Journal of Molecular Structure, Journal Year: 2021, Volume and Issue: 1230, P. 129928 - 129928
Published: Jan. 12, 2021
Language: Английский
Molecules, Journal Year: 2021, Volume and Issue: 26(6), P. 1770 - 1770
Published: March 22, 2021
Gums are carbohydrate biomolecules that have the potential to bind water and form gels. regularly linked with proteins minerals in their construction. several forms, such as mucilage gums, seed exudate etc. Plant gums one of most important because bioavailability. Plant-derived been used by humans since ancient times for numerous applications. The main features make them appropriate use different applications high stabilization, viscosity, adhesive property, emulsification action, surface-active activity. In many pharmaceutical formulations, plant-based mucilages key ingredients due bioavailability, widespread accessibility, non-toxicity, reasonable prices. These compete polymeric materials pharmaceuticals today’s time created a significant achievement from being an excipient innovative drug carriers. particular, scientists pharmacy industries around world drawn uncover secret through deeper understanding physicochemical characteristics development safety profile information. This unique class products, useful advanced delivery applications, gene therapy, biosynthesis, has developed modification mucilages. this review, both fundamental novel medicinal aspects mucilages, along capacity pharmacology nanomedicine, were demonstrated.
Language: Английский
Citations
155
Marine Drugs, Journal Year: 2022, Volume and Issue: 20(7), P. 460 - 460
Published: July 17, 2022
Chitin and its derivative chitosan are highly abundant polymers in nature, appearing both the shells exoskeletons of various marine non-marine species. Since they possess favorable properties, such as biocompatibility, biodegradability, non-toxicity, non-immunogenicity, have gained recent attention due to their enormous potential biomedical applications. The polycationic surface enables it form hydrogenic ionic bonds with drug molecules, which is one most useful properties. Because biocompatible, can therefore be used delivery systems. development chitosan-based nanoparticles has also contributed significance chitin a system that deliver drugs topically. Furthermore, cancer treatment vehicle for delivering specific site an antiproliferative effect by reducing viability cells. Finally, wound dressing order promote faster regeneration skin epithelial cells collagen production fibroblasts. As discussed this review, diverse applications medical field. Recognizing these two essential future research tissue engineering nanobiotechnology.
Language: Английский
Citations
140
International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 3735 - 3749
Published: Aug. 1, 2022
Abstract: Cancer remains the most devastating disease and major cause of mortality worldwide. Although early diagnosis treatment are key approach in fighting against cancer, available conventional diagnostic therapeutic methods not efficient. Besides, ineffective cancer cell selectivity toxicity traditional chemotherapy remain significant challenge. These limitations entail need for development both safe effective options. Due to its robust application, nanotechnology could be a promising method in-vivo imaging detection cells biomarkers. Nanotechnology provide quick, safe, cost-effective, efficient management. It also provides simultaneous using nano-theragnostic particles that facilitate selective destruction cells. Updated recent discussions important selecting best diagnosis, treatment, management options, new insights on designing protocols utmost important. This review discusses application therapeutics, theragnosis future perspectives field. Keywords: nanotechnology, theragnostics
Language: Английский
Citations
107
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Jan. 10, 2022
Abstract Surface charge of biological and medical nanocarriers has been demonstrated to play an important role in cellular uptake. Owing the unique physicochemical properties, charge-reversal delivery strategy rapidly developed as a promising approach for drug application, especially cancer treatment. Charge-reversal are neutral/negatively charged at physiological conditions while could be triggered positively by specific stimuli (i.e., pH, redox, ROS, enzyme, light or temperature) achieve prolonged blood circulation enhanced tumor uptake, thus potentiate antitumor effects delivered therapeutic agents. In this review, we comprehensively summarized recent advances nanocarriers, including: (i) effect surface on uptake; (ii) charge-conversion mechanisms responding several stimuli; (iii) relation between chemical structure reversal activity; (iv) polymeric materials that commonly applied systems. Graphical
Language: Английский
Citations
96
Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Jan. 31, 2022
