Journal of Dairy Science, Journal Year: 2024, Volume and Issue: 108(3), P. 2182 - 2198
Published: Dec. 7, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116722 - 116722
Published: May 9, 2024
Ulcerative colitis (UC) is a complex immune-mediated chronic inflammatory bowel disease. It mainly characterized by diffuse inflammation of the colonic and rectal mucosa with barrier function impairment. Identifying new biomarkers for development more effective UC therapies remains pressing task current research. Ferroptosis newly identified form regulated cell death iron-dependent lipid peroxidation. As research deepens, ferroptosis has been demonstrated to be involved in pathological processes numerous diseases. A growing body evidence suggests that pathogenesis associated ferroptosis, regulation provides opportunities treatment. However, specific mechanisms which participates remain fully thoroughly investigated. Therefore, this review, we focus on advances mechanism recent years describe potential role UC. In addition, explore underlying crosslinked pathway between other such as macrophages, neutrophils, autophagy, endoplasmic reticulum stress, gut microbiota Finally, also summarize compounds may act inhibitors future.
Language: Английский
Citations
17
Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2961 - 2986
Published: Aug. 10, 2024
Language: Английский
Citations
15
MedComm, Journal Year: 2024, Volume and Issue: 5(12)
Published: Nov. 20, 2024
Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.
Language: Английский
Citations
9
Foods, Journal Year: 2025, Volume and Issue: 14(1), P. 137 - 137
Published: Jan. 6, 2025
Background: Ulcerative colitis (UC) is a chronic intestinal disease of growing global concern. Bacteria associated with fermented food or probiotics regulate immune and inflammatory responses, playing key role in homeostasis. Results: Five relatively good antioxidant effects, namely Lactiplantibacillus plantarum H6, Latilactobacillus sakei QC9, Limosilactobacillus fermentum E7, Bacillus subtills D1, licheniformis Q13, were screened out from 30 strains through vitro assays. The five had varying degrees alleviating effects on UC mice improved various physiological indicators, such as oxidative stress parameters histopathological sections. Q13 more pronounced. Furthermore, E7 effectively regulated mouse microbiota composition, increased short-chain fatty acid concentration, promoted the expression anti-inflammatory factors, interleukin 10 (IL-10), while suppressing that pro-inflammatory 1β (IL-1β), 6 (IL-6), tumor necrosis factor α (TNF-α). Meanwhile, D1 only exhibited partial effects. Finally, tight junction proteins colon tissues. Conclusions: showed superior efficacy to other UC, offering novel therapeutic prospects for safer effective management UC.
Language: Английский
Citations
1
Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103303 - 103303
Published: Aug. 8, 2024
The notable decline in the number of Tregs within Necrotizing enterocolitis (NEC) intestinal tissues,contribute to excessive inflammation and necrosis, yet precise underlying factors remain enigmatic. Ferroptosis, a novel cell death stemming from disrupted lipid redox metabolism, is focus this investigation. Specifically, study delves into ferroptosis Treg cells context NEC observes protective effects exerted by vitamin E intervention, which aims mitigate cells. To investigate reduction intestine, we analyzed its association with multiple angles. We constructed mouse specific knockout Gpx4 cells, aiming examine impact on injury localized inflammation. Ultimately, employed treatment intestine's monitoring subsequent amelioration inflammatory damage. diminution attributed diminished GPX4 expression. Gpx4-deficient exhibit impaired immunosuppressive function are susceptible ferroptosis. This exacerbates damage response NEC. Notably, Vitamin can inhibit subsequently alleviating Additionally, bolsters anti-lipid peroxidation capability upregulating expression GPX4. In NEC, represents significant factor contributing tissue an exaggerated response. pivotal for viability functionality exhibits thereby enhancing their function, plays crucial role mitigating
Language: Английский
Citations
8
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: May 15, 2024
Abstract Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients energy the host, but also plays crucial role immune modulation balance. In this review, we explore pathways associated with impact on host metabolism. We subsequently summarize recent studies influence regulation by discuss potential mechanisms through which affects ferroptosis. Additionally, conduct bibliometric analysis relationship between context chronic kidney disease. This can provide new insights into current research status future microbiota.
Language: Английский
Citations
7
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: June 4, 2024
Ulcerative colitis (UC), a subtype of inflammatory bowel disease, manifests with symptoms such as abdominal pain, diarrhea, and mucopurulent, bloody stools. The pathogenesis UC is not fully understood. At present, the incidence has increased significantly around world. Conventional therapeutic arsenals are relatively limited, often poor efficacy many adverse effects. In contrast, traditional Chinese medicine (TCM) holds promise due to their notable effectiveness, reduced recurrence rates, minimal side recent years, significant progress been made in basic research on TCM for treatment. It found that inhibition ferroptosis through intervention can promote intestinal mucosal healing reverse UC. mechanism action involves multiple targets pathways. Aim review This summarizes experimental studies targeted regulation by its impact aiming provide theoretical basis prevention, treatment, further drug development Results Ferroptosis disrupts antioxidant mechanisms epithelial cells, damages mucosa, participates pathological process acts various pathways Nrf2 / HO-1 GSH/GPX4, blocking progression inhibiting damage thereby alleviating Conclusion diverse array single herbs, extracts herbal formulas facilitates selective innovative new methods targeting Although studying compound formulas, extracts, there still issues clinical designs, necessitating in-depth scientific exploration research.
Language: Английский
Citations
4
Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11
Published: July 22, 2024
Weaning is an important period in the growth and development of lambs. Thus, effectively reducing occurrence weaning stress critical for maintaining lamb production. Coated sodium butyrate has been shown to reduce inflammation, promote intestinal health, maintain homeostasis. However, application potential mechanism coated alleviating lambs are still unclear. To evaluate effects on performance, antioxidant capacity, gut microbiota weaned lambs, 10 21-day-old were randomly divided into two groups: CON group (basal diet) NaB diet +3 g/kg butyrate). The trial lasted 21 days. experimental results showed that compared group, supplementation significantly increased average daily weight gain feed intake ( p < 0.05). In addition, addition also decreased serum MDA level Notably, did not have a significant effect cecal microbiota, while increasing diversity colonic promoting abundance Lachnospiraceae , Verrucomicrobiota Akkermansia Roseburia Sinobacteraceae which associated with nutrient absorption These indicate dietary could capacity alleviate stress.
Language: Английский
Citations
4
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(9)
Published: Sept. 19, 2024
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Large-scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, higher abundance of III secretion system (T3SS) virulence factors Enterobacteriaceae/Escherichia-Shigella in patients with T2DM-related-ASCVD, which correlates their stenosis is reported. Overexpression T3SS via Citrobacter rodentium (CR) infection Apoe-/- T2DM mice exacerbated lesion formation increased permeability. Non-targeted metabolomic proteomic analysis mouse serum showed that caused abnormal glycerophospholipid metabolism mice. Proteomics, RNA sequencing, functional analyses induced ferroptosis intestinal epithelial cells, partly due to expression ferritin heavy chains (FTH1). This findings first demonstrated increases disrupting barrier upregulation phosphatidylcholine, thereby exacerbating T2DM-related ASCVD.
Language: Английский
Citations
0