Neurochemistry International,
Journal Year:
2021,
Volume and Issue:
148, P. 105072 - 105072
Published: May 28, 2021
Central
nervous
system
(CNS)
disorders
are
some
of
the
most
complex
and
challenging
diseases
because
intricate
structure
functions
CNS.
Long
non-coding
RNA
(LncRNA)
H19,
which
had
been
mistaken
for
"transcription
noise"
previously,
has
now
found
to
be
closely
related
development
homeostasis
Several
recent
studies
indicate
that
it
plays
an
important
role
in
pathogenesis,
treatment,
even
prognosis
CNS
disorders.
LncRNA
H19
is
correlated
with
susceptibility
various
such
as
intracranial
aneurysms,
ischemic
stroke,
glioma,
neuroblastoma.
Moreover,
participates
pathogenesis
by
regulating
transcription,
translation,
signaling
pathways,
suggesting
a
promising
biomarker
therapeutic
target
these
This
article
reviews
mechanisms
lncRNA
disorders,
including
cerebral
ischemia,
hemorrhage,
pituitary
adenoma,
neuroblastoma,
Parkinson's
disease,
Alzheimer's
traumatic
spinal
cord
injury,
neuropathic
pain,
temporal
lobe
epilepsy,
provide
theoretical
basis
further
research
on
Journal of Translational Medicine,
Journal Year:
2019,
Volume and Issue:
17(1)
Published: April 8, 2019
Cancer
is
a
serious
health
issue
in
the
world
due
to
large
body
of
cancer-related
human
deaths,
and
there
no
current
treatment
available
efficiently
treat
disease
as
tumor
often
diagnosed
at
stage.
Moreover,
cells
are
resistant
chemotherapy,
radiotherapy,
molecular-targeted
therapy.
Upon
further
knowledge
mechanisms
tumorigenesis,
aggressiveness,
metastasis,
resistance
treatments,
it
necessary
detect
an
earlier
stage
for
better
response
The
hippo
pathway
possesses
unique
capacity
lead
tumorigenesis.
Mutations
altered
expression
its
core
components
(MST1/2,
LATS1/2,
YAP
TAZ)
promote
migration,
invasion,
malignancy
cancer
cells.
biological
significance
deregulation
have
received
interests
past
few
years.
Further
understanding
will
be
responsible
treatment.
In
this
review,
we
try
discover
function
different
diversity
cancers,
discuss
how
Hippo
contributes
other
cellular
signaling
pathways.
Also,
describe
microRNAs,
circRNAs,
ZNFs
regulate
process
cancer.
It
find
new
therapy
strategies
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(17), P. 4246 - 4246
Published: Aug. 30, 2019
Preeclampsia,
a
systemic
vascular
disorder
characterized
by
new-onset
hypertension
and
proteinuria
after
20
weeks
of
gestation,
is
the
leading
cause
maternal
perinatal
morbidity
mortality.
Maternal
endothelial
dysfunction
caused
placental
factors
has
long
been
accepted
with
respect
to
pathophysiology
preeclampsia.
Over
past
decade,
increased
production
antiangiogenic
identified
as
factor
dysfunction.
This
review
summarizes
recent
advances
in
understanding
molecular
mechanisms
factors,
novel
clinical
strategies
based
on
these
discoveries.
Arteriosclerosis Thrombosis and Vascular Biology,
Journal Year:
2019,
Volume and Issue:
39(4), P. 558 - 568
Published: Feb. 21, 2019
Cardiovascular
disease
remains
a
leading
cause
of
morbidity
and
mortality
in
people
with
types
1
or
2
diabetes
mellitus.
Although
beneficial
roles
for
strict
control
hyperglycemia
have
been
suggested,
such
strategy
is
not
without
liabilities.
Specifically,
the
risk
hypoglycemia
its
consequences
remain
an
omnipresent
threat
approaches.
The
advent
CVOT
(Cardiovascular
Outcomes
Trials)
new
antidiabetes
mellitus
treatments
has
uncovered
unexpected
benefits
cardiovascular
protection
some
classes
agents,
as
GLP-1
RAs
(glucagon-like
peptide-1
receptor
agonists)
SGLT-2
(sodium-glucose
cotransporter-2)
inhibitors.
Further,
state-of-the-art
approaches,
antibodies
to
PCKSK9
(proprotein
convertase
subtilisin-kexin
type
9);
RNA
therapeutics;
agents
targeting
distinct
components
immune/inflammatory
response;
novel
small
molecules
that
block
actions
RAGE
(receptor
advanced
glycation
end
products)
signaling,
also
hold
potential
therapies
disease.
Finally,
interventions
weight
loss,
through
bariatric
surgery,
may
promise
benefit
In
this
Brief
Review,
approaches
emerging
targets
treatment
are
discussed.
Ultimately,
identification
optimal
timing
combinations
interventions,
especially
context
personalized
together
disease-modifying
holds
great
reduce
burden
poses
system.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 7910 - 7910
Published: April 26, 2023
Recent
advances
have
greatly
improved
our
understanding
of
the
molecular
mechanisms
behind
atherosclerosis
pathogenesis.
However,
there
is
still
a
need
to
systematize
this
data
from
general
pathology
perspective,
particularly
with
regard
atherogenesis
patterns
in
context
both
canonical
and
non-classical
inflammation
types.
In
review,
we
analyze
various
typical
phenomena
outcomes
cellular
pro-inflammatory
stress
atherosclerosis,
as
well
role
endothelial
dysfunction
local
systemic
manifestations
low-grade
inflammation.
