International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7415 - 7471
Published: July 1, 2024
Abstract:
Cancer,
as
the
foremost
challenge
among
human
diseases,
has
plagued
medical
professionals
for
many
years.
While
there
have
been
numerous
treatment
approaches
in
clinical
practice,
they
often
cause
additional
harm
to
patients.
The
emergence
of
nanotechnology
brought
new
directions
cancer
treatment,
which
can
deliver
anticancer
drugs
specifically
tumor
areas.
This
article
first
introduces
application
scenarios
nanotherapies
and
strategies
nanomedicine.
Then,
noteworthy
characteristics
exhibited
by
biopolymer
materials
were
described,
make
biopolymers
stand
out
polymeric
nanomedicine
delivery.
Next,
we
focus
on
summarizing
state-of-art
studies
five
categories
proteins
(Albumin,
Gelatin,
Silk
fibroin,
Zein,
Ferritin),
nine
varieties
polysaccharides
(Chitosan,
Starch,
Hyaluronic
acid,
Dextran,
cellulose,
Fucoidan,
Carrageenan,
Lignin,
Pectin)
liposomes
field
drug
Finally,
also
provide
a
summary
advantages
limitations
these
biopolymers,
discuss
prevailing
impediments
their
application,
detail
prospective
research
directions.
review
not
only
helps
readers
understand
current
development
status
nano
delivery
systems
based
but
is
helpful
properties
various
find
suitable
solutions
this
through
comparative
reading.
Keywords:
delivery,
nanoformulations,
polymer,
proteins,
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(22)
Published: June 2, 2022
Abstract
Tumor
immunotherapy
is
only
effective
in
a
fraction
of
patients
due
to
low
response
rate
and
severe
side
effects,
these
challenges
clinics
can
be
addressed
through
induction
immunogenic
cell
death
(ICD).
ICD
elicited
from
many
antitumor
therapies
release
danger
associated
molecular
patterns
(DAMPs)
tumor‐associated
antigens
facilitate
maturation
dendritic
cells
(DCs)
infiltration
cytotoxic
T
lymphocytes
(CTLs).
The
process
reverse
the
tumor
immunosuppressive
microenvironment
improve
sensitivity
immunotherapy.
Nanostructure‐based
drug
delivery
systems
(NDDSs)
are
explored
induce
by
incorporating
therapeutic
molecules
for
chemotherapy,
photosensitizers
(PSs)
photodynamic
therapy
(PDT),
photothermal
conversion
agents
(PTT),
radiosensitizers
radiotherapy
(RT).
These
NDDSs
loaded
at
right
dose
place
time,
resulting
greater
effectiveness
lower
toxicity.
Immunotherapeutic
also
combined
with
achieve
synergic
effect
multi‐modality
approach.
In
this
review,
harnessed
load
multiple
PDT,
PTT,
RT
combination
promote
reduce
effects
cancer
treatment.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(8), P. 6314 - 6332
Published: Feb. 12, 2024
Immune
checkpoint
blockade
(ICB)
therapy
still
suffers
from
insufficient
immune
response
and
adverse
effect
of
ICB
antibodies.
Chemodynamic
(CDT)
has
been
demonstrated
to
be
an
effective
way
synergize
with
therapy.
However,
a
low
generation
rate
reactive
oxygen
species
poor
tumor
penetration
CDT
platforms
decline
the
effects.
Herein,
charge-reversal
nanohybrid
Met@BF
containing
both
Fe3O4
BaTiO3
nanoparticles
in
core
Metformin
(Met)
on
surface
was
fabricated
for
microenvironment
(TME)-
ultrasound
(US)-activated
piezocatalysis-chemodynamic
immunotherapy
cancer.
Interestingly,
had
negative
charge
blood
circulation,
which
rapidly
changed
into
positive
when
exposed
acidic
TME
attributed
quaternization
tertiary
amine
Met,
facilitating
deep
penetration.
Subsequently,
US
irradiation,
produced
H2O2
based
piezocatalysis
BaTiO3,
greatly
enhanced
Fenton
reaction
Fe3O4,
thus
boosting
robust
antitumor
response.
