Atypical Manifestations of Syphilis: A 10-Year Retrospective Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1603 - 1603

Published: March 11, 2024

Background: The incidence of syphilis has increased in high-income countries the past few decades, especially among men who have sex with men. In present study, we aimed to analyze correlations between atypical manifestations and demographic, clinical, laboratory features patients review unusual presentations reported literature. Methods: We conducted a retrospective analysis 307 diagnosed 1 January 2013 31 October 2023 at sexually transmitted infection (STI) centers University Genoa Foggia both typical disease. Results: our series, were detected 25.8% patients, secondary stage Lesions annular morphology lesions presenting as itchy erythematous scaly plaques psoriasiform appearance most common syphilis. A statistical revealed that homosexual orientation, reinfection, venereal disease research (VDRL) titers > 1:32 correlated manifestations. Conclusions: Our study demonstrates spectrum manifestations, all stages disease, is wide; often pose diagnostic challenges, may delay provision appropriate treatment, facilitate spread infection.

Language: Английский

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Prevention strategies for sexually transmitted infections, HIV, and viral hepatitis in Europe

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 34, P. 100738 - 100738

Published: Oct. 26, 2023

The current prevention efforts for STIs, HIV and viral hepatitis in the WHO European Region, especially Central Eastern subregions, are hindered by healthcare disparities, data gaps, limited resources. In this comprehensive narrative review, we aim to highlight both achievements persisting challenges while also exploring new developments that could significantly impact of these infections near future. While pre-exposure prophylaxis (PrEP) has been broadly approved implemented 38 out 53 countries region, remain, including cost, licensing, incomplete adherence. We explore innovative approaches like on-demand PrEP, long-acting injectable cabotegravir, intravaginal rings have shown promising results, alongside use six-monthly lenacapavir, outcomes which pending. Additionally, potential doxycycline post-exposure discussed, revealing efficacy reducing chlamydia syphilis risk, but effectiveness against gonorrhoea being contingent on tetracycline resistance rates, need further determine development other bacteria its gut microbiome. examine successful vaccination campaigns HBV HPV, ongoing vaccines chlamydia, syphilis, herpesvirus, gonorrhoea, vaccine research, lines research with significant sequential immunization, T-cell responses, mRNA technology. This review underscores endeavors pave way a more resilient robust approach combating HIV, region.

Language: Английский

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Treatment of bacterial sexually transmitted infections in Europe: gonorrhoea, Mycoplasma genitalium, and syphilis

The Lancet Regional Health - Europe, Journal Year: 2023, Volume and Issue: 34, P. 100737 - 100737

Published: Oct. 26, 2023

This review explores the therapeutic challenges of sexually transmitted infections (STI) in Europe, which include increasing antimicrobial resistance and limited progress drug discovery. We primarily focus on gonorrhoea,

Language: Английский

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45 years of tetracycline post exposure prophylaxis for STIs and the risk of tetracycline resistance: a systematic review and meta-analysis

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 4, 2024

Abstract There is considerable interest in the use of doxycycline post exposure prophylaxis (PEP) to reduce incidence bacterial sexually transmitted infections (STIs). An important concern that this could select for tetracycline resistance these STIs and other species. We searched PubMed Google Scholar, (1948–2023) randomized controlled trials comparing PEP with non-tetracycline controls. The primary outcome was antimicrobial (AMR) tetracyclines all species available data. Our search yielded 140 studies, which three met inclusion criteria. Tetracycline associated an increasedprevalence Neisseria gonorrhoeae , but effect not statistically significant (Pooled OR 2.3, 95% CI 0.9-3.4). had a marked on N. MIC distribution one study where assessed. Prophylactic efficacy 100% at low MICs 0% high MICs. In assessed, resulted increase commensal compared control group (OR 2.9, 1.5-5.5) no prevalence Staphylococcus aureus . evidence suggests be selecting

Language: Английский

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Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial

The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(4), P. 404 - 416

Published: Jan. 8, 2024

Management of syphilis, a sexually transmitted infection (STI) with increasing incidence, is challenged by drug shortages, scarcity randomised trial data, an absence non-penicillin alternatives for pregnant women penicillin allergy (other than desensitisation), extended parenteral administration neurosyphilis and congenital macrolide resistance. Linezolid was shown to be active against Treponema pallidum, the causative agent in vitro rabbit model. We aimed assess efficacy linezolid treating early syphilis adults compared standard care benzathine G (BPG).

Language: Английский

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Sexually transmitted infections and the HPV-related burden: evolution of Italian epidemiology and policy

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 15, 2024

Sexually transmitted infections (STIs) are a major public health problem worldwide, with high prevalence between the ages of 15 and 25 in most Western countries. High notification rates chlamydia, gonorrhea, syphilis reported WHO European Region, differences In Italy, total number STIs alerts increased by 18% from 2020 to 2021. HPV is common sexually infection; globally one seven women infected this virus, certain sexual behaviors important risk factors for HPV-related cancers, particularly cervical cancer (CC), anogenital cancers head neck. The burden CC relevant particular Europe third leading cause cancer-related deaths aged 15-44. This tumor preventable through combined strategy vaccination screening precursor lesions. coverage organized varies region average rate still far expected optimal threshold 95% at age 12. To address challenges promotion prevention, priority actions needed such as: promoting education information every level, schools healthcare professionals. adolescents on reproductive health, remains critical, regionally inhomogeneous much lower than other Equitable measures need be taken, an place activities.

