The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment DOI Creative Commons
Reza Mosaddeghi-Heris, Milad Shirvaliloo, Sanaz Abbaspour‐Aghdam

et al.

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 28, 2022

Abstract Parkinson's disease (PD) is the second most predominant neurodegenerative worldwide. It recognized clinically by severe complications in motor function caused progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As current standard treatment focused on alleviating symptoms through Levodopa, developing neuroprotective techniques critical for adopting a more pathology-oriented therapeutic approach. Regenerative cell therapy has provided us with an unrivalled platform evaluating potentially effective novel methods treating illnesses over last two decades. Mesenchymal stem cells (MSCs) are promising, as they can differentiate into produce neurotrophic substances. The precise process which repair neuronal injury unknown, MSC-derived exosomes suggested to be responsible significant portion such effects. present review discusses application mesenchymal PD treatment.

Language: Английский

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects DOI Open Access
Seyed Hossein Shahcheraghi, Fateme Salemi,

Shlomo Small

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(4), P. 1590 - 1605

Published: Feb. 8, 2023

Abstract Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a polyphenol got from red wine peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', hinders destructive effects inflammatory causes oxygen radicals several tissues. The nuclear erythroid 2‐related factor 2 related to transcription with anti‐inflammatory, antioxidant possessions which complicated enzyme biotransformation biosynthesis carbohydrates. review provides current understanding information about character against stress regulation inflammation via Nrf2 signaling pathway.

Language: Английский

Citations

56
The Vitamin D Receptor as a Potential Target for the Treatment of Age-Related Neurodegenerative Diseases Such as Alzheimer’s and Parkinson’s Diseases: A Narrative Review DOI Creative Commons
Władysław Lasoń, Danuta Jantas, Monika Leśkiewicz

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 660 - 660

Published: Feb. 19, 2023

The vitamin D receptor (VDR) belongs to the nuclear superfamily of transcription factors. VDR is expressed in diverse brain regions and has been implicated neuroprotective, antiaging, prosurvival, anti-inflammatory action D. Accordingly, a relationship between insufficiency susceptibility neurodegenerative diseases suggested. However, due multitargeted mechanisms its often overlapping genomic nongenomic effects, role pathologies remains obscure. In this narrative review, we present progress deciphering molecular mechanism VDR-mediated effects on prosurvival signaling pathway activity within central nervous system. line with concept neurovascular unit pathomechanisms diseases, discussion regulating immune vascular systems also included. Next, discuss results preclinical clinical studies evaluating significance status efficacy supplementation treatment Parkinson’s Alzheimer’s emphasizing possible these phenomena. Finally, associations some polymorphisms higher risks severity disorders are briefly summarized.

Language: Английский

Citations

56
A Comprehensive Review on Advancements in Artificial Intelligence Approaches and Future Perspectives for Early Diagnosis of Parkinson's Disease DOI Creative Commons

Aiesha Mahmoud Ibrahim,

Mazin Abed Mohammed

International Journal of Mathematics Statistics and Computer Science, Journal Year: 2024, Volume and Issue: 2, P. 173 - 182

Published: Jan. 26, 2024

Parkinson's disease (PD) is a neurological condition that generally strikes people in their average age of onset for PD disorder, 55 and up. A wide variety motor non-motor symptoms can be observed patients with PD. The medical community has made great strides recent years, but still no treatment or cure. Therefore, exploring possible ways early identification an intriguing scientific endeavor. Full may not appear years due to the progressive nature Thus, diagnosis vital enhance patient's quality life. Symptoms will usually worsen time, so keep mind. Several neurodegenerative disorders share very similar symptoms, making crucial prediction. Many are starting pay attention using Artificial Intelligence (AI) methods diagnostics because they process massive volumes data make reliable statistical predictions. This paper covers all bases when it comes artificial intelligence approaches diagnosis, including many deep machine learning-based have been deployed how opened new avenues research. Furthermore, study explores current situation future possibilities data-driven AI diagnosis. excellent resource as review article researchers interested creating prediction models employing different AI-based modalities.

Language: Английский

Citations

18
m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP+/MPTP-Induced Parkinson’s Disease Model DOI

Zhengyu Li,

Xin Chen,

Wenwen Xiang

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the involvement of ferroptosis in its pathological mechanism. In this study, effects and mechanism BRCA1-associated protein 1 (BAP1) on neuronal PD were evaluated. Methods: A mouse model was constructed injecting mice with MPTP. Nissl staining, immunohistochemistry, immunofluorescence, Prussian blue staining evaluated histopathology iron distribution. The cell subjecting SK-N-SH cells to MPP+. m6A level BAP1 assessed MeRIP. mRNA levels BAP1, FTO, IGF2BP1, METTL3, YTHDF2, SLC7A11 utilizing RT-qPCR. Protein SLC7A11, p53 measured Western blot. Cell viability using CCK-8 assay, TUNEL used for assessing apoptosis. MDA, GSH, SOD, Fe2+ also measured. interactions among molecules verified RIP dual luciferase reporter ChIP assay. Results: treated MPP+ showed decrease overall BAP1. FTO facilitated demethylation leading an increased expression m6A-binding protein, YTHDF2 recognized decayed methylated reduced stability. FTO/BAP1 axis promoted MPP+-induced suppressing SLC7A11. collaboration p53, Knocking down mitigated MPTP model. Conclusion: m6A-mediated modification regulates cooperating Thus, may be potential therapeutic target treatment.