Furthermore,
PD-L1
expression
inhibited
by
local
released
Met
further
augment
effect,
achieving
inhibitions
primary
metastatic
tumors.
Such
combination
piezocatalysis-enhanced
chemodynamic
Met-mediated
downregulation
provides
promising
strategy
cancer
immunotherapy.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(6), P. 1966 - 2006
Published: Jan. 1, 2024
Neoplasias
pose
a
significant
threat
to
aging
society,
underscoring
the
urgent
need
overcome
limitations
of
traditional
chemotherapy
through
pioneering
strategies.
Targeted
drug
delivery
is
an
evolving
frontier
in
cancer
therapy,
aiming
enhance
treatment
efficacy
while
mitigating
undesirable
side
effects.
One
promising
avenue
utilizes
cell
membrane
receptors
like
folate
receptor
guide
transporters
precisely
malignant
cells.
Based
on
cellular
as
hallmark,
targeted
nanocarriers
and
small
molecule-drug
conjugates
have
been
developed
that
comprise
different
(bio)
chemistries
and/or
mechanical
properties
with
individual
advantages
challenges.
Such
modern
folic
acid-conjugated
stimuli-responsive
provide
systemic
controlled
release,
enabling
reduced
dosages,
circumvention
resistance,
diminished
adverse
Since
transporters'
structure-based
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(1), P. 187 - 187
Published: Jan. 15, 2024
In
recent
years,
the
field
of
drug
delivery
has
witnessed
remarkable
progress,
driven
by
quest
for
more
effective
and
precise
therapeutic
interventions.
Among
myriad
strategies
employed,
integration
aptamers
as
targeting
moieties
stimuli-responsive
systems
emerged
a
promising
avenue,
particularly
in
context
anticancer
therapy.
This
review
explores
cutting-edge
advancements
targeted
drug-delivery
systems,
focusing
on
platforms
enhanced
spatial
aptamer-based
we
delve
into
versatile
applications
aptamers,
examining
their
conjugation
with
gold,
silica,
carbon
materials.
The
synergistic
interplay
between
these
materials
is
discussed,
emphasizing
potential
achieving
delivery.
Additionally,
explore
an
emphasis
Tumor
microenvironment-responsive
nanoparticles
are
elucidated,
capacity
to
exploit
dynamic
conditions
within
cancerous
tissues
controlled
release
detailed.
External
strategies,
including
ultrasound-mediated,
photo-responsive,
magnetic-guided
examined
role
effects.
integrates
diverse
approaches
precision
medicine,
showcasing
revolutionize
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 651 - 671
Published: Jan. 1, 2024
Background:
Polyvinyl
alcohol/Chitosan
hydrogel
is
often
employed
as
a
carrier
because
it
non-toxic,
biodegradable,
and
has
three-dimensional
network
structure.
Meanwhile,
Magnesium-doped
nano-hydroxyapatite(Mg-nHA)
demonstrated
high
characterization
to
promote
the
osteogenic
differentiation
of
bone
marrow
derived
mesenchymal
stem
cell(BMSCs).
Therefore,
in
order
develop
porous
scaffold
for
application
tissue
engineering,
an
appropriate-type
Mg-nHA
was
developed
evaluated.
Methods:
A
composite
containing
magnesium-doped
nano-hydroxyapatite
(Mg-nHA/PVA/CS)
using
magnetic
stirring-ion
exchange
method
cyclic
freeze-thaw
design,
with
polyvinyl
alcohol
chitosan
main
components.
Fourier
transform
infrared
spectra
(FTIR),
electron
energy
dispersive
spectroscopy
(EDS),
X-ray
photoelectron
spectrometer
(XPS)
scanning
microscopy
(SEM)
were
analyze
chemical
structure,
porosity,
elemental
composition
each
hydrogels.
The
equilibrium
swelling
degree,
moisture
content,
pH
change,
potential
biomineralization,
biocompatibility,
magnesium
ion
release
rate
also
Results:
SEM
analysis
revealed
well-defined
3D
spatial
structure
micropores
synthesised
hydrogel.
