Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(5), P. 820 - 820
Published: May 11, 2023
Cell
death
includes
programmed
and
nonprogrammed
cell
death.
The
former
mainly
ferroptosis,
necroptosis,
pyroptosis,
autophagy,
apoptosis,
while
the
latter
refers
to
necrosis.
Accumulating
evidence
shows
that
pyroptosis
play
essential
regulatory
roles
in
development
of
intestinal
diseases.
In
recent
years,
incidence
inflammatory
bowel
disease
(IBD),
colorectal
cancer
(CRC),
injury
induced
by
ischemia-reperfusion
(I/R),
sepsis,
radiation
have
gradually
increased,
posing
a
significant
threat
human
health.
advancement
targeted
therapies
for
diseases
based
on
provides
new
strategies
treating
Herein,
we
review
with
respect
regulation
highlight
underlying
molecular
mechanisms
potential
therapeutic
applications.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Journal Year:
2023,
Volume and Issue:
1870(2), P. 166984 - 166984
Published: Dec. 6, 2023
Oxidative
stress
and
intestinal
inflammation
are
main
pathological
features
of
ulcerative
colitis
(UC).
Ferroptosis,
characterized
by
iron
accumulation
lipid
peroxidation,
is
closely
related
to
the
pathologic
process
UC.
16S
rRNA
sequencing
for
microbiota
analysis
gas
chromatography-mass
spectrometry
(GC-MS)
short-chain
fatty
acid
(SCFA)
contents
clearly
demonstrated
lower
amounts
butyrate-producing
bacteria
butyrate
in
mice.
However,
precise
mechanisms
sodium
(NaB)
treating
UC
remain
largely
unclear.
We
found
that
ferroptosis
occurred
models,
as
evidenced
inflammatory
response,
intracellular
level,
mitochondria
ultrastructural
observations
associated
protein
expression.
NaB
inhibited
colitis,
significantly
rescued
weight
loss
colon
shortening
mice
reduced
lesions
mitochondrial
damage.
Furthermore,
improved
barrier
integrity
markedly
suppressed
expression
pro-ferroptosis
proteins.
Conversely,
anti-ferroptosis
markers
including
nuclear
factor
erythroid-related
Factor
2
(Nrf2)
glutathione
peroxidase
4
(GPX4),
was
upregulated
with
treatment.
Moreover,
knockdown
Nrf2
reversed
anti-colitis
effect
NaB.
Taken
together,
exhibited
a
protective
ameliorating
experimental
through
Nrf2/GPX4
signaling
improving
integrity,
which
provides
novel
mechanism
prevention
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 13, 2023
Ferroptosis
is
an
iron-dependent
programmed
cell
death
characterized
by
reactive
oxygen
species-induced
lipid
peroxidation
and
resultant
membrane
damage.
Recent
research
has
elucidated
the
mechanism
of
ferroptosis
investigated
relationship
between
various
diseases,
including
degenerative
cancer,
inflammation.
associated
with
inflammation-related
intestinal
diseases
such
as
colitis
colitis-associated
cancer.
New
insights
into
role
in
pathogenesis
gut
have
suggested
novel
therapeutic
targets.
In
this
review,
we
summarize
current
information
on
molecular
mechanisms
describe
its
emerging
potential
diseases.
International Journal of Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
51(6)
Published: May 16, 2023
Ferroptosis,
a
novel
form
of
regulated
cell
death,
is
characterized
by
the
accumulation
labile
iron
and
lipid
peroxidation,
excessive
production
reactive
oxygen
species
(ROS).
Although
ferroptosis
lies
at
center
crucial
biological
activities
involving
O2,
polyunsaturated
fatty
acids
(PUFAs),
which
are
essential
for
proliferation
growth,
interaction
between
these
molecules
could
also
mediate
toxic
levels
ROS
peroxides,
can
then
cause
damage
to
cellular
membranes
ultimately
result
in
death.
Recent
reports
have
indicated
that
participates
development
progression
inflammatory
bowel
disease
(IBD),
offering
new
exploratory
field
may
aid
more
in‑depth
understanding
pathogenesis
therapeutic
targets
IBD.
Of
note,
mitigation
characteristic
features
ferroptosis,
such
as
depleted
glutathione
(GSH)
levels,
inactivated
peroxidase
4
(GPX4),
elevated
peroxidation
overload
significantly
relieve
This
has
attracted
attention
researches
aiming
examine
agents
inhibit
IBD,
including
radical‑trapping
antioxidants,
enzyme
inhibitors,
chelators,
protein
degradation
stem
cell‑derived
exosomes
oral
N‑acetylcysteine
or
glutathione.
The
present
review
summarizes
discusses
current
data
implicate
IBD
its
inhibition
alternate
target
mechanisms
key
mediators
GSH/GPX4,
PUFAs,
organic
peroxides
discussed.
relatively
new,
regulation
exhibited
promising
outcomes
treatment
avenue
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(5), P. 820 - 820
Published: May 11, 2023
Cell
death
includes
programmed
and
nonprogrammed
cell
death.
The
former
mainly
ferroptosis,
necroptosis,
pyroptosis,
autophagy,
apoptosis,
while
the
latter
refers
to
necrosis.
Accumulating
evidence
shows
that
pyroptosis
play
essential
regulatory
roles
in
development
of
intestinal
diseases.
In
recent
years,
incidence
inflammatory
bowel
disease
(IBD),
colorectal
cancer
(CRC),
injury
induced
by
ischemia-reperfusion
(I/R),
sepsis,
radiation
have
gradually
increased,
posing
a
significant
threat
human
health.
advancement
targeted
therapies
for
diseases
based
on
provides
new
strategies
treating
Herein,
we
review
with
respect
regulation
highlight
underlying
molecular
mechanisms
potential
therapeutic
applications.
