Population Behavior Changes Underlying Phasic Shifts of SARS-CoV-2 Exposure Settings Across 3 Omicron Epidemic Waves in Hong Kong: Prospective Cohort Study (Preprint) DOI
Chin Pok Chan, Shui Shan Lee, Tsz Ho Kwan

et al.

Published: Aug. 2, 2023

BACKGROUND Exposure risk was shown to have affected individual susceptibility and the epidemic spread of COVID-19. The dynamics by across exposure settings alongside variations following implementation social distancing interventions are understudied. OBJECTIVE This study aims examine population’s trajectory in different its association with SARS-CoV-2 infection 3 consecutive Omicron waves Hong Kong. METHODS From March June 2022, invitation letters were posted 41,132 randomly selected residential addresses for recruitment households into a prospective population cohort. Through web-based monthly surveys coupled email reminders, representative from each enrolled household self-reported incidents infections, COVID-19 vaccination uptake, their activity pattern workplace, daily preceding month. As proxy risk, reported trend setting differentiated trajectories based on latent class growth analyses. associations overall wave (wave 1: February-April; 2: May-September; 3: October-December) 2022 evaluated using Cox proportional hazards models Kaplan-Meier analysis. RESULTS In total, 33,501 responses observation period February-December collected 5321 individuals, 41.7% (2221/5321) being male median age 46 (IQR 34-57) years. Against an expanding coverage 81.9% 95.9% 2 doses 20% 77.7% doses, cumulative incidence escalated <0.2% 25.3%, 32.4%, 43.8% end 1, 2, 3, respectively. Throughout 52.2% (647/1240) participants had worked regularly on-site, 28.7% (356/1240) remotely, 19.1% (237/1240) showed assorted pattern. For settings, 4 5 identified, respectively, 11.5% (142/1240) 14.6% (181/1240) gauged high risk. Compared remote working, working on-site (adjusted hazard ratio [aHR] 1.47, 95% CI 1.19-1.80) living larger (aHR 1.12, 1.06-1.18) associated higher 1. Those highest 1.46, 1.07-2.00) second 1.52, 1.18-1.97) also at increased relative lowest trajectory. CONCLUSIONS infection-naive population, transmission predominantly initiated accelerated household, perpetuated environments, as stringent restrictions scaled down. These patterns highlight phasic shift which is important informing effective calibration targeted measures alternative lockdown.

Language: Английский

Assessing COVID-19 vaccine effectiveness against Omicron subvariants: Report from a meeting of the World Health Organization DOI Open Access
Daniel R. Feikin, Melissa M. Higdon, Nick Andrews

et al.

Vaccine, Journal Year: 2023, Volume and Issue: 41(14), P. 2329 - 2338

Published: Feb. 9, 2023

Language: Английский

Citations

29
Waning neutralizing antibodies through 180 days after homologous and heterologous boosters of inactivated COVID-19 vaccine DOI Creative Commons
Zhifei Chen,

Fangqin Xie,

Hairong Zhang

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 28, 2025

To enhance the personal immunity to COVID-19, a third booster dose of inactivated COVID-19 vaccines program campaign was implemented in China. Our study endeavored compare dynamics neutralizing antibodies generated by four distinct against three kinds live SARS-CoV-2 virus (wild-type, Delta AY.23, and Omicron BA5.2). This cohort involved 320 healthy individuals, who were randomly assigned groups, receive boosters with vaccine (COVac BIBP), adenovirus type-5-vectored (Convidecia), recombinant protein-based (Zifivax), respectively, all studied had Wuhan variant as their parental variant. Participants recruited from December 2021 June 2022, follow-up period 180 days. We evaluated humoral immune responses longevity measuring geometric mean titers (GMTs) at various time points post-boost. After days follow-up, 310 participants completed study. Across wild-type declined sharply within first 90 days, accounting for an 81.24 92.34% reduction, then slowed down gradually decreasing decay rates. By day 14 post-boost, ability neutralize slightly diminished compared wild-type, whereas exhibited more pronounced decline, ranging 10.78 19.88 times lower than those wild-type. Notably, heterologous boosting Convidecia maintained higher GMTs both variants other boosters. At substantially decreased, yet individuals received still In summary, antibody levels significantly waned after dose, most decline occurring initial Heterologous demonstrated robust, durable, broad response or Zifivax, suggesting that vector possess special advantage realm development preventing infectious diseases.

Language: Английский

Citations

1
Effectiveness and durability of BNT162b2 vaccine against hospital and emergency department admissions due to SARS-CoV-2 omicron sub-lineages BA.1 and BA.2 in a large health system in the USA: a test-negative, case-control study DOI
Sara Y. Tartof, Jeff Slezak, Laura Puzniak

et al.

The Lancet Respiratory Medicine, Journal Year: 2022, Volume and Issue: 11(2), P. 176 - 187

Published: Oct. 7, 2022

Language: Английский

Citations

29
SARS-CoV-2 infection following booster vaccination: Illness and symptom profile in a prospective, observational community-based case-control study DOI Creative Commons
Michela Antonelli, Rose Penfold, Liane S. Canas

et al.