FTIR
showed
that
doping
nanoparticles
had
little
effect
on
hydrogel's
both
5%
Mg-nHA/PVA/CS
10%
groups
promoted
amide
bond
formation.
EDS
observation
indicated
new
material
exhibited
favourable
biomineralization
ability,
optimal
performance
seen
group.
not
only
displayed
water
enhanced
porosity
(similar
human
cancellous
bone),
but
maintained
degree
released
ions
created
alkaline
environment
around
it.
Additionally,
facilitated
proliferation
cells
their
differentiation.
Conclusion:
demonstrates
significant
field
repair,
making
excellent
engineering.
Keywords:
nano-hydroxyapatite,
alcohol,
chitosan,
hydrogel,
physical
crosslinking
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(24)
Published: March 12, 2023
Abstract
Metal‐organic
frameworks
(MOFs)
featuring
good
biocompatibility
and
tunable
microstructures
are
developed
to
generate
reactive
oxygen
species
(ROS)
for
nanocatalytic
therapy.
However,
the
relatively
low
catalytic
activity
of
MOF
intracellular
ion
homeostasis,
a
self‐protective
mechanism
resist
accumulation
metal
ions,
results
in
undesirable
efficacy
tumor
Herein,
therapeutic
strategy
is
introduced
breaking
iron
homeostasis
therapy
synergy
with
autophagy
amplification‐promoted
ferroptosis,
based
on
etched
nanocatalyst
(denoted
COS@MOF),
which
self‐etched
by
thiamine
pyrophosphate
(TPP)
further
modified
agonist
chitosan
oligosaccharides
(COS).
Such
exhibit
an
open
cavity
structure
that
more
conducive
adsorbing
molecules
producing
active
sites,
enhanced
Fe(II)/Fe(III)
ratio,
reinforcing
ROS
generation.
The
process
COS@MOF
can
be
accelerated
overexpressed
endogenous
hydrogen
sulfide
(H
2
S)
within
colorectal
tumors
reduces
Fe
3+
into
2+
.
In
vitro
vivo
demonstrate
amplifies
break
facilitating
production
promote
achieving
synergetic
nanocatalytic/ferroptosis
This
study
provides
promising
paradigm
elevate
MOF‐based
performance
ferroptosis
efficacy.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2216 - 2216
Published: Aug. 27, 2023
Polymer–drug
conjugates
(PDCs)
have
shown
great
promise
in
enhancing
the
efficacy
and
safety
of
cancer
therapy.
These
combine
advantageous
properties
both
polymers
drugs,
leading
to
improved
pharmacokinetics,
controlled
drug
release,
targeted
delivery
tumor
tissues.
This
review
provides
a
comprehensive
overview
recent
developments
PDCs
for
First,
various
types
used
these
are
discussed,
including
synthetic
polymers,
such
as
poly(↋-caprolactone)
(PCL),
D-α-tocopheryl
polyethylene
glycol
(TPGS),
(PEG),
well
natural
hyaluronic
acid
(HA).
The
choice
polymer
is
crucial
achieving
desired
properties,
stability,
biocompatibility,
release.
Subsequently,
strategies
conjugating
drugs
explored,
covalent
bonding,
which
enables
stable
linkage
between
drug,
ensuring
release
minimizing
premature
use
can
extend
circulation
time
facilitating
enhanced
accumulation
within
tissues
through
permeability
retention
(EPR)
effect.
This,
turn,
results
reduced
systemic
toxicity.
Moreover,
importance
tumor-targeting
ligands
highlighted.
Various
ligands,
antibodies,
peptides,
aptamers,
folic
acid,
herceptin,
HA,
be
incorporated
into
selectively
deliver
cells,
reducing
off-target
effects
improving
therapeutic
outcomes.
In
conclusion,
emerged
versatile
effective
approach
Their
ability
advantages
offers
delivery,
treatment,
thereby
overall
therapies.
Further
research
development
this
field
has
potential
advance
personalized
treatment
options.
