Analysis of the role of the Hippo pathway in cancer

Journal of Translational Medicine, Journal Year: 2019, Volume and Issue: 17(1)

Published: April 8, 2019

Cancer is a serious health issue in the world due to large body of cancer-related human deaths, and there no current treatment available efficiently treat disease as tumor often diagnosed at stage. Moreover, cells are resistant chemotherapy, radiotherapy, molecular-targeted therapy. Upon further knowledge mechanisms tumorigenesis, aggressiveness, metastasis, resistance treatments, it necessary detect an earlier stage for better response The hippo pathway possesses unique capacity lead tumorigenesis. Mutations altered expression its core components (MST1/2, LATS1/2, YAP TAZ) promote migration, invasion, malignancy cancer cells. biological significance deregulation have received interests past few years. Further understanding will be responsible treatment. In this review, we try discover function different diversity cancers, discuss how Hippo contributes other cellular signaling pathways. Also, describe microRNAs, circRNAs, ZNFs regulate process cancer. It find new therapy strategies

Language: Английский

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Mechanisms of lncRNA/microRNA interactions in angiogenesis

Life Sciences, Journal Year: 2019, Volume and Issue: 254, P. 116900 - 116900

Published: Nov. 28, 2019

Language: Английский

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Preeclampsia: Maternal Systemic Vascular Disorder Caused by Generalized Endothelial Dysfunction Due to Placental Antiangiogenic Factors

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(17), P. 4246 - 4246

Published: Aug. 30, 2019

Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation, is the leading cause maternal perinatal morbidity mortality. Maternal endothelial dysfunction caused placental factors has long been accepted with respect to pathophysiology preeclampsia. Over past decade, increased production antiangiogenic identified as factor dysfunction. This review summarizes recent advances in understanding molecular mechanisms factors, novel clinical strategies based on these discoveries.

Language: Английский

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Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers

Journal of the American College of Cardiology, Journal Year: 2020, Volume and Issue: 75(5), P. 525 - 538

Published: Feb. 1, 2020

Language: Английский

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Diabetes Mellitus and Cardiovascular Disease

Arteriosclerosis Thrombosis and Vascular Biology, Journal Year: 2019, Volume and Issue: 39(4), P. 558 - 568

Published: Feb. 21, 2019

Cardiovascular disease remains a leading cause of morbidity and mortality in people with types 1 or 2 diabetes mellitus. Although beneficial roles for strict control hyperglycemia have been suggested, such strategy is not without liabilities. Specifically, the risk hypoglycemia its consequences remain an omnipresent threat approaches. The advent CVOT (Cardiovascular Outcomes Trials) new antidiabetes mellitus treatments has uncovered unexpected benefits cardiovascular protection some classes agents, as GLP-1 RAs (glucagon-like peptide-1 receptor agonists) SGLT-2 (sodium-glucose cotransporter-2) inhibitors. Further, state-of-the-art approaches, antibodies to PCKSK9 (proprotein convertase subtilisin-kexin type 9); RNA therapeutics; agents targeting distinct components immune/inflammatory response; novel small molecules that block actions RAGE (receptor advanced glycation end products) signaling, also hold potential therapies disease. Finally, interventions weight loss, through bariatric surgery, may promise benefit In this Brief Review, approaches emerging targets treatment are discussed. Ultimately, identification optimal timing combinations interventions, especially context personalized together disease-modifying holds great reduce burden poses system.

Language: Английский

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Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7910 - 7910

Published: April 26, 2023

Recent advances have greatly improved our understanding of the molecular mechanisms behind atherosclerosis pathogenesis. However, there is still a need to systematize this data from general pathology perspective, particularly with regard atherogenesis patterns in context both canonical and non-classical inflammation types. In review, we analyze various typical phenomena outcomes cellular pro-inflammatory stress atherosclerosis, as well role endothelial dysfunction local systemic manifestations low-grade inflammation. We also present features immune development productive stable unstable plaques, along their similarities differences compared There are numerous factors that act inducers inflammatory process including vascular endothelium aging, metabolic dysfunctions, autoimmune, some cases, infectious damage factors. Life-critical complications such cardiogenic shock severe strokes, associated acute hyperinflammation. Additionally, critical atherosclerotic ischemia lower extremities induces paracoagulation chronic Conversely, sepsis, other conditions, diseases contribute atherogenesis. summary, can be characterized an independent form inflammation, sharing but having fundamental variants (classic vasculitis).