Language: Английский

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Sexually Transmitted Infections in Adolescents and Young Adults: A Cross Section of Public Health

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(4), P. 501 - 501

Published: April 19, 2024

Introduction. Sexually transmitted infections (STIs) can be caused by a number of microorganisms that vary greatly in size, life cycle, clinical manifestations, and sensitivity to available treatments. Transmission STIs occur during unprotected (or condomless) sexual contact through the exchange body fluids any type activity. The prevalence sexually diseases remains high world, despite diagnostic therapeutic improvements for these infectious rapidly eliminate contagiousness patients. Our study determines STI pathogens adolescents young adults population Province Macerata (Italy). We will analyze data correspondence age gender, we compare our results international studies. Materials Method. analyzed test from entire database Provincial Health Authority period 2021–2022. samples came following groups: 0–12, 13–18, 19–25, 26–35 2021 2022. vaginal cervical swabs (for females); urethral, rectal, pharyngeal males seminal fluid males) infections: HPV, Chlamydia trachomatis, Mycoplasma genitalium, Ureaplasmas, Gardnerella, Trichomonas vaginalis, Neisseria gonorrhoeae, Treponema pallidum. also blood tests HIV, hepatitis C, B, pallidum (TPHA, VDRL). In addition, examined urine chlamydia, trichomonas, Conclusions. literature other countries reports need comprehensive, culturally developmentally sensitive care address sexuality-related issues adults, applies Italy. These great importance adopting evidence-based control programs Marche Region. This could, indeed, represent landmark public health officials professionals, with aim promoting adolescents’ access services receive useful information, strengthening preventive measures younger groups, designing education programs.

Language: Английский

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PERFIL EPIDEMIOLÓGICO DE IDOSOS COM SÍFILIS NO OESTE DO PARANÁ ENTRE 2016 E 2020

Revista Multidisciplinar do Nordeste Mineiro, Journal Year: 2025, Volume and Issue: 8(1), P. 1 - 15

Published: April 30, 2025

A sífilis adquiria é uma doença infecciosa crônica que ainda se faz muito presente e permanece como questão relevante de saúde pública. Pode manifestar em diferentes estágios- primário, secundário, latente terciário seu tratamento realizado através antibioticoterapia específica. O objetivo do estudo foi analisar a incidência adquirida idosos no oeste Paraná período 2016 2020. Estudo ecológico, série temporal, abordagem quantitativa natureza descritiva, com dados obtidos partir SINAN/ DATASUS. Foram incluídos todos os casos notificados 2020 estado nos municípios pertencem à região pessoas cima 60 anos. análise mostrou um aumento progressivo até 2019, queda nas notificações 2020, fato possivelmente relacionado pandemia da COVID-19. Observou-se maior sexo masculino ambas as regiões analisadas, refletindo associação fatores culturais, sociais comportamentais distanciam o homem serviço contribui para cenário vulnerabilidade. comparativo entre certa homogeneidade na distribuição dos notificados, sugerindo boa estrutura regionalização acesso aos serviços básicos saúde. Conclui-se crescimento reforça alta doença, necessitando abordagens públicas voltadas especificamente população idosa.

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Bacterial sexually transmitted infections among men who have sex with men and transgender women using oral pre-exposure prophylaxis in Latin America (ImPrEP): a secondary analysis of a prospective, open-label, multicentre study

The Lancet HIV, Journal Year: 2024, Volume and Issue: 11(10), P. e670 - e679

Published: Sept. 5, 2024

Language: Английский

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A new STI in the city: MPOX in Barcelona. First outbreak (5/2022-5/2023) and subsequent resurgence

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0296141 - e0296141

Published: Jan. 16, 2025

In May 2022, after the suspension of mobility restrictions due to COVID-19 pandemic, first outbreak MPOX virus, transmitted from human human, was detected outside Africa, affecting mostly sexually active men who have sex with men. Our aim is report in Barcelona city period 5/2022 5/2023 and subsequent surge cases 8/2023. We performed a descriptive study all notified residents, obtained through epidemiological surveys. The analyses are presented for hospitalized key population Of 2037 cases, 82.6% were confirmed. cumulative incidence general 1.03 (95%CI 1.00-1.06) per 1000 inhabitants 2.13 (2.01-2.17) Men older than women, median age 37 years (interquartile range 31-43). While 84.5% reported having partners same gender, 70.9% women only opposite gender. Complications occurred 4.1% infected persons, 1.6% required hospitalization, no deaths registered. Georeferencing highly associated gay venues. Gay, bisexual other (GBMSM) accounted most severe attending public venues not providing contact tracing information. Digital printed prevention campaign materials developed GBMSM. 2022 posed major challenge surveillance sexual health services worldwide. With new re-infections on rise, may become regular infection be incorporated STI testing management guidelines. has some characteristics that facilitate occurrence spread emergencies related health.

Language: Английский

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