Population Behavior Changes Underlying Phasic Shifts of SARS-CoV-2 Exposure Settings Across 3 Omicron Epidemic Waves in Hong Kong: Prospective Cohort Study (Preprint) DOI
Chin Pok Chan, Shui Shan Lee, Tsz Ho Kwan

et al.

Published: Aug. 2, 2023

BACKGROUND Exposure risk was shown to have affected individual susceptibility and the epidemic spread of COVID-19. The dynamics by across exposure settings alongside variations following implementation social distancing interventions are understudied. OBJECTIVE This study aims examine population’s trajectory in different its association with SARS-CoV-2 infection 3 consecutive Omicron waves Hong Kong. METHODS From March June 2022, invitation letters were posted 41,132 randomly selected residential addresses for recruitment households into a prospective population cohort. Through web-based monthly surveys coupled email reminders, representative from each enrolled household self-reported incidents infections, COVID-19 vaccination uptake, their activity pattern workplace, daily preceding month. As proxy risk, reported trend setting differentiated trajectories based on latent class growth analyses. associations overall wave (wave 1: February-April; 2: May-September; 3: October-December) 2022 evaluated using Cox proportional hazards models Kaplan-Meier analysis. RESULTS In total, 33,501 responses observation period February-December collected 5321 individuals, 41.7% (2221/5321) being male median age 46 (IQR 34-57) years. Against an expanding coverage 81.9% 95.9% 2 doses 20% 77.7% doses, cumulative incidence escalated <0.2% 25.3%, 32.4%, 43.8% end 1, 2, 3, respectively. Throughout 52.2% (647/1240) participants had worked regularly on-site, 28.7% (356/1240) remotely, 19.1% (237/1240) showed assorted pattern. For settings, 4 5 identified, respectively, 11.5% (142/1240) 14.6% (181/1240) gauged high risk. Compared remote working, working on-site (adjusted hazard ratio [aHR] 1.47, 95% CI 1.19-1.80) living larger (aHR 1.12, 1.06-1.18) associated higher 1. Those highest 1.46, 1.07-2.00) second 1.52, 1.18-1.97) also at increased relative lowest trajectory. CONCLUSIONS infection-naive population, transmission predominantly initiated accelerated household, perpetuated environments, as stringent restrictions scaled down. These patterns highlight phasic shift which is important informing effective calibration targeted measures alternative lockdown.

Language: Английский

Population Behavior Changes Underlying Phasic Shifts of SARS-CoV-2 Exposure Settings Across 3 Omicron Epidemic Waves in Hong Kong: Prospective Cohort Study DOI Creative Commons
Chin Pok Chan, Shui Shan Lee, Tsz Ho Kwan

et al.

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e51498 - e51498

Published: June 19, 2024

Background Exposure risk was shown to have affected individual susceptibility and the epidemic spread of COVID-19. The dynamics by across exposure settings alongside variations following implementation social distancing interventions are understudied. Objective This study aims examine population’s trajectory in different its association with SARS-CoV-2 infection 3 consecutive Omicron waves Hong Kong. Methods From March June 2022, invitation letters were posted 41,132 randomly selected residential addresses for recruitment households into a prospective population cohort. Through web-based monthly surveys coupled email reminders, representative from each enrolled household self-reported incidents infections, COVID-19 vaccination uptake, their activity pattern workplace, daily preceding month. As proxy risk, reported trend setting differentiated trajectories based on latent class growth analyses. associations overall wave (wave 1: February-April; 2: May-September; 3: October-December) 2022 evaluated using Cox proportional hazards models Kaplan-Meier analysis. Results In total, 33,501 responses observation period February-December collected 5321 individuals, 41.7% (2221/5321) being male median age 46 (IQR 34-57) years. Against an expanding coverage 81.9% 95.9% 2 doses 20% 77.7% doses, cumulative incidence escalated <0.2% 25.3%, 32.4%, 43.8% end 1, 2, 3, respectively. Throughout 52.2% (647/1240) participants had worked regularly on-site, 28.7% (356/1240) remotely, 19.1% (237/1240) showed assorted pattern. For settings, 4 5 identified, respectively, 11.5% (142/1240) 14.6% (181/1240) gauged high risk. Compared remote working, working on-site (adjusted hazard ratio [aHR] 1.47, 95% CI 1.19-1.80) living larger (aHR 1.12, 1.06-1.18) associated higher 1. Those highest 1.46, 1.07-2.00) second 1.52, 1.18-1.97) also at increased relative lowest trajectory. Conclusions infection-naive population, transmission predominantly initiated accelerated household, perpetuated environments, as stringent restrictions scaled down. These patterns highlight phasic shift which is important informing effective calibration targeted measures alternative lockdown.

