Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: July 28, 2022
Abstract
Parkinson's
disease
(PD)
is
the
second
most
predominant
neurodegenerative
worldwide.
It
recognized
clinically
by
severe
complications
in
motor
function
caused
progressive
degeneration
of
dopaminergic
neurons
(DAn)
and
dopamine
depletion.
As
current
standard
treatment
focused
on
alleviating
symptoms
through
Levodopa,
developing
neuroprotective
techniques
critical
for
adopting
a
more
pathology-oriented
therapeutic
approach.
Regenerative
cell
therapy
has
provided
us
with
an
unrivalled
platform
evaluating
potentially
effective
novel
methods
treating
illnesses
over
last
two
decades.
Mesenchymal
stem
cells
(MSCs)
are
promising,
as
they
can
differentiate
into
produce
neurotrophic
substances.
The
precise
process
which
repair
neuronal
injury
unknown,
MSC-derived
exosomes
suggested
to
be
responsible
significant
portion
such
effects.
present
review
discusses
application
mesenchymal
PD
treatment.
Cell & Bioscience,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: April 27, 2021
Abstract
Alzheimer’s
disease
(AD)
is
the
most
common
cause
of
dementia
and
characterized
by
deposition
extracellular
aggregates
amyloid-β
(Aβ),
formation
intraneuronal
tau
neurofibrillary
tangles
microglial
activation-mediated
neuroinflammation.
One
key
molecules
involved
in
activation
galectin-3
(Gal-3).
In
recent
years,
extensive
studies
have
dissected
mechanisms
which
Gal-3
modulates
activation,
impacting
Aβ
deposition,
both
animal
models
human
studies.
this
review
article,
we
focus
on
emerging
role
biology
pathobiology,
including
its
origin,
functions
regulating
neuroinflammation,
emergence
as
a
biomarker
AD
other
neurodegenerative
diseases.
These
aspects
are
important
to
elucidate
involvement
pathogenesis
may
provide
novel
insights
into
use
for
diagnosis
therapy.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: Dec. 13, 2022
Crocin
is
a
bioactive
compound
that
naturally
occurs
in
some
medicinal
plants,
especially
saffron
and
gardenia
fruit.
Different
conventional
novel
methods
are
used
for
its
extraction.
Due
to
control
conditions,
recent
such
as
ultrasonic
extraction,
supercritical
fluid
enzyme-associated
microwave
pulsed
electric
field
extraction
widely
because
these
give
more
yield
efficiency.
incorporated
into
different
food
products
make
functional
foods.
However,
it
can
also
aid
the
stability
of
products.
ability
protect
against
brain
diseases,
demand
crocin
has
been
rising
pharmaceutical
industry.
It
contain
antioxidant,
anti-inflammatory,
anticancer
antidepressant
qualities.
This
review
aims
describe
role
developing
food,
bioavailability
various
brain-related
diseases.
The
results
literature
strongly
support
importance
diseases
use
making
Aging and Disease,
Journal Year:
2022,
Volume and Issue:
13(4), P. 1146 - 1146
Published: Jan. 1, 2022
The
ketogenic
diet
(KD)
is
a
low-carbohydrate,
high-fat
and
adequate-protein
diet.
As
mimicking
fasting,
it
triggers
the
production
of
ketone
bodies
(KBs)
brings
body
into
state
ketosis.
Recent
accumulating
studies
on
humans
animal
models
have
shown
that
KD
beneficial
to
neurodegenerative
diseases
through
modulating
central
peripheral
metabolism,
mitochondrial
function,
inflammation,
oxidative
stress,
autophagy,
gut
microbiome.
Complicated
interplay
microbiome,
other
mechanisms
can
regulate
neuroinflammation
in
by
activating
multiple
molecular
cellular
pathways.
In
this
review,
we
detail
physiological
basis
KD,
its
functions
regulating
neuroinflammation,
protective
role
normal
brain
aging
diseases,
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS),
Huntington’s
(HD).
We
aimed
elucidate
underlying
neuroinflammatory
therapies
provide
novel
insights
their
application
for
prevention
treatment.
Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: July 28, 2022
Abstract
Parkinson's
disease
(PD)
is
the
second
most
predominant
neurodegenerative
worldwide.
It
recognized
clinically
by
severe
complications
in
motor
function
caused
progressive
degeneration
of
dopaminergic
neurons
(DAn)
and
dopamine
depletion.
As
current
standard
treatment
focused
on
alleviating
symptoms
through
Levodopa,
developing
neuroprotective
techniques
critical
for
adopting
a
more
pathology-oriented
therapeutic
approach.
Regenerative
cell
therapy
has
provided
us
with
an
unrivalled
platform
evaluating
potentially
effective
novel
methods
treating
illnesses
over
last
two
decades.
Mesenchymal
stem
cells
(MSCs)
are
promising,
as
they
can
differentiate
into
produce
neurotrophic
substances.
The
precise
process
which
repair
neuronal
injury
unknown,
MSC-derived
exosomes
suggested
to
be
responsible
significant
portion
such
effects.
present
review
discusses
application
mesenchymal
PD
treatment.