We
also
present
features
immune
development
productive
stable
unstable
plaques,
along
their
similarities
differences
compared
There
are
numerous
factors
that
act
inducers
inflammatory
process
including
vascular
endothelium
aging,
metabolic
dysfunctions,
autoimmune,
some
cases,
infectious
damage
factors.
Life-critical
complications
such
cardiogenic
shock
severe
strokes,
associated
acute
hyperinflammation.
Additionally,
critical
atherosclerotic
ischemia
lower
extremities
induces
paracoagulation
chronic
Conversely,
sepsis,
other
conditions,
diseases
contribute
atherogenesis.
summary,
can
be
characterized
an
independent
form
inflammation,
sharing
but
having
fundamental
variants
(classic
vasculitis).
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(7), P. 1658 - 1658
Published: April 3, 2019
Physical
inactivity
and
sedentary
lifestyle
contribute
to
the
widespread
epidemic
of
obesity
among
both
adults
children
leading
rising
cases
diabetes.
Cardiovascular
disease
complications
associated
with
diabetes
are
closely
linked
insulin
resistance
its
complex
implications
on
vascular
cells
particularly
endothelial
cells.
Endoplasmic
reticulum
(ER)
stress
is
activated
following
disruption
in
post-translational
protein
folding
maturation
within
ER
metabolic
conditions
characterized
by
heavy
demand
synthesis,
such
as
has
gained
much
interest
a
key
bridging
converging
molecular
link
between
resistance,
oxidative
stress,
cell
dysfunction
and,
hence,
represents
an
interesting
drug
target
for
cardiovascular
complications.
We
reviewed
here
role
dysfunction,
primary
step
onset
atherosclerosis
disease.
specifically
focused
contribution
death,
cellular
inflammation
caused
process
atherogenesis.
Biomolecules,
Journal Year:
2019,
Volume and Issue:
9(7), P. 286 - 286
Published: July 17, 2019
Endothelial
dysfunction
is
a
key
feature
of
cardiovascular
disorders
associated
with
obesity
and
diabetes.
Several
studies
identified
protein
tyrosine
phosphatase
(PTP)-1B,
member
the
PTP
superfamily,
as
major
negative
regulator
for
insulin
receptor
signaling
novel
molecular
player
in
endothelial
disease.
Unlike
other
anti-diabetic
approaches,
genetic
deletion
or
pharmacological
inhibition
PTP1B
was
found
to
improve
glucose
homeostasis
without
causing
lipid
buildup
liver,
which
represents
an
advantage
over
existing
therapies.
Furthermore,
reported
contribute
disturbances,
at
various
levels,
places
this
enzyme
unique
single
therapeutic
target
both
diabetes
disorders.
Synthesizing
selective
small
molecule
inhibitors
faced
multiple
challenges
linked
its
similarity
sequence
PTPs;
however,
overcoming
these
would
pave
way
approaches
treat
concurrent
complications.
In
review
article,
we
summarized
roles
disease
special
emphasis
on
interplay
resistance.
discussed
some
hindering
synthesis
PTP1B.
Biochemical Society Transactions,
Journal Year:
2021,
Volume and Issue:
49(1), P. 313 - 325
Published: Feb. 1, 2021
The
endothelial
cell
response
to
glucose
plays
an
important
role
in
both
health
and
disease.
Endothelial
glucose-induced
dysfunction
was
first
studied
diabetic
animal
models
cells
cultured
hyperglycemia.
Four
classical
pathways
were
identified,
which
later
shown
result
from
the
common
mechanism
of
mitochondrial
superoxide
overproduction.
More
recently,
non-coding
RNA,
extracellular
vesicles,
sodium-glucose
cotransporter-2
inhibitors
affect
dysfunction.
also
metabolize
for
their
own
energetic
needs.
Research
over
past
decade
highlighted
how
manipulation
glycolysis
can
be
used
control
angiogenesis
microvascular
permeability
diseases
such
as
cancer.
Finally,
transport
blood
vessel
wall
parenchymal
tissue.
Increasing
evidence
blood-brain
barrier
peripheral
vasculature
suggests
that
regulate
through
transporters
move
apical
basolateral
side
cell.
Future
studies
should
begin
integrate
dysfunction,
metabolism
into
experimental
computational
approaches
consider
heterogeneity,
metabolic
diversity,
tissue
interactions.
Hypertension,
Journal Year:
2019,
Volume and Issue:
74(1), P. 184 - 193
Published: June 3, 2019
Gut
microbial
metabolites
have
been
implicated
in
contributing
to
blood
pressure
regulation;
however,
only
a
few
examined
date.
In
this
study,
we
hypothesized
that
an
unbiased
screen
for
changes
gut
chronic
Ang
II
(angiotensin
II)
infusion
model
would
identify
novel
associated
with
regulation.
To
accomplish
this,
used
both
conventional
and
germ-free
mice,
which
had
implanted
minipumps
infuse
either
saline
or
II.
Our
aim
was
were
altered
treatment
but
not
indicating
they
are
dependent
on
the
microbiota.
Both
plasma
feces
samples
processed
analyzed
using
liquid
chromatography-tandem
mass
spectroscopy.
plasma,
identified
4
significantly
upregulated
8
downregulated
mice;
none
of
these
changed
mice.
Similarly,
feces,
25
71
Finally,
fecal
16S
sequencing
revealed
significant
shifts
microbiome
mice
treatment,
including
sex-specific
changes.
These
data
demonstrate
differentially
regulated
microbiome.