Language: Английский

Citations

2
LINC02282 promotes DNA methylation of TRIM6 by recruiting DNMTs to inhibit the progression of Parkinson's disease DOI Creative Commons
Lu Han, Chuansheng Zhao,

Jin Feng

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111224 - 111224

Published: Jan. 1, 2025

Parkinson's disease (PD) is the second most common neurodegenerative disease. Long non-coding RNAs (lncRNAs) are closely linked to occurrence and development of diseases, while underlying mechanisms remain elusive. The goal present study was elucidate mechanism by which LINC02282, a significantly downregulated lncRNA in GEO database, elicits neuroprotective effects on PD. LINC02282 poorly expressed SH-SY5Y SK-N-AS cells exposed MPP+ mice injected with MPTP. overexpression plasmids inhibited apoptosis promoted proliferation cells. In addition, using an adeno-associated virus reduced neuronal damage PD mice. mainly localized nucleus, methylation tripartite motif-containing protein 6 (TRIM6) promoter inhibit TRIM6 expression. bound DNA methyltransferases (DNMTs) increases binding DNMTs promoter. Overexpression alone induced PD-like symptoms combined upregulation effect both vitro vivo. summary, alleviated injury recruiting region inhibiting

Language: Английский

Citations

2
Mitochondria in brain diseases: Bridging structural-mechanistic insights into precision-targeted therapies DOI Creative Commons
Jun Liao, Wenxiu He, Lisha Li

et al.

Published: Feb. 1, 2025

Language: Английский

Citations

2
Neuroprotective Effect of Ropinirole Lipid Nanoparticles Enriched Hydrogel for Parkinson’s Disease: In Vitro, Ex Vivo, Pharmacokinetic and Pharmacodynamic Evaluation DOI Creative Commons

Narendar Dudhipala,

Thirupathi Gorre

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(5), P. 448 - 448

Published: May 13, 2020

Parkinson's disease (rp) is a progressive neurodegenerative disorder. Ropinirole (RP) newer generation dopamine agonist used for the treatment of PD. It prescribed as oral dosage form. However, limited bioavailability and frequent dosing limits RP usage. The objective current investigation was to develop, optimize, evaluate pharmacokinetic (PK) pharmacodynamic (PCD) activity loaded solid lipid nanoparticles (RP-SLNs) nanostructured carriers (RP-NLCs) containing hydrogel (RP-SLN-C RP-NLC-C) formulations improved topical delivery. were optimized converted using carbopol 934 gelling polymer. PK PCD studies in haloperidol-induced PD conducted male Wistar rats. In vitro ex vivo permeation showed sustained release profile enhanced compared with control formulations. Differential scanning calorimeter X-ray diffraction revealed amorphous transformation; electron microscope spherical shape nanoparticles. 2.1 2.7-folds enhancement from RP-SLN RP-NLC administration, 3.0 3.3-folds RP-SLN-C RP-NLC-C formulations, respectively. 1.4 1.2-folds dopamine, glutathione, catalase levels reduced peroxidation levels, model. Overall, results demonstrated that corresponding can be considered an alternative delivery approach effective

Language: Английский

Citations

97
Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids DOI Creative Commons

Tae Yeon Kim,

Eunju Leem,

Jae Man Lee

et al.

Antioxidants, Journal Year: 2020, Volume and Issue: 9(7), P. 583 - 583

Published: July 3, 2020

Oxidative stress reflects an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense systems, it can be associated with pathogenesis progression neurodegenerative diseases such as multiple sclerosis, stroke, Parkinson's disease (PD). The application antioxidants, which defend against oxidative stress, is able to detoxify intermediates prevent neurodegeneration resulting from excessive ROS production. There are many reports showing that numerous flavonoids, a large group natural phenolic compounds, act antioxidants flavonoids has beneficial effects in adult brain. For instance, well known long-term consumption green tea-derived catechin epigallocatechin gallate (EGCG) attenuate onset PD. Also, ampelopsin pinocembrin inhibit mitochondrial dysfunction neuronal death through regulation gene expression nuclear factor erythroid 2-related 2 (Nrf2) pathway. Additionally, established exhibit anti-apoptosis anti-inflammatory cellular signaling pathways, those involving (ERK), glycogen synthase kinase-3β (GSK-3β), (Akt), neuroprotection. In this review article, we have described involved PD explained therapeutic potential protect nigrostriatal DA system, may useful

Language: Английский

Citations

88
Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease DOI
Sha Xiong, Zhongjun Li, Yao Liu

et al.

Biomaterials, Journal Year: 2020, Volume and Issue: 260, P. 120339 - 120339

Published: Aug. 23, 2020

Language: Английский

Citations

88
Recent Advances in the Application of Two-Dimensional Nanomaterials for Neural Tissue Engineering and Regeneration DOI
Alexander Halim,

Kai-Yun Qu,

Xiaofeng Zhang

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2021, Volume and Issue: 7(8), P. 3503 - 3529

Published: July 22, 2021

The complexity of the nervous system structure and function, its slow regeneration rate, makes it more difficult to treat compared other tissues in human body when an injury occurs. Moreover, current therapeutic approaches including use autografts, allografts, pharmacological agents have several drawbacks can not fully restore injuries. Recently, nanotechnology tissue engineering attracted many researchers guide effective manner. Owing their remarkable physicochemical biological properties, two-dimensional (2D) nanomaterials been extensively studied regenerative medicine field. great conductivity these materials them a promising candidate for development novel scaffolds neural application. high loading capacity 2D also has utilize as drug/gene delivery method various devastating disorders. This review will first introduce fundamental properties used biomedicine supporting inducing neuroregeneration, biocompatibility on cells, ability promote differentiation stem immunomodulatory which are beneficial alleviating chronic inflammation at site injury. It discusses types nanomaterials-based applications. Then, latest progress disorder treatment is summarized. Finally, discussion challenges prospects applications provided.

Language: Английский

Citations

78