contribution clearer understanding Serbia, public policies, interventions educational programmes, which would contribute reducing inequalities, outcomes, targeted initiatives.

Language: Английский

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