Language: Английский

Citations

2
Ultrapotent class I neutralizing antibodies post Omicron breakthrough infection overcome broad SARS-CoV-2 escape variants DOI Creative Commons

Mengxiao Luo,

Runhong Zhou, Bingjie Tang

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105354 - 105354

Published: Sept. 27, 2024

Language: Английский

Citations

2
The effectiveness of COVID–19 vaccination against all–cause mortality in patients with type 2 diabetes mellitus: The observation during the initial period of the cancellation of the “Dynamic Zero Policy” in mainland China DOI Open Access
Shijun Liu, Caixia Jiang, Yan Liu

et al.

Diabetes Research and Clinical Practice, Journal Year: 2023, Volume and Issue: 200, P. 110694 - 110694

Published: May 8, 2023

Language: Английский

Citations

6
Independent Protection and Influence of the Spike-Specific Antibody Response of SARS-CoV-2 Nucleocapsid Protein (N) in Whole-Virion Vaccines DOI Creative Commons

Huijie Yang,

Ying Xie, Shuaiyao Lu

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(11), P. 1681 - 1681

Published: Nov. 2, 2023

Of all of the components in SARS-CoV-2 inactivated vaccines, nucleocapsid protein (N) is most abundant and highly conserved protein. However, function N these especially its influence on targeted spike protein’s response, remains unknown. In this study, immunization mice with alone was shown to reduce viral load, alleviating pulmonary pathological lesions after challenge virus. addition, co-immunization pre-immunization were found induce higher S-specific antibody titers rather than compromise them. Remarkably, same trend also observed when administered as booster dose whole virus vaccination. N-specific IFN-γ-secreting T cell response detected groups exhibited a certain relationship IgG improvements. Together, data indicate that has an independent role vaccine-induced protection improves revealing interplay mechanism may exist immune responses complex components.

Language: Английский

Citations

5
Dynamic immune landscape in vaccinated-BA.5-XBB.1.9.1 reinfections revealed a 5-month protection-duration against XBB infection and a shift in immune imprinting DOI Creative Commons
Tingting Cui, Xiaoling Su, Jing Sun

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104903 - 104903

Published: Dec. 7, 2023

The impact of previous vaccination on protective immunity, duration, and immune imprinting in the context BA.5-XBB.1.9.1 reinfection remains unknown.

Language: Английский

Citations

4
Vaccination status for mild and asymptomatic infections with SARS‐CoV‐2 Omicron BA.2 variant in Shanghai DOI

Yong Yin,

Jilei Lin, Shuhua Yuan

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(5)

Published: May 1, 2023

This study aimed to evaluate the effects of different vaccine regimens on mild and asymptomatic infections with SARS-CoV-2 Omicron BA.2 variant in Shanghai. All patients those symptoms were recruited from three major Fangcang shelter hospitals between March 26, 2022 May 20, 2022. Nucleic acid for by real-time reverse-transcription polymerase chain reaction methods nasopharyngeal swabs was assessed every day during hospitalization. The value cycle threshold lower than 35 considered as positive result SARS-CoV-2. A total 214 592 cases included this study. proportion 76.90% 23.10% had symptoms. median (interquartile range [IQR]: 25-75) duration viral shedding (DVS) 7 (5-10) days among all participants. DVS varied greatly age groups. Children elderly longer compared adults. booster shot inactivated contributed shorter aged ≥70 years unvaccinated (8 [6-11] vs. 9 [6-12] days, p = 0.002]. Full regimen 3-6 (7 [5-9] 8 [5-10] 0.001]. In conclusion, full children appeared be effective reducing DVS. should rigorously promoted implemented.