Abstract Targeted cancer therapy has become one of the most important medical methods because spreading and metastatic nature cancer. Based on introduction AS1411 its four-chain structure, this paper reviews research progress in detection drug delivery systems by modifying aptamers based graphene, mesoporous silica, silver gold. The application treatment use as a targeting agent for markers such nucleoli were summarized from three aspects active targeting, passive targeted nucleic acid apharmers. Although been withdrawn clinical trials, surrounding structural optimization is still very popular. Further made modification nanoparticles loaded with TCM extracts AS1411. Graphical
Language: Английский
Citations
72
3 Biotech, Journal Year: 2022, Volume and Issue: 12(3)
Published: Feb. 9, 2022
Language: Английский
Citations
71
Process Biochemistry, Journal Year: 2023, Volume and Issue: 127, P. 82 - 91
Published: Feb. 10, 2023
Language: Английский
Citations
42
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105599 - 105599
Published: March 26, 2024
Despite considerable progress in patient care, the global incidence of various cancer types continues to rise. Developing safer and more efficient anti-cancer treatment approaches are great interest. In recent decades, nanotechnology has emerged as a promising innovative medical approach for diagnosis treatment. However, nanomedicine advances, it is important understand address challenges. Herein, we identify gaps current understanding effectiveness on clinical outcomes provide an outlook improved application medicine. We discuss use different nanoparticles therapy impact efficiency existing treatments, such chemotherapeutic, anti-angiogenic, immunotherapeutic drugs, radiotherapy. Additionally, update status trials nanoparticle-based treatments provided.
Language: Английский
Citations
21
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14
Published: Jan. 8, 2025
Gynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. These pose a significant threat to women's health, impacting life expectancy, quality of life, and fertility. Nanoparticles, with their small size, large surface area, high permeability, have become key focus in targeted cancer therapy. The aim this study is review recent advancements nanoparticles applied gynecologic cancers, providing valuable insights for future research. We retrieved all literature on from Web Science Core Collection (WOSCC) database between January 1, 2004, June 4, 2024. Data analysis visualization were conducted using R software (version 4.4.0), VOSviewer 1.6.19.0), CiteSpace 6.1). A total 2,843 publications 2024 searched. Over past 20 years, there has been increase publications. leading countries institutions terms productivity China Chinese Academy Sciences. most prolific author co-cited Sood, K Siegel, Rl. top journals International Journal Nanomedicine (n=97), followed ACS Applied Materials & Interfaces (n=72) Chemistry B (n=53). Keyword shows current research focuses two main areas: application drug delivery broader applications cancers. Future will likely "silver nanoparticles," "gold "green synthesis." decades, rapidly advanced field Research primarily focused applications. trends point toward optimizing synthesis techniques advancing preclinical studies clinical applications, particularly silver gold nanoparticles. findings provide scientific researchers.
Language: Английский
Citations
2
Cancers, Journal Year: 2021, Volume and Issue: 13(9), P. 2214 - 2214
Published: May 5, 2021
Bladder cancer (BC) is the second most common of urinary tract in men and fourth women, its incidence rises with age. There are many conventional methods for diagnosis treatment BC. some current biomarkers clinical tests For example, radiotherapy combined chemotherapy surgical, but residual tumor cells mostly cause recurrence. In addition, after transurethral resection causes high side effects, lack selectivity, low sensitivity sensing. Therefore, it essential to improve new procedures Nanotechnology has recently sparked an interest a variety areas, including medicine, chemistry, physics, biology. Nanoparticles (NP) have been used therapies as appropriate tools enhancing drug delivery efficacy enabling therapeutic performance. It noteworthy, nanomaterial could be reduced limitation treatments. Since, major disadvantages drugs their insolubility aqueous solvent, instance, paclitaxel (PTX) one important agents utilized treating BC, due ability prevent cell growth. However, problem poor solubility, which confirmed challenge when improving stable formulations BC treatment. order reduce this challenge, anti-cancer can loaded into NPs that water solubility. our review, we state several nanosystem, effective useful diagnosis, We investigate function metal NPs, polymeric liposomes, exosomes accompanied Therapy, then focused on potential nanotechnology approaches
Language: Английский
Citations
79