Journal of Infection, Journal Year: 2023, Volume and Issue: 87(6), P. 506 - 515

Published: Sept. 28, 2023

Booster COVID-19 vaccines have shown efficacy in clinical trials and effectiveness real-world data against symptomatic severe illness. However, some people still become infected with SARS-CoV-2 following a third (booster) vaccination. This study describes the characteristics of illness vaccination assesses risk progression to disease individuals time since

Language: Английский

Citations

20
Effectiveness of COVID-19 Vaccine Booster Shot Compared with Non-Booster: A Meta-Analysis DOI Creative Commons
Yajuan Zhu, Shuang Liu,

Dingmei Zhang

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(9), P. 1396 - 1396

Published: Aug. 25, 2022

The analysis of the effectiveness booster shots compared with primary vaccination is extremely vital. This paper aimed to summarize results all available evidence studies on against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Articles published up 21 June 2022 were systematically searched through PubMed and EMBASE databases. independently assessed for quality using Newcastle–Ottawa Scale. Results: Seven (nine datasets) met criteria included in this study. pooled demonstrated a 71% (OR = 0.29, 95% CI 0.17–0.48) reduction SARS-CoV-2 infection rates among subjects who received shot those did not receive disease (COVID-19) vaccine. In addition, emphasized that during period when Delta variant was predominant, showed an 82% 0.18, 0.13–0.25) rates. Moreover, dominance Omicron variant, displayed 47% 0.53, 0.35–0.81) finding confirmed significantly less effective than variant. pandemic periods, correlations between dominant efficacy COVID-19 vaccine should be considered making plans.

Language: Английский

Citations

26
Systemic immune profiling of Omicron-infected subjects inoculated with different doses of inactivated virus vaccine DOI Creative Commons
Shanhe Yu,

Yingni Lin,

Yong Li

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(21), P. 4615 - 4631.e16

Published: Sept. 27, 2023

SARS-CoV-2 primary strain-based vaccination exerts a protective effect against Omicron variants-initiated infection, symptom occurrence, and disease severity in booster-dependent manner. Yet, the underlying mechanisms remain unclear. During 2022 outbreak Shanghai, we enrolled 122 infected adults 50 uninfected controls who had been unvaccinated or vaccinated with two three doses of COVID-19 inactive vaccines performed integrative analysis 41-plex CyTOF, RNA-seq, Olink on their peripheral blood samples. The frequencies HLA-DRhi classical monocytes, non-classical Th1-like Tem tended to increase, whereas frequency Treg was reduced by booster vaccine, they influenced occurrence vaccine dose-dependent Intercorrelation mechanistic suggested that induced monocytic training, which would prime activation maturation rather than differentiating into myeloid-derived suppressive cells upon infections. Overall, our study provides insights how elaborates immunity across variants.

Language: Английский

Citations

15
A live attenuated SARS-CoV-2 vaccine constructed by dual inactivation of NSP16 and ORF3a DOI
Zi‐Wei Ye, Chon Phin Ong,

Hehe Cao

et al.

EBioMedicine, Journal Year: 2025, Volume and Issue: 114, P. 105662 - 105662

Published: March 25, 2025

Language: Английский

Citations

0
Vaccination against rapidly evolving pathogens and the entanglements of memory DOI
Sarah Cobey

Nature Immunology, Journal Year: 2024, Volume and Issue: 25(11), P. 2015 - 2023

Published: Oct. 9, 2024

Language: Английский

Citations

3
SARS-CoV-2 vaccine-induced antibodies protect against Omicron breakthrough infection DOI Creative Commons
Eva Anna Marianne Baerends, Astrid Korning Hvidt, Joanne Reekie

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(9), P. 107621 - 107621

Published: Aug. 14, 2023

SARS-CoV-2 Omicron quickly spread globally, also in regions with high vaccination coverage, emphasizing the importance of exploring immunological requirements for protection against breakthrough infection. The test-negative matched case-control study (N = 964) characterized infections triple-vaccinated individuals from ENFORCE cohort. Within 60 days before a PCR test spike-specific IgG levels were significantly lower cases compared to controls (GMR [95% CI] BA.2: 0.83 [0.73-0.95], p 0.006). Multivariable logistic regression showed significant associations between antibody and odds infection (aOR BA.2 IgG: 0.65 [0.48-0.88], 0.006 ACE2-blocking antibodies: 0.46 [0.30-0.69], 0.0002). A sex-stratified analysis more pronounced females than males. High vaccine-induced antibodies provide partial infections. This is important knowledge further characterize threshold new variants estimate necessity timing booster vaccination.

Language: Английский

Citations

9
Evaluation of antibody kinetics and durability in healthy individuals vaccinated with inactivated COVID-19 vaccine (CoronaVac): A cross-sectional and cohort study in Zhejiang, China DOI Creative Commons
Hangjie Zhang,

Qianhui Hua,

Nani Xu

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 16, 2023

Background: Although inactivated COVID-19 vaccines are proven to be safe and effective in the general population, dynamic response duration of antibodies after vaccination real world should further assessed. Methods: We enrolled 1067 volunteers who had been vaccinated with one or two doses CoronaVac Zhejiang Province, China. Another 90 healthy adults without previous vaccinations were recruited three CoronaVac, 28 days 6 months apart. Serum samples collected from multiple timepoints analyzed for specific IgM/IgG neutralizing (NAbs) immunogenicity evaluation. Antibody responses Delta Omicron variants measured by pseudovirus-based neutralization tests. Results: Our results revealed that binding antibody IgM peaked 14–28 dose while IgG NAbs approximately 1 month second then declined slightly over time. waned became undetectable majority individuals at 12 months. Levels live SARS-CoV-2 correlated anti-SARS-CoV-2 pseudovirus, but not IgM. Homologous booster around primary activated anamnestic immunity raised 25.5-fold. The neutralized fraction subsequently rose 36.0% (p=0.03) 4.3% (p=0.004), rate 7.9% (7/89)–17.8% (16/90). Conclusions: Two vaccine resulted limited protection a short duration. can reverse decrease levels prime strain, it does elicit potent against Omicron; therefore, optimization procedures is vital. Funding: Key Research Development Program Province; Health Commission Province/ Science Foundation National Commission; Major Municipal Natural Foundation; Explorer Foundation.

Language: Английский

Citations

7