Cardiovascular and Metabolic Science, Journal Year: 2024, Volume and Issue: 35(4), P. 124 - 126
Published: Jan. 1, 2024
Therapeutics and Clinical Risk Management, Journal Year: 2024, Volume and Issue: Volume 20, P. 711 - 718
Published: Oct. 1, 2024
Our study evaluated the risk factors for new postoperative atrial fibrillation (POAF) by analyzing data collected from patients who underwent first coronary artery bypass grafting (CABG).
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 34 - 34
Published: Dec. 25, 2024
Background/Objectives: Atrial fibrillation (AF) is the most frequent arrhythmia in adult population associated with a high rate of severe consequences leading to significant morbidity and mortality worldwide. Therefore, its prompt recognition clinical importance. AF detection often remains challenging due unspecific symptoms lack reliable biomarkers for prediction. Herein, novel bioanalytical methodologies, such as metabolomics, offer new opportunities better understanding underlying pathological mechanisms cardiovascular diseases, including AF. The metabolome, considered complete set small molecules present organism, directly reflects current phenotype studied system highly sensitive any changes, arrhythmia’s onset. A growing body evidence suggests that metabolite profiling has prognostic value prediction, highlighting potential role not only early diagnosis but also guiding therapeutic interventions. By identifying specific metabolites disease biomarker or recognising particular metabolomic pathways involved pathomechanisms, metabolomics could be great further decision-making, risk stratification, an individual personalised approach. presented narrative review aims summarise state knowledge on special emphasis implications practice medicine.
Language: Английский
Citations
1
The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 37, P. 100827 - 100827
Published: Feb. 1, 2024
Language: Английский
Citations
1
International Journal of Cardiovascular Practice, Journal Year: 2024, Volume and Issue: 9(1)
Published: June 8, 2024
Background: Patients with lone atrial fibrillation (AF) are ideal subjects for investigating the relationship between AF and genetic factors. MicroRNAs regulatory factors closely related to pathways leading heart diseases, including AF. Objectives: This investigation aimed examine expression levels of miRNAs involved in pathogenesis this disease as non-invasive diagnostic prognostic biomarkers. Methods: The participants case-control study included 35 individuals healthy controls. After collecting blood samples from all participants, miR-126 miR-199a were evaluated using Real-Time PCR on RNA extracted these samples. two then compared groups. Results: Although level patients was significantly lower controls, did not show a significant difference cases Additionally, miR-126, an AUC 0.96, demonstrated very good power occurrence Conclusions: A decreased associated could be used biomarker excellent power. change proposed mediator that accelerates complications
Language: Английский
Citations
0
Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2376 - 2376
Published: Oct. 25, 2024
Atrial fibrillation (AF) signifies the most prevalent supraventricular arrhythmia in humans and may lead to cerebral stroke, cardiac failure, even premature demise. Aggregating strong evidence points genetic components as a cornerstone etiopathogenesis of familial AF. However, determinants for AF patients remain elusive.
Language: Английский
Citations
0
JCI Insight, Journal Year: 2024, Volume and Issue: 10(1)
Published: Nov. 14, 2024
Acute atrial ischemia is a well-known cause of postoperative fibrillation (POAF). However, mechanisms through which contributes to the development POAF are not well understood. In this study, ex vivo Langendorff perfusion was used induce acute and reperfusion in heart order mimic POAF. Inducibility (AF) evaluated using programmed electrical stimulation confirmed with open-atrium optical mapping. Compared control group without ischemia, 25 minutes substantially increased incidence AF. The right atrium more susceptible AF than left atrium. Administering insulin for 30 before during greatly reduced vulnerability treatment only did show substantial benefits against Optical mapping studies showed that mitigates ischemia-induced abnormal electrophysiology, including shortened action potential duration effective refractory period, slowed conduction velocity, heterogeneity, altered calcium transients. conclusion, risk ischemia/reperfusion-induced via improving electrophysiology handling cardiomyocytes, provides therapy
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)
Published: Nov. 21, 2024
Abstract Atrial cardiomyopathy is characterized by electrical and structural remodeling of the atria, which can predispose to arrhythmias thromboembolic stroke. Changes in atrial size function are frequently observed athletes engaged endurance sports, a phenomenon known as “athlete’s heart.” Common left observations may include larger volumes but lower atrioventricular volume ratios, mildly reduced strain, possible mild fibrosis, longer P-wave duration, greater ectopic activity. However, it remains unclear whether these changes represent physiological adaptations exercise or disease-promoting pathology. While athlete’s heart considered benign phenomenon, have an established risk fibrillation. Therefore, represents significant consideration disease prognostication development management strategies for athletes. This review examines current literature with respect clinical features, causes, consequences
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7417 - 7417
Published: Dec. 5, 2024
In patients with atrial fibrillation and contraindications for oral anticoagulation, in which an increased risk of stroke remains, a left appendage exclusion should be considered elimination, because the is most common site thrombus. The aim this study to present first-in-human results Sierra Aegis Left Atrial Appendage Ligation System, new epicardial-only closure system.
Language: Английский
Citations
0
European Cardiology Review, Journal Year: 2024, Volume and Issue: 19
Published: Dec. 23, 2024
Despite significant advances in its management, AF remains a major healthcare burden affecting millions of individuals. Rhythm control with antiarrhythmic drugs or catheter ablation has been shown to improve symptoms and outcomes patients, but current treatment options have limited efficacy and/or side-effects. Novel mechanism-based approaches could potentially be more effective, enabling improved therapeutic strategies for managing AF. Small-conductance calcium-activated potassium (SK KCa2.x) channels encoded by KCNN1-3 recently gathered interest as novel targets potential atrial-predominant effects. Here, the molecular composition smallconductance their complex regulation basis understanding distinct mechanism action pore-blockers (apamin, UCL1684, ICAGEN) modulators calcium-dependent activation (NS8593, AP14145, AP30663) are summarised. Furthermore, preclinical early clinical evidence role small-conductance channel inhibitors reviewed.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)
Published: Dec. 4, 2024
Atrial fibrillation (AF), the most common sustained arrhythmia, increases stroke and heart failure risks. Here we review genes linked to AF mechanisms by which they alter risk. We highlight gene expression differences between atrial ventricular cardiomyocytes, regulatory responsible for these differences, their potential contribution AF. Understanding through lens of regulation is crucial improving treatment.
Language: Английский
Citations
0