Language: Английский

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Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(7), P. 1658 - 1658

Published: April 3, 2019

Physical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity among both adults children leading rising cases diabetes. Cardiovascular disease complications associated with diabetes are closely linked insulin resistance its complex implications on vascular cells particularly endothelial cells. Endoplasmic reticulum (ER) stress is activated following disruption in post-translational protein folding maturation within ER metabolic conditions characterized by heavy demand synthesis, such as has gained much interest a key bridging converging molecular link between resistance, oxidative stress, cell dysfunction and, hence, represents an interesting drug target for cardiovascular complications. We reviewed here role dysfunction, primary step onset atherosclerosis disease. specifically focused contribution death, cellular inflammation caused process atherogenesis.

Language: Английский

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The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance

Biomolecules, Journal Year: 2019, Volume and Issue: 9(7), P. 286 - 286

Published: July 17, 2019

Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, member the PTP superfamily, as major negative regulator for insulin receptor signaling novel molecular player in endothelial disease. Unlike other anti-diabetic approaches, genetic deletion or pharmacological inhibition PTP1B was found to improve glucose homeostasis without causing lipid buildup liver, which represents an advantage over existing therapies. Furthermore, reported contribute disturbances, at various levels, places this enzyme unique single therapeutic target both diabetes disorders. Synthesizing selective small molecule inhibitors faced multiple challenges linked its similarity sequence PTPs; however, overcoming these would pave way approaches treat concurrent complications. In review article, we summarized roles disease special emphasis on interplay resistance. discussed some hindering synthesis PTP1B.

Language: Английский

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Endothelial response to glucose: dysfunction, metabolism, and transport

Biochemical Society Transactions, Journal Year: 2021, Volume and Issue: 49(1), P. 313 - 325

Published: Feb. 1, 2021

The endothelial cell response to glucose plays an important role in both health and disease. Endothelial glucose-induced dysfunction was first studied diabetic animal models cells cultured hyperglycemia. Four classical pathways were identified, which later shown result from the common mechanism of mitochondrial superoxide overproduction. More recently, non-coding RNA, extracellular vesicles, sodium-glucose cotransporter-2 inhibitors affect dysfunction. also metabolize for their own energetic needs. Research over past decade highlighted how manipulation glycolysis can be used control angiogenesis microvascular permeability diseases such as cancer. Finally, transport blood vessel wall parenchymal tissue. Increasing evidence blood-brain barrier peripheral vasculature suggests that regulate through transporters move apical basolateral side cell. Future studies should begin integrate dysfunction, metabolism into experimental computational approaches consider heterogeneity, metabolic diversity, tissue interactions.

Language: Английский

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Gut Microbiota Plays a Central Role to Modulate the Plasma and Fecal Metabolomes in Response to Angiotensin II

Hypertension, Journal Year: 2019, Volume and Issue: 74(1), P. 184 - 193

Published: June 3, 2019

Gut microbial metabolites have been implicated in contributing to blood pressure regulation; however, only a few examined date. In this study, we hypothesized that an unbiased screen for changes gut chronic Ang II (angiotensin II) infusion model would identify novel associated with regulation. To accomplish this, used both conventional and germ-free mice, which had implanted minipumps infuse either saline or II. Our aim was were altered treatment but not indicating they are dependent on the microbiota. Both plasma feces samples processed analyzed using liquid chromatography-tandem mass spectroscopy. plasma, identified 4 significantly upregulated 8 downregulated mice; none of these changed mice. Similarly, feces, 25 71 Finally, fecal 16S sequencing revealed significant shifts microbiome mice treatment, including sex-specific changes. These data demonstrate differentially regulated microbiome.

Language: Английский

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