Language: Английский

Citations

3
The Impact of Vaccine Type and Booster Dose on the Magnitude and Breadth of Sars-Cov-2-Specific Mucosal Iga DOI

Hoi‐Wah Tsoi,

Miko Ka-Wai Ng,

Jian‐Piao Cai

et al.

Published: Jan. 1, 2024

The level of mucosal IgA correlates with protection, but how vaccine types and booster doses affect remain incompletely understood. Furthermore, there is a lack data comparing the breadth systemic IgG. In this cross-sectional study, we compared levels IgG in saliva serum specimens 108 individuals who received BNT162b2 (Pfizer) or CoronaVac (SinoVac) vaccine. While (vs CoronaVac) two doses) were associated higher IgG, these not significantly salivary among without prior infection. Among non-infected individuals, against ancestral strain than Omicron BA.2 sublineage, was no significant difference between different strains. Salivary had weakest correlation (r=0.337) when (r=0.629) (r=0.597). Our findings suggest that intramuscular COVID-19 vaccines elicit distinct response differs from response. As independently trials should include as an outcome measure.

Language: Английский

Citations

0
Longitudinal Analysis of Neutralizing Antibodies Against SARS-CoV-1 and Different SARS-CoV-2 Strains in Breakthrough and Unvaccinated Covid-19 Patients in Thailand DOI
Prapassorn Poolchanuan,

Vichapon Tiacharoen,

Adul Dulsuk

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
The impact of vaccine type and booster dose on the magnitude and breadth of SARS-CoV-2-specific systemic and mucosal antibodies among COVID-19 vaccine recipients DOI Creative Commons

Hoi‐Wah Tsoi,

Miko Ka-Wai Ng,

Jian‐Piao Cai

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35334 - e35334

Published: July 27, 2024

The COVID-19 pandemic has had a major impact on global health and economy, which was significantly mitigated by the availability of vaccines. levels systemic mucosal antibodies against SARS-CoV-2 correlated with protection. However, there is limited data how vaccine type booster doses affect antibody response, breadth compares. In this cross-sectional study, we compared magnitude in 108 individuals who received either BNT162b2 (Pfizer) or CoronaVac (SinoVac) vaccine. We found that (vs CoronaVac) two doses) were associated higher serum IgG levels, but not salivary IgA regardless prior infection status. Among non-infected individuals, IgG, ancestral strain than Omicron BA.2 sublineage, did differ between strains. Salivary weakest correlation (r = 0.34) 0.63) 0.60). Our findings suggest intramuscular vaccines elicit distinct response differs from response. As independently correlates protection, trials should include as an outcome measure.

Language: Английский

Citations

0
Adjuvant activities of immunostimulating natural products: Astragalus membranaceus (Fisch.) Bge. and Coriolus versicolor in BNT162b2 vaccination against COVID-19 infection DOI
Ben Chung-Lap Chan,

Peiting Li,

Miranda Sin‐Man Tsang

et al.

Journal of Leukocyte Biology, Journal Year: 2023, Volume and Issue: 115(1), P. 177 - 189

Published: Sept. 15, 2023

Abstract The global pandemic of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been developing all over the world for more than 3 years. In late 2020, several variants concern SARS-CoV-2 virus emerged, with increased viral fitness and transmissibility mutations spike proteins particle, denting hopes use early-generation vaccines a widespread protective immunity against infection. adjuvants may enhance immune responses conventional application COVID-19 vaccine. We have shown that water extract β-glucan–enriched immunostimulating natural products, Astragalus membranaceus (Fisch.) Bge. (AM) Coriolus versicolor (CV), could induce innate immunity-related cytokines from human monocytes (CCL5, interleukin [IL]-6, IL-10, tumor necrosis factor α) monocyte-derived dendritic cells (IL-1β, IL-12, α). Using BALB/c mice, orally administrated AM CV (1,384 742 mg/kg/d) 4 d after vaccination, respectively, (1) immunoglobulin G binding activities BNT162b2 vaccination ancestral Delta 5.8- 4.3-fold, respectively; (2) G3 subclass production variant proteins; (3) in vitro antibody-neutralizing vaccinated mice. conclusion, combining was effective acting as an oral adjuvant messenger RNA vaccine to improve antigen proteins, probably via trained macrophages cells.

Language: Английский

